PEDEMONTE, NICOLETTA
PEDEMONTE, NICOLETTA
A Novel LC-MS/MS Method for the Measurement of Elexacaftor, Tezacaftor and Ivacaftor in Plasma, Dried Plasma Spot (DPS) and Whole Blood in Volumetric Absorptive Microsampling (VAMS) Devices
2025-01-01 Pigliasco, F.; Cafaro, A.; Barco, S.; Cresta, F.; Casciaro, R.; Pedemonte, N.; Mattioli, F.; Castellani, C.; Cangemi, G.
Alternative splicing and residual function potentially expand the therapeutic landscape of the CFTRdele2ins182 variant
2025-01-01 Pastorino, Cristina; Menta, Ludovica; Pesce, Emanuela; Lena, Mariateresa; Tomati, Valeria; Capurro, Valeria; Di Duca, Marco; Terlizzi, Vito; Gramegna, Andrea; Blasi, Francesco; Castellani, Carlo; Cappato, Serena; Zara, Federico; Pedemonte, Nicoletta; Bocciardi, Renata
Beyond Trikafta: new models to assess tissue dependent rescue of N1303K-CFTR
2025-01-01 Pranke, Iwona; Capurro, Valeria; Chevalier, Benoit; Pesce, Emanuela; Tomati, Valeria; Pastorino, Cristina; Kelly-Aubert, Mairead; Hatton, Aurelie; Dreano, Elise; Lena, Mariateresa; Bocciardi, Renata; Zara, Federico; Pantano, Stefano; Terlizzi, Vito; Lucanto, Cristina; Costa, Stefano; Claut, Laura; Daccò, Valeria; Poli, Piercarlo; Maschio, Massimo; Fabrizzi, Benedetta; Caporelli, Nicole; Cipolli, Marco; Volpi, Sonia; Chedevergne, Frederique; Cosson, Laure; Macey, Julie; Ramel, Sophie; Weiss, Laurence; Grenet, Dominique; Le Clainche-Viala, Laurence; Douvry, Benoit; Ravoninjatovo, Bruno; Audousset, Camille; Tatopoulos, Aurélie; Richaud-Thiriez, Bénédicte; Baravalle, Melissa; Thouvenin, Guillaume; Labbé, Guillaume; Mittaine, Marie; Reix, Philippe; Durieu, Isabelle; Mankikian, Julie; Bui, Stéphanie; Nguyen-Khoa, Thao; Khoukh, Karim; Martin, Clémence; Da Silva, Jennifer; De Carli, Paola; Castellani, Carlo; Cresta, Federico; Galietta, Luis; Guillemaut, Anne; Girodon, Emmanuelle; Remus, Natacha; Bulcaen, Mathis; Ensinck, Marjolein; Zajac, Miroslaw; Carlon, Marianne; Lebihan, Jean; Burgel, Pierre-Régis; Sermet-Gaudelus, Isabelle; Hinzpeter, Alexandre; Pedemonte, Nicoletta
Clinical Consequences and Functional Impact of the Rare S737F CFTR Variant and Its Responsiveness to CFTR Modulators
2023-01-01 Terlizzi, V.; Pesce, E.; Capurro, V.; Tomati, V.; Lena, M.; Pastorino, C.; Bocciardi, R.; Zara, F.; Centrone, C.; Taccetti, G.; Castellani, C.; Pedemonte, N.
Comprehensive analysis of combinatorial pharmacological treatments to correct nonsense mutations in the cftr gene
2021-01-01 Venturini, A.; Borrelli, A.; Musante, I.; Scudieri, P.; Capurro, V.; Renda, M.; Pedemonte, N.; Galietta, L. J. V.
Cyclic diacyl thioureas enhance activity of corrector Lumacaftor on F508del‐CFTR
2024-01-01 Spallarossa, Andrea; Pedemonte, Nicoletta; Pesce, Emanuela; Millo, Enrico; Cichero, Elena; Rosano, Camillo; Lusardi, Matteo; Iervasi, Erika; Ponassi, Marco
De novo variants in DENND5B cause a neurodevelopmental disorder
2024-01-01 Scala, Marcello; Tomati, Valeria; Ferla, Matteo; Lena, Mariateresa; Cohen, Julie S; Fatemi, Ali; Brokamp, Elly; Bican, Anna; Phillips, John A; Koziura, Mary E; Nicouleau, Michael; Rio, Marlene; Siquier, Karine; Boddaert, Nathalie; Musante, Ilaria; Tamburro, Serena; Baldassari, Simona; Iacomino, Michele; Scudieri, Paolo; Rosenfeld, Jill A; Bellus, Gary; Reed, Sara; Al Saif, Hind; Russo, Rossana Sanchez; Walsh, Matthew B; Cantagrel, Vincent; Crunk, Amy; Gustincich, Stefano; Ruggiero, Sarah M; Fitzgerald, Mark P; Helbig, Ingo; Striano, Pasquale; Severino, Mariasavina; Salpietro, Vincenzo; Pedemonte, Nicoletta; Zara, Federico
Genotype-phenotype correlations and disease mechanisms in PEX13-related Zellweger spectrum disorders
2022-01-01 Borgia, Paola; Baldassari, Simona; Pedemonte, Nicoletta; Alkhunaizi, Ebba; D'Onofrio, Gianluca; Tortora, Domenico; Calì, Elisa; Scudieri, Paolo; Balagura, Ganna; Musante, Ilaria; Diana, Maria Cristina; Pedemonte, Marina; Vari, Maria Stella; Iacomino, Michele; Riva, Antonella; Chimenz, Roberto; Mangano, Giuseppe D; Mohammadi, Mohammad Hasan; Toosi, Mehran Beiraghi; Ashrafzadeh, Farah; Imannezhad, Shima; Karimiani, Ehsan Ghayoor; Accogli, Andrea; Schiaffino, Maria Cristina; Maghnie, Mohamad; Soler, Miguel Angel; Echiverri, Karl; Abrams, Charles K; Striano, Pasquale; Fortuna, Sara; Maroofian, Reza; Houlden, Henry; Zara, Federico; Fiorillo, Chiara; Salpietro, Vincenzo
Interplay between ALK2R206H mutant receptor and autophagy signaling regulates receptor stability and its chondrogenic functions
2025-01-01 Coculo, Laura; Wits, Marius; Mariani, Irene; Fianco, Giulia; Cappato, Serena; Bocciardi, Renata; Pedemonte, Nicoletta; Volpe, Elisabetta; Ciolfi, Serena; Sessa, Rosario Luigi; Rinaldo, Serena; Cutruzzolà, Francesca; Trisciuoglio, Daniela; Goumans, Marie-Josè; Sanchez-Duffhues, Gonzalo; Stagni, Venturina
Journey on VX-809-Based Hybrid Derivatives towards Drug-like F508del-CFTR Correctors: From Molecular Modeling to Chemical Synthesis and Biological Assays
2022-01-01 Parodi, Alice; Righetti, Giada; Pesce, Emanuela; Salis, Annalisa; Tomati, Valeria; Pastorino, Cristina; Tasso, Bruno; Benvenuti, Mirko; Damonte, Gianluca; Pedemonte, Nicoletta; Cichero, Elena; Millo, Enrico
LEAD OPTIMIZATION OF MKT-077 ANALOGUES AS HSP70 ALLOSTERIC INHIBITORS COMBINED WITH F508DEL CFTR CORRECTORS: A MULTI DRUG APPROACH TO CONTRAST CYSTIC FIBROSIS
2024-01-01 Lunaccio, Dario; Garrone, Irene; Pesce, Emanuela; Caushi, Bujar; Salis, Annalisa; Pedemonte, Nicoletta; Sturla, Laura; Bruzzone, Santina; Cichero, Elena; Millo, Enrico
Neutrophil Extracellular Traps in Systemic Lupus Erythematosus Stimulate IgG2 Production From B Lymphocytes
2021-01-01 Bertelli, R.; Schena, F.; Antonini, F.; Reverberi, D.; Signa, S.; Pedemonte, N.; Consolaro, A.; Gattorno, M.; Negrini, S.; Pupo, F.; Volpi, S.; Ghiggeri, G. M.
Partial rescue of f508del-cftr stability and trafficking defects by double corrector treatment
2021-01-01 Capurro, V.; Tomati, V.; Sondo, E.; Renda, M.; Borrelli, A.; Pastorino, C.; Guidone, D.; Venturini, A.; Giraudo, A.; Bertozzi, S. M.; Musante, I.; Bertozzi, F.; Bandiera, T.; Zara, F.; Galietta, L. J. V.; Pedemonte, N.
Patient's dermal fibroblasts as disease markers for visceral myopathy
2023-01-01 Viti, Federica; Pramotton, Francesca Micaela; Martufi, Michela; Magrassi, Raffaella; Pedemonte, Nicoletta; Nizzari, Mario; Zanacchi, Francesca Cella; De Michele, Benedetta; Alampi, Manuela; Zambito, Martina; Santamaria, Giuseppe; Bajetto, Adriana; Sardar, Sabah; Tomati, Valeria; Gandullia, Paolo; Giampietro, Costanza; Florio, Tullio; Beltrame, Francesco; Vassalli, Massimo; Ceccherini, Isabella
Probing Allosteric Hsp70 Inhibitors by Molecular Modelling Studies to Expedite the Development of Novel Combined F508del CFTR Modulators
2021-01-01 Sabbadini, Roberto; Pesce, Emanuela; Parodi, Alice; Mustorgi, Eleonora; Bruzzone, Santina; Pedemonte, Nicoletta; Casale, Monica; Millo, Enrico; Cichero, Elena
Quantification of Ivacaftor, Tezacaftor and Elexacaftor in plasma of cystic fibrosis patients treated with Kaftrio by a validated liquid chromatography-tandem mass spectrometric (LC-MS/MS) method”
2022-01-01 Cafaro, A.; Pigliasco, F.; Barco, S.; Stella, M.; Pedemonte, N.; Cresta, F.; Casciaro, R.; Castellani, C.; Cangemi, G.; Mattioli, F.
QUANTIFICATION OF IVACAFTOR, TEZACAFTOR, AND ELEXACAFTOR IN PLASMA OF CYSTIC FIBROSIS PATIENTS BY AN HPLC–MS/MS METHOD
2023-01-01 Pigliasco, F.; Cafaro, A.; Stella, M.; Baiardi, G.; Barco, S.; Pedemonte, N.; D'Orsi, C.; Cresta, F.; Casciaro, R.; Castellani, C.; Calevo, M. G.; Cangemi, G.; Mattioli, F.
Rescue by elexacaftor-tezacaftor-ivacaftor of the G1244E cystic fibrosis mutation's stability and gating defects are dependent on cell background
2023-01-01 Tomati, Valeria; Costa, Stefano; Capurro, Valeria; Pesce, Emanuela; Pastorino, Cristina; Lena, Mariateresa; Sondo, Elvira; Di Duca, Marco; Cresta, Federico; Cristadoro, Simona; Zara, Federico; Galietta, Luis J V; Bocciardi, Renata; Castellani, Carlo; Lucanto, Maria Cristina; Pedemonte, Nicoletta
Simultaneous Quantification of Ivacaftor, Tezacaftor, and Elexacaftor in Cystic Fibrosis Patients’ Plasma by a Novel LC–MS/MS Method
2023-01-01 Pigliasco, Federica; Cafaro, Alessia; Stella, Manuela; Baiardi, Giammarco; Barco, Sebastiano; Pedemonte, Nicoletta; D'Orsi, Claudia; Cresta, Federico; Casciaro, Rosaria; Castellani, Carlo; Grazia Calevo, Maria; Mattioli, Francesca; Cangemi, Giuliana
Structure-guided combination of novel CFTR correctors to improve the function of F508del-CFTR in airway epithelial cells
2025-01-01 Lunaccio, Dario; Allegretta, Caterina; Pesce, Emanuela; Scarano, Naomi; Vinci, Virginia; Salis, Annalisa; Tasso, Bruno; Brullo, Chiara; Capitanio, Nazzareno; Piccoli, Claudia; Pedemonte, Nicoletta; Cichero, Elena; Millo, Enrico; Laselva, Onofrio
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A Novel LC-MS/MS Method for the Measurement of Elexacaftor, Tezacaftor and Ivacaftor in Plasma, Dried Plasma Spot (DPS) and Whole Blood in Volumetric Absorptive Microsampling (VAMS) Devices | 1-gen-2025 | Pigliasco, F.; Cafaro, A.; Barco, S.; Cresta, F.; Casciaro, R.; Pedemonte, N.; Mattioli, F.; Castellani, C.; Cangemi, G. | |
| Alternative splicing and residual function potentially expand the therapeutic landscape of the CFTRdele2ins182 variant | 1-gen-2025 | Pastorino, Cristina; Menta, Ludovica; Pesce, Emanuela; Lena, Mariateresa; Tomati, Valeria; Capurro, Valeria; Di Duca, Marco; Terlizzi, Vito; Gramegna, Andrea; Blasi, Francesco; Castellani, Carlo; Cappato, Serena; Zara, Federico; Pedemonte, Nicoletta; Bocciardi, Renata | |
| Beyond Trikafta: new models to assess tissue dependent rescue of N1303K-CFTR | 1-gen-2025 | Pranke, Iwona; Capurro, Valeria; Chevalier, Benoit; Pesce, Emanuela; Tomati, Valeria; Pastorino, Cristina; Kelly-Aubert, Mairead; Hatton, Aurelie; Dreano, Elise; Lena, Mariateresa; Bocciardi, Renata; Zara, Federico; Pantano, Stefano; Terlizzi, Vito; Lucanto, Cristina; Costa, Stefano; Claut, Laura; Daccò, Valeria; Poli, Piercarlo; Maschio, Massimo; Fabrizzi, Benedetta; Caporelli, Nicole; Cipolli, Marco; Volpi, Sonia; Chedevergne, Frederique; Cosson, Laure; Macey, Julie; Ramel, Sophie; Weiss, Laurence; Grenet, Dominique; Le Clainche-Viala, Laurence; Douvry, Benoit; Ravoninjatovo, Bruno; Audousset, Camille; Tatopoulos, Aurélie; Richaud-Thiriez, Bénédicte; Baravalle, Melissa; Thouvenin, Guillaume; Labbé, Guillaume; Mittaine, Marie; Reix, Philippe; Durieu, Isabelle; Mankikian, Julie; Bui, Stéphanie; Nguyen-Khoa, Thao; Khoukh, Karim; Martin, Clémence; Da Silva, Jennifer; De Carli, Paola; Castellani, Carlo; Cresta, Federico; Galietta, Luis; Guillemaut, Anne; Girodon, Emmanuelle; Remus, Natacha; Bulcaen, Mathis; Ensinck, Marjolein; Zajac, Miroslaw; Carlon, Marianne; Lebihan, Jean; Burgel, Pierre-Régis; Sermet-Gaudelus, Isabelle; Hinzpeter, Alexandre; Pedemonte, Nicoletta | |
| Clinical Consequences and Functional Impact of the Rare S737F CFTR Variant and Its Responsiveness to CFTR Modulators | 1-gen-2023 | Terlizzi, V.; Pesce, E.; Capurro, V.; Tomati, V.; Lena, M.; Pastorino, C.; Bocciardi, R.; Zara, F.; Centrone, C.; Taccetti, G.; Castellani, C.; Pedemonte, N. | |
| Comprehensive analysis of combinatorial pharmacological treatments to correct nonsense mutations in the cftr gene | 1-gen-2021 | Venturini, A.; Borrelli, A.; Musante, I.; Scudieri, P.; Capurro, V.; Renda, M.; Pedemonte, N.; Galietta, L. J. V. | |
| Cyclic diacyl thioureas enhance activity of corrector Lumacaftor on F508del‐CFTR | 1-gen-2024 | Spallarossa, Andrea; Pedemonte, Nicoletta; Pesce, Emanuela; Millo, Enrico; Cichero, Elena; Rosano, Camillo; Lusardi, Matteo; Iervasi, Erika; Ponassi, Marco | |
| De novo variants in DENND5B cause a neurodevelopmental disorder | 1-gen-2024 | Scala, Marcello; Tomati, Valeria; Ferla, Matteo; Lena, Mariateresa; Cohen, Julie S; Fatemi, Ali; Brokamp, Elly; Bican, Anna; Phillips, John A; Koziura, Mary E; Nicouleau, Michael; Rio, Marlene; Siquier, Karine; Boddaert, Nathalie; Musante, Ilaria; Tamburro, Serena; Baldassari, Simona; Iacomino, Michele; Scudieri, Paolo; Rosenfeld, Jill A; Bellus, Gary; Reed, Sara; Al Saif, Hind; Russo, Rossana Sanchez; Walsh, Matthew B; Cantagrel, Vincent; Crunk, Amy; Gustincich, Stefano; Ruggiero, Sarah M; Fitzgerald, Mark P; Helbig, Ingo; Striano, Pasquale; Severino, Mariasavina; Salpietro, Vincenzo; Pedemonte, Nicoletta; Zara, Federico | |
| Genotype-phenotype correlations and disease mechanisms in PEX13-related Zellweger spectrum disorders | 1-gen-2022 | Borgia, Paola; Baldassari, Simona; Pedemonte, Nicoletta; Alkhunaizi, Ebba; D'Onofrio, Gianluca; Tortora, Domenico; Calì, Elisa; Scudieri, Paolo; Balagura, Ganna; Musante, Ilaria; Diana, Maria Cristina; Pedemonte, Marina; Vari, Maria Stella; Iacomino, Michele; Riva, Antonella; Chimenz, Roberto; Mangano, Giuseppe D; Mohammadi, Mohammad Hasan; Toosi, Mehran Beiraghi; Ashrafzadeh, Farah; Imannezhad, Shima; Karimiani, Ehsan Ghayoor; Accogli, Andrea; Schiaffino, Maria Cristina; Maghnie, Mohamad; Soler, Miguel Angel; Echiverri, Karl; Abrams, Charles K; Striano, Pasquale; Fortuna, Sara; Maroofian, Reza; Houlden, Henry; Zara, Federico; Fiorillo, Chiara; Salpietro, Vincenzo | |
| Interplay between ALK2R206H mutant receptor and autophagy signaling regulates receptor stability and its chondrogenic functions | 1-gen-2025 | Coculo, Laura; Wits, Marius; Mariani, Irene; Fianco, Giulia; Cappato, Serena; Bocciardi, Renata; Pedemonte, Nicoletta; Volpe, Elisabetta; Ciolfi, Serena; Sessa, Rosario Luigi; Rinaldo, Serena; Cutruzzolà, Francesca; Trisciuoglio, Daniela; Goumans, Marie-Josè; Sanchez-Duffhues, Gonzalo; Stagni, Venturina | |
| Journey on VX-809-Based Hybrid Derivatives towards Drug-like F508del-CFTR Correctors: From Molecular Modeling to Chemical Synthesis and Biological Assays | 1-gen-2022 | Parodi, Alice; Righetti, Giada; Pesce, Emanuela; Salis, Annalisa; Tomati, Valeria; Pastorino, Cristina; Tasso, Bruno; Benvenuti, Mirko; Damonte, Gianluca; Pedemonte, Nicoletta; Cichero, Elena; Millo, Enrico | |
| LEAD OPTIMIZATION OF MKT-077 ANALOGUES AS HSP70 ALLOSTERIC INHIBITORS COMBINED WITH F508DEL CFTR CORRECTORS: A MULTI DRUG APPROACH TO CONTRAST CYSTIC FIBROSIS | 1-gen-2024 | Lunaccio, Dario; Garrone, Irene; Pesce, Emanuela; Caushi, Bujar; Salis, Annalisa; Pedemonte, Nicoletta; Sturla, Laura; Bruzzone, Santina; Cichero, Elena; Millo, Enrico | |
| Neutrophil Extracellular Traps in Systemic Lupus Erythematosus Stimulate IgG2 Production From B Lymphocytes | 1-gen-2021 | Bertelli, R.; Schena, F.; Antonini, F.; Reverberi, D.; Signa, S.; Pedemonte, N.; Consolaro, A.; Gattorno, M.; Negrini, S.; Pupo, F.; Volpi, S.; Ghiggeri, G. M. | |
| Partial rescue of f508del-cftr stability and trafficking defects by double corrector treatment | 1-gen-2021 | Capurro, V.; Tomati, V.; Sondo, E.; Renda, M.; Borrelli, A.; Pastorino, C.; Guidone, D.; Venturini, A.; Giraudo, A.; Bertozzi, S. M.; Musante, I.; Bertozzi, F.; Bandiera, T.; Zara, F.; Galietta, L. J. V.; Pedemonte, N. | |
| Patient's dermal fibroblasts as disease markers for visceral myopathy | 1-gen-2023 | Viti, Federica; Pramotton, Francesca Micaela; Martufi, Michela; Magrassi, Raffaella; Pedemonte, Nicoletta; Nizzari, Mario; Zanacchi, Francesca Cella; De Michele, Benedetta; Alampi, Manuela; Zambito, Martina; Santamaria, Giuseppe; Bajetto, Adriana; Sardar, Sabah; Tomati, Valeria; Gandullia, Paolo; Giampietro, Costanza; Florio, Tullio; Beltrame, Francesco; Vassalli, Massimo; Ceccherini, Isabella | |
| Probing Allosteric Hsp70 Inhibitors by Molecular Modelling Studies to Expedite the Development of Novel Combined F508del CFTR Modulators | 1-gen-2021 | Sabbadini, Roberto; Pesce, Emanuela; Parodi, Alice; Mustorgi, Eleonora; Bruzzone, Santina; Pedemonte, Nicoletta; Casale, Monica; Millo, Enrico; Cichero, Elena | |
| Quantification of Ivacaftor, Tezacaftor and Elexacaftor in plasma of cystic fibrosis patients treated with Kaftrio by a validated liquid chromatography-tandem mass spectrometric (LC-MS/MS) method” | 1-gen-2022 | Cafaro, A.; Pigliasco, F.; Barco, S.; Stella, M.; Pedemonte, N.; Cresta, F.; Casciaro, R.; Castellani, C.; Cangemi, G.; Mattioli, F. | |
| QUANTIFICATION OF IVACAFTOR, TEZACAFTOR, AND ELEXACAFTOR IN PLASMA OF CYSTIC FIBROSIS PATIENTS BY AN HPLC–MS/MS METHOD | 1-gen-2023 | Pigliasco, F.; Cafaro, A.; Stella, M.; Baiardi, G.; Barco, S.; Pedemonte, N.; D'Orsi, C.; Cresta, F.; Casciaro, R.; Castellani, C.; Calevo, M. G.; Cangemi, G.; Mattioli, F. | |
| Rescue by elexacaftor-tezacaftor-ivacaftor of the G1244E cystic fibrosis mutation's stability and gating defects are dependent on cell background | 1-gen-2023 | Tomati, Valeria; Costa, Stefano; Capurro, Valeria; Pesce, Emanuela; Pastorino, Cristina; Lena, Mariateresa; Sondo, Elvira; Di Duca, Marco; Cresta, Federico; Cristadoro, Simona; Zara, Federico; Galietta, Luis J V; Bocciardi, Renata; Castellani, Carlo; Lucanto, Maria Cristina; Pedemonte, Nicoletta | |
| Simultaneous Quantification of Ivacaftor, Tezacaftor, and Elexacaftor in Cystic Fibrosis Patients’ Plasma by a Novel LC–MS/MS Method | 1-gen-2023 | Pigliasco, Federica; Cafaro, Alessia; Stella, Manuela; Baiardi, Giammarco; Barco, Sebastiano; Pedemonte, Nicoletta; D'Orsi, Claudia; Cresta, Federico; Casciaro, Rosaria; Castellani, Carlo; Grazia Calevo, Maria; Mattioli, Francesca; Cangemi, Giuliana | |
| Structure-guided combination of novel CFTR correctors to improve the function of F508del-CFTR in airway epithelial cells | 1-gen-2025 | Lunaccio, Dario; Allegretta, Caterina; Pesce, Emanuela; Scarano, Naomi; Vinci, Virginia; Salis, Annalisa; Tasso, Bruno; Brullo, Chiara; Capitanio, Nazzareno; Piccoli, Claudia; Pedemonte, Nicoletta; Cichero, Elena; Millo, Enrico; Laselva, Onofrio |