Topiramate, Naltrexone, and Acamprosate in the Treatment of Alcohol Use Disorders

Pharmacological treatments for Alcohol Use Disorders (AUDs) are effective, especially in combination with other behavioral or psychosocial interventions. Acamprosate is useful to maintain abstinence in patient with late-onset alcoholism and relief craving, patients suffering from cognitive dysfunction and patients with comorbid somatic pathology. Naltrexone is effective to maintain abstinence in alcoholic patient with reward craving and with a high amount of Heavy Drinking Days. Topiramate shows a greater beneficial effect in subjects with a typology of craving characterized by drinking obsessions and automaticity of drinking.