Cobalt ferrite (CoFe₂O₄) nanoparticles with an average diameter of ~15 nm were synthesised in three different morphological variants through thermal decomposition. The resulting highly crystalline nanostructures were characterised using X-ray diffraction (XRD), superconducting quantum interference device (SQUID) magnetometry, X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM), in order to assess their structural, magnetic, and magnetothermal properties. TEM imaging confirmed the morphological variations of cubic, spherical and octapod-shaped nanoparticles. XRD analysis verified the formation of the cobalt ferrite inverse spinel phase, while SQUID magnetometry demonstrated high saturation magnetisation and large coercive fields. Particle size distributions obtained from XRD and SQUID analyses were in close agreement. The elemental composition, and in particular the Co/Fe cation ratio within the spinel lattice, was evaluated by XPS. Owing to their high coercivity, the nanoparticles were further examined for their magnetothermal response, which revealed promising performance for application in magnetic particle hyperthermia.
Cancer therapy by magnetic hyperthermia: impact of cobalt ferrite nanoparticles
Zaneta Fabriciova;Davide Peddis;Pierfrancesco Maltoni;
2025-01-01
Abstract
Cobalt ferrite (CoFe₂O₄) nanoparticles with an average diameter of ~15 nm were synthesised in three different morphological variants through thermal decomposition. The resulting highly crystalline nanostructures were characterised using X-ray diffraction (XRD), superconducting quantum interference device (SQUID) magnetometry, X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM), in order to assess their structural, magnetic, and magnetothermal properties. TEM imaging confirmed the morphological variations of cubic, spherical and octapod-shaped nanoparticles. XRD analysis verified the formation of the cobalt ferrite inverse spinel phase, while SQUID magnetometry demonstrated high saturation magnetisation and large coercive fields. Particle size distributions obtained from XRD and SQUID analyses were in close agreement. The elemental composition, and in particular the Co/Fe cation ratio within the spinel lattice, was evaluated by XPS. Owing to their high coercivity, the nanoparticles were further examined for their magnetothermal response, which revealed promising performance for application in magnetic particle hyperthermia.
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