IRIS
FLORIO, TULLIO
 Distribuzione geografica
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Continente #
EU - Europa 36.607
AS - Asia 67
SA - Sud America 18
NA - Nord America 3
AF - Africa 1
Totale 36.696
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Nazione #
IT - Italia 36.606
CN - Cina 58
BR - Brasile 17
SG - Singapore 6
VN - Vietnam 3
US - Stati Uniti d'America 2
AR - Argentina 1
DO - Repubblica Dominicana 1
MA - Marocco 1
UA - Ucraina 1
Totale 36.696
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Città #
Genova 20.899
Genoa 10.344
Vado Ligure 2.756
Rapallo 2.540
Bordighera 66
Beijing 29
Singapore 4
Ashburn 2
Ho Chi Minh City 2
São Paulo 2
Alfenas 1
Andaraí 1
Boa Vista 1
Brasília 1
Camboriú 1
Colatina 1
Goiânia 1
Ituiutaba 1
Ivano-Frankivsk 1
Ivinhema 1
Lagoa Santa 1
Lấp Vò 1
Merlo 1
Nova Iguaçu 1
Passo Fundo 1
Rabat 1
Recife 1
Santo Domingo 1
São Benedito do Sul 1
Taquara 1
Totale 36.664
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Nome #
Development of an Injectable Slow-Release Metformin Formulation and Evaluation of Its Potential Antitumor Effects 230
Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets. 215
NDM29, a RNA polymerase III-dependent non coding RNA, promotes amyloidogenic processing of APP and amyloid β secretion 213
The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma 213
Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells 211
Amyloid precursor protein modulates ERK1/2 signaling 210
Calcium binding promotes Prion Protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure 206
Characterization of the pro-apoptotic intracellular mechanisms induced by a toxic conformer of the recombinant human prion protein fragment 90-231 205
Biomimetic hybrid vesicles for boron neutron capture therapy of glioblastoma 202
New molecules and old drugs as emerging approaches to selectively target human glioblastoma cancer stem cells 202
Peptide Receptor Targeting in Cancer: The Somatostatin Paradigm 198
Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells. 198
17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease 195
Apoptotic cell death and impairment of L-type voltage sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment 106-126 192
Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis 189
Protective effects of some creatine derivatives in brain tissue anoxia. 187
A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates 187
Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231 184
In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity 184
Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity. 183
Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells 182
Adiponectin as Novel Regulator of Cell Proliferation in Human Glioblastoma 179
In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors 179
Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro 177
An Alu-like RNA promotes cell differentiation and reduces malignancy of human neuroblastoma cells. 177
Chemokines and chemokine receptors: New actors in neuroendocrine regulations 173
Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death 173
Amyloid precursor protein and presenilin involvement in cell signaling 172
Complexity and Selectivity of γ-Secretase Cleavage on Multiple Substrates: Consequences in Alzheimer's Disease and Cancer 172
Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity 172
Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current 171
Phenotypical and Pharmacological Characterization of Stem-Like Cells in Human Pituitary Adenomas 171
Perhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA 170
Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors 170
Differential toxicity, conformation and morphology of typical initial aggregation states of Aβ1-42 and Aβpy3-42 beta-amyloids 170
Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90–231 Neurotoxic Effects in Cerebellar Granule Neurons 168
The inhibition of 45A ncRNA expression reduces tumor formation, affecting tumor nodules compactness and metastatic potential in neuroblastoma cells 167
Endometrial stem cells and human reproductive failure 167
Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells 166
A novel snRNA-like transcript affects amyloidogenesis and cell cycle progression through perturbation of Fe65L1 (APBB2) alternative splicing. 166
Human glioblastoma-derived cell membrane nanovesicles: a novel, cell-specific strategy for boron neutron capture therapy of brain tumors 165
Metformin inhibition of neuroblastoma cell proliferation is differently modulated by cell differentiation induced by retinoic acid or overexpression of NDM29 non-coding RNA 165
A Novel Collection of snRNA-Like Promoters with Tissue-Specific Transcription Properties 165
Down-regulation of 21A Alu RNA as a tool to boost proliferation maintaining the tissue regeneration potential of progenitor cells 165
Receptor tyrosine kinase inhibitors and cytotoxic drugs affect pleural mesothelioma cell proliferation: insight into EGFR and ERK1/2 as antitumor targets 164
SDF1 controls pituitary cell proliferation through the activation of ERK1/2 and the Ca2+-dependent cytosolic tyrosine kinase, Pyk2. 164
The somatostatin analogue octreotide confers sensitivity to rapamycin treatment on pituitary tumor cells 163
Drug-repositioning opportunities for cancer therapy: Novel molecular targets for known compounds 163
Co-Administration of Fendiline Hydrochloride Enhances Chemotherapeutic Efficacy of Cisplatin in Neuroblastoma Treatment 163
Different structural stability and toxicity of PrPARR and PrPARQ sheep prion protein variants 162
An interaction between hepatocyte growth factor and its receptor (c-MET) prolongs the survival of chronic lymphocytic leukemic cells through STAT3 phosphorylation: a potential role of mesenchymal cells in the disease 162
Drug design strategies focusing on the CXCR4/CXCR7/CXCL12 pathway in leukemia and lymphoma 162
Inhibition of chloride intracellular channel 1 (CLIC1) as biguanide class-effect to impair human glioblastoma stem cell viability 162
Emerging targets in pituitary adenomas: role of the CXCL12/CXCR4-R7 system 161
Differential efficacy of SSTR1, 2 and 5 agonists in the inhibition of C6 glioma growth in nude mice 160
Contribution of two conserved glycine residues to fibrillogenesis of the 106-126 prion protein fragment. Evidence that a soluble variant of the 106-126 peptide is neurotoxic 159
Adult pituitary stem cells 159
Anti-proliferative and anti-secretory effects of everolimus on human pancreatic neuroendocrine tumors primary cultures: is there any benefit from combination with somatostatin analogs? 159
SOMATOSTATIN ACTIVATION OF MITOGEN ACTIVATED PROTEIN KINASE VIA SOMATOSTATIN RECEPTOR 1 (SSTR1) 158
Proteostasis unbalance in prion diseases: mechanisms of neurodegeneration and therapeutic targets 156
G PROTEIN ACTIVATION OF A HORMONE-STIMULATED PHOSPHATASE IN HUMAN TUMOR CELLS 155
b25-35 alters calcium homeostasis and induces neurotoxicity in cerebellar granule cells 154
Effects of Prion Protein on Aβ42 and Pyroglutamate-Modified AβpΕ3-42 Oligomerization and Toxicity 154
Glioblastoma cancer stem cells: response to epidermal growth factor receptor kinase inhibitors 153
Patient-derived xenograft in zebrafish embryos: a new platform for translational research in neuroendocrine tumors 153
Canine osteosarcoma cell lines contain stem-like cancer cells: Biological and pharmacological characterization 153
Different response of human glioma tumor-initiating cells to EGFR kinase inhibitors. 152
Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction 152
Sorafenib selectively depletes human glioblastoma tumor-initiating cells from primary cultures 152
Novel celecoxib analogues inhibit glial production of prostaglandinE2, nitric oxide, and oxygen radicals reverting the neuroinflammatoryresponses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide 151
Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: involvement of A2, purinergic receptor subtypes 151
Excitotoxicity Through NMDA Receptors Mediates Cerebellar Granule Neuron Apoptosis Induced by Prion Protein 90-231 Fragment 150
Neuroblastoma: Inhibition by Alu-Like RNA 149
Pyrrolidinedithiocarbamate induces apoptosis in cerebellar granule cells: involvement of AP-1 and MAP kinases 149
Cultured astrocyte proliferation induced by extracellular guanosine involves endogenous adenosine and is raised by the co-presence of microglia 149
Molecular pharmacology of malignant pleural mesothelioma: Challenges and perspectives from preclinical and clinical studies 149
Minimalist hybrid ligand/receptor-based pharmacophore model for CXCR4 applied to a small-library of marine natural products led to the identification of Phidianidine A as a new CXCR4 ligand exhibiting antagonist activity 148
Amyloid precursor protein and presenilin1 interact with the adaptor GRB2 and modulate ERK1,2 signaling 148
Chemokines and their receptors in the CNS: expression of CXCL12/SDF-1 and CXCR4 and their role in astrocyte proliferation 147
Balance between somatostatin and D2 receptor expression drives TSH-secreting adenoma response to somatostatin analogs and dopastatins 147
A novel splice variant of the protein tyrosine phosphatase PTPRJ that encodes for a soluble protein involved in angiogenesis 147
Chemokine stromal cell-derived factor 1α induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals 146
The chemokine SDF1/CXCL12: a novel autocrine/paracrine factor involved in pituitary adenoma development 146
Steroid modulation of prolactin release from single lactotropes in male and female rats studied by the reverse hemolytic plaque assay 146
Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives 145
Molecular mechanisms of the antiproliferative activity of somatostatin receptors (SSTRs) in neuroendocrine tumors 144
ERK1/2 and p38 MAP kinases control prion protein fragment 90-231-induced astrocyte proliferation and microglia activation 144
Primary Cultures from Human GH-secreting or Clinically Non-functioning Pituitary Adenomas 144
Overexpression of stromal cell-derived factor 1 and its receptor CXCR4 induces autocrine/paracrine cell proliferation in human pituitary adenomas 144
Chemokines and their receptors in the central nervous system 143
The creatine transporter mediates the uptake of creatine by brain tissue, but not the uptake of two creatine-derived compounds 143
A. novel mechanism for the melatonin inhibition of testosterone secretion by rat Leydig cells: reduction of GnRH-induced cytosolic Ca2+ rise 143
Conformation dependent pro-apoptotic activity of the recombinant human prion protein fragment 90-231 143
Biological and Biochemical Basis of the Differential Efficacy of First and Second Generation Somatostatin Receptor Ligands in Neuroendocrine Neoplasms 143
Expression of CXCR7 chemokine receptor in human meningioma cells and in intratumoral microvasculature 142
Composti e metodi per rilevare lesioni aterosclerotiche precoci in vasi sanguigni 142
Age-related alterations of somatostatin gene expression in different rat brain areas 141
FGFR4 polymorphism as molecular determinant of the efficacy of mTOR inhibitors in GH-secreting pituitary adenomas 141
Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation 141
The phosphotyrosine phosphatase PTPh mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2 141
Totale 16.568
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Categoria #
all - tutte 121.649
article - articoli 108.836
book - libri 0
conference - conferenze 5.988
curatela - curatele 0
other - altro 0
patent - brevetti 1.107
selected - selezionate 0
volume - volumi 5.718
Totale 243.298
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.723 0 0 0 177 213 215 121 179 188 302 179 149
2021/20223.663 152 379 195 400 110 262 269 813 147 281 172 483
2022/20233.127 308 199 36 308 436 553 7 246 547 42 384 61
2023/20241.980 121 213 51 237 139 386 149 122 114 58 120 270
2024/20256.841 200 458 216 531 942 681 637 1.219 262 280 613 802
2025/20263.984 1.390 368 1.383 843 0 0 0 0 0 0 0 0
Totale 37.550