IRIS
CEA, MICHELE
 Distribuzione geografica
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Continente #
EU - Europa 14.369
AS - Asia 1.693
NA - Nord America 837
SA - Sud America 157
AF - Africa 31
OC - Oceania 3
Totale 17.090
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Nazione #
IT - Italia 14.019
US - Stati Uniti d'America 790
SG - Singapore 691
CN - Cina 447
VN - Vietnam 364
FR - Francia 119
BR - Brasile 92
HK - Hong Kong 64
DE - Germania 50
FI - Finlandia 45
AR - Argentina 37
GB - Regno Unito 32
MX - Messico 23
BD - Bangladesh 20
JP - Giappone 20
IN - India 18
IQ - Iraq 17
ID - Indonesia 13
NL - Olanda 13
CA - Canada 12
CH - Svizzera 12
ES - Italia 10
UA - Ucraina 10
SE - Svezia 8
AT - Austria 7
EC - Ecuador 7
IE - Irlanda 7
CO - Colombia 6
MA - Marocco 6
PY - Paraguay 6
RU - Federazione Russa 6
GR - Grecia 5
PK - Pakistan 5
ZA - Sudafrica 5
BE - Belgio 4
HR - Croazia 4
PH - Filippine 4
SA - Arabia Saudita 4
TH - Thailandia 4
TR - Turchia 4
VE - Venezuela 4
AU - Australia 3
DZ - Algeria 3
EG - Egitto 3
KE - Kenya 3
TN - Tunisia 3
UY - Uruguay 3
UZ - Uzbekistan 3
BH - Bahrain 2
CL - Cile 2
DO - Repubblica Dominicana 2
ET - Etiopia 2
HN - Honduras 2
HU - Ungheria 2
KR - Corea 2
LB - Libano 2
PA - Panama 2
PL - Polonia 2
RS - Serbia 2
SI - Slovenia 2
SY - Repubblica araba siriana 2
AE - Emirati Arabi Uniti 1
AL - Albania 1
AO - Angola 1
BG - Bulgaria 1
BY - Bielorussia 1
BZ - Belize 1
CR - Costa Rica 1
CZ - Repubblica Ceca 1
DK - Danimarca 1
GA - Gabon 1
GT - Guatemala 1
HT - Haiti 1
JO - Giordania 1
KG - Kirghizistan 1
KH - Cambogia 1
KZ - Kazakistan 1
LT - Lituania 1
MD - Moldavia 1
MG - Madagascar 1
MT - Malta 1
NG - Nigeria 1
NI - Nicaragua 1
NP - Nepal 1
OM - Oman 1
PT - Portogallo 1
RO - Romania 1
SN - Senegal 1
TT - Trinidad e Tobago 1
TZ - Tanzania 1
Totale 17.090
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Città #
Genova 6.805
Genoa 4.964
Rapallo 1.092
Vado Ligure 1.015
Singapore 324
San Jose 247
Ashburn 171
Ho Chi Minh City 114
Lauterbourg 107
Beijing 93
Hanoi 85
Council Bluffs 66
Hong Kong 63
Frankfurt am Main 43
Helsinki 39
Santa Clara 28
New York 27
Bordighera 21
Tokyo 19
Los Angeles 18
Haiphong 17
Orem 15
Da Nang 14
Rome 13
Tianjin 13
Mexico City 12
São Paulo 12
Zurich 12
Amsterdam 10
Chicago 10
Milan 10
Can Tho 9
Cardiff 9
Schiavon 9
Baghdad 8
Biên Hòa 8
Turin 8
City of London 7
Phủ Lý 7
Buenos Aires 6
Dublin 6
Hải Dương 6
Lappeenranta 6
London 6
Montreal 6
Buffalo 5
Denver 5
Kyiv 5
Madrid 5
Nha Trang 5
Paris 5
Phoenix 5
Poplar 5
Stockholm 5
Bắc Ninh 4
Changsha 4
Dhaka 4
Zagreb 4
Antwerp 3
Belo Horizonte 3
Brasília 3
Brescia 3
Brooklyn 3
Cuenca 3
Djursholm 3
Guangzhou 3
Istanbul 3
Johannesburg 3
Montevideo 3
Nairobi 3
Ninh Bình 3
Parma 3
Perugia 3
Rio de Janeiro 3
Tashkent 3
Thái Bình 3
Addis Ababa 2
Agadir 2
Algiers 2
Athens 2
Atlanta 2
Bandung 2
Basra 2
Belgrade 2
Bogotá 2
Bologna 2
Boston 2
Budapest 2
Bến Tre 2
Casablanca 2
Chennai 2
Dallas 2
Elk Grove Village 2
Formosa 2
Guayaquil 2
Hermosillo 2
La Plata 2
Lambaré 2
Ljubljana 2
Louisville 2
Totale 15.743
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Nome #
APO866 increases antitumor activity of cyclosporin - A by inducing mitochondrial and endoplasmic reticulum stress in leukemia cells 257
APO866 activity in hematologic malignancies: a preclinical in vitro study. 245
Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of AKT-mediated gene repression 245
APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment 242
Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells vulnerability to DNA-damaging agents 240
Autophagy in blood cancers: biological role and therapeutic implications. 235
Nicotinic acid phosphoribosyltransferase regulates cancer cell metabolism, susceptibility to NAMPT inhibitors and DNA repair. 229
Regulation and Function of Extracellular Nicotinamide Phosphoribosyltransferase/Visfatin. 224
A simple cytofluorimetric score may optimize testing for biallelic CEBPA mutations in patients with acute myeloid leukemia 218
Catastrophic NAD(+) Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE 216
SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells 211
Dexamethasone, oxaliplatin and cytarabine (R-DHAOx) as salvage and stem cells mobilizing therapy in relapsed/refractory diffuse large B cell lymphomas 203
Ras-induced resistance to lapatinib is overcome by MEK inhibition 199
SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects 198
Nicotinamide phosphoribosyltransferase promotes epithelial-to-mesenchymal transition as a soluble factor independent of its enzymatic activity. 198
Induction of cell killing and autophagy by amphiphilic pyrrolidine derivatives on human pancreatic cancer cells 197
Sirt6 regulates dendritic cell differentiation, maturation, and function 195
Monoclonal antibodies for non-Hodgkin's lymphoma: state of the art and perspectives. 189
Molecular diagnosis and monitoring of chronic myelogenous leukemia: BCR-Abl and more. 189
Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells. 186
Fasting potentiates the anticancer activity of tyrosin kinase inhibitors by strenghtening MAPK signalling inhibition. 185
Treatment with KLEPTOSE® CRYSMEB reduces mouse atherogenesis by impacting on lipid profile and Th1 lymphocyte response 182
Early minimal residual disease assessment after AML induction with fludarabine, cytarabine and idarubicin (FLAI) provides the most useful prognostic information 179
Peripheral blood vs. bone marrow for molecular monitoring of BCR-ABL1 levels in chronic myelogenous leukemia, a retrospective analysis in allogeneic bone marrow recipients. 178
EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition 178
Evaluating treatment response of chronic myeloid leukemia: emerging science and technology. 176
Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors As Therapeutics: Rationales, Controversies, Clinical Experience. 173
Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols. 172
Hedgehog Signaling Is Useful as a Novel Molecular Marker for Predicting Relapse and Resistance During Chronic Myeloid Leukemia Treatment 172
Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells 171
Evaluation of prognostic indices in elderly hospitalized patients 171
Post-Transplant Nivolumab Plus Unselected Autologous Lymphocytes in Refractory Hodgkin Lymphoma: A Feasible and Promising Salvage Therapy Associated With Expansion and Maturation of NK Cells 170
The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival 169
Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis 168
The new small tyrosine-kinase inhibitor ARQ531 targets acute myeloid leukemia cells by disrupting multiple tumor-addicted programs 166
Prognostic relevance of a blastic plasmacytoid dendritic cell neoplasm-like immunophenotype in cytogenetically normal acute myeloid leukemia patients 166
Biological Insights into Myeloma and Other B Cell Malignancies 165
Longitudinal minimal residual disease (MRD) evaluation in acute myeloid leukaemia with NPM1 mutation: from definition of molecular relapse to MRD-driven salvage approach 164
CD38-Induced Metabolic Dysfunction Primes Multiple Myeloma Cells for NAD+-Lowering Agents 163
Abstract CT075: Fasting-mimicking diet and hormone therapy modulates metabolic factors to promote breast cancer regression and reduce side effects 163
CXCR4 regulates extra-medullary myeloma through epithelial-mesenchymal-transition-like transcriptional activation 162
Nicotinamide Phosphoribosyltransferase As A Target In Inflammation-Related Disorders. 159
Tracking molecular relapse of chronic myeloid leukemia by measuring Hedgehog signaling status 156
Catastrophic NAD+ Depletion through Nampt Inhibition in Activated T Lymphocytes Reduces Demyelination and Disability in EAE. 155
Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells. 155
Exploiting tumor vulnerabilities: NAD+-depleting agents combined with anti-tumor drugs as innovative strategy to treat hematological malignancies 154
Radiomics and artificial intelligence analysis of CT data for the identification of prognostic features in multiple myeloma 154
Predictive values of two frailty screening tools in older patients with solid cancer: a comparison of SAOP2 and G8 154
Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives 152
Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma 152
Synthesis of Pyrrolidine 3,4-Diol Derivatives with Anticancer Activity on Pancreatic Tumor Cells 151
Differentiating diffuse from focal pattern on Computed Tomography in multiple myeloma: Added value of a Radiomics approach 151
A T315I mutation in e19a2 BCR/ABL1 chronic myeloid leukemia responding to dasatinib 148
New insights into biology of chronic myeloid leukemia: implications in therapy. 147
HDAC INHIBITORS SYNERGISTICALLY ENHANCE AP0866 ACTIVITY IN HUMAN LEUKEMIA CELLS: EVIDENCE FOR CONVERGING MECHANISMS OF SIRT1 INHIBITION 146
Amino acid depletion triggered by L-asparaginase sensitizes MM cells to carfilzomib by inducing mitochondria ROS-mediated cell death 146
Targeting NAD(+) Salvage Pathway Induces Autophagy in Multiple Myeloma Cells 145
CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: Molecular mechanisms and therapeutic implications 145
Novel 2-[(benzylamino)methyl]pyrrolidine-3,4-diol derivatives as alpha-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies. 143
Fludarabine, high-dose cytarabine and idarubicin-based induction may overcome the negative prognostic impact of flt3-itd in npm1 mutated aml, irrespectively of flt3-itd allelic Burden 140
Safety and feasibility of fasting‐mimicking diet and effects on nutritional status and circulating metabolic and inflammatory factors in cancer patients undergoing active treatment 140
Radiomics and artificial intelligence for outcome prediction in multiple myeloma patients undergoing autologous transplantation: A feasibility study with ct data 140
Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma 139
Targeting NAD+ Salvage Pathway Induces Autophagy in Multiple Myeloma Cells via mTORC1 and Extracellular Signal-Regulated Kinase (ERK1/2) Inhibition 138
Intracellular NAD⁺ depletion enhances bortezomib-induced anti-myeloma activity. 138
New insights into the treatment of multiple myeloma with histone deacetylase inhibitors. 138
Subcutaneous bortezomib-containing regimens as up-front treatment of newly diagnosed transplant-eligible multiple myeloma patients: a retrospective, non-interventional observational study 137
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses. 136
Long non-coding RNA NEAT1 targeting impairs the DNA repair machinery and triggers anti-tumor activity in multiple myeloma 135
SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice 135
Nutrients in the Prevention of Alzheimer's Disease 134
Post-Transplant Nivolumab Plus Unselected Autologous Lymphocytes in Refractory Hodgkin Lymphoma: A Feasible and Promising Salvage Therapy Associated With Expansion and Maturation of NK Cells 129
Apoptosis reprogramming triggered by splicing inhibitors sensitizes multiple myeloma cells to Venetoclax treatment 129
Targeting Inflammation in Primary Cardiovascular Prevention 126
Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity. 123
SIRT6 inhibition as a novel approach for treating Acute Myeloid Leukemia 123
Depletion of the intracellular coenzyme NAD plus in activated T-cells ameliorates experimental autoimmune encephalomyelitis 123
NAD+ METABOLISM RESTRICTION BOOSTS HIGH-DOSE MELPHALAN EFFICACY IN PATIENTS WITH MULTIPLE MYELOMA 121
Novel anti-B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma 121
Intracellular NAD+ depletion induces autophagic-death in Multiple Myeloma cells 121
Harnessing Immune Response in Acute Myeloid Leukemia 120
Effect of Geriatric Comanagement in Older Patients Undergoing Surgery for Gastrointestinal Cancer: A Retrospective, Before-and-After Study 120
Cyclic fasting bolsters cholesterol biosynthesis inhibitors' anticancer activity 117
Current standards and future strategies in immunochemotherapy of non-Hodgkin's lymphoma. 115
A Blastic Plasmacytoid Dendritic Cell Neoplasm-like Phenotype Identifies a Subgroup of NPM1-Mutated AML Patients with Worse Prognosis While Has Not Predictive Value in NPM1-Wt AML 111
Potent Synergistic Activity of the NAD plus Synthesis Inhibitor APO866 and of the Apoptosis Inducer TRAIL in in Vitro and Ex Vivo Cellular Models of Non Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia. 111
Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells 108
Dual NAMPT and BTK targeting leads to synergistic killing of Waldenström macroglobulinemia cells regardless of MYD88 and CXCR4 somatic mutation status 106
Daratumumab in the treatment of C3 glomerulopathy with monoclonal gammopathy: a case report and literature review 105
Synergistic Interaction Between P-glycoprotein Inhibitors and APO866 in Primary Leukemic Cells 104
Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies 100
Author Correction: Cyclic fasting bolsters cholesterol biosynthesis inhibitors' anticancer activity 100
The Novel Phosphatidylinositol-3-Kinase (PI3K) Inhibitor Alpelisib Effectively Inhibits Growth of PTEN-Haploinsufficient Lipoma Cells 100
Calciphylaxis in a patient with POEMS syndrome without renal failure and/or hyperparathyroidism. A case report 99
Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery 99
CD56 expression modulates NAD+ metabolic landscape and predicts sensitivity to anti-CD38 therapies in multiple myeloma 98
Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model 98
Nicotinic acid phosphoribosyltransferase is overexpressed in solid tumors and regulates cancer cell metabolism and susceptibility to FK866 92
Resistin, oxidative stress and amyloid beta: a possible link in Alzheimer' disease 90
A real-world efficacy and safety analysis of combined carfilzomib, lenalidomide, and dexamethasone (KRd) in relapsed/refractory multiple myeloma 90
Totale 15.471
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Categoria #
all - tutte 55.612
article - articoli 54.131
book - libri 0
conference - conferenze 1.481
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 111.224
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021281 0 0 0 0 0 0 0 0 0 115 97 69
2021/20221.250 43 63 100 156 63 102 69 247 72 110 63 162
2022/20231.379 145 153 17 142 228 177 9 82 200 28 175 23
2023/20241.006 36 92 33 144 96 182 79 96 31 21 72 124
2024/20252.977 124 186 63 236 288 289 276 563 89 176 328 359
2025/20265.039 670 227 599 520 707 371 747 277 409 512 0 0
Totale 17.466