IRIS
CICHERO, ELENA
 Distribuzione geografica
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Continente #
EU - Europa 11.867
AS - Asia 1.626
NA - Nord America 1.373
SA - Sud America 143
AF - Africa 19
OC - Oceania 3
Continente sconosciuto - Info sul continente non disponibili 1
Totale 15.032
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Nazione #
IT - Italia 11.606
US - Stati Uniti d'America 1.299
SG - Singapore 650
CN - Cina 398
VN - Vietnam 288
BD - Bangladesh 102
FR - Francia 89
BR - Brasile 82
HK - Hong Kong 71
DE - Germania 36
FI - Finlandia 36
CA - Canada 32
AR - Argentina 23
JP - Giappone 22
MX - Messico 20
IN - India 18
GB - Regno Unito 16
CH - Svizzera 13
ES - Italia 12
NL - Olanda 11
ID - Indonesia 10
IQ - Iraq 10
VE - Venezuela 10
CL - Cile 9
PH - Filippine 9
RU - Federazione Russa 8
TW - Taiwan 8
CO - Colombia 6
IE - Irlanda 6
JM - Giamaica 6
PK - Pakistan 6
UA - Ucraina 6
CZ - Repubblica Ceca 5
ZA - Sudafrica 5
BO - Bolivia 4
MA - Marocco 4
PY - Paraguay 4
SA - Arabia Saudita 4
SE - Svezia 4
TH - Thailandia 4
TR - Turchia 4
AU - Australia 3
JO - Giordania 3
SI - Slovenia 3
AT - Austria 2
CR - Costa Rica 2
EC - Ecuador 2
ET - Etiopia 2
GT - Guatemala 2
GY - Guiana 2
HN - Honduras 2
HR - Croazia 2
KZ - Kazakistan 2
LB - Libano 2
LI - Liechtenstein 2
MY - Malesia 2
NP - Nepal 2
PL - Polonia 2
SV - El Salvador 2
TT - Trinidad e Tobago 2
UZ - Uzbekistan 2
AE - Emirati Arabi Uniti 1
AF - Afghanistan, Repubblica islamica di 1
AL - Albania 1
AW - Aruba 1
AZ - Azerbaigian 1
BA - Bosnia-Erzegovina 1
BN - Brunei Darussalam 1
BS - Bahamas 1
CD - Congo 1
CI - Costa d'Avorio 1
DK - Danimarca 1
DZ - Algeria 1
EE - Estonia 1
EG - Egitto 1
GE - Georgia 1
IL - Israele 1
IS - Islanda 1
KE - Kenya 1
LA - Repubblica Popolare Democratica del Laos 1
LC - Santa Lucia 1
LT - Lituania 1
LY - Libia 1
MN - Mongolia 1
MQ - Martinica 1
PA - Panama 1
PE - Perù 1
PS - Palestinian Territory 1
PT - Portogallo 1
SK - Slovacchia (Repubblica Slovacca) 1
SL - Sierra Leone 1
SN - Senegal 1
VG - Isole Vergini Britanniche 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 15.032
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Città #
Genova 5.848
Genoa 3.816
Vado Ligure 949
Rapallo 720
San Jose 354
Singapore 331
Ashburn 170
Council Bluffs 98
Ho Chi Minh City 92
Lauterbourg 74
Hanoi 72
Hong Kong 65
Beijing 58
New York 49
Milan 41
Santa Clara 32
Frankfurt am Main 31
Helsinki 31
Los Angeles 29
Tokyo 21
Rome 18
Buffalo 16
Boardman 15
Bordighera 15
Mexico City 14
Biên Hòa 13
Chicago 13
Zurich 12
Naples 11
Da Nang 10
Dallas 10
Padua 10
São Paulo 10
Turin 10
Orem 9
Haiphong 8
Hải Dương 8
Paris 8
Philadelphia 8
Phoenix 8
Tianjin 8
Atlanta 7
Phủ Lý 7
Amsterdam 5
Brescia 5
Chennai 5
Dublin 5
Lappeenranta 5
Miami 5
Monroe 5
Pierre 5
San Francisco 5
Santiago 5
Thái Nguyên 5
Toronto 5
Baghdad 4
Bari 4
Bologna 4
Brooklyn 4
Carmichael 4
Carrollton 4
City of London 4
Davenport 4
Denver 4
Guangzhou 4
Houston 4
Hyderabad 4
Kingston 4
Phillipsburg 4
Teverola 4
Vancouver 4
Alessandria 3
Amman 3
Boydton 3
Campo Grande 3
Can Tho 3
Caracas 3
Cardiff 3
Catania 3
Cleveland 3
Detroit 3
East Windsor 3
Florence 3
Georgetown 3
Greenville 3
Hangzhou 3
Jakarta 3
Las Vegas 3
Ljubljana 3
London 3
Louisville 3
Madrid 3
Manchester 3
Marseille 3
Montreal 3
Newark 3
Nha Trang 3
Owensboro 3
Pisa 3
Porto Alegre 3
Totale 13.340
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Nome #
Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists 275
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment 260
Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis 248
Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools 243
Molecular Chaperones in the Pathogenesis of Amyotrophic Lateral Sclerosis: The Role of HSPB1 234
1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: Structure-affinity/activity relationship at alpha(1)-adrenoceptor subtypes and at 5-HT(1A) receptors. 234
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation 225
Ligand-based homology modelling of the human CB2 receptor SR144528 antagonist binding site: a computational approach to explore the 1,5-diaryl pyrazole scaffold 222
Identification of a high affinity binding site for abscisic acid on human Lanthionine synthetase component C-like protein 2 214
Fast course ALS presenting with vocal cord paralysis: clinical features, bioinformatic and modelling analysis of the novel SOD1 Gly147Ser mutation. 203
3,4,5-Trisubstituted-1,2,4-4H-triazoles as WT and Y188L mutant HIV-1 non-nucleoside reverse transcriptase inhibitors: docking-based CoMFA and CoMSIA analyses. 203
Rational design, chemical synthesis and biological evaluation of novel biguanides exploring species-specificity responsiveness of TAAR1 agonists 198
Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR) 198
CoMFA and CoMSIA analyses on 1,2,3,4-tetrahydropyrrolo[3,4-b]indole and benzimidazole derivatives as selective CB2 receptor agonists. 194
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles 193
Hit-to-lead optimization of mouse Trace Amine Associated Receptor 1 (mTAAR1) agonists with a diphenylmethane-scaffold: Design, Synthesis, and biological study 193
Exploring the QSAR of pyrazolo[3,4-b]pyridine, pyrazolo[3,4-b]pyridone and pyrazolo[3,4-b]pyrimidine derivatives as antagonists for A1 adenosine receptor. 188
Discovery of Guanfacine as a Novel TAAR1 Agonist: A Combination Strategy through Molecular Modeling Studies and Biological Assays 185
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5 185
Synthesis, in vitro antiplatelet activity and molecular modelling studies of 10-substituted 2-(1-piperazinyl)pyrimido[1,2-a]benzimidazol-4(10H)-ones 182
Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics 178
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus 176
Synthesis, molecular modeling and SAR study of novel pyrazolo[5,1-f][1,6]naphthyridines as CB2receptor antagonists/inverse agonists 171
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists 170
Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB1receptor ligand antagonists 167
T137A variant is a pathogenetic SOD1 mutation associated with a slowly progressive ALS phenotype. 165
Docking-based CoMFA and CoMSIA analyses of tetrahydro-β-carboline derivatives as type-5 phosphodiesterase inhibitors. 163
CoMFA and CoMSIA analyses on 4-oxo-1,4-dihydroquinoline and 4-oxo-1,4-dihydro-1,5-, -1,6- and -1,8-naphthyridine derivatives as selective CB2 receptor agonists 160
Impaired Chaperone Activity of Human Heat Shock Protein Hsp27 Site-Specifically Modified with Argpyrimidine 157
Discovery of novel VX-809 hybrid derivatives as F508del-CFTR correctors by molecular modeling, chemical synthesis and biological assays 157
Computational approaches for the design and chemical synthesis of novel F508del correctors in the treatment of cystic fibrosis 157
New arylsparteine derivatives as positive inotropic drugs 155
New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies 150
New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking 150
Novel pyrrolocycloalkylpyrazole analogues as CB1 ligands 149
SIRT6 pharmacological inhibition delays skin cancer progression in the squamous cell carcinoma 148
Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors 148
In silico evaluation of human small heat shock protein HSP27: Homology modeling, mutation analyses and docking studies 144
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands 143
Synthesis and structure-activity relationship of aminoarylthiazole derivatives as potential potentiators of the chloride transport defect in cystic fibrosis 143
Exploring the binding features of rimonabant analogues and acyclic CB1 antagonists: docking studies and QSAR analysis 142
Charcot-Marie-Tooth Type 2B: A New Phenotype Associated with a Novel RAB7A Mutation and Inhibited EGFR Degradation 140
Journey on VX-809-Based Hybrid Derivatives towards Drug-like F508del-CFTR Correctors: From Molecular Modeling to Chemical Synthesis and Biological Assays 138
Discovery of Novel Thiazole-Based SIRT2 Inhibitors as Anticancer Agents: Molecular Modeling, Chemical Synthesis and Biological Assays 137
Combining repositioning and de novo synthesis of pyrazolo[3,4-d]pyrimidines to discover potent SIRT-2 inhibitors 136
Docking-based 3D-QSAR analyses of pyrazole derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors. 135
LEAD OPTIMIZATION OF MKT-077 ANALOGUES AS HSP70 ALLOSTERIC INHIBITORS COMBINED WITH F508DEL CFTR CORRECTORS: A MULTI DRUG APPROACH TO CONTRAST CYSTIC FIBROSIS 134
Novel Triazol-imidazo[1,2-b]pyrazoles Selectively Impair Melanoma Cell Survival While Preserving Healthy Keratinocyte Viability 132
Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1 and 5-HT1A receptor ligand: an in vitro and computational study 131
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors. 130
Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties. 129
Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT1A receptor agonists for CNS disorders and neuropathic pain 129
Novel biguanide-based derivatives scouted as TAAR1 agonists: synthesis, biological evaluation, ADME prediction and molecular docking studies 127
Further Insights Into the Pharmacology of the Human Trace Amine-Associated Receptors: Discovery of Novel Ligands for TAAR1 by a Virtual Screening Approach. 126
Fight against H1N1 Influenza A Virus: Recent Insights towards the Development of Druggable Compounds 125
Exploring the effectiveness of novel benzimidazoles as CB2 ligands: synthesis, biological evaluation, molecular docking studies and ADMET prediction 125
New insights into the binding features of f508del cftr potentiators: A molecular docking, pharmacophore mapping and qsar analysis approach 125
PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES AS SIRTUIN INHIBITORS: DESIGN, SYNTHESIS AND PRELIMINARY in vitro EVALUATION 124
Cyclic diacyl thioureas enhance activity of corrector Lumacaftor on F508del‐CFTR 122
Structure-Activity Relationships within a Series of sigma1 and sigma2 Receptor Ligands: Identification of a sigma2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma 120
A family of nitrogen-containing heterocycles as sirtuin inhibitors: synthesis and invitro biological evaluation 120
Discovery of a Novel Chemo-Type for TAAR1 Agonism via Molecular Modeling 118
Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays 118
Speeding up the identification of cystic fibrosis transmembrane conductance regulator-targeted drugs: An approach based on bioinformatics strategies and surface plasmon resonance 118
Discovery of Novel Trace Amine-Associated Receptor 5 (TAAR5) Antagonists Using a Deep Convolutional Neural Network 117
Scouting in silico different chemo-types of PDE4 inhibitors to guide the design of new anti-inflammatory/antioxidant agents 116
Pyrazolo[3,4-d]pyrimidines as Sirtuin Inhibitors: A Preliminary Synthetic and Biological Study 116
null 116
Virtual Screening Combined with Enzymatic Assays to Guide the Discovery of Novel SIRT2 Inhibitors 115
Synthesis and biological evaluation of novel (thio)semicarbazone-based benzimidazoles as antiviral agents against human respiratory viruses 115
Probing Allosteric Hsp70 Inhibitors by Molecular Modelling Studies to Expedite the Development of Novel Combined F508del CFTR Modulators 115
Virtual Screening in the Identification of Sirtuins' Activity Modulators 114
Scouting new molecular targets for CFTR therapy: the HSC70/BAG-1 complex. A computational study. 114
Molecular Docking and QSAR Studies as Computational Tools Exploring the Rescue Ability of F508del CFTR Correctors 114
Probing In Silico the Benzimidazole Privileged Scaffold for the Development of Drug-like Anti-RSV Agents 114
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives 112
Synthesis, Biological Evaluation and Docking Studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at adrenergic alpha1- and 5-HT1A receptors. 108
Homology modeling, docking studies and molecular dynamic simulations using GPU architecture to probe the type-11 Phosphodiesterase (PDE11) catalytic site: a computational approach for the rational design of selective inhibitors. 108
In Silico and In Vitro Evaluation of the Mechanism of Action of Three VX809-Based Hybrid Derivatives as Correctors of the F508del CFTR Protein 107
A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists 106
Novel 1-amidino-4-phenylpiperazines as potent agonists at human taar1 receptor: Rational design, synthesis, biological evaluation and molecular docking studies 102
Nbd2 is required for the rescue of mutant f508del cftr by a thiazole-based molecule: A class ii corrector for the multi-drug therapy of cystic fibrosis 102
Immunoregulatory properties of cell free DNA 101
New Insights into the LANCL2-ABA Binding Mode towards the Evaluation of New LANCL Agonists 100
Insights into the structure and pharmacology of the human trace amine-associated receptor 1 (hTAAR1): homology modeling and docking studies. 100
null 99
Pharmacophore and pharmacokinetic filtering tools guiding for the design and synthesis of novel thiazole-containing and VX-809 hybrid derivatives as F508del correctors. 99
Triazole-imidazo[1,2-b]pyrazoles Able to Counteract Melanoma Cell Survival Without Compromising the Viability of Healthy Keratinocytes 97
null 95
Computational studies of the binding mode and 3D-QSAR analyses of symmetric formimidoester disulfides: a new class of non-nucleoside HIV-1 reverse transcriptase inhibitors 93
New pyrazolyl thioureas active against the Staphylococcus genus 92
Recent strategic advances in CFTR drug discovery: an overview 86
Acylthiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors: docking studies and ligand-based CoMFA and CoMSIA analyses 86
Opportunities and challenges in the design of selective TAAR1 agonists: an editorial 85
RESCUING DEFECTIVE CFTR APPLYING A DRUG REPOSITIONING STRATEGY 83
In silico drug repositioning on F508del-CFTR: a proof-of concept study on the AIFA library 83
In silico exploration of LANCL2-ABA binding mode towards the identification of novel LANCL2 agonists 82
Computational studies of the LANCL2 protein and abscissic acid towards the discovery of new ligands 81
Recent Advances in the Discovery of SIRT1/2 Inhibitors via Computational Methods: A Perspective 80
Structure-guided combination of novel CFTR correctors to improve the function of F508del-CFTR in airway epithelial cells 79
Totale 14.141
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Categoria #
all - tutte 48.916
article - articoli 44.472
book - libri 0
conference - conferenze 4.444
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 97.832
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.144 53 22 109 96 31 101 55 226 89 110 77 175
2022/2023882 85 45 16 83 165 124 1 76 157 11 97 22
2023/2024688 26 76 31 98 37 78 31 50 38 34 84 105
2024/20252.528 90 128 120 164 309 258 282 349 112 186 236 294
2025/20264.828 488 141 524 395 643 316 706 287 394 427 230 277
2026/2027385 385 0 0 0 0 0 0 0 0 0 0 0
Totale 15.451