IRIS
CORSARO, ALESSANDRO
 Distribuzione geografica
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Continente #
EU - Europa 10.550
AS - Asia 1.005
NA - Nord America 519
SA - Sud America 107
AF - Africa 20
OC - Oceania 4
Continente sconosciuto - Info sul continente non disponibili 1
Totale 12.206
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Nazione #
IT - Italia 10.390
US - Stati Uniti d'America 500
SG - Singapore 433
CN - Cina 262
VN - Vietnam 190
FR - Francia 74
BR - Brasile 66
HK - Hong Kong 38
DE - Germania 26
AR - Argentina 14
GB - Regno Unito 14
ID - Indonesia 13
IQ - Iraq 11
MX - Messico 11
FI - Finlandia 10
JP - Giappone 10
BD - Bangladesh 8
CO - Colombia 8
IN - India 8
EC - Ecuador 7
ZA - Sudafrica 7
CA - Canada 6
CH - Svizzera 6
CL - Cile 5
JO - Giordania 4
NL - Olanda 4
PH - Filippine 4
PK - Pakistan 4
TH - Thailandia 4
AU - Australia 3
BO - Bolivia 3
DK - Danimarca 3
TR - Turchia 3
UA - Ucraina 3
VE - Venezuela 3
AT - Austria 2
BH - Bahrain 2
ES - Italia 2
IE - Irlanda 2
KE - Kenya 2
KZ - Kazakistan 2
MY - Malesia 2
PL - Polonia 2
RO - Romania 2
RU - Federazione Russa 2
TN - Tunisia 2
TZ - Tanzania 2
BE - Belgio 1
BG - Bulgaria 1
BY - Bielorussia 1
CY - Cipro 1
DZ - Algeria 1
GA - Gabon 1
GP - Guadalupe 1
HR - Croazia 1
KR - Corea 1
LK - Sri Lanka 1
LT - Lituania 1
LV - Lettonia 1
LY - Libia 1
MA - Marocco 1
NC - Nuova Caledonia 1
NG - Nigeria 1
NO - Norvegia 1
NP - Nepal 1
OM - Oman 1
SA - Arabia Saudita 1
SI - Slovenia 1
SY - Repubblica araba siriana 1
TG - Togo 1
TT - Trinidad e Tobago 1
UG - Uganda 1
UY - Uruguay 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 12.206
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Città #
Genova 5.616
Genoa 2.996
Vado Ligure 868
Rapallo 833
Singapore 208
San Jose 180
Ashburn 113
Lauterbourg 72
Ho Chi Minh City 55
Beijing 40
Hong Kong 37
Hanoi 34
Council Bluffs 29
Bordighera 26
New York 25
Frankfurt am Main 22
Santa Clara 18
Milan 10
St Louis 10
Da Nang 9
Haiphong 9
Los Angeles 9
Tianjin 9
Tokyo 9
Helsinki 7
São Paulo 7
Jakarta 6
Zurich 6
Chicago 5
Mexico City 5
Rio de Janeiro 5
Amman 4
City of London 4
Hải Dương 4
Johannesburg 4
Nha Trang 4
Quito 4
Rome 4
Santiago 4
Thái Bình 4
Amsterdam 3
Baghdad 3
Bangkok 3
Biên Hòa 3
Cardiff 3
Curitiba 3
Erbil 3
Lappeenranta 3
London 3
Ninh Bình 3
Shanghai 3
Suzhou 3
Verona 3
Acalanes Ridge 2
Bari 2
Belo Horizonte 2
Berazategui 2
Brasília 2
Bắc Ninh 2
Can Tho 2
Charlotte 2
Copenhagen 2
Dar es Salaam 2
Dublin 2
Glasgow 2
Guangzhou 2
Karachi 2
Kuala Selangor 2
Kyiv 2
La Paz 2
Madrid 2
Manama 2
Medellín 2
Montreal 2
Nairobi 2
Nanjing 2
Orem 2
Paris 2
San Luis 2
Santo André 2
Turin 2
Vienna 2
Vĩnh Tường 2
Warsaw 2
Abuja 1
Agrolândia 1
Algiers 1
Araranguá 1
Araucária 1
Arraias 1
Atlanta 1
Babahoyo 1
Barcelona 1
Basingstoke 1
Belleville 1
Big Bear Lake 1
Boa Vista 1
Bolzano 1
Boston 1
Brantford 1
Totale 11.431
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Nome #
Characterization of the pro-apoptotic intracellular mechanisms induced by a toxic conformer of the recombinant human prion protein fragment 90-231 247
Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells 242
Amyloid precursor protein modulates ERK1/2 signaling 241
Calcium binding promotes Prion Protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure 231
Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors 230
Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells. 224
Human glioblastoma-derived cell membrane nanovesicles: a novel, cell-specific strategy for boron neutron capture therapy of brain tumors 221
Peptide Receptor Targeting in Cancer: The Somatostatin Paradigm 220
A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates 219
In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity 218
Apoptotic cell death and impairment of L-type voltage sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment 106-126 215
Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis 214
Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231 209
Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro 204
Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells 197
Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death 196
Differential toxicity, conformation and morphology of typical initial aggregation states of Aβ1-42 and Aβpy3-42 beta-amyloids 195
Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity 195
Amyloid precursor protein and presenilin involvement in cell signaling 194
Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90–231 Neurotoxic Effects in Cerebellar Granule Neurons 193
SDF1 controls pituitary cell proliferation through the activation of ERK1/2 and the Ca2+-dependent cytosolic tyrosine kinase, Pyk2. 190
Proteostasis unbalance in prion diseases: mechanisms of neurodegeneration and therapeutic targets 185
Different structural stability and toxicity of PrPARR and PrPARQ sheep prion protein variants 180
Contribution of two conserved glycine residues to fibrillogenesis of the 106-126 prion protein fragment. Evidence that a soluble variant of the 106-126 peptide is neurotoxic 180
Canine osteosarcoma cell lines contain stem-like cancer cells: Biological and pharmacological characterization 180
Emerging targets in pituitary adenomas: role of the CXCL12/CXCR4-R7 system 178
Effects of Prion Protein on Aβ42 and Pyroglutamate-Modified AβpΕ3-42 Oligomerization and Toxicity 176
Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction 173
ACTIVATION OF AUTOPHAGY PATHWAY AS NEUROPROTECTIVE MECHANISM AGAINST AMYLOIDOGENIC PRION PEPTIDE 172
The chemokine SDF1/CXCL12: a novel autocrine/paracrine factor involved in pituitary adenoma development 171
Chemokine stromal cell-derived factor 1α induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals 170
Excitotoxicity Through NMDA Receptors Mediates Cerebellar Granule Neuron Apoptosis Induced by Prion Protein 90-231 Fragment 170
Conformation dependent pro-apoptotic activity of the recombinant human prion protein fragment 90-231 166
ERK1/2 and p38 MAP kinases control prion protein fragment 90-231-induced astrocyte proliferation and microglia activation 165
The phosphotyrosine phosphatase PTPh mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2 159
Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation 158
Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity 156
Role of prion protein aggregation in neurotoxicity 153
Celecoxib, a COX-2 inhibitor, blocks microglial activation induced by a neurotoxic conformer of hPrP90-231 153
Addressing thermal and mechanical stability of human prion protein with single molecule and ensemble measurements 153
p38 MAP Kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells 151
Aminoterminally truncated human Prion protein fragment 90-231 forms intracellular aggregates and causes lysosomal loss of impermeability 150
Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein 149
High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein 147
Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2 145
Emerging Role of Cellular Prion Protein in the Maintenance and Expansion of Glioma Stem Cells 145
Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity 145
Antitumor Potential of Antiepileptic Drugs in Human Glioblastoma: Pharmacological Targets and Clinical Benefits 143
Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt 137
Cabergoline modulation of alpha-subunits and FSH secretion in a gonadotroph adenoma 134
The expression of the phosphotyrosine phosphatase DEP-1/PTPeta dictates the responsivity of glioma cells to somatostatin inhibition of cell proliferation 133
Experimental Evidence and Clinical Implications of Pituitary Adenoma Stem Cells 133
INTRACELLULAR MECHANISMS MEDIATING THE NEURONAL CELL DEATH AND ASTROGLIOSIS INDUCED BY THE PRION PROTEIN FRAGMENT 106-126 129
Molecular mechanisms involved in the aggregation and fibril formation of the recombinant human prion fragment PrP90-231 129
Identification of a conserved N-capping box important for the structural autonomy of the prion alpha 3-helix: the disease associated D202N mutation destabilizes the helical conformation 124
Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor 3 (SSTR3) mediated regulation of endothelial NOS and MAP kinase activities” 124
In vitro and in vivo expression of somatostatin receptors in intermediate and malignant soft tissue tumors 123
Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling 123
Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231 (hPrP90-231), as possible mechanism of its neurotoxic effects 122
Prion protein fragment 90-231 induces microglia activation: role of ERK1/2 and p38 MAP kinases in nitric oxide production and CCL5 secretion 121
Nitric oxide production stimulated by the basic fibroblast growth factor requires the synthesis of ceramide 121
Study of the Molecular Mechanism Responsible of the Conformational Changes Induced by E200K and D202N Pathological PrP Mutation 112
Expression of somatostatin receptors mRNA in human meningiomas and their implication in in vitro antiproliferative activity 109
The activation of the phosphotyrosine phosphatase h (r-PTPh) is responsible for the somatostatin inhibition of PC Cl3 thyroid cell proliferation 106
Molecular mechanisms mediating the neuroprotective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231) 106
Study of the molecular mechanisms responsible of the transition of the prion protein fragment 90-231 in a neurotoxic conformation. 106
In vitro effect of human recombinant leptin and expression of leptin receptors on growth hormone-secreting human pituitary adenomas 104
Prolonged treatment with alpha-glycerylphosphorylethanolamine facilitates the acquisition of an active avoidance behavior and selectively increases neuronal signal transduction in rats 104
Somatostatin controls Kaposi sarcoma growth through inhibition of angiogenesis 100
Somatostatinergic control of Kaposi’s sarcoma growth through the inhibition of angiogenesis 96
The expression of pro-prion, a transmembrane isoform of the prion protein, leads to the constitutive activation of the canonical Wnt/β-catenin pathway to sustain the stem-like phenotype of human glioblastoma cells 93
Somatostatin and its analog lanreotide inhibit the proliferation of dispersed human non-functioning pituitary adenoma cells in vitro 91
Neurotoxicity of the recombinant prion protein fragment 90-231 in SH-SY5Y cells is dependent on its conversion in beta-structured-isoform 89
N6-isopentenyladenosine hinders the vasculogenic mimicry in human glioblastoma cells through Src-120 catenin pathway modulation and RhoA activity inhibition 89
Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro 80
Somatostatin receptor subtype-dependent regulation of NO release: involvement of different intracellular pathways 80
The interaction of humic substances with the human prion protein fragment 90-231 affects its protease K resistance and cell internalization 76
New therapeutic strategies for Alzheimer’s disease by determination of structure and toxicity of oligomeric beta-amyloids aggregation states 75
The activation of the phosphotyrosine phosphatase eta is responsible for the somatostatin inhibition of PC Cl3 thyroid cell proliferation 65
A floating endometrial organoid model recapitulates epithelial-stromal cell interactions in vitro 61
Chemokine signaling in tumors: potential role of CXC chemokines and their receptors as glioblastoma therapeutic targets 61
Simple and Rapid Model to Generate Differentiated Endometrial Floating Organoids 28
Drug enteric metabolism in gut microbiota-brain crosstalk 27
Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231, as possible mechanism of its neurotoxic effects 18
Totale 12.397
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Categoria #
all - tutte 35.928
article - articoli 34.062
book - libri 0
conference - conferenze 1.529
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 337
Totale 71.856
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021132 0 0 0 0 0 0 0 0 0 57 35 40
2021/2022978 28 102 56 99 36 71 76 230 31 77 44 128
2022/2023975 70 56 11 91 163 169 3 95 148 5 152 12
2023/2024553 27 55 10 84 40 149 39 30 23 13 32 51
2024/20252.061 55 114 59 197 282 231 188 374 74 70 192 225
2025/20263.029 396 79 487 284 383 244 441 163 231 321 0 0
Totale 12.397