IRIS
BRUZZONE, SANTINA
 Distribuzione geografica
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Continente #
EU - Europa 29.151
NA - Nord America 4.084
AS - Asia 3.826
Continente sconosciuto - Info sul continente non disponibili 481
SA - Sud America 380
AF - Africa 76
OC - Oceania 7
Totale 38.005
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Nazione #
IT - Italia 28.459
US - Stati Uniti d'America 3.861
SG - Singapore 1.455
CN - Cina 938
VN - Vietnam 739
BD - Bangladesh 285
FR - Francia 242
BR - Brasile 207
HK - Hong Kong 155
DE - Germania 97
CA - Canada 83
FI - Finlandia 74
GB - Regno Unito 71
AR - Argentina 70
MX - Messico 57
JP - Giappone 56
IN - India 33
NL - Olanda 32
VE - Venezuela 26
ES - Italia 25
EC - Ecuador 24
IQ - Iraq 24
CO - Colombia 21
ID - Indonesia 19
PH - Filippine 16
ZA - Sudafrica 16
CH - Svizzera 15
UA - Ucraina 15
CL - Cile 14
CR - Costa Rica 14
JM - Giamaica 14
TR - Turchia 13
TW - Taiwan 13
PK - Pakistan 12
DK - Danimarca 11
IE - Irlanda 11
EG - Egitto 10
MA - Marocco 10
PL - Polonia 10
RU - Federazione Russa 10
HN - Honduras 9
SE - Svezia 9
PY - Paraguay 8
RO - Romania 8
GT - Guatemala 7
KE - Kenya 7
AE - Emirati Arabi Uniti 6
AU - Australia 6
BG - Bulgaria 6
JO - Giordania 6
PT - Portogallo 6
SA - Arabia Saudita 6
TH - Thailandia 6
AT - Austria 5
DZ - Algeria 5
LT - Lituania 5
MY - Malesia 5
NI - Nicaragua 5
SC - Seychelles 5
SV - El Salvador 5
TT - Trinidad e Tobago 5
BE - Belgio 4
HR - Croazia 4
IL - Israele 4
KZ - Kazakistan 4
NG - Nigeria 4
RS - Serbia 4
SK - Slovacchia (Repubblica Slovacca) 4
TN - Tunisia 4
UY - Uruguay 4
AL - Albania 3
BB - Barbados 3
BO - Bolivia 3
BS - Bahamas 3
CG - Congo 3
CZ - Repubblica Ceca 3
DO - Repubblica Dominicana 3
GR - Grecia 3
HU - Ungheria 3
KR - Corea 3
KW - Kuwait 3
MM - Myanmar 3
NP - Nepal 3
PA - Panama 3
PE - Perù 3
SN - Senegal 3
AZ - Azerbaigian 2
BH - Bahrain 2
CY - Cipro 2
ET - Etiopia 2
GD - Grenada 2
KG - Kirghizistan 2
KN - Saint Kitts e Nevis 2
LB - Libano 2
LC - Santa Lucia 2
LV - Lettonia 2
MK - Macedonia 2
NO - Norvegia 2
OM - Oman 2
PR - Porto Rico 2
Totale 37.499
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Città #
Genova 14.772
Genoa 8.801
Rapallo 2.291
Vado Ligure 2.024
San Jose 873
Singapore 682
Ashburn 432
Ho Chi Minh City 217
Lauterbourg 203
Council Bluffs 185
Beijing 167
Hanoi 166
Hong Kong 140
Los Angeles 112
New York 106
Santa Clara 99
Milan 78
Frankfurt am Main 73
Helsinki 68
Bordighera 64
Phoenix 53
Dallas 50
Rome 49
Chicago 46
Tokyo 45
Buffalo 41
Mexico City 41
Da Nang 40
Haiphong 39
Atlanta 23
Boardman 23
Houston 23
Orem 23
Brooklyn 22
Naples 22
San Francisco 21
Biên Hòa 20
Amsterdam 19
Miami 19
Philadelphia 17
Can Tho 16
Montreal 16
São Paulo 16
Cardiff 15
Newark 15
City of London 14
Tianjin 14
Turin 14
Denver 13
Hải Dương 13
Las Vegas 13
Paris 13
Sacramento 13
Springfield 13
Washington 13
Zurich 13
Charlotte 12
Nuremberg 12
St Louis 12
Baghdad 11
Johannesburg 11
Manchester 11
Minneapolis 11
Salt Lake City 11
Dublin 10
Florence 10
Guangzhou 10
Jacksonville 10
London 10
San José 10
Toronto 10
Bắc Ninh 9
Guayaquil 9
Piscataway 9
Rio de Janeiro 9
The Bronx 9
Brasília 8
Columbus 8
Kingston 8
Kyiv 8
Madrid 8
Phú Thọ 8
Queens 8
Quito 8
Rochester 8
Thái Nguyên 8
Warsaw 8
Bakersfield 7
Brescia 7
Changsha 7
Columbia 7
Guatemala City 7
Long Xuyen 7
Porto Alegre 7
Quảng Ngãi 7
Thái Bình 7
Vancouver 7
Amman 6
Ankara 6
Baltimore 6
Totale 32.795
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Nome #
APO866 increases antitumor activity of cyclosporin - A by inducing mitochondrial and endoplasmic reticulum stress in leukemia cells 328
Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo 271
Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP-ribose as second messenger. 265
APO866 activity in hematologic malignancies: a preclinical in vitro study. 256
Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells vulnerability to DNA-damaging agents 253
Nicotinic acid phosphoribosyltransferase regulates cancer cell metabolism, susceptibility to NAMPT inhibitors and DNA repair. 249
G-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2 247
Impaired increase of plasma abscisic acid in response to oral glucose load in type 2 diabetes and in gestational diabetes 242
Regulation and Function of Extracellular Nicotinamide Phosphoribosyltransferase/Visfatin. 236
G(s) protein dysfunction in allergen-challenged human isolated passively sensitized bronchi. 231
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics 230
Binding of abscisic acid to human LANCL2 230
Catastrophic NAD(+) Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE 228
Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo 226
Abscisic acid ameliorates the systemic sclerosis fibroblast phenotype in vitro. 223
Abscisic acid released by human monocytes activates monocytes and vascular smooth muscle cell responses involved in atherogenesis 223
SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells 221
Abscisic Acid Stimulates Glucagon-Like Peptide-1 Secretion from L-Cells and Its Oral Administration Increases Plasma Glucagon-Like Peptide-1 Levels in Rats 220
Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger. 218
Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody 216
LANCL2 is necessary for Abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells 214
Inhibition of Nicotinamide Phosphoribosyltransferase Reduces Neutrophil-Mediated Injury in Myocardial Infarction. 213
CD38 downregulation modulates NAD+ and NADP(H) levels in thermogenic adipose tissues 212
Abscisic acid and cyclic ADP-ribose are first and second messanger in inflammatory cells, hematopoietic progenitors and pancreatic beta-cells 210
ABA- and cADPR-mediated effects on respiration and filtration downstream of the temperature-signaling cascade in sponges 209
Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model 209
Nicotinamide phosphoribosyltransferase promotes epithelial-to-mesenchymal transition as a soluble factor independent of its enzymatic activity. 208
Tolerability and efficacy study of P2X7 inhibition in experimental Charcot-Marie-Tooth type 1A (CMT1A) neuropathy 208
SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects 207
Discovery of novel and selective SIRT6 inhibitors. 206
ABA says NO to UV-B: a universal response? 205
The diadenosine homodinucleotide P18 improves in vitro myelination in experimental Charcot-Marie-Tooth type 1A 204
Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration 201
Regulation of human mesenchymal stem cell functions by an autocrine loop involving NAD+ release and P2Y11-mediated signaling. 197
Extracellular NAD+ regulates intracellular calcium levels and induces activation of human granulocytes 197
Autocrine abscisic acid mediates the UV-B-induced inflammatory response in human granulocytes and keratinocytes 195
CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells. 195
Adenylic dinucleotides produced by CD38 are negative endogenous modulators of platelet aggregation 195
Abscisic Acid: A Conserved Hormone in Plants and Humans and a Promising Aid to Combat Prediabetes and the Metabolic Syndrome. 194
Differential modulation of SIRT6 deacetylase and deacylase activities by lysine-based small molecules 194
A self restricted CD38-connexin 43 cross-talk affects NAD+ and cyclic ADP-ribose metabolism and regulates intracellular calcium in 3T3 fibroblasts 193
Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells. 193
Abscisic acid activates the murine microglial cell line N9 through the second messenger cyclic ADP-ribose 192
Concentrative influx of functionally active cyclic ADP-ribose in dimethylsulfoxide-differentiated HL-60 cells 190
Abscisic acid signaling through cyclic ADP-ribose in hydroid regeneration 189
Mesenchymal stem cells shape microglia effector functions through the release of CX3CL1 189
Functional characterization of a synthetic abscisic acid analog with anti-inflammatory activity on human granulocytes and monocytes 188
Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors As Therapeutics: Rationales, Controversies, Clinical Experience. 188
Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice. 188
Abscisic acid and cyclic ADP-ribose are first and second messengers in inflammatory cells and hemopoietic progenitors 187
The plant hormone abscisic acid stimulates the proliferation of human hemopoietic progenitors through the second messenger cyclic ADP-ribose 187
Abscisic Acid: A Novel Nutraceutical for Glycemic Control 185
CD38-Induced Metabolic Dysfunction Primes Multiple Myeloma Cells for NAD+-Lowering Agents 182
Impaired increase of plasma abscisic acid in response to oral glucose load in type 2 diabetes and in gestational diabetes 182
Cyclic ADP-ribose generation by CD38 improves human hemopoietic stem cell engraftment into NOD/SCID mice 182
NAD+ METABOLISM RESTRICTION BOOSTS HIGH-DOSE MELPHALAN EFFICACY IN PATIENTS WITH MULTIPLE MYELOMA 181
The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting. 181
Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells 181
Concentrative uptake of cyclic ADP-ribose generated by BST-1+ stroma stimulates proliferation of human hematopoietic progenitors 181
Subcellular and intercellular traffic of NAD+, NAD+ precursors and NAD+-derived signalmetabolites and second messengers: Old and new topological paradoxes 179
Abscisic acid produced by human monocytes stimulates monocyte and vascular smooth muscle cell responses involved in the development of the atherosclerotic lesion 179
LANCL2 is the abscisic acid receptor in human granulocytes and in rat insulinoma cells. 178
Abscisic acid is an endogenous stimulator of insulin release from human release from human pancreatic islets with cyclic ADP-ribose as second messenger. 175
Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated proliferation of human peripheral blood mononuclear cells. 175
A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes. 175
Abscisic acid and cyclic ADP-ribose increase intracellular Ca2+ and stimulate proliferation of human mesenchymal stem cells. 173
Nicotinamide Phosphoribosyltransferase As A Target In Inflammation-Related Disorders. 173
Abscisic acid enhances adipocyte diffentiation and glucose uptake in murine 3T3-L1 and in human ATMSC 171
Selectivity hot-spots of sirtuin catalytic cores 171
ADP-ribosyl cyclases generate two unusual adenine homodinucleotides with cytotoxic activity on mammalian cells. 170
Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells. 170
The danger signal extracellular ATP is involved in the immunomediated damage of α-sarcoglycan deficient muscular dystrophy 170
Catastrophic NAD+ Depletion through Nampt Inhibition in Activated T Lymphocytes Reduces Demyelination and Disability in EAE. 169
Mitochondrial dysfunction induced by a cytotoxic adenine dinucleotide produced by ADP-ribosyl cyclases from cADPR. 167
Expression of CD38 increases intracellular calcium concentration and reduces doubling time in HeLa and 3T3 cells. 165
LANCL2 is the abscisic acid receptor in in human granulocytes and in rat insulinoma cells 165
Abscisic acid produced by human monocyte and vascular smooth muscle cell responses involved in the development of the atherosclerotic lesion. 165
Equilibrative and concentrative nucleoside transporters mediate the influx of Cyclic ADP-ribose into 3T3 murine fibroblasts. 164
Amino acid depletion triggered by L-asparaginase sensitizes MM cells to carfilzomib by inducing mitochondria ROS-mediated cell death 164
Autocrine abscisic acid plays a key role in quartz-induced macrophage activation 163
NAD+ Levels Control Ca2+ Store Replenishment and Mitogen-induced Increase of Cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 Channel Gating in Human T Lymphocytes. 162
Dimeric and tetrameric forms of catalytically active transmembrane CD38 in transfected HeLa cells 161
Synthetic analogues of abscisic acid with anti-inflammatory and insulin release stimulation effects on human cells 161
The TRPM2 ion channel regulates the browning process in human adipose tissue 160
The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism 159
NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases 158
Paracrine roles of NAD+ and Cyclic ADP-ribose in increasing intracellular calcium and enhancing cell proliferation of 3T3 fibroblasts 158
Abscisic acid and cyclic ADP-ribose increase intracellular Ca++ and stimulate proliferation of human mesenchymal stem cells 158
A P2X7 antagonist improves muscle strength and motor distal amplitude in CMT1A rats: preliminary results from an in vivo trial 158
Toward a medicine-oriented use of the human hormone/nutritional supplement Abscisic Acid 158
Abscisic acid is an endogenous pro-inflammatory cytokine in human granulocytes with cyclic ADP-ribose as second messenger 158
Abscisic acid stimulates the release of insulin and of GLP-1 in the rat perfused pancreas and intestine 158
Rejuvenating sirtuins: the rise of a new family of cancer drug targets 158
SIRT6 pharmacological inhibition delays skin cancer progression in the squamous cell carcinoma 157
The plant hormone abscisic acid increases in human plasma after hyperglycemia and stimulates glucose consumption by adipocytes and myoblasts 157
The plant hormone abscisic acid stimulates the proliferation of human hemopoietic progenitors through the second messenger cyclic ADP-ribose. 157
Abscisic acid: a new human adipose tissue-derived hormone? 154
P2X7 antagonists improve “in vitro” myelination in organotypic dorsal root ganglia (DRG) cultures from a rat model of CMT1A neuropathy 153
Autocrine and paracrine calcium signalling by the CD38/NAD+/cyclic ADP-ribose system 152
Fluridone as a new anti-inflammatory drug 152
Totale 19.155
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Categoria #
all - tutte 120.065
article - articoli 92.231
book - libri 0
conference - conferenze 24.122
curatela - curatele 0
other - altro 0
patent - brevetti 3.351
selected - selezionate 0
volume - volumi 361
Totale 240.130
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20222.355 0 0 246 280 86 146 178 584 118 248 94 375
2022/20232.769 253 217 43 293 489 404 15 210 443 12 357 33
2023/20241.987 84 195 72 272 186 396 124 118 99 58 128 255
2024/20255.591 303 340 227 427 576 459 502 972 189 292 606 698
2025/202610.609 1.282 294 693 882 1.498 832 1.514 571 845 1.010 604 584
2026/20271.944 1.133 377 434 0 0 0 0 0 0 0 0 0
Totale 38.005