IRIS
BRULLO, CHIARA
 Distribuzione geografica
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Continente #
EU - Europa 16.929
AS - Asia 2.678
NA - Nord America 2.373
Continente sconosciuto - Info sul continente non disponibili 456
SA - Sud America 217
AF - Africa 37
OC - Oceania 2
Totale 22.692
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Nazione #
IT - Italia 16.518
US - Stati Uniti d'America 2.243
SG - Singapore 1.088
CN - Cina 681
VN - Vietnam 443
FR - Francia 151
BR - Brasile 138
BD - Bangladesh 125
HK - Hong Kong 125
DE - Germania 66
JP - Giappone 63
FI - Finlandia 51
CA - Canada 46
MX - Messico 37
AR - Argentina 34
GB - Regno Unito 29
TW - Taiwan 29
NL - Olanda 21
IN - India 20
ES - Italia 17
ID - Indonesia 15
IQ - Iraq 14
EC - Ecuador 13
EG - Egitto 11
JM - Giamaica 11
KR - Corea 11
RU - Federazione Russa 11
TR - Turchia 10
TH - Thailandia 9
VE - Venezuela 9
CO - Colombia 8
PL - Polonia 8
CR - Costa Rica 7
IE - Irlanda 7
PK - Pakistan 7
SA - Arabia Saudita 7
UA - Ucraina 7
ZA - Sudafrica 6
CH - Svizzera 5
CL - Cile 5
GT - Guatemala 5
HR - Croazia 5
PH - Filippine 5
PR - Porto Rico 5
PY - Paraguay 5
AL - Albania 4
LB - Libano 4
MA - Marocco 4
SE - Svezia 4
SV - El Salvador 4
TT - Trinidad e Tobago 4
AZ - Azerbaigian 3
DZ - Algeria 3
JO - Giordania 3
PA - Panama 3
RO - Romania 3
UZ - Uzbekistan 3
BO - Bolivia 2
BS - Bahamas 2
CZ - Repubblica Ceca 2
DK - Danimarca 2
EE - Estonia 2
ET - Etiopia 2
KE - Kenya 2
KG - Kirghizistan 2
KW - Kuwait 2
MY - Malesia 2
NO - Norvegia 2
NP - Nepal 2
PE - Perù 2
PT - Portogallo 2
SC - Seychelles 2
SI - Slovenia 2
SN - Senegal 2
AG - Antigua e Barbuda 1
AM - Armenia 1
AT - Austria 1
AU - Australia 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BE - Belgio 1
BG - Bulgaria 1
BY - Bielorussia 1
CI - Costa d'Avorio 1
CM - Camerun 1
CY - Cipro 1
DO - Repubblica Dominicana 1
GR - Grecia 1
GY - Guiana 1
HN - Honduras 1
HU - Ungheria 1
KH - Cambogia 1
LC - Santa Lucia 1
LT - Lituania 1
LV - Lettonia 1
LY - Libia 1
MD - Moldavia 1
MN - Mongolia 1
NE - Niger 1
NZ - Nuova Zelanda 1
Totale 22.233
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Città #
Genova 8.400
Genoa 5.257
Vado Ligure 1.329
Rapallo 1.215
San Jose 605
Singapore 564
Ashburn 298
Lauterbourg 128
Ho Chi Minh City 126
Hanoi 110
Council Bluffs 104
Beijing 100
Hong Kong 93
New York 93
Tokyo 56
Frankfurt am Main 55
Santa Clara 51
Los Angeles 46
Helsinki 44
Milan 38
Bordighera 27
Mexico City 26
Boardman 23
Haiphong 23
Rome 22
Dallas 20
Buffalo 18
Da Nang 18
Naples 18
São Paulo 18
Amsterdam 17
Orem 17
Tianjin 17
Atlanta 16
Chicago 16
Phoenix 14
Houston 11
Montreal 11
Taipei 11
Turin 11
Cairo 10
Brooklyn 9
Hải Dương 9
Ribeirão Preto 9
Toronto 9
Catania 8
Davenport 8
Florence 8
Iowa City 8
Miami 8
Paris 8
Biên Hòa 7
Can Tho 7
Des Moines 7
Dhaka 7
Dublin 7
Lappeenranta 7
Palermo 7
Philadelphia 7
Quảng Ngãi 7
Basingstoke 6
Birmingham 6
Chennai 6
Kingston 6
Las Vegas 6
Ninh Bình 6
Padua 6
San José 6
Seattle 6
Warsaw 6
Baghdad 5
Brescia 5
Cardiff 5
Charlotte 5
Columbia 5
Denver 5
Detroit 5
Hangzhou 5
North Bergen 5
North Charleston 5
Taichung 5
Thái Nguyên 5
Zagreb 5
Bari 4
Bắc Ninh 4
Carmichael 4
Carrollton 4
City of London 4
Fort Myers 4
Istanbul 4
Kwai Chung 4
Kyiv 4
Leipzig 4
Louisville 4
Madrid 4
Memphis 4
Nuremberg 4
Phillipsburg 4
Phủ Lý 4
Pierre 4
Totale 19.416
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Nome #
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment 260
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation 227
Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease. 217
Analogs, formulations and derivatives of imatinib: A patent review 207
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors 207
A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. 203
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors 197
ATP-competitive inhibitors of mTOR: an update. 195
GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. 193
The pyrazolyl-urea GeGe3 inhibits tumor angiogenesis and reveals dystrophia myotonica protein Kinase (DMPK)1 as a novel angiogenesis target 192
Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors 188
An update on dual Src/Abl inhibitors 188
Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors. 187
Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma 186
Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma. 184
Synthesis and biological evaluation of neutrophilic inflammation inhibitors 184
Bcr-Abl tyrosine kinase inhibitors: A patent review 180
2-Aryl-3-phenylamino-4,5-dihydro-2h-benz[g]indazoles with analgesic activity 180
Fyn kinase in brain diseases and cancer: the search for inhibitors. 179
Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines 175
Synthesis and biological evaluation of N-pyrazolyl-N'-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis 165
Pyrazole and imidazo[1,2-b]pyrazole derivatives as new potential anti-tuberculosis agents. 165
2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: New potent inhibitors of fMLP-induced neutrophil chemotaxis 163
N-Aryl-2-phenyl-2,3-dihydro-imidazo[1,2-b]pyrazole-1-carboxamides 7-substituted strongly inhibiting both fMLP-OMe- and IL-8-induced human neutrophil chemotaxis. 161
2-Amino/Azido/Hydrazino-5-alkoxy-5H-[1]benzopyrano[4,3-d]pyrimidines: Synthesis and Pharmacological Evaluation 158
Derivati dell'1,3-benzodiossolo, potenziali inibitori delle PDE5 157
Computational approaches for the design and chemical synthesis of novel F508del correctors in the treatment of cystic fibrosis 157
Amino-Pyrazoles in Medicinal Chemistry: A Review 157
Src kinase inhibitors: an update on patented compounds 156
Neutrophil chemotaxis inhibitors: new tools against cancer metastasis? 155
A1 receptors ligands: past, present and future trends. 154
Differential inhibition of signaling pathways by two new imidazo-pyrazoles molecules in fMLF-OMe- and IL8-stimulated human neutrophil 154
Synthesis and pharmacological evaluation of 5H-[1]benzopyrano[4,3-d]pyrimidines effective as antiplatelet/analgesic agents 154
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 154
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 153
3-Cyclopentyloxy-4-Methoxyphenyl-isoxazoline derivatives as new PDE4 inhibitors. 152
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors. 152
Pyrrolo[2,3-d]pyrimidines as kinase inhibitors 152
Biologically driven synthesis of pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors: an old scaffold as a new tool for medicinal chemistry and chemical biology studies 151
New compounds having a selective PDE4D inhibiting activity 150
New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets 149
Hit identification and biological evaluation of anticancer pyrazolopyrimidines endowed with anti-inflammatory activity 148
Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors 148
An Update on JAK Inhibitors 148
4-Amino-pyrazolo[3,4-d]pyrimidines with antiproliferative activity on osteosarcoma cell line SaOS-2 147
Design, synthesis and biological evaluation of new pyrazolyl-ureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis 147
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant. 146
Biological evaluation of pyrazolyl-urea and dihydro-imidazopyrazolyl-urea derivatives as potential anti-angiogenetic agents in the treatment of neuroblastoma 146
Insights into the Pharmacological Activity of the Imidazo-Pyrazole Scaffold 145
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells 143
New halogenated 4-aminopyrazolo[3,4-b]pyridines A1 adenosine receptor ligands 142
2,3-Dihydro-1H-imidazo[1,2-b]pyrazole derivatives as potential neutrophils functions inhibitors 141
GEBR-32A, A NEW PROMISING PDE4D INHIBITOR FOR TREATMENT OF ALZHEIMER'S DISEASE 140
Novel Triazol-imidazo[1,2-b]pyrazoles Selectively Impair Melanoma Cell Survival While Preserving Healthy Keratinocyte Viability 139
Small molecules ATP-competitive inhibitors of FLT3: a chemical overview. 138
5-alkoxy-2-hydrazino and 5-methoxy-2-amino-5H-[1]benzopyrano[4,3-d]pyrimidines: synthesis and pharmacological activity 138
Gebr-7b, a novel selective PDE4D inhibitor, increases beta amyloid secretion in neuronal cultured cells and improves cognitive function in rodents 138
Growth inhibition of medullary thyroid carcinoma cells by pyrazolo-pyrimidine derivatives 137
Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model. 137
6-Substituted pyrazolo[3,4-d]pyrimidines: new promising compounds in the fight against Neuroblastoma 137
Synthesis and pharmacological evaluation of 2,5-Cycloamino-5H[1]benzopyrano[4,3-d]pyrimidines endowed with in vitro antiplatelet activity 137
Combining repositioning and de novo synthesis of pyrazolo[3,4-d]pyrimidines to discover potent SIRT-2 inhibitors 136
Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study. 136
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 136
Treatment with 1-(2-hydroxyalkyl/phenyl/naphtylureido)-1H-pyrazole-4-carboxylic acid ethyl esters abrogates neutrophil migration towards fMLP and CXCL8 via the inhibition of defined signalling pathways 134
Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors. 133
Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents. 133
A Proteomics Approach Identifies RREB1 as a Crucial Molecular Target of Imidazo–Pyrazole Treatment in SKMEL-28 Melanoma Cells 132
Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells 132
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities 132
Preparation and Physicochemical Characterization of Water-Soluble Pyrazole-Based Nanoparticles by Dendrimer Encapsulation of an Insoluble Bioactive Pyrazole Derivative 132
New fluorinated PDE4D inhibitors for the treatment of memory impairments. 130
Btk inhibitors: a medicinal chemistry and drug delivery perspective 130
Novel dual Src/Abl inhibitors for hematologic and solid malignancies. 128
PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES AS SIRTUIN INHIBITORS: DESIGN, SYNTHESIS AND PRELIMINARY in vitro EVALUATION 125
Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones  124
Design and synthesis of new multitarget drugs for autoimmune inflammatory diseases 123
Synthesis of pyrazolo[3,4-d]pyrimidine derivatives active in a preclinical glioblastoma model. 123
Development of imidazo-pyrazole derivatives as potential antimetastatic agents in neuroblastoma 122
Current advances in the development of anticancer drugs targeting tyrosine kinases of the Src family 122
Discovery of New Antiproliferative Imidazopyrazole Acylhydrazones Able To Interact with Microtubule Systems 121
Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology 120
Synthesis of new 2-phenyl-1-arylcarbamoyl-2,3-dihydro-1h-imidazo[1,2-b]pyrazoles 7-substituted as potential neutrophil chemotaxis inhibitors 120
A family of nitrogen-containing heterocycles as sirtuin inhibitors: synthesis and invitro biological evaluation 120
Pyrazolo[3,4-d]pyrimidines as Sirtuin Inhibitors: A Preliminary Synthetic and Biological Study 119
Synthesis of new pyrazolo [3,4-d]pyrimidines Bcr-Abl tyrosine kinase inhibitors 118
New selective PDE4D inhibitors devoid of sedative effects in mice 118
New PDE4D selective inhibitors able to restore memory function 118
Progress in 5H-[1]benzopyrano[4,3-d]pyrimidin-5-amine series: 2-methoxy derivatives effective as antiplatelet agents with analgesic activity 118
New opportunities to treat the T315I-Bcr-Abl mutant in chronic myeloid leukaemia: tyrosine kinase inhibitors and molecules that act by alternative mechanisms. 117
Hck inhibitors as potential therapeutic agents in cancer and HIV infection 117
Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines 117
Scouting in silico different chemo-types of PDE4 inhibitors to guide the design of new anti-inflammatory/antioxidant agents 116
New rolipram related PDE4 inhibitors: synthesis, enantiomers separation and enzymatic activity 116
null 116
Virtual Screening Combined with Enzymatic Assays to Guide the Discovery of Novel SIRT2 Inhibitors 115
Preparation of ureidopyrazolecarboxylates with neutrophil chemotaxis inhibiting activity. 115
New pyrazolo[3,4-d]pyrimidines 4-benzylamino substituted endowed with antiproliferative activity on chronic myeloid leukemia cell line 115
Synthesis of pyrazolo[3,4-d]pyridines selective antagonists of A1 adenosine receptors 115
N-substituted ureas of ethyl 1-(2-hydroxy-2-phenylethyl)-1H-pyrazole-4-carboxylate as potent and selective IL-8 receptor inhibitors 114
Totale 14.848
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Categoria #
all - tutte 73.851
article - articoli 50.787
book - libri 0
conference - conferenze 21.495
curatela - curatele 0
other - altro 0
patent - brevetti 1.291
selected - selezionate 0
volume - volumi 278
Totale 147.702
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.590 49 100 137 202 42 101 110 379 64 133 75 198
2022/20231.516 159 118 15 165 215 220 7 114 273 21 185 24
2023/20241.244 54 164 41 157 120 159 55 61 64 44 96 229
2024/20253.392 104 251 114 268 418 326 334 439 153 232 308 445
2025/20267.183 714 205 501 577 949 533 1.059 515 629 733 357 411
2026/2027729 729 0 0 0 0 0 0 0 0 0 0 0
Totale 22.692