IRIS
BRULLO, CHIARA
 Distribuzione geografica
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Continente #
EU - Europa 16.831
AS - Asia 2.582
NA - Nord America 1.566
SA - Sud America 187
AF - Africa 35
OC - Oceania 2
Continente sconosciuto - Info sul continente non disponibili 1
Totale 21.204
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Nazione #
IT - Italia 16.436
US - Stati Uniti d'America 1.483
SG - Singapore 1.085
CN - Cina 677
VN - Vietnam 438
FR - Francia 148
HK - Hong Kong 124
BR - Brasile 123
DE - Germania 64
JP - Giappone 62
FI - Finlandia 51
BD - Bangladesh 49
MX - Messico 37
AR - Argentina 29
TW - Taiwan 29
CA - Canada 28
GB - Regno Unito 28
IN - India 20
NL - Olanda 19
ES - Italia 16
ID - Indonesia 13
IQ - Iraq 12
EC - Ecuador 11
EG - Egitto 11
KR - Corea 11
RU - Federazione Russa 11
TR - Turchia 10
TH - Thailandia 9
IE - Irlanda 7
PL - Polonia 7
SA - Arabia Saudita 7
UA - Ucraina 7
VE - Venezuela 7
PK - Pakistan 6
ZA - Sudafrica 6
CH - Svizzera 5
HR - Croazia 5
PH - Filippine 5
PY - Paraguay 5
AL - Albania 4
CL - Cile 4
CO - Colombia 4
JM - Giamaica 4
LB - Libano 4
MA - Marocco 4
PR - Porto Rico 4
AZ - Azerbaigian 3
DZ - Algeria 3
JO - Giordania 3
SE - Svezia 3
UZ - Uzbekistan 3
BO - Bolivia 2
CZ - Repubblica Ceca 2
DK - Danimarca 2
EE - Estonia 2
ET - Etiopia 2
KE - Kenya 2
KG - Kirghizistan 2
KW - Kuwait 2
NO - Norvegia 2
NP - Nepal 2
PA - Panama 2
SI - Slovenia 2
SN - Senegal 2
SV - El Salvador 2
TT - Trinidad e Tobago 2
AM - Armenia 1
AT - Austria 1
AU - Australia 1
BB - Barbados 1
BE - Belgio 1
BS - Bahamas 1
BY - Bielorussia 1
CI - Costa d'Avorio 1
CM - Camerun 1
CR - Costa Rica 1
CY - Cipro 1
GR - Grecia 1
GT - Guatemala 1
GY - Guiana 1
HU - Ungheria 1
KH - Cambogia 1
LT - Lituania 1
LV - Lettonia 1
LY - Libia 1
MD - Moldavia 1
MN - Mongolia 1
MY - Malesia 1
NE - Niger 1
NZ - Nuova Zelanda 1
PE - Perù 1
PT - Portogallo 1
RO - Romania 1
SX - ???statistics.table.value.countryCode.SX??? 1
SY - Repubblica araba siriana 1
TN - Tunisia 1
Totale 21.204
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Città #
Genova 8.400
Genoa 5.245
Vado Ligure 1.329
Rapallo 1.215
Singapore 564
San Jose 448
Ashburn 227
Lauterbourg 128
Ho Chi Minh City 125
Hanoi 106
Council Bluffs 104
Beijing 97
Hong Kong 93
New York 88
Frankfurt am Main 55
Tokyo 55
Helsinki 44
Santa Clara 44
Los Angeles 39
Milan 33
Bordighera 27
Mexico City 26
Boardman 23
Haiphong 23
Da Nang 18
São Paulo 18
Amsterdam 17
Orem 17
Tianjin 17
Rome 15
Buffalo 11
Chicago 11
Naples 11
Taipei 11
Cairo 10
Dallas 10
Hải Dương 9
Montreal 9
Atlanta 8
Paris 8
Phoenix 8
Biên Hòa 7
Can Tho 7
Catania 7
Des Moines 7
Dublin 7
Lappeenranta 7
Quảng Ngãi 7
Turin 7
Basingstoke 6
Chennai 6
Dhaka 6
Ninh Bình 6
Toronto 6
Warsaw 6
Baghdad 5
Brescia 5
Cardiff 5
Charlotte 5
Hangzhou 5
North Bergen 5
Padua 5
Taichung 5
Thái Nguyên 5
Zagreb 5
Bari 4
Brooklyn 4
Bắc Ninh 4
City of London 4
Denver 4
Florence 4
Houston 4
Istanbul 4
Kwai Chung 4
Kyiv 4
Leipzig 4
Nuremberg 4
Phủ Lý 4
Salt Lake City 4
Thái Bình 4
Yuanlin 4
Zurich 4
Agugliano 3
Amman 3
Asunción 3
Baku 3
Bangkok 3
Brasília 3
Campinas 3
Detroit 3
Dobong-gu 3
Erbil 3
Guangzhou 3
Guarulhos 3
Guayaquil 3
Kingston 3
Lahore 3
London 3
Lấp Vò 3
Madrid 3
Totale 19.010
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Nome #
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment 257
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation 222
Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease. 212
Analogs, formulations and derivatives of imatinib: A patent review 201
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors 200
A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. 196
ATP-competitive inhibitors of mTOR: an update. 192
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors 192
GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. 187
The pyrazolyl-urea GeGe3 inhibits tumor angiogenesis and reveals dystrophia myotonica protein Kinase (DMPK)1 as a novel angiogenesis target 184
An update on dual Src/Abl inhibitors 183
Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors. 183
Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma. 180
Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma 180
Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors 178
Synthesis and biological evaluation of neutrophilic inflammation inhibitors 177
2-Aryl-3-phenylamino-4,5-dihydro-2h-benz[g]indazoles with analgesic activity 176
Fyn kinase in brain diseases and cancer: the search for inhibitors. 176
Bcr-Abl tyrosine kinase inhibitors: A patent review 174
Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines 170
Synthesis and biological evaluation of N-pyrazolyl-N'-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis 162
Pyrazole and imidazo[1,2-b]pyrazole derivatives as new potential anti-tuberculosis agents. 160
N-Aryl-2-phenyl-2,3-dihydro-imidazo[1,2-b]pyrazole-1-carboxamides 7-substituted strongly inhibiting both fMLP-OMe- and IL-8-induced human neutrophil chemotaxis. 160
Computational approaches for the design and chemical synthesis of novel F508del correctors in the treatment of cystic fibrosis 156
2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: New potent inhibitors of fMLP-induced neutrophil chemotaxis 156
Derivati dell'1,3-benzodiossolo, potenziali inibitori delle PDE5 153
2-Amino/Azido/Hydrazino-5-alkoxy-5H-[1]benzopyrano[4,3-d]pyrimidines: Synthesis and Pharmacological Evaluation 151
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 150
Src kinase inhibitors: an update on patented compounds 149
Neutrophil chemotaxis inhibitors: new tools against cancer metastasis? 149
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors. 149
A1 receptors ligands: past, present and future trends. 148
3-Cyclopentyloxy-4-Methoxyphenyl-isoxazoline derivatives as new PDE4 inhibitors. 148
Synthesis and pharmacological evaluation of 5H-[1]benzopyrano[4,3-d]pyrimidines effective as antiplatelet/analgesic agents 147
Amino-Pyrazoles in Medicinal Chemistry: A Review 147
Biologically driven synthesis of pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors: an old scaffold as a new tool for medicinal chemistry and chemical biology studies 146
New compounds having a selective PDE4D inhibiting activity 146
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 146
Differential inhibition of signaling pathways by two new imidazo-pyrazoles molecules in fMLF-OMe- and IL8-stimulated human neutrophil 144
4-Amino-pyrazolo[3,4-d]pyrimidines with antiproliferative activity on osteosarcoma cell line SaOS-2 144
New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets 144
An Update on JAK Inhibitors 144
Insights into the Pharmacological Activity of the Imidazo-Pyrazole Scaffold 143
Design, synthesis and biological evaluation of new pyrazolyl-ureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis 143
Biological evaluation of pyrazolyl-urea and dihydro-imidazopyrazolyl-urea derivatives as potential anti-angiogenetic agents in the treatment of neuroblastoma 143
Hit identification and biological evaluation of anticancer pyrazolopyrimidines endowed with anti-inflammatory activity 142
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant. 142
Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors 142
Pyrrolo[2,3-d]pyrimidines as kinase inhibitors 142
New halogenated 4-aminopyrazolo[3,4-b]pyridines A1 adenosine receptor ligands 140
2,3-Dihydro-1H-imidazo[1,2-b]pyrazole derivatives as potential neutrophils functions inhibitors 136
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells 136
5-alkoxy-2-hydrazino and 5-methoxy-2-amino-5H-[1]benzopyrano[4,3-d]pyrimidines: synthesis and pharmacological activity 135
GEBR-32A, A NEW PROMISING PDE4D INHIBITOR FOR TREATMENT OF ALZHEIMER'S DISEASE 135
Synthesis and pharmacological evaluation of 2,5-Cycloamino-5H[1]benzopyrano[4,3-d]pyrimidines endowed with in vitro antiplatelet activity 135
Small molecules ATP-competitive inhibitors of FLT3: a chemical overview. 134
Growth inhibition of medullary thyroid carcinoma cells by pyrazolo-pyrimidine derivatives 133
Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model. 133
Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents. 132
Treatment with 1-(2-hydroxyalkyl/phenyl/naphtylureido)-1H-pyrazole-4-carboxylic acid ethyl esters abrogates neutrophil migration towards fMLP and CXCL8 via the inhibition of defined signalling pathways 132
Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study. 131
6-Substituted pyrazolo[3,4-d]pyrimidines: new promising compounds in the fight against Neuroblastoma 131
Gebr-7b, a novel selective PDE4D inhibitor, increases beta amyloid secretion in neuronal cultured cells and improves cognitive function in rodents 130
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 129
Combining repositioning and de novo synthesis of pyrazolo[3,4-d]pyrimidines to discover potent SIRT-2 inhibitors 128
Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells 128
Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors. 128
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities 128
Btk inhibitors: a medicinal chemistry and drug delivery perspective 128
New fluorinated PDE4D inhibitors for the treatment of memory impairments. 126
A Proteomics Approach Identifies RREB1 as a Crucial Molecular Target of Imidazo–Pyrazole Treatment in SKMEL-28 Melanoma Cells 125
Novel dual Src/Abl inhibitors for hematologic and solid malignancies. 125
PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES AS SIRTUIN INHIBITORS: DESIGN, SYNTHESIS AND PRELIMINARY in vitro EVALUATION 122
Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones  121
Design and synthesis of new multitarget drugs for autoimmune inflammatory diseases 120
Current advances in the development of anticancer drugs targeting tyrosine kinases of the Src family 119
Development of imidazo-pyrazole derivatives as potential antimetastatic agents in neuroblastoma 118
Synthesis of pyrazolo[3,4-d]pyrimidine derivatives active in a preclinical glioblastoma model. 118
Preparation and Physicochemical Characterization of Water-Soluble Pyrazole-Based Nanoparticles by Dendrimer Encapsulation of an Insoluble Bioactive Pyrazole Derivative 118
Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology 116
Synthesis of new pyrazolo [3,4-d]pyrimidines Bcr-Abl tyrosine kinase inhibitors 116
New selective PDE4D inhibitors devoid of sedative effects in mice 116
null 116
Discovery of New Antiproliferative Imidazopyrazole Acylhydrazones Able To Interact with Microtubule Systems 116
Synthesis of new 2-phenyl-1-arylcarbamoyl-2,3-dihydro-1h-imidazo[1,2-b]pyrazoles 7-substituted as potential neutrophil chemotaxis inhibitors 115
A family of nitrogen-containing heterocycles as sirtuin inhibitors: synthesis and invitro biological evaluation 115
New PDE4D selective inhibitors able to restore memory function 114
Progress in 5H-[1]benzopyrano[4,3-d]pyrimidin-5-amine series: 2-methoxy derivatives effective as antiplatelet agents with analgesic activity 114
Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines 114
New pyrazolo[3,4-d]pyrimidines 4-benzylamino substituted endowed with antiproliferative activity on chronic myeloid leukemia cell line 113
New rolipram related PDE4 inhibitors: synthesis, enantiomers separation and enzymatic activity 113
New selective PDE4D inhibitors able to discriminate between long, short and supershort isoforms 112
Hck inhibitors as potential therapeutic agents in cancer and HIV infection 112
Scouting in silico different chemo-types of PDE4 inhibitors to guide the design of new anti-inflammatory/antioxidant agents 111
Benzopirano[4,3-d]pirimidin-5-oni 2,4-disostituiti:sintesi ed attività antipiastrinica 111
Synthesis of pyrazolo[3,4-d]pyridines selective antagonists of A1 adenosine receptors 111
New opportunities to treat the T315I-Bcr-Abl mutant in chronic myeloid leukaemia: tyrosine kinase inhibitors and molecules that act by alternative mechanisms. 111
Virtual Screening Combined with Enzymatic Assays to Guide the Discovery of Novel SIRT2 Inhibitors 110
Inhibition of Bcr-Abl Phosphorylation and Induction of Apoptosis by Pyrazolo[3,4-d]pyrimidines in Human Leukemia Cells 110
Preparation of ureidopyrazolecarboxylates with neutrophil chemotaxis inhibiting activity. 109
Totale 14.345
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Categoria #
all - tutte 69.240
article - articoli 47.549
book - libri 0
conference - conferenze 20.198
curatela - curatele 0
other - altro 0
patent - brevetti 1.232
selected - selezionate 0
volume - volumi 261
Totale 138.480
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202170 0 0 0 0 0 0 0 0 0 0 0 70
2021/20221.590 49 100 137 202 42 101 110 379 64 133 75 198
2022/20231.516 159 118 15 165 215 220 7 114 273 21 185 24
2023/20241.244 54 164 41 157 120 159 55 61 64 44 96 229
2024/20253.392 104 251 114 268 418 326 334 439 153 232 308 445
2025/20266.877 714 205 501 577 949 533 1.059 515 629 733 362 100
Totale 21.657