IRIS
BRULLO, CHIARA
 Distribuzione geografica
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Continente #
EU - Europa 16.169
AS - Asia 39
SA - Sud America 11
NA - Nord America 4
AF - Africa 1
Totale 16.224
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Nazione #
IT - Italia 16.168
CN - Cina 25
SG - Singapore 10
BR - Brasile 8
US - Stati Uniti d'America 4
VN - Vietnam 3
AR - Argentina 1
CL - Cile 1
FI - Finlandia 1
ID - Indonesia 1
PY - Paraguay 1
ZA - Sudafrica 1
Totale 16.224
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Città #
Genova 8.400
Genoa 5.197
Vado Ligure 1.329
Rapallo 1.215
Bordighera 27
Beijing 10
Singapore 8
Ashburn 4
Antofagasta 1
Belo Horizonte 1
Brasília 1
Bắc Giang 1
Carapicuíba 1
Fazenda Rio Grande 1
Fighiera 1
Ha Long 1
Ho Chi Minh City 1
Lappeenranta 1
Magelang 1
Mauá 1
Stellenbosch 1
São Paulo 1
São Vicente 1
Tailândia 1
Totale 16.206
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Nome #
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment 231
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation 201
Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease. 184
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors 174
Analogs, formulations and derivatives of imatinib: A patent review 171
Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma. 165
Fyn kinase in brain diseases and cancer: the search for inhibitors. 161
Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines 160
A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. 160
GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. 159
Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma 157
ATP-competitive inhibitors of mTOR: an update. 156
Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors 155
2-Aryl-3-phenylamino-4,5-dihydro-2h-benz[g]indazoles with analgesic activity 155
Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors. 154
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors 153
Synthesis and biological evaluation of neutrophilic inflammation inhibitors 151
Bcr-Abl tyrosine kinase inhibitors: A patent review 147
The pyrazolyl-urea GeGe3 inhibits tumor angiogenesis and reveals dystrophia myotonica protein Kinase (DMPK)1 as a novel angiogenesis target 146
An update on dual Src/Abl inhibitors 144
N-Aryl-2-phenyl-2,3-dihydro-imidazo[1,2-b]pyrazole-1-carboxamides 7-substituted strongly inhibiting both fMLP-OMe- and IL-8-induced human neutrophil chemotaxis. 140
Pyrazole and imidazo[1,2-b]pyrazole derivatives as new potential anti-tuberculosis agents. 139
Src kinase inhibitors: an update on patented compounds 136
Synthesis and biological evaluation of N-pyrazolyl-N'-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis 136
Differential inhibition of signaling pathways by two new imidazo-pyrazoles molecules in fMLF-OMe- and IL8-stimulated human neutrophil 133
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant. 132
Synthesis and pharmacological evaluation of 5H-[1]benzopyrano[4,3-d]pyrimidines effective as antiplatelet/analgesic agents 130
Hit identification and biological evaluation of anticancer pyrazolopyrimidines endowed with anti-inflammatory activity 128
New compounds having a selective PDE4D inhibiting activity 128
2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: New potent inhibitors of fMLP-induced neutrophil chemotaxis 128
Design, synthesis and biological evaluation of new pyrazolyl-ureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis 127
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 126
Computational approaches for the design and chemical synthesis of novel F508del correctors in the treatment of cystic fibrosis 125
Small molecules ATP-competitive inhibitors of FLT3: a chemical overview. 124
Derivati dell'1,3-benzodiossolo, potenziali inibitori delle PDE5 123
Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors 123
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 123
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors. 122
Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents. 120
2-Amino/Azido/Hydrazino-5-alkoxy-5H-[1]benzopyrano[4,3-d]pyrimidines: Synthesis and Pharmacological Evaluation 120
Synthesis and pharmacological evaluation of 2,5-Cycloamino-5H[1]benzopyrano[4,3-d]pyrimidines endowed with in vitro antiplatelet activity 120
Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study. 118
A1 receptors ligands: past, present and future trends. 117
3-Cyclopentyloxy-4-Methoxyphenyl-isoxazoline derivatives as new PDE4 inhibitors. 117
Neutrophil chemotaxis inhibitors: new tools against cancer metastasis? 117
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities 117
Biologically driven synthesis of pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors: an old scaffold as a new tool for medicinal chemistry and chemical biology studies 117
Pyrrolo[2,3-d]pyrimidines as kinase inhibitors 117
Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors. 116
null 116
An Update on JAK Inhibitors 116
Novel dual Src/Abl inhibitors for hematologic and solid malignancies. 114
Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells 113
New halogenated 4-aminopyrazolo[3,4-b]pyridines A1 adenosine receptor ligands 112
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells 112
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 112
Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model. 111
Treatment with 1-(2-hydroxyalkyl/phenyl/naphtylureido)-1H-pyrazole-4-carboxylic acid ethyl esters abrogates neutrophil migration towards fMLP and CXCL8 via the inhibition of defined signalling pathways 110
Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones  109
4-Amino-pyrazolo[3,4-d]pyrimidines with antiproliferative activity on osteosarcoma cell line SaOS-2 108
5-alkoxy-2-hydrazino and 5-methoxy-2-amino-5H-[1]benzopyrano[4,3-d]pyrimidines: synthesis and pharmacological activity 107
Gebr-7b, a novel selective PDE4D inhibitor, increases beta amyloid secretion in neuronal cultured cells and improves cognitive function in rodents 106
Growth inhibition of medullary thyroid carcinoma cells by pyrazolo-pyrimidine derivatives 105
2,3-Dihydro-1H-imidazo[1,2-b]pyrazole derivatives as potential neutrophils functions inhibitors 103
New fluorinated PDE4D inhibitors for the treatment of memory impairments. 103
6-Substituted pyrazolo[3,4-d]pyrimidines: new promising compounds in the fight against Neuroblastoma 102
null 101
Progress in 5H-[1]benzopyrano[4,3-d]pyrimidin-5-amine series: 2-methoxy derivatives effective as antiplatelet agents with analgesic activity 101
New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets 100
Insights into the Pharmacological Activity of the Imidazo-Pyrazole Scaffold 99
Current advances in the development of anticancer drugs targeting tyrosine kinases of the Src family 99
New pyrazolo[3,4-d]pyrimidines 4-benzylamino substituted endowed with antiproliferative activity on chronic myeloid leukemia cell line 98
Inhibition of Bcr-Abl Phosphorylation and Induction of Apoptosis by Pyrazolo[3,4-d]pyrimidines in Human Leukemia Cells 98
GEBR-32A, A NEW PROMISING PDE4D INHIBITOR FOR TREATMENT OF ALZHEIMER'S DISEASE 98
New rolipram related PDE4 inhibitors: synthesis, enantiomers separation and enzymatic activity 97
Synthesis of new 2-phenyl-1-arylcarbamoyl-2,3-dihydro-1h-imidazo[1,2-b]pyrazoles 7-substituted as potential neutrophil chemotaxis inhibitors 97
Design and synthesis of new multitarget drugs for autoimmune inflammatory diseases 97
Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines 97
New opportunities to treat the T315I-Bcr-Abl mutant in chronic myeloid leukaemia: tyrosine kinase inhibitors and molecules that act by alternative mechanisms. 96
Benzopirano[4,3-d]pirimidin-5-oni 2,4-disostituiti:sintesi ed attività antipiastrinica 95
Synthesis of new pyrazolo [3,4-d]pyrimidines Bcr-Abl tyrosine kinase inhibitors 95
New PDE4D selective inhibitors able to restore memory function 95
Biological evaluation of pyrazolyl-urea and dihydro-imidazopyrazolyl-urea derivatives as potential anti-angiogenetic agents in the treatment of neuroblastoma 95
Synthesis of pyrazolo[3,4-d]pyridines selective antagonists of A1 adenosine receptors 94
New selective PDE4D inhibitors able to discriminate between long, short and supershort isoforms 94
New selective PDE4D inhibitors devoid of sedative effects in mice 94
Combining repositioning and de novo synthesis of pyrazolo[3,4-d]pyrimidines to discover potent SIRT-2 inhibitors 93
Hck inhibitors as potential therapeutic agents in cancer and HIV infection 93
Synthesis of pyrazolo[3,4-d]pyrimidine derivatives active in a preclinical glioblastoma model. 93
Development of imidazo-pyrazole derivatives as potential antimetastatic agents in neuroblastoma 91
N-substituted ureas of ethyl 1-(2-hydroxy-2-phenylethyl)-1H-pyrazole-4-carboxylate as potent and selective IL-8 receptor inhibitors 90
Substituted pyrazolo[3,4-b]pyridines as human A(1) adenosine antagonists: Developments in understanding the receptor stereoselectivity 88
Synthesis of new pyrazolo[3,4-d]pyrimidines 6-alkyl substituted Bcr-Abl tyrosine kinase inhibitors 88
New N-substituted N'[1-(2-hydroxy-2-phenylethyl)-1H-pyrazol-5-yl]ureas inhibiting CXCL8 induced neutrophil chemotaxis 87
A family of nitrogen-containing heterocycles as sirtuin inhibitors: synthesis and invitro biological evaluation 86
Discovery of New Antiproliferative Imidazopyrazole Acylhydrazones Able To Interact with Microtubule Systems 85
Preparation of ureidopyrazolecarboxylates with neutrophil chemotaxis inhibiting activity. 84
Synthesis and antiplatelet activity of 2-azido/2-methanesulphonyl and 2-methoxy-5H-[1]benzopyrano[4,3-d]pyrimidines 5-alkoxy/phenoxy substituted” 84
Synthesis of pyrazolo[3,4-d]pyrimidine derivatives active against the T315I Abl mutation. 83
Benzopirano[4,3-d]pirimidine e Benzopirano[4,3-d]pirimidin-5-oni 2,4-disostituiti: sintesi ed attività antipiastrinica 82
Totale 11.929
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Categoria #
all - tutte 57.862
article - articoli 39.945
book - libri 0
conference - conferenze 16.654
curatela - curatele 0
other - altro 0
patent - brevetti 1.043
selected - selezionate 0
volume - volumi 220
Totale 115.724
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021682 0 0 0 45 51 70 61 79 105 122 79 70
2021/20221.590 49 100 137 202 42 101 110 379 64 133 75 198
2022/20231.516 159 118 15 165 215 220 7 114 273 21 185 24
2023/20241.244 54 164 41 157 120 159 55 61 64 44 96 229
2024/20253.392 104 251 114 268 418 326 334 439 153 232 308 445
2025/20261.867 714 205 501 447 0 0 0 0 0 0 0 0
Totale 16.647