IRIS
BRULLO, CHIARA
 Distribuzione geografica
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Continente #
EU - Europa 17.005
NA - Nord America 3.031
AS - Asia 2.715
Continente sconosciuto - Info sul continente non disponibili 459
SA - Sud America 240
AF - Africa 42
OC - Oceania 2
Totale 23.494
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Nazione #
IT - Italia 16.579
US - Stati Uniti d'America 2.854
SG - Singapore 1.091
CN - Cina 693
VN - Vietnam 448
BR - Brasile 152
FR - Francia 152
BD - Bangladesh 128
HK - Hong Kong 127
DE - Germania 67
CA - Canada 63
JP - Giappone 63
FI - Finlandia 51
MX - Messico 37
GB - Regno Unito 36
AR - Argentina 35
TW - Taiwan 29
NL - Olanda 22
IN - India 21
JM - Giamaica 20
ES - Italia 17
ID - Indonesia 17
EC - Ecuador 15
IQ - Iraq 14
VE - Venezuela 12
CO - Colombia 11
EG - Egitto 11
KR - Corea 11
RU - Federazione Russa 11
TH - Thailandia 11
TR - Turchia 11
CR - Costa Rica 10
PL - Polonia 9
HN - Honduras 7
IE - Irlanda 7
PH - Filippine 7
PK - Pakistan 7
SA - Arabia Saudita 7
TT - Trinidad e Tobago 7
UA - Ucraina 7
PR - Porto Rico 6
ZA - Sudafrica 6
CH - Svizzera 5
CL - Cile 5
GT - Guatemala 5
HR - Croazia 5
MY - Malesia 5
PY - Paraguay 5
SE - Svezia 5
SV - El Salvador 5
AL - Albania 4
KE - Kenya 4
LB - Libano 4
MA - Marocco 4
NI - Nicaragua 4
PT - Portogallo 4
SC - Seychelles 4
AZ - Azerbaigian 3
DZ - Algeria 3
JO - Giordania 3
PA - Panama 3
RO - Romania 3
UZ - Uzbekistan 3
BB - Barbados 2
BE - Belgio 2
BO - Bolivia 2
BS - Bahamas 2
CZ - Repubblica Ceca 2
DK - Danimarca 2
EE - Estonia 2
ET - Etiopia 2
KG - Kirghizistan 2
KW - Kuwait 2
NO - Norvegia 2
NP - Nepal 2
PE - Perù 2
SI - Slovenia 2
SN - Senegal 2
AG - Antigua e Barbuda 1
AM - Armenia 1
AT - Austria 1
AU - Australia 1
BA - Bosnia-Erzegovina 1
BG - Bulgaria 1
BM - Bermuda 1
BY - Bielorussia 1
CG - Congo 1
CI - Costa d'Avorio 1
CM - Camerun 1
CY - Cipro 1
DO - Repubblica Dominicana 1
GR - Grecia 1
GY - Guiana 1
HU - Ungheria 1
KH - Cambogia 1
LA - Repubblica Popolare Democratica del Laos 1
LC - Santa Lucia 1
LT - Lituania 1
LV - Lettonia 1
LY - Libia 1
Totale 23.027
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Città #
Genova 8.400
Genoa 5.273
Vado Ligure 1.329
Rapallo 1.215
San Jose 727
Singapore 565
Ashburn 370
Ho Chi Minh City 128
Lauterbourg 128
Hanoi 112
Council Bluffs 106
Beijing 105
New York 100
Hong Kong 95
Santa Clara 72
Tokyo 56
Frankfurt am Main 55
Los Angeles 55
Milan 46
Helsinki 44
Phoenix 35
Chicago 30
Dallas 30
Bordighera 27
Mexico City 26
Rome 26
Boardman 25
Haiphong 23
Naples 21
Buffalo 19
Brooklyn 18
Da Nang 18
São Paulo 18
Amsterdam 17
Atlanta 17
Orem 17
Tianjin 17
Montreal 15
Brasília 12
Houston 12
Miami 12
Turin 12
Catania 11
Kingston 11
Newark 11
Taipei 11
Cairo 10
Florence 10
Davenport 9
Hải Dương 9
Las Vegas 9
Philadelphia 9
Ribeirão Preto 9
Toronto 9
Des Moines 8
Iowa City 8
Palermo 8
Paris 8
San José 8
The Bronx 8
Biên Hòa 7
Can Tho 7
Charlotte 7
Dhaka 7
Dublin 7
Lappeenranta 7
Quảng Ngãi 7
Salt Lake City 7
Seattle 7
Warsaw 7
Basingstoke 6
Birmingham 6
Bologna 6
Chennai 6
Cleveland 6
Detroit 6
Jacksonville 6
London 6
Ninh Bình 6
North Bergen 6
Padua 6
San Francisco 6
Washington 6
Baghdad 5
Brescia 5
Cardiff 5
Chaguanas 5
Columbia 5
Denver 5
Hangzhou 5
Louisville 5
Memphis 5
North Charleston 5
Quito 5
San Salvador 5
Taichung 5
Tampa 5
Thái Nguyên 5
Zagreb 5
Bari 4
Totale 19.826
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Nome #
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment 262
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation 237
Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease. 218
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors 218
Analogs, formulations and derivatives of imatinib: A patent review 209
A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. 206
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors 204
ATP-competitive inhibitors of mTOR: an update. 199
GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. 195
The pyrazolyl-urea GeGe3 inhibits tumor angiogenesis and reveals dystrophia myotonica protein Kinase (DMPK)1 as a novel angiogenesis target 194
Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors. 193
An update on dual Src/Abl inhibitors 191
Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors 190
Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma 188
Bcr-Abl tyrosine kinase inhibitors: A patent review 185
Synthesis and biological evaluation of neutrophilic inflammation inhibitors 185
Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma. 184
2-Aryl-3-phenylamino-4,5-dihydro-2h-benz[g]indazoles with analgesic activity 183
Fyn kinase in brain diseases and cancer: the search for inhibitors. 179
Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines 177
Pyrazole and imidazo[1,2-b]pyrazole derivatives as new potential anti-tuberculosis agents. 174
Pyrrolo[2,3-d]pyrimidines as kinase inhibitors 172
Amino-Pyrazoles in Medicinal Chemistry: A Review 170
Synthesis and biological evaluation of N-pyrazolyl-N'-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis 167
2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: New potent inhibitors of fMLP-induced neutrophil chemotaxis 166
Computational approaches for the design and chemical synthesis of novel F508del correctors in the treatment of cystic fibrosis 164
N-Aryl-2-phenyl-2,3-dihydro-imidazo[1,2-b]pyrazole-1-carboxamides 7-substituted strongly inhibiting both fMLP-OMe- and IL-8-induced human neutrophil chemotaxis. 163
Derivati dell'1,3-benzodiossolo, potenziali inibitori delle PDE5 162
2-Amino/Azido/Hydrazino-5-alkoxy-5H-[1]benzopyrano[4,3-d]pyrimidines: Synthesis and Pharmacological Evaluation 161
Neutrophil chemotaxis inhibitors: new tools against cancer metastasis? 159
A1 receptors ligands: past, present and future trends. 158
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 158
Src kinase inhibitors: an update on patented compounds 157
3-Cyclopentyloxy-4-Methoxyphenyl-isoxazoline derivatives as new PDE4 inhibitors. 157
Differential inhibition of signaling pathways by two new imidazo-pyrazoles molecules in fMLF-OMe- and IL8-stimulated human neutrophil 156
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors. 156
Synthesis and pharmacological evaluation of 5H-[1]benzopyrano[4,3-d]pyrimidines effective as antiplatelet/analgesic agents 156
Biologically driven synthesis of pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors: an old scaffold as a new tool for medicinal chemistry and chemical biology studies 154
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 154
An Update on JAK Inhibitors 153
4-Amino-pyrazolo[3,4-d]pyrimidines with antiproliferative activity on osteosarcoma cell line SaOS-2 152
New compounds having a selective PDE4D inhibiting activity 152
2,3-Dihydro-1H-imidazo[1,2-b]pyrazole derivatives as potential neutrophils functions inhibitors 151
Novel Triazol-imidazo[1,2-b]pyrazoles Selectively Impair Melanoma Cell Survival While Preserving Healthy Keratinocyte Viability 151
Hit identification and biological evaluation of anticancer pyrazolopyrimidines endowed with anti-inflammatory activity 150
Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors 150
New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets 150
Insights into the Pharmacological Activity of the Imidazo-Pyrazole Scaffold 149
Design, synthesis and biological evaluation of new pyrazolyl-ureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis 149
Biological evaluation of pyrazolyl-urea and dihydro-imidazopyrazolyl-urea derivatives as potential anti-angiogenetic agents in the treatment of neuroblastoma 148
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant. 146
New halogenated 4-aminopyrazolo[3,4-b]pyridines A1 adenosine receptor ligands 145
GEBR-32A, A NEW PROMISING PDE4D INHIBITOR FOR TREATMENT OF ALZHEIMER'S DISEASE 145
6-Substituted pyrazolo[3,4-d]pyrimidines: new promising compounds in the fight against Neuroblastoma 145
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells 143
Preparation and Physicochemical Characterization of Water-Soluble Pyrazole-Based Nanoparticles by Dendrimer Encapsulation of an Insoluble Bioactive Pyrazole Derivative 143
Gebr-7b, a novel selective PDE4D inhibitor, increases beta amyloid secretion in neuronal cultured cells and improves cognitive function in rodents 142
A Proteomics Approach Identifies RREB1 as a Crucial Molecular Target of Imidazo–Pyrazole Treatment in SKMEL-28 Melanoma Cells 141
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 141
Combining repositioning and de novo synthesis of pyrazolo[3,4-d]pyrimidines to discover potent SIRT-2 inhibitors 140
Small molecules ATP-competitive inhibitors of FLT3: a chemical overview. 140
5-alkoxy-2-hydrazino and 5-methoxy-2-amino-5H-[1]benzopyrano[4,3-d]pyrimidines: synthesis and pharmacological activity 140
Synthesis and pharmacological evaluation of 2,5-Cycloamino-5H[1]benzopyrano[4,3-d]pyrimidines endowed with in vitro antiplatelet activity 139
Growth inhibition of medullary thyroid carcinoma cells by pyrazolo-pyrimidine derivatives 138
Treatment with 1-(2-hydroxyalkyl/phenyl/naphtylureido)-1H-pyrazole-4-carboxylic acid ethyl esters abrogates neutrophil migration towards fMLP and CXCL8 via the inhibition of defined signalling pathways 137
Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model. 137
Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study. 136
Btk inhibitors: a medicinal chemistry and drug delivery perspective 136
Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells 135
Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents. 135
Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors. 134
New fluorinated PDE4D inhibitors for the treatment of memory impairments. 134
Synthesis of pyrazolo[3,4-d]pyrimidine derivatives active in a preclinical glioblastoma model. 134
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities 133
Novel dual Src/Abl inhibitors for hematologic and solid malignancies. 131
PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES AS SIRTUIN INHIBITORS: DESIGN, SYNTHESIS AND PRELIMINARY in vitro EVALUATION 129
Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones  128
Design and synthesis of new multitarget drugs for autoimmune inflammatory diseases 128
Development of imidazo-pyrazole derivatives as potential antimetastatic agents in neuroblastoma 126
A family of nitrogen-containing heterocycles as sirtuin inhibitors: synthesis and invitro biological evaluation 126
Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology 125
Pyrazolo[3,4-d]pyrimidines as Sirtuin Inhibitors: A Preliminary Synthetic and Biological Study 124
Current advances in the development of anticancer drugs targeting tyrosine kinases of the Src family 124
Synthesis of new 2-phenyl-1-arylcarbamoyl-2,3-dihydro-1h-imidazo[1,2-b]pyrazoles 7-substituted as potential neutrophil chemotaxis inhibitors 123
New opportunities to treat the T315I-Bcr-Abl mutant in chronic myeloid leukaemia: tyrosine kinase inhibitors and molecules that act by alternative mechanisms. 122
Discovery of New Antiproliferative Imidazopyrazole Acylhydrazones Able To Interact with Microtubule Systems 122
New selective PDE4D inhibitors devoid of sedative effects in mice 121
New PDE4D selective inhibitors able to restore memory function 121
Progress in 5H-[1]benzopyrano[4,3-d]pyrimidin-5-amine series: 2-methoxy derivatives effective as antiplatelet agents with analgesic activity 121
Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines 121
Synthesis of new pyrazolo [3,4-d]pyrimidines Bcr-Abl tyrosine kinase inhibitors 120
Scouting in silico different chemo-types of PDE4 inhibitors to guide the design of new anti-inflammatory/antioxidant agents 119
New rolipram related PDE4 inhibitors: synthesis, enantiomers separation and enzymatic activity 119
N-substituted ureas of ethyl 1-(2-hydroxy-2-phenylethyl)-1H-pyrazole-4-carboxylate as potent and selective IL-8 receptor inhibitors 119
Synthesis of pyrazolo[3,4-d]pyridines selective antagonists of A1 adenosine receptors 119
Benzopirano[4,3-d]pirimidin-5-oni 2,4-disostituiti:sintesi ed attività antipiastrinica 118
Virtual Screening Combined with Enzymatic Assays to Guide the Discovery of Novel SIRT2 Inhibitors 117
Preparation of ureidopyrazolecarboxylates with neutrophil chemotaxis inhibiting activity. 117
New pyrazolo[3,4-d]pyrimidines 4-benzylamino substituted endowed with antiproliferative activity on chronic myeloid leukemia cell line 117
Hck inhibitors as potential therapeutic agents in cancer and HIV infection 117
Totale 15.229
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Categoria #
all - tutte 77.721
article - articoli 53.346
book - libri 0
conference - conferenze 22.726
curatela - curatele 0
other - altro 0
patent - brevetti 1.356
selected - selezionate 0
volume - volumi 293
Totale 155.442
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.441 0 0 137 202 42 101 110 379 64 133 75 198
2022/20231.516 159 118 15 165 215 220 7 114 273 21 185 24
2023/20241.244 54 164 41 157 120 159 55 61 64 44 96 229
2024/20253.392 104 251 114 268 418 326 334 439 153 232 308 445
2025/20267.183 714 205 501 577 949 533 1.059 515 629 733 357 411
2026/20271.531 740 331 460 0 0 0 0 0 0 0 0 0
Totale 23.494