IRIS
FEDELE, ERNESTO
 Distribuzione geografica
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Continente #
EU - Europa 20.756
AS - Asia 2.388
NA - Nord America 1.785
Continente sconosciuto - Info sul continente non disponibili 488
SA - Sud America 226
AF - Africa 42
OC - Oceania 2
Totale 25.687
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Nazione #
IT - Italia 20.341
US - Stati Uniti d'America 1.658
SG - Singapore 1.020
CN - Cina 663
VN - Vietnam 377
FR - Francia 186
BR - Brasile 139
BD - Bangladesh 96
HK - Hong Kong 96
DE - Germania 56
AR - Argentina 50
CA - Canada 49
FI - Finlandia 49
JP - Giappone 37
IN - India 25
MX - Messico 24
CH - Svizzera 22
GB - Regno Unito 22
JM - Giamaica 22
NL - Olanda 20
ZA - Sudafrica 16
IQ - Iraq 15
CR - Costa Rica 10
EC - Ecuador 9
ID - Indonesia 9
RU - Federazione Russa 9
VE - Venezuela 9
CO - Colombia 8
ES - Italia 7
EG - Egitto 6
IE - Irlanda 5
NI - Nicaragua 5
SE - Svezia 5
TH - Thailandia 5
TW - Taiwan 5
UA - Ucraina 5
BE - Belgio 4
DZ - Algeria 4
HN - Honduras 4
KR - Corea 4
PH - Filippine 4
PL - Polonia 4
PY - Paraguay 4
RO - Romania 4
SA - Arabia Saudita 4
CL - Cile 3
GT - Guatemala 3
JO - Giordania 3
KE - Kenya 3
LB - Libano 3
MA - Marocco 3
MD - Moldavia 3
PE - Perù 3
PK - Pakistan 3
TN - Tunisia 3
AE - Emirati Arabi Uniti 2
AZ - Azerbaigian 2
CG - Congo 2
GR - Grecia 2
IR - Iran 2
LT - Lituania 2
MY - Malesia 2
PS - Palestinian Territory 2
SI - Slovenia 2
SK - Slovacchia (Repubblica Slovacca) 2
SN - Senegal 2
SV - El Salvador 2
TT - Trinidad e Tobago 2
UZ - Uzbekistan 2
AF - Afghanistan, Repubblica islamica di 1
AL - Albania 1
AU - Australia 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BS - Bahamas 1
CY - Cipro 1
CZ - Repubblica Ceca 1
DO - Repubblica Dominicana 1
GY - Guiana 1
KW - Kuwait 1
KZ - Kazakistan 1
LC - Santa Lucia 1
MK - Macedonia 1
ML - Mali 1
MU - Mauritius 1
NC - Nuova Caledonia 1
NO - Norvegia 1
NP - Nepal 1
OM - Oman 1
PA - Panama 1
PR - Porto Rico 1
RS - Serbia 1
SC - Seychelles 1
TR - Turchia 1
Totale 25.199
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Città #
Genova 12.140
Genoa 4.850
Rapallo 1.813
Vado Ligure 1.349
Singapore 509
San Jose 468
Lauterbourg 174
Ashburn 138
Ho Chi Minh City 114
Beijing 102
Hong Kong 89
Hanoi 76
New York 69
Council Bluffs 61
Frankfurt am Main 51
Helsinki 45
Santa Clara 42
Tokyo 37
Bordighera 33
Los Angeles 29
Da Nang 22
Zurich 20
Haiphong 18
Atlanta 17
Chicago 17
Milan 17
Rome 16
São Paulo 16
Tianjin 16
Amsterdam 15
Dallas 15
Turin 14
Buffalo 12
Kingston 12
Naples 11
Biên Hòa 10
Brooklyn 10
Orem 10
Guangzhou 9
Mexico City 9
Boston 8
Phoenix 8
Boardman 7
Cape Town 7
Cardiff 7
Kansas City 7
Montreal 7
Philadelphia 7
Columbus 6
Denver 6
Des Moines 6
Houston 6
Hải Dương 6
Jacksonville 6
San José 6
Shanghai 6
Toronto 6
Tualatin 6
Baltimore 5
Brescia 5
Bắc Ninh 5
Can Tho 5
Curitiba 5
Erie 5
Guayaquil 5
Indpls 5
Lakeland 5
Managua 5
Miami 5
Mumbai 5
Providence 5
San Francisco 5
The Bronx 5
Tây Ninh 5
Alexandria 4
Baghdad 4
Basingstoke 4
Cairo 4
Chennai 4
Cincinnati 4
Cleveland 4
Dayton 4
Dhaka 4
Dublin 4
Garland 4
Lansdowne 4
Lappeenranta 4
Murfreesboro 4
Newark 4
Norfolk 4
Pisa 4
St Louis 4
Tampa 4
Thái Bình 4
Virginia Beach 4
Warsaw 4
Zibo 4
Ahmedabad 3
Algiers 3
Amman 3
Totale 22.774
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Nome #
A novel PDE4D inhibitor increases amyloid-beta deposition in neuronal cultured cells and improves memory in rats 338
Age-related decrease of the NMDA receptor-mediated noradrenaline release in rat hippocampus and partial restoration by D-cycloserine 317
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment 260
Presynaptic GLP-1 receptors enhance the depolarization-evoked release of Glutamate and GABA in the mouse cortex and hippocampus 242
Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease. 217
Amyloid β: Walking on the dark side of the moon 208
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors 207
D-SERINE MODULATES THE NMDA RECEPTOR/NITRIC OXIDE/cGMP PATHWAY IN THE RAT CEREBELLUM DURING IN VIVO MICRODIALYSIS 200
Amyloid Beta and the Brain: Where Are We Now? 198
[3H]Glycine uptake in rat hippocampus: kinetic analysis and autoradiographic localization. 197
Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites 197
Evaluating the role of hnRNP-C and FMRP in the cAMP-induced APP metabolism 195
Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis. 194
GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. 193
Phosphodiesterase-4D: an enzyme to remember 192
Antagonizing α7 nicotinic receptors with methyllycaconitine (MLA) potentiates receptor activity and memory acquisition 192
A physiological role for amyloid beta in the cyclic AMP-stimulated long term potentiation. 189
Alterations of glutamate release in the spinal cord of mice with experimental autoimmune encephalomyelitis 189
Enhanced Function and Overexpression of Metabotropic Glutamate Receptors 1 and 5 in the Spinal Cord of the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis during Disease Progression 188
Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors. 187
Acetylcholine release from rat hippocampal slices is modulated by 5-hydroxytryptamine. 186
Glycine modulates 3H-noradrenaline release in rat hippocampus through a strychnine-sensitive receptor 184
A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: role of amyloid beta 180
Cyclooxygenase-1 and -2 differently contribute to prostaglandin E2 synthesis and lipid peroxidation after in vivo activation of N-methyl-D-aspartate receptors in rat hippocampus. 180
l-Aspartate as an amino acid neurotransmitter: mechanisms of the depolarization-induced release from cerebrocortical synaptosomes. 178
Amyloid-beta peptide is needed for cGMP-induced long-term potentiation and memory 176
INTRACEREBRAL ADMINISTRATION OF L-KYNURENINE DECREASES N-METHYL-D-ASPARTATE RECEPTOR-MEDIATED PRODUCTION OF cGMP IN THE CEREBELLUM AND HIPPOCAMPUS OF UNANAESTHETIZED RATS SUBJECTED TO TRANSCEREBRAL MICRODIALYSIS 173
The amyloid cascade hypothesis in Alzheimer’s disease: it’s time to change our mind 173
Glucagon-Like Peptide 1, Neuroprotection and Neurodegenerative Disorders 172
Mechanisms of glutamate release elicited in rat cerebrocortical nerve endings by ‘pathologically’ elevated extraterminal K+ concentrations 171
Presynaptic nicotinic receptors evoke endogenous glutamate and aspartate release from hippocampal synaptosomes by way of distinct coupling mechanisms 170
Altered Fronto-Striatal Functions in the Gdi1-null Mouse Model of X-linked Intellectual Disability 169
ACTIVATION OF BRAIN NITRIC OXIDE SYNTHASE IN DEPOLARIZED HUMAN TEMPORAL CORTEX SLICES: DIFFERENTIAL ROLE OF VOLTAGE-SENSITIVE CALCIUM CHANNELS 168
Release-regulating GABAB autoreceptors in rat cerebral cortex slices 166
Reduced GABA Content in the Motor Thalamus during Effective Deep Brain Stimulation of the Subthalamic Nucleus. 166
In vivo studies of glutamatergic receptors and NO pathways in brain 163
In vivo activation of N-methyl-D-aspartate receptors in the rat hippocampus increases prostaglandin E2 extracellular levels and triggers lipid peroxidation through cyclooxygenase-mediated mechanisms 163
The complex phenotype and function of spinal cord microglia during ALS progression and the impact of metabotropic glutamate receptor type 5 down-regulation in SOD1G93A mice 162
Presynaptic nicotinic α7 and non-α7 receptors stimulate endogenous GABA release from rat hippocampal synaptosomes through two mechanisms of action. 162
Native human neocortex release-regulating dopamine D2 type autoreceptors are dopamine D2 subtype 162
Release-regulating dopamine autoreceptors in human cerebral cortex. 161
In vivo effects of phosphodiesterase inhibition on basal cGMP levels in the pre-frontal cortex, hippocampus and cerebellum of freely moving rats. 160
Cyclic adenosine monophosphate as an endogenous modulator of the amyloid-β precursor protein metabolism 158
Neuropeptide S inhibits release of 5-HT and glycine in mouse amygdala and frontal/prefrontal cortex through activation of the neuropeptide S receptor 158
PDE4D inhibitors: a potential strategy for the treatment of memory impairment? 158
DESENSITIZATION OF AMPA RECEPTORS AND AMPA-NMDA RECEPTOR INTERACTION: AN IN VIVO CYCLIC GMP MICRODIALYSIS STUDY IN RAT CEREBELLUM 157
Serotonin receptors regulating transmitter release 157
cAMP-induced Aβ production and its role in the expression of LTP. 153
Evaluation of the mechanisms underlying the kainate-induced impairment of [3H]dopamine release in the rat striatum. 153
Age-related decrease of the NMDA receptor-mediated noradrenaline release in rat hippocampus and partial restoration by D-cycloserine 152
Glycine stimulates [3H]noradrenaline release by activating a strychnine-sensitive receptor present in rat hippocampus. 151
Microdialysis in Parkinsonian patient basal ganglia: acute apomorphine-induced clinical and electrophysiological effects not paralleled by changes in the release of neuroactive amino acids 150
Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition 150
New compounds having a selective PDE4D inhibiting activity 150
Delayed administration may improve entacapone effects in parkinsonian patients non-responding to the drug. 150
Subthalamic stimulation activates internal pallidus: evidence from cGMP microdialysis in PD patients 149
Investigating the amyloid-beta enhancing effect of cGMP in neuro2a cells 149
Isolation of hydroxyoctaprenyl-1’,4’-hydroquinone, a new octaprenylhydroquinone from the marine sponge Sarcotragus spinosulus and evaluation of its pharmacological activity on acetylcholine and glutamate release in the rat Central Nervous System. 149
A novel cAMP/PKA/APP/Abeta pathway modulates hippocampal LTP 148
Activation of presynaptic Neuropeptide S receptors inhibits the release of 5-HT and glycine in mouse frontal/prefrontal cortex and amygdala 147
γ-Aminobutyric acid (GABA) stimulates somatostatin release following activation of a GABA uptake carrier located on somatostatin nerve endings of rat cerebral cortex. 147
TRANSMITTER RELEASE ASSOCIATED WITH LONG-TERM SYNAPTIC DEPRESSION IN RAT CORTICOSTRIATAL SLICES 145
Autoradiographical evaluation of [3H]glycine uptake in rat forebrain: cellular localization in the hippocampus. 142
In vivo studies of glutamatergic receptors and NO pathways in brain 142
In vivo investigation of the NMDA/NOS/CGMP pathway during aging in the hippocampus and cerebellum of freely-moving rats 142
Functional damage of dopamine nerve terminals following intrastriatal kainic acid injection 141
Dopamine release and dopaminergic inhibition of acetylcholine release in rat striatal slices after nigro-striatal hemitransection and parenteral ganglioside administration 140
GEBR-32A, A NEW PROMISING PDE4D INHIBITOR FOR TREATMENT OF ALZHEIMER'S DISEASE 140
Effects of phosphodiesterase inhibition on cortical spreading depression and associated changes in extracellular cyclic GMP 140
γ-Aminobutyric acidB receptors mediate inhibition of somatostatin release from cerebrocortex nerve terminals. 139
Stimulation of the amyloid-β precursor protein metabolism by cAMP 139
THE GLUTAMATE RECEPTOR/NO/CYCLIC GMP PATHWAY IN THE HIPPOCAMPUS OF FREELY-MOVING RATS: MODULATION BY CYCLOTHIAZIDE, INTERACTION WITH GABA AND THE BEHAVIOURAL CONSEQUENCES 138
Gebr-7b, a novel selective PDE4D inhibitor, increases beta amyloid secretion in neuronal cultured cells and improves cognitive function in rodents 138
The clinical efficacy of L-DOPA and STN-DBS share a common marker: reduced GABA content in the motor thalamus. 137
An evaluation of the role of extracellular amino acids in the delayed neurodegeneration induced by quinolinic acid in the rat striatum. 135
cAMP, cGMP and Amyloid Beta: three ideal partners for memory formation 135
Biochemical and electrophysiological changes of substantia nigra pars reticolata driver by subthalamic stimulation in patients with Parkinson’s disease 134
IN VIVO MICRODIALYSIS STUDY OF A SPECIFIC INHIBITOR OF SOLUBLE GUANYLYL CYCLASE ON THE GLUTAMATE RECEPTOR/NITRIC OXIDE/CYCLIC GMP PATHWAY 134
Cholinergic modulation of 3H-dopamine release from dendrosomes of rat substantia nigra 133
Clinical and electrophysiological effects of apomorphine in Parkinson's disease are not paralleled by aminoacid release changes: a microdialysis study 132
Microdialysis study in vivo of the nitric oxide/cGMP pathway in the hippocampus and cerebellum of adult and aged rats 132
Homovanillic acid in CSF of mild stage Parkinson’s disease patients correlates with motor impairment 132
The NOS/sGC pathway in the rat central nervous system: a microdialysis overview 131
GABAA, but not NMDA, receptors modulate in vivo NO-mediated cGMP synthesis in the rat cerebral cortex 131
LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex 130
Deep brain stimulation in Parkinson’s disease patients: biochemical evidence 130
Correlation between changes in CSF dopamine turnover and development of dyskinesia in Parkinson’s disease. 129
cGMP favors the interaction between APP and BACE1 by inhibiting Rab5 GTPase activity 129
Native human release-regulating dopamine autoreceptors in the cerebral cortex belong to the D2 type D2 subtype 128
Effects of dopamine receptor agonists on the efflux of excitatory and inhibitory amino acids in Parkinson's disease patients: A microdialysis approach 127
Alterations of glutamatergic transmission in a murine model of multiple sclerosis: preliminary results 127
Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D 127
Stimulation of the amyloid beta precursor protein metabolism by cAMP 125
Release-regulating GABA autoreceptors in human and rat central nervous system 125
Acute and Chronic Dopaminergic Depletion Differently Affect Motor Thalamic Function 125
Alterations of glutamate neurotransmission in the spinal cord of EAE mice 124
Long term effects of helicobacter pylory eradication on l-dopa absorption in Parkinson’s disease patients 123
Alterations of glutamate release in the spinal cord of mice affected by experimental autoimmune encephalomyelitis 123
cAMP-induced amyloid-β production and its role in long term potentiation 123
Temporal administration of entacapone with slow release l-dopa: pharmacokinetic profile and clinical outcome. 122
Totale 16.100
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Categoria #
all - tutte 79.907
article - articoli 56.771
book - libri 0
conference - conferenze 20.407
curatela - curatele 0
other - altro 0
patent - brevetti 343
selected - selezionate 0
volume - volumi 2.386
Totale 159.814
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20222.128 49 212 137 224 55 134 124 541 121 183 99 249
2022/20232.179 218 154 46 215 346 408 15 153 417 11 162 34
2023/20241.056 52 177 24 160 86 181 60 64 39 24 60 129
2024/20253.456 70 266 125 244 393 374 365 532 176 179 275 457
2025/20265.812 691 116 280 430 865 546 1.016 380 413 550 222 303
2026/2027612 612 0 0 0 0 0 0 0 0 0 0 0
Totale 25.687