IRIS
FEDELE, ERNESTO
 Distribuzione geografica
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Continente #
EU - Europa 20.206
AS - Asia 827
SA - Sud America 142
NA - Nord America 81
AF - Africa 19
OC - Oceania 1
Totale 21.276
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Nazione #
IT - Italia 20.174
SG - Singapore 371
CN - Cina 252
VN - Vietnam 141
BR - Brasile 85
US - Stati Uniti d'America 57
AR - Argentina 40
HK - Hong Kong 26
MX - Messico 17
IN - India 9
ZA - Sudafrica 9
EC - Ecuador 7
RU - Federazione Russa 7
BD - Bangladesh 5
ID - Indonesia 5
IQ - Iraq 5
GB - Regno Unito 4
NL - Olanda 4
VE - Venezuela 4
CA - Canada 3
LB - Libano 3
MA - Marocco 3
UA - Ucraina 3
CR - Costa Rica 2
DE - Germania 2
EG - Egitto 2
JP - Giappone 2
KE - Kenya 2
LT - Lituania 2
MD - Moldavia 2
PE - Perù 2
PL - Polonia 2
PY - Paraguay 2
SE - Svezia 2
TN - Tunisia 2
AF - Afghanistan, Repubblica islamica di 1
AZ - Azerbaigian 1
BE - Belgio 1
CL - Cile 1
CO - Colombia 1
DO - Repubblica Dominicana 1
ES - Italia 1
JO - Giordania 1
KW - Kuwait 1
MK - Macedonia 1
NC - Nuova Caledonia 1
NI - Nicaragua 1
NP - Nepal 1
OM - Oman 1
PK - Pakistan 1
SK - Slovacchia (Repubblica Slovacca) 1
SN - Senegal 1
UZ - Uzbekistan 1
Totale 21.276
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Città #
Genova 12.140
Genoa 4.831
Rapallo 1.813
Vado Ligure 1.349
Singapore 180
Beijing 71
Ho Chi Minh City 48
Bordighera 33
Hanoi 28
Hong Kong 26
Ashburn 17
Tianjin 15
Haiphong 11
Biên Hòa 10
São Paulo 8
Mexico City 7
Boston 6
Cape Town 6
Guangzhou 6
Da Nang 5
Los Angeles 5
Guayaquil 4
Amsterdam 3
Bình Dương 3
Bắc Ninh 3
Chicago 3
Fortaleza 3
Hải Dương 3
Mumbai 3
New York 3
Rio de Janeiro 3
Salvador 3
Turin 3
Tây Ninh 3
Zhengzhou 3
Atlanta 2
Baghdad 2
Belo Horizonte 2
Belén de Escobar 2
Brasília 2
Can Tho 2
Casablanca 2
Chennai 2
Chisinau 2
Jakarta 2
José C. Paz 2
Lanús 2
Lima 2
Maracaibo 2
Milan 2
Patos 2
Pedro Leopoldo 2
Phú Thọ 2
Poplar 2
Querétaro 2
Resistencia 2
San José 2
San Juan 2
Santo André 2
Sorocaba 2
Stockholm 2
Tokyo 2
Tunis 2
Warsaw 2
Ajuricaba 1
Americana 1
Amman 1
Anápolis 1
Araraquara 1
Arenillas 1
Aristóbulo del Valle 1
As Sālimīyah 1
Baie-D'Urfé 1
Baku 1
Banī Suwayf 1
Barro Alto 1
Beirut 1
Benito Juarez 1
Berlin 1
Bismarck 1
Bragança Paulista 1
Brescia 1
Brooklyn 1
Brussels 1
Buenos Aires 1
Campanha 1
Campinas 1
Candelaria 1
Canoas 1
Capelinha 1
Caraguatatuba 1
Carapicuíba 1
Cariacica 1
Carney 1
Changchun 1
Changsha 1
Chascomús 1
Cholula 1
Ciudad Nezahualcoyotl 1
Coronel Suárez 1
Totale 20.752
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Nome #
A novel PDE4D inhibitor increases amyloid-beta deposition in neuronal cultured cells and improves memory in rats 309
Age-related decrease of the NMDA receptor-mediated noradrenaline release in rat hippocampus and partial restoration by D-cycloserine 294
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment 240
Presynaptic GLP-1 receptors enhance the depolarization-evoked release of Glutamate and GABA in the mouse cortex and hippocampus 198
Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease. 191
Amyloid β: Walking on the dark side of the moon 180
D-SERINE MODULATES THE NMDA RECEPTOR/NITRIC OXIDE/cGMP PATHWAY IN THE RAT CEREBELLUM DURING IN VIVO MICRODIALYSIS 180
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors 180
[3H]Glycine uptake in rat hippocampus: kinetic analysis and autoradiographic localization. 178
Evaluating the role of hnRNP-C and FMRP in the cAMP-induced APP metabolism 177
Phosphodiesterase-4D: an enzyme to remember 175
Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis. 175
Antagonizing α7 nicotinic receptors with methyllycaconitine (MLA) potentiates receptor activity and memory acquisition 173
Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites 173
Glycine modulates 3H-noradrenaline release in rat hippocampus through a strychnine-sensitive receptor 171
Acetylcholine release from rat hippocampal slices is modulated by 5-hydroxytryptamine. 170
l-Aspartate as an amino acid neurotransmitter: mechanisms of the depolarization-induced release from cerebrocortical synaptosomes. 169
GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. 168
Alterations of glutamate release in the spinal cord of mice with experimental autoimmune encephalomyelitis 167
Amyloid Beta and the Brain: Where Are We Now? 166
Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors. 164
A physiological role for amyloid beta in the cyclic AMP-stimulated long term potentiation. 159
A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: role of amyloid beta 156
The amyloid cascade hypothesis in Alzheimer’s disease: it’s time to change our mind 156
Enhanced Function and Overexpression of Metabotropic Glutamate Receptors 1 and 5 in the Spinal Cord of the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis during Disease Progression 155
Amyloid-beta peptide is needed for cGMP-induced long-term potentiation and memory 154
INTRACEREBRAL ADMINISTRATION OF L-KYNURENINE DECREASES N-METHYL-D-ASPARTATE RECEPTOR-MEDIATED PRODUCTION OF cGMP IN THE CEREBELLUM AND HIPPOCAMPUS OF UNANAESTHETIZED RATS SUBJECTED TO TRANSCEREBRAL MICRODIALYSIS 153
ACTIVATION OF BRAIN NITRIC OXIDE SYNTHASE IN DEPOLARIZED HUMAN TEMPORAL CORTEX SLICES: DIFFERENTIAL ROLE OF VOLTAGE-SENSITIVE CALCIUM CHANNELS 153
Presynaptic nicotinic receptors evoke endogenous glutamate and aspartate release from hippocampal synaptosomes by way of distinct coupling mechanisms 151
Release-regulating dopamine autoreceptors in human cerebral cortex. 150
Release-regulating GABAB autoreceptors in rat cerebral cortex slices 149
Mechanisms of glutamate release elicited in rat cerebrocortical nerve endings by ‘pathologically’ elevated extraterminal K+ concentrations 149
Glucagon-Like Peptide 1, Neuroprotection and Neurodegenerative Disorders 149
Cyclooxygenase-1 and -2 differently contribute to prostaglandin E2 synthesis and lipid peroxidation after in vivo activation of N-methyl-D-aspartate receptors in rat hippocampus. 149
Reduced GABA Content in the Motor Thalamus during Effective Deep Brain Stimulation of the Subthalamic Nucleus. 147
Cyclic adenosine monophosphate as an endogenous modulator of the amyloid-β precursor protein metabolism 146
Native human neocortex release-regulating dopamine D2 type autoreceptors are dopamine D2 subtype 146
Neuropeptide S inhibits release of 5-HT and glycine in mouse amygdala and frontal/prefrontal cortex through activation of the neuropeptide S receptor 145
In vivo studies of glutamatergic receptors and NO pathways in brain 144
In vivo activation of N-methyl-D-aspartate receptors in the rat hippocampus increases prostaglandin E2 extracellular levels and triggers lipid peroxidation through cyclooxygenase-mediated mechanisms 144
Presynaptic nicotinic α7 and non-α7 receptors stimulate endogenous GABA release from rat hippocampal synaptosomes through two mechanisms of action. 144
PDE4D inhibitors: a potential strategy for the treatment of memory impairment? 144
DESENSITIZATION OF AMPA RECEPTORS AND AMPA-NMDA RECEPTOR INTERACTION: AN IN VIVO CYCLIC GMP MICRODIALYSIS STUDY IN RAT CEREBELLUM 142
Altered Fronto-Striatal Functions in the Gdi1-null Mouse Model of X-linked Intellectual Disability 142
Delayed administration may improve entacapone effects in parkinsonian patients non-responding to the drug. 138
Microdialysis in Parkinsonian patient basal ganglia: acute apomorphine-induced clinical and electrophysiological effects not paralleled by changes in the release of neuroactive amino acids 137
Evaluation of the mechanisms underlying the kainate-induced impairment of [3H]dopamine release in the rat striatum. 136
Glycine stimulates [3H]noradrenaline release by activating a strychnine-sensitive receptor present in rat hippocampus. 135
In vivo effects of phosphodiesterase inhibition on basal cGMP levels in the pre-frontal cortex, hippocampus and cerebellum of freely moving rats. 135
New compounds having a selective PDE4D inhibiting activity 134
Serotonin receptors regulating transmitter release 133
Autoradiographical evaluation of [3H]glycine uptake in rat forebrain: cellular localization in the hippocampus. 131
Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition 131
Investigating the amyloid-beta enhancing effect of cGMP in neuro2a cells 131
Isolation of hydroxyoctaprenyl-1’,4’-hydroquinone, a new octaprenylhydroquinone from the marine sponge Sarcotragus spinosulus and evaluation of its pharmacological activity on acetylcholine and glutamate release in the rat Central Nervous System. 130
A novel cAMP/PKA/APP/Abeta pathway modulates hippocampal LTP 129
cAMP-induced Aβ production and its role in the expression of LTP. 128
Age-related decrease of the NMDA receptor-mediated noradrenaline release in rat hippocampus and partial restoration by D-cycloserine 128
Dopamine release and dopaminergic inhibition of acetylcholine release in rat striatal slices after nigro-striatal hemitransection and parenteral ganglioside administration 127
Subthalamic stimulation activates internal pallidus: evidence from cGMP microdialysis in PD patients 127
In vivo studies of glutamatergic receptors and NO pathways in brain 127
Activation of presynaptic Neuropeptide S receptors inhibits the release of 5-HT and glycine in mouse frontal/prefrontal cortex and amygdala 127
In vivo investigation of the NMDA/NOS/CGMP pathway during aging in the hippocampus and cerebellum of freely-moving rats 126
TRANSMITTER RELEASE ASSOCIATED WITH LONG-TERM SYNAPTIC DEPRESSION IN RAT CORTICOSTRIATAL SLICES 126
The clinical efficacy of L-DOPA and STN-DBS share a common marker: reduced GABA content in the motor thalamus. 125
Effects of phosphodiesterase inhibition on cortical spreading depression and associated changes in extracellular cyclic GMP 125
Stimulation of the amyloid-β precursor protein metabolism by cAMP 123
Functional damage of dopamine nerve terminals following intrastriatal kainic acid injection 123
THE GLUTAMATE RECEPTOR/NO/CYCLIC GMP PATHWAY IN THE HIPPOCAMPUS OF FREELY-MOVING RATS: MODULATION BY CYCLOTHIAZIDE, INTERACTION WITH GABA AND THE BEHAVIOURAL CONSEQUENCES 122
γ-Aminobutyric acidB receptors mediate inhibition of somatostatin release from cerebrocortex nerve terminals. 122
Homovanillic acid in CSF of mild stage Parkinson’s disease patients correlates with motor impairment 122
γ-Aminobutyric acid (GABA) stimulates somatostatin release following activation of a GABA uptake carrier located on somatostatin nerve endings of rat cerebral cortex. 122
IN VIVO MICRODIALYSIS STUDY OF A SPECIFIC INHIBITOR OF SOLUBLE GUANYLYL CYCLASE ON THE GLUTAMATE RECEPTOR/NITRIC OXIDE/CYCLIC GMP PATHWAY 121
LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex 119
Deep brain stimulation in Parkinson’s disease patients: biochemical evidence 119
GABAA, but not NMDA, receptors modulate in vivo NO-mediated cGMP synthesis in the rat cerebral cortex 118
cAMP, cGMP and Amyloid Beta: three ideal partners for memory formation 118
Cholinergic modulation of 3H-dopamine release from dendrosomes of rat substantia nigra 118
An evaluation of the role of extracellular amino acids in the delayed neurodegeneration induced by quinolinic acid in the rat striatum. 117
Microdialysis study in vivo of the nitric oxide/cGMP pathway in the hippocampus and cerebellum of adult and aged rats 117
Clinical and electrophysiological effects of apomorphine in Parkinson's disease are not paralleled by aminoacid release changes: a microdialysis study 115
Gebr-7b, a novel selective PDE4D inhibitor, increases beta amyloid secretion in neuronal cultured cells and improves cognitive function in rodents 115
The NOS/sGC pathway in the rat central nervous system: a microdialysis overview 114
Correlation between changes in CSF dopamine turnover and development of dyskinesia in Parkinson’s disease. 114
Native human release-regulating dopamine autoreceptors in the cerebral cortex belong to the D2 type D2 subtype 114
Effects of dopamine receptor agonists on the efflux of excitatory and inhibitory amino acids in Parkinson's disease patients: A microdialysis approach 113
Biochemical and electrophysiological changes of substantia nigra pars reticolata driver by subthalamic stimulation in patients with Parkinson’s disease 109
Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D 107
GEBR-32A, A NEW PROMISING PDE4D INHIBITOR FOR TREATMENT OF ALZHEIMER'S DISEASE 107
Temporal administration of entacapone with slow release l-dopa: pharmacokinetic profile and clinical outcome. 106
The pharmacological blockade of medial forebrain bundle induces an acute pathological synchronization of the cortico-subthalamic nucleus-globus pallidus pathway 106
Microdialysis in parkinsonian patient basal ganglia: apomorphine effect without changes in the release of neuroactive amino acids 106
Helicobacter Pylori-induced reduction of l-dopa acute absorption in Parkinson’s disease patients 105
Long term effects of helicobacter pylory eradication on l-dopa absorption in Parkinson’s disease patients 105
GEBR-7b a novel selective PDE4D inhibitor that increases hippocampal cAMP and ameliorates memory without emetic effects 105
cAMP-induced amyloid-β production and its role in long term potentiation 105
Reduced L-DOPA absorption and increased clinical fluctuation in Helicobacter Pylori-infected Parkinson's disease patients 104
Stimulation of the amyloid beta precursor protein metabolism by cAMP 104
Glutamic acid and GABA modulate each other's release through heterocarriers sited on the axon terminal of rat brain 104
Subtype of 5-HT1 receptor regulating [3H]acetylcholine release from superfused hippocampal slices and synaptosomes 104
Totale 14.134
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Categoria #
all - tutte 69.054
article - articoli 49.234
book - libri 0
conference - conferenze 17.461
curatela - curatele 0
other - altro 0
patent - brevetti 297
selected - selezionate 0
volume - volumi 2.062
Totale 138.108
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021830 0 0 0 0 0 179 125 92 94 143 104 93
2021/20222.128 49 212 137 224 55 134 124 541 121 183 99 249
2022/20232.179 218 154 46 215 346 408 15 153 417 11 162 34
2023/20241.056 52 177 24 160 86 181 60 64 39 24 60 129
2024/20253.456 70 266 125 244 393 374 365 532 176 179 275 457
2025/20262.493 691 116 280 430 865 111 0 0 0 0 0 0
Totale 21.756