IRIS
FEDELE, ERNESTO
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
EU - Europa 20.644
AS - Asia 2.255
NA - Nord America 833
SA - Sud America 199
AF - Africa 41
OC - Oceania 2
Totale 23.974
Salva come PNG Salva come JPEG
Nazione #
IT - Italia 20.249
SG - Singapore 1.010
US - Stati Uniti d'America 792
CN - Cina 644
VN - Vietnam 375
FR - Francia 183
BR - Brasile 123
HK - Hong Kong 84
DE - Germania 55
FI - Finlandia 49
AR - Argentina 47
JP - Giappone 37
IN - India 25
MX - Messico 24
CH - Svizzera 20
GB - Regno Unito 20
NL - Olanda 17
ZA - Sudafrica 16
IQ - Iraq 15
BD - Bangladesh 12
CA - Canada 11
RU - Federazione Russa 9
EC - Ecuador 8
VE - Venezuela 8
ID - Indonesia 7
EG - Egitto 6
SE - Svezia 5
TH - Thailandia 5
TW - Taiwan 5
UA - Ucraina 5
DZ - Algeria 4
ES - Italia 4
IE - Irlanda 4
PH - Filippine 4
PL - Polonia 4
PY - Paraguay 4
SA - Arabia Saudita 4
BE - Belgio 3
CL - Cile 3
CO - Colombia 3
JO - Giordania 3
KE - Kenya 3
LB - Libano 3
MA - Marocco 3
PK - Pakistan 3
RO - Romania 3
TN - Tunisia 3
AZ - Azerbaigian 2
CG - Congo 2
CR - Costa Rica 2
IR - Iran 2
KR - Corea 2
LT - Lituania 2
MD - Moldavia 2
PE - Perù 2
PS - Palestinian Territory 2
SI - Slovenia 2
SK - Slovacchia (Repubblica Slovacca) 2
SN - Senegal 2
UZ - Uzbekistan 2
AE - Emirati Arabi Uniti 1
AF - Afghanistan, Repubblica islamica di 1
AL - Albania 1
AU - Australia 1
CY - Cipro 1
CZ - Repubblica Ceca 1
DO - Repubblica Dominicana 1
GR - Grecia 1
GY - Guiana 1
KW - Kuwait 1
KZ - Kazakistan 1
MK - Macedonia 1
ML - Mali 1
MU - Mauritius 1
MY - Malesia 1
NC - Nuova Caledonia 1
NI - Nicaragua 1
NO - Norvegia 1
NP - Nepal 1
OM - Oman 1
PA - Panama 1
RS - Serbia 1
TR - Turchia 1
TT - Trinidad e Tobago 1
Totale 23.974
Salva come PNG Salva come JPEG
Città #
Genova 12.140
Genoa 4.839
Rapallo 1.813
Vado Ligure 1.349
Singapore 505
San Jose 344
Lauterbourg 174
Ho Chi Minh City 114
Beijing 85
Hong Kong 78
Hanoi 76
Ashburn 66
Council Bluffs 61
Frankfurt am Main 50
New York 48
Helsinki 45
Tokyo 37
Bordighera 33
Santa Clara 28
Da Nang 22
Zurich 20
Haiphong 18
Tianjin 16
Amsterdam 15
Los Angeles 14
São Paulo 13
Biên Hòa 10
Milan 10
Orem 10
Guangzhou 9
Mexico City 9
Rome 8
Cape Town 7
Cardiff 7
Chicago 7
Boston 6
Des Moines 6
Shanghai 6
Atlanta 5
Brescia 5
Bắc Ninh 5
Can Tho 5
Dallas 5
Guayaquil 5
Hải Dương 5
Mumbai 5
Naples 5
Turin 5
Tây Ninh 5
Baghdad 4
Basingstoke 4
Buffalo 4
Cairo 4
Chennai 4
Curitiba 4
Dublin 4
Lappeenranta 4
Montreal 4
Thái Bình 4
Warsaw 4
Zibo 4
Ahmedabad 3
Algiers 3
Amman 3
Bangkok 3
Bologna 3
Bình Dương 3
Changsha 3
City of London 3
Dhaka 3
Fortaleza 3
Johannesburg 3
Leipzig 3
Maracaibo 3
Pisa 3
Quận Bình Thạnh 3
Rio de Janeiro 3
Salvador 3
Santiago 3
Sherwood Park 3
Stockholm 3
Toronto 3
Zhengzhou 3
Avezzano 2
Belo Horizonte 2
Belén de Escobar 2
Brasília 2
Brussels 2
Buenos Aires 2
Bến Tre 2
Cagliari 2
Campinas 2
Caracas 2
Casablanca 2
Charlotte 2
Chisinau 2
Dakar 2
Delhi 2
Denver 2
Ha Long 2
Totale 22.301
Salva come PNG Salva come JPEG
Nome #
A novel PDE4D inhibitor increases amyloid-beta deposition in neuronal cultured cells and improves memory in rats 332
Age-related decrease of the NMDA receptor-mediated noradrenaline release in rat hippocampus and partial restoration by D-cycloserine 308
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment 256
Presynaptic GLP-1 receptors enhance the depolarization-evoked release of Glutamate and GABA in the mouse cortex and hippocampus 232
Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease. 210
Amyloid β: Walking on the dark side of the moon 199
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors 198
D-SERINE MODULATES THE NMDA RECEPTOR/NITRIC OXIDE/cGMP PATHWAY IN THE RAT CEREBELLUM DURING IN VIVO MICRODIALYSIS 195
Evaluating the role of hnRNP-C and FMRP in the cAMP-induced APP metabolism 190
[3H]Glycine uptake in rat hippocampus: kinetic analysis and autoradiographic localization. 190
Phosphodiesterase-4D: an enzyme to remember 189
Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites 189
Amyloid Beta and the Brain: Where Are We Now? 187
Antagonizing α7 nicotinic receptors with methyllycaconitine (MLA) potentiates receptor activity and memory acquisition 185
Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis. 185
GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. 184
Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors. 182
Glycine modulates 3H-noradrenaline release in rat hippocampus through a strychnine-sensitive receptor 181
Acetylcholine release from rat hippocampal slices is modulated by 5-hydroxytryptamine. 180
Alterations of glutamate release in the spinal cord of mice with experimental autoimmune encephalomyelitis 178
A physiological role for amyloid beta in the cyclic AMP-stimulated long term potentiation. 177
Enhanced Function and Overexpression of Metabotropic Glutamate Receptors 1 and 5 in the Spinal Cord of the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis during Disease Progression 177
l-Aspartate as an amino acid neurotransmitter: mechanisms of the depolarization-induced release from cerebrocortical synaptosomes. 176
Amyloid-beta peptide is needed for cGMP-induced long-term potentiation and memory 172
A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: role of amyloid beta 169
INTRACEREBRAL ADMINISTRATION OF L-KYNURENINE DECREASES N-METHYL-D-ASPARTATE RECEPTOR-MEDIATED PRODUCTION OF cGMP IN THE CEREBELLUM AND HIPPOCAMPUS OF UNANAESTHETIZED RATS SUBJECTED TO TRANSCEREBRAL MICRODIALYSIS 167
Cyclooxygenase-1 and -2 differently contribute to prostaglandin E2 synthesis and lipid peroxidation after in vivo activation of N-methyl-D-aspartate receptors in rat hippocampus. 167
The amyloid cascade hypothesis in Alzheimer’s disease: it’s time to change our mind 166
Glucagon-Like Peptide 1, Neuroprotection and Neurodegenerative Disorders 164
Presynaptic nicotinic receptors evoke endogenous glutamate and aspartate release from hippocampal synaptosomes by way of distinct coupling mechanisms 163
Mechanisms of glutamate release elicited in rat cerebrocortical nerve endings by ‘pathologically’ elevated extraterminal K+ concentrations 162
ACTIVATION OF BRAIN NITRIC OXIDE SYNTHASE IN DEPOLARIZED HUMAN TEMPORAL CORTEX SLICES: DIFFERENTIAL ROLE OF VOLTAGE-SENSITIVE CALCIUM CHANNELS 161
Altered Fronto-Striatal Functions in the Gdi1-null Mouse Model of X-linked Intellectual Disability 161
Release-regulating GABAB autoreceptors in rat cerebral cortex slices 160
In vivo studies of glutamatergic receptors and NO pathways in brain 160
Reduced GABA Content in the Motor Thalamus during Effective Deep Brain Stimulation of the Subthalamic Nucleus. 158
Presynaptic nicotinic α7 and non-α7 receptors stimulate endogenous GABA release from rat hippocampal synaptosomes through two mechanisms of action. 157
Native human neocortex release-regulating dopamine D2 type autoreceptors are dopamine D2 subtype 157
Release-regulating dopamine autoreceptors in human cerebral cortex. 156
In vivo activation of N-methyl-D-aspartate receptors in the rat hippocampus increases prostaglandin E2 extracellular levels and triggers lipid peroxidation through cyclooxygenase-mediated mechanisms 156
DESENSITIZATION OF AMPA RECEPTORS AND AMPA-NMDA RECEPTOR INTERACTION: AN IN VIVO CYCLIC GMP MICRODIALYSIS STUDY IN RAT CEREBELLUM 154
Neuropeptide S inhibits release of 5-HT and glycine in mouse amygdala and frontal/prefrontal cortex through activation of the neuropeptide S receptor 154
Cyclic adenosine monophosphate as an endogenous modulator of the amyloid-β precursor protein metabolism 153
In vivo effects of phosphodiesterase inhibition on basal cGMP levels in the pre-frontal cortex, hippocampus and cerebellum of freely moving rats. 152
PDE4D inhibitors: a potential strategy for the treatment of memory impairment? 151
Serotonin receptors regulating transmitter release 150
cAMP-induced Aβ production and its role in the expression of LTP. 149
Microdialysis in Parkinsonian patient basal ganglia: acute apomorphine-induced clinical and electrophysiological effects not paralleled by changes in the release of neuroactive amino acids 148
The complex phenotype and function of spinal cord microglia during ALS progression and the impact of metabotropic glutamate receptor type 5 down-regulation in SOD1G93A mice 147
Glycine stimulates [3H]noradrenaline release by activating a strychnine-sensitive receptor present in rat hippocampus. 146
New compounds having a selective PDE4D inhibiting activity 146
Evaluation of the mechanisms underlying the kainate-induced impairment of [3H]dopamine release in the rat striatum. 146
Delayed administration may improve entacapone effects in parkinsonian patients non-responding to the drug. 145
A novel cAMP/PKA/APP/Abeta pathway modulates hippocampal LTP 144
Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition 142
Activation of presynaptic Neuropeptide S receptors inhibits the release of 5-HT and glycine in mouse frontal/prefrontal cortex and amygdala 142
Investigating the amyloid-beta enhancing effect of cGMP in neuro2a cells 142
Autoradiographical evaluation of [3H]glycine uptake in rat forebrain: cellular localization in the hippocampus. 141
Age-related decrease of the NMDA receptor-mediated noradrenaline release in rat hippocampus and partial restoration by D-cycloserine 141
Subthalamic stimulation activates internal pallidus: evidence from cGMP microdialysis in PD patients 140
γ-Aminobutyric acid (GABA) stimulates somatostatin release following activation of a GABA uptake carrier located on somatostatin nerve endings of rat cerebral cortex. 140
Isolation of hydroxyoctaprenyl-1’,4’-hydroquinone, a new octaprenylhydroquinone from the marine sponge Sarcotragus spinosulus and evaluation of its pharmacological activity on acetylcholine and glutamate release in the rat Central Nervous System. 140
Functional damage of dopamine nerve terminals following intrastriatal kainic acid injection 138
TRANSMITTER RELEASE ASSOCIATED WITH LONG-TERM SYNAPTIC DEPRESSION IN RAT CORTICOSTRIATAL SLICES 138
Dopamine release and dopaminergic inhibition of acetylcholine release in rat striatal slices after nigro-striatal hemitransection and parenteral ganglioside administration 137
In vivo studies of glutamatergic receptors and NO pathways in brain 137
γ-Aminobutyric acidB receptors mediate inhibition of somatostatin release from cerebrocortex nerve terminals. 136
In vivo investigation of the NMDA/NOS/CGMP pathway during aging in the hippocampus and cerebellum of freely-moving rats 136
Effects of phosphodiesterase inhibition on cortical spreading depression and associated changes in extracellular cyclic GMP 135
Stimulation of the amyloid-β precursor protein metabolism by cAMP 134
THE GLUTAMATE RECEPTOR/NO/CYCLIC GMP PATHWAY IN THE HIPPOCAMPUS OF FREELY-MOVING RATS: MODULATION BY CYCLOTHIAZIDE, INTERACTION WITH GABA AND THE BEHAVIOURAL CONSEQUENCES 133
The clinical efficacy of L-DOPA and STN-DBS share a common marker: reduced GABA content in the motor thalamus. 133
GEBR-32A, A NEW PROMISING PDE4D INHIBITOR FOR TREATMENT OF ALZHEIMER'S DISEASE 133
An evaluation of the role of extracellular amino acids in the delayed neurodegeneration induced by quinolinic acid in the rat striatum. 131
IN VIVO MICRODIALYSIS STUDY OF A SPECIFIC INHIBITOR OF SOLUBLE GUANYLYL CYCLASE ON THE GLUTAMATE RECEPTOR/NITRIC OXIDE/CYCLIC GMP PATHWAY 130
Deep brain stimulation in Parkinson’s disease patients: biochemical evidence 129
Homovanillic acid in CSF of mild stage Parkinson’s disease patients correlates with motor impairment 129
Cholinergic modulation of 3H-dopamine release from dendrosomes of rat substantia nigra 129
Clinical and electrophysiological effects of apomorphine in Parkinson's disease are not paralleled by aminoacid release changes: a microdialysis study 128
Biochemical and electrophysiological changes of substantia nigra pars reticolata driver by subthalamic stimulation in patients with Parkinson’s disease 128
Microdialysis study in vivo of the nitric oxide/cGMP pathway in the hippocampus and cerebellum of adult and aged rats 128
cAMP, cGMP and Amyloid Beta: three ideal partners for memory formation 128
The NOS/sGC pathway in the rat central nervous system: a microdialysis overview 127
GABAA, but not NMDA, receptors modulate in vivo NO-mediated cGMP synthesis in the rat cerebral cortex 127
Gebr-7b, a novel selective PDE4D inhibitor, increases beta amyloid secretion in neuronal cultured cells and improves cognitive function in rodents 127
LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex 126
Effects of dopamine receptor agonists on the efflux of excitatory and inhibitory amino acids in Parkinson's disease patients: A microdialysis approach 124
Correlation between changes in CSF dopamine turnover and development of dyskinesia in Parkinson’s disease. 123
Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D 123
Native human release-regulating dopamine autoreceptors in the cerebral cortex belong to the D2 type D2 subtype 123
Microdialysis in parkinsonian patient basal ganglia: apomorphine effect without changes in the release of neuroactive amino acids 119
Alterations of glutamate neurotransmission in the spinal cord of EAE mice 119
cAMP-induced amyloid-β production and its role in long term potentiation 118
cGMP favors the interaction between APP and BACE1 by inhibiting Rab5 GTPase activity 118
Temporal administration of entacapone with slow release l-dopa: pharmacokinetic profile and clinical outcome. 117
Alterations of glutamate release in the spinal cord of mice affected by experimental autoimmune encephalomyelitis 117
The pharmacological blockade of medial forebrain bundle induces an acute pathological synchronization of the cortico-subthalamic nucleus-globus pallidus pathway 116
Long term effects of helicobacter pylory eradication on l-dopa absorption in Parkinson’s disease patients 116
Stimulation of the amyloid beta precursor protein metabolism by cAMP 116
GEBR-7b a novel selective PDE4D inhibitor that increases hippocampal cAMP and ameliorates memory without emetic effects 116
Totale 15.471
Salva come PNG Salva come JPEG
Categoria #
all - tutte 72.926
article - articoli 51.809
book - libri 0
conference - conferenze 18.634
curatela - curatele 0
other - altro 0
patent - brevetti 316
selected - selezionate 0
volume - volumi 2.167
Totale 145.852
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021340 0 0 0 0 0 0 0 0 0 143 104 93
2021/20222.128 49 212 137 224 55 134 124 541 121 183 99 249
2022/20232.179 218 154 46 215 346 408 15 153 417 11 162 34
2023/20241.056 52 177 24 160 86 181 60 64 39 24 60 129
2024/20253.456 70 266 125 244 393 374 365 532 176 179 275 457
2025/20265.196 691 116 280 430 865 546 1.016 380 413 459 0 0
Totale 24.459