IRIS
THELLUNG DE COURTELARY, STEFANO
 Distribuzione geografica
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Continente #
EU - Europa 11.883
AS - Asia 63
SA - Sud America 17
NA - Nord America 4
AF - Africa 1
Totale 11.968
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Nazione #
IT - Italia 11.882
CN - Cina 50
BR - Brasile 13
VN - Vietnam 7
SG - Singapore 5
EC - Ecuador 3
US - Stati Uniti d'America 3
CO - Colombia 1
IQ - Iraq 1
MA - Marocco 1
MX - Messico 1
RU - Federazione Russa 1
Totale 11.968
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Città #
Genova 6.524
Genoa 3.485
Vado Ligure 946
Rapallo 897
Bordighera 27
Beijing 26
Ho Chi Minh City 6
Ashburn 3
Singapore 2
São Paulo 2
Baghdad 1
Belo Horizonte 1
Boa Vista 1
Bolzano 1
Fortaleza 1
Guayaquil 1
Hải Dương 1
Ituiutaba 1
Ivinhema 1
Marliéria 1
Medellín 1
Mexico City 1
Monte Alegre de Sergipe 1
Muriaé 1
Nova Iguaçu 1
Quito 1
Rabat 1
Ribeirão Preto 1
Riobamba 1
Taquara 1
Usinsk 1
Verona 1
Totale 11.940
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Nome #
Amyloid precursor protein modulates ERK1/2 signaling 212
Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells 211
Characterization of the pro-apoptotic intracellular mechanisms induced by a toxic conformer of the recombinant human prion protein fragment 90-231 207
Calcium binding promotes Prion Protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure 207
Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells. 199
Peptide Receptor Targeting in Cancer: The Somatostatin Paradigm 198
Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis 192
Apoptotic cell death and impairment of L-type voltage sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment 106-126 192
Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231 185
In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity 184
Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro 180
In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors 179
Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death 173
Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity 173
Human glioblastoma-derived cell membrane nanovesicles: a novel, cell-specific strategy for boron neutron capture therapy of brain tumors 168
Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90–231 Neurotoxic Effects in Cerebellar Granule Neurons 168
Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells 167
Drug-repositioning opportunities for cancer therapy: Novel molecular targets for known compounds 165
SDF1 controls pituitary cell proliferation through the activation of ERK1/2 and the Ca2+-dependent cytosolic tyrosine kinase, Pyk2. 164
Different structural stability and toxicity of PrPARR and PrPARQ sheep prion protein variants 162
Drug design strategies focusing on the CXCR4/CXCR7/CXCL12 pathway in leukemia and lymphoma 162
Emerging targets in pituitary adenomas: role of the CXCL12/CXCR4-R7 system 161
Proteostasis unbalance in prion diseases: mechanisms of neurodegeneration and therapeutic targets 156
Canine osteosarcoma cell lines contain stem-like cancer cells: Biological and pharmacological characterization 153
Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction 152
Novel celecoxib analogues inhibit glial production of prostaglandinE2, nitric oxide, and oxygen radicals reverting the neuroinflammatoryresponses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide 151
Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: involvement of A2, purinergic receptor subtypes 151
The chemokine SDF1/CXCL12: a novel autocrine/paracrine factor involved in pituitary adenoma development 150
Excitotoxicity Through NMDA Receptors Mediates Cerebellar Granule Neuron Apoptosis Induced by Prion Protein 90-231 Fragment 150
Molecular pharmacology of malignant pleural mesothelioma: Challenges and perspectives from preclinical and clinical studies 150
Chemokine stromal cell-derived factor 1α induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals 146
Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives 146
ERK1/2 and p38 MAP kinases control prion protein fragment 90-231-induced astrocyte proliferation and microglia activation 145
A. novel mechanism for the melatonin inhibition of testosterone secretion by rat Leydig cells: reduction of GnRH-induced cytosolic Ca2+ rise 144
Conformation dependent pro-apoptotic activity of the recombinant human prion protein fragment 90-231 144
Biological and Biochemical Basis of the Differential Efficacy of First and Second Generation Somatostatin Receptor Ligands in Neuroendocrine Neoplasms 144
Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation 141
Role of prion protein aggregation in neurotoxicity 140
Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein 139
Ruta graveolens L. induces death of glioblastoma cells and neural progenitors, but not of neurons, via ERK 1/2 and AKT activation 139
ACTIVATION OF AUTOPHAGY PATHWAY AS NEUROPROTECTIVE MECHANISM AGAINST AMYLOIDOGENIC PRION PEPTIDE 138
In silico identification and experimental validation of novel anti-Alzheimer's multitargeted ligands from marine source featuring a "2-amino-imidazole plus aromatic group" scaffold 137
p38 MAP Kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells 135
Stem-like signatures in human meningioma cells are under the control of CXCL11/CXCL12 chemokine activity 134
Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity 134
Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity 134
CXCR4 expression in feline mammary carcinoma cells: evidence of a proliferative role for the SDF-1/CXCR4 axis 133
High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein 132
Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2 132
Isolation of stem-like cells from spontaneous feline mammary carcinomas: phenotypic characterization and tumorigenic potential 131
In vitro study of uptake and synthesis of creatine and its precursors by cerebellar granule cells and astrocytes suggests some hypotheses on the physiopathology of the inherited disorders of creatine metabolism 131
Aminoterminally truncated human Prion protein fragment 90-231 forms intracellular aggregates and causes lysosomal loss of impermeability 126
Celecoxib, a COX-2 inhibitor, blocks microglial activation induced by a neurotoxic conformer of hPrP90-231 126
Molecular mechanisms mediating neuronal cell death in experimental models of prion diseases, in vitro 123
Addressing thermal and mechanical stability of human prion protein with single molecule and ensemble measurements 123
Prion protein fragment 106-126 induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell line. 121
Emerging Role of Cellular Prion Protein in the Maintenance and Expansion of Glioma Stem Cells 121
INTRACELLULAR MECHANISMS MEDIATING THE NEURONAL CELL DEATH AND ASTROGLIOSIS INDUCED BY THE PRION PROTEIN FRAGMENT 106-126 116
TGF-beta1 prevents gp120-induced impairment of Ca++ homeostasis and rescues cortical neurons from apoptotic death 114
Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor 3 (SSTR3) mediated regulation of endothelial NOS and MAP kinase activities” 111
Experimental Evidence and Clinical Implications of Pituitary Adenoma Stem Cells 111
Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231 (hPrP90-231), as possible mechanism of its neurotoxic effects 110
Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling 110
Molecular mechanisms involved in the aggregation and fibril formation of the recombinant human prion fragment PrP90-231 109
Nitric oxide production stimulated by the basic fibroblast growth factor requires the synthesis of ceramide 108
Identification of a conserved N-capping box important for the structural autonomy of the prion alpha 3-helix: the disease associated D202N mutation destabilizes the helical conformation 107
MCM2 and Carbonic Anhydrase 9 Are Novel Potential Targets for Neuroblastoma Pharmacological Treatment 105
Identification of the hydantoin alkaloids parazoanthines as novel CXCR4 antagonists by computational and in vitro functional characterization 104
Oncogene transformation of PC Cl3 clonal thyroid cell line induces an autonomous pattern of proliferation that correlates with a loss of basal and stimulated phosphotyrosine phosphatase activity 102
Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies 101
Effect of nitric Oxide Donors on GABA Uptake by Rat Brain Synaptosomes. Neurochem. Research 100
Study of the Molecular Mechanism Responsible of the Conformational Changes Induced by E200K and D202N Pathological PrP Mutation 98
Expression of somatostatin receptors mRNA in human meningiomas and their implication in in vitro antiproliferative activity 98
null 96
Prion protein fragment 90-231 induces microglia activation: role of ERK1/2 and p38 MAP kinases in nitric oxide production and CCL5 secretion 95
The activation of the phosphotyrosine phosphatase h (r-PTPh) is responsible for the somatostatin inhibition of PC Cl3 thyroid cell proliferation 94
Synthesis of guanidinoacetate and creatine in neurons and glial cells 92
Somatostatin controls Kaposi sarcoma growth through inhibition of angiogenesis 92
Molecular mechanisms mediating the neuroprotective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231) 91
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 91
Prolonged treatment with alpha-glycerylphosphorylethanolamine facilitates the acquisition of an active avoidance behavior and selectively increases neuronal signal transduction in rats 90
Somatostatinergic control of Kaposi’s sarcoma growth through the inhibition of angiogenesis 88
Intracellular transducing mechanisms modulated by activated brain somatostatin receptors 87
Study of the molecular mechanisms responsible of the transition of the prion protein fragment 90-231 in a neurotoxic conformation. 84
Somatostatin and its analog lanreotide inhibit the proliferation of dispersed human non-functioning pituitary adenoma cells in vitro 83
Nitric Oxide and GABAA Receptor Function in the Rat Cerebral Cortex and Cerebellar Granule Cells. 78
Bioinspired nanoparticles for glioblastoma treatment 77
Neurotoxicity of the recombinant prion protein fragment 90-231 in SH-SY5Y cells is dependent on its conversion in beta-structured-isoform 77
Development and validation of a GC-MS method for determination of metformin in normal brain and in glioblastoma tissues 74
Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro 60
The expression of pro-prion, a transmembrane isoform of the prion protein, leads to the constitutive activation of the canonical Wnt/β-catenin pathway to sustain the stem-like phenotype of human glioblastoma cells 59
The activation of the phosphotyrosine phosphatase eta is responsible for the somatostatin inhibition of PC Cl3 thyroid cell proliferation 53
Chemokine signaling in tumors: potential role of CXC chemokines and their receptors as glioblastoma therapeutic targets 40
Consensus based recommendations for diagnosis and medical management of Poland syndrome (sequence) 25
A floating endometrial organoid model recapitulates epithelial-stromal cell interactions in vitro 22
Ruta graveolens, but Not Rutin, Inhibits Survival, Migration, Invasion, and Vasculogenic Mimicry of Glioblastoma Cells 19
Totale 12.232
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Categoria #
all - tutte 38.574
article - articoli 36.447
book - libri 0
conference - conferenze 1.424
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 703
Totale 77.148
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021586 0 0 0 64 87 58 48 72 56 104 52 45
2021/20221.107 35 102 62 119 36 87 87 249 41 86 53 150
2022/20231.064 91 63 9 107 168 183 1 95 170 6 156 15
2023/2024667 45 71 16 88 45 151 44 39 28 24 44 72
2024/20252.357 71 128 72 207 309 245 225 434 92 86 229 259
2025/20261.391 454 104 515 318 0 0 0 0 0 0 0 0
Totale 12.232