IRIS
THELLUNG DE COURTELARY, STEFANO
 Distribuzione geografica
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Continente #
EU - Europa 12.209
AS - Asia 1.295
NA - Nord America 1.151
Continente sconosciuto - Info sul continente non disponibili 273
SA - Sud America 133
AF - Africa 19
OC - Oceania 4
Totale 15.084
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Nazione #
IT - Italia 12.012
US - Stati Uniti d'America 1.074
SG - Singapore 498
CN - Cina 338
VN - Vietnam 237
BD - Bangladesh 98
FR - Francia 82
BR - Brasile 76
HK - Hong Kong 42
CA - Canada 26
DE - Germania 26
AR - Argentina 24
MX - Messico 19
FI - Finlandia 14
GB - Regno Unito 14
EC - Ecuador 12
CO - Colombia 11
IQ - Iraq 11
JP - Giappone 11
CH - Svizzera 10
ID - Indonesia 10
PH - Filippine 8
HN - Honduras 7
IN - India 7
NL - Olanda 7
JM - Giamaica 6
PL - Polonia 6
ZA - Sudafrica 6
PK - Pakistan 5
UA - Ucraina 5
JO - Giordania 4
RO - Romania 4
TH - Thailandia 4
VE - Venezuela 4
AU - Australia 3
BH - Bahrain 3
CR - Costa Rica 3
KR - Corea 3
LV - Lettonia 3
PR - Porto Rico 3
RU - Federazione Russa 3
SV - El Salvador 3
TR - Turchia 3
AT - Austria 2
BE - Belgio 2
BO - Bolivia 2
CY - Cipro 2
DK - Danimarca 2
ES - Italia 2
GT - Guatemala 2
IE - Irlanda 2
KE - Kenya 2
LT - Lituania 2
MA - Marocco 2
MY - Malesia 2
PT - Portogallo 2
RS - Serbia 2
SC - Seychelles 2
TN - Tunisia 2
TT - Trinidad e Tobago 2
AL - Albania 1
AZ - Azerbaigian 1
BG - Bulgaria 1
BS - Bahamas 1
BZ - Belize 1
CL - Cile 1
DZ - Algeria 1
GA - Gabon 1
GP - Guadalupe 1
GR - Grecia 1
HR - Croazia 1
KH - Cambogia 1
KY - Cayman, isole 1
KZ - Kazakistan 1
LK - Sri Lanka 1
LY - Libia 1
MD - Moldavia 1
NC - Nuova Caledonia 1
NI - Nicaragua 1
NP - Nepal 1
OM - Oman 1
PA - Panama 1
PE - Perù 1
PY - Paraguay 1
SE - Svezia 1
SI - Slovenia 1
SY - Repubblica araba siriana 1
TG - Togo 1
TW - Taiwan 1
TZ - Tanzania 1
UY - Uruguay 1
UZ - Uzbekistan 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 14.812
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Città #
Genova 6.524
Genoa 3.503
Vado Ligure 946
Rapallo 897
San Jose 273
Singapore 243
Ashburn 138
Lauterbourg 81
Ho Chi Minh City 68
Beijing 60
Hanoi 47
Council Bluffs 41
Hong Kong 40
New York 36
Santa Clara 33
Bordighera 27
Frankfurt am Main 22
Los Angeles 18
Milan 17
Chicago 16
Haiphong 13
Brooklyn 12
Da Nang 12
Helsinki 11
Tokyo 11
Mexico City 10
Zurich 10
Rome 9
São Paulo 9
Tianjin 9
Dallas 7
Warsaw 7
Amsterdam 6
Bologna 6
Buffalo 6
City of London 6
Hải Dương 6
Louisville 6
Phoenix 6
Quito 6
Biên Hòa 5
Charlotte 5
Des Moines 5
Jakarta 5
Las Vegas 5
Montreal 5
Nashville 5
Nha Trang 5
Ninh Bình 5
Rio de Janeiro 5
Baghdad 4
Boardman 4
Brasília 4
Medellín 4
Memphis 4
Pittsburgh 4
Princeton 4
San Pedro Sula 4
Savannah 4
Tampa 4
Thái Bình 4
Waterbury 4
Amman 3
Atlanta 3
Bari 3
Belo Horizonte 3
Detroit 3
Florence 3
Guayaquil 3
Johannesburg 3
Karachi 3
Kyiv 3
Lappeenranta 3
London 3
Miami 3
Naples 3
Orem 3
Quận Ba 3
San José 3
Seneca 3
Suzhou 3
The Bronx 3
Verona 3
Virginia Beach 3
Anaheim 2
Anna 2
Arlington 2
Bangkok 2
Berazategui 2
Boston 2
Brussels 2
Buenos Aires 2
Calgary 2
Camden 2
Can Tho 2
Cao Lanh 2
Cheyenne 2
Cincinnati 2
Clanton 2
Clearwater 2
Totale 13.394
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Nome #
Characterization of the pro-apoptotic intracellular mechanisms induced by a toxic conformer of the recombinant human prion protein fragment 90-231 259
Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells 255
Amyloid precursor protein modulates ERK1/2 signaling 253
Calcium binding promotes Prion Protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure 238
Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells. 231
Human glioblastoma-derived cell membrane nanovesicles: a novel, cell-specific strategy for boron neutron capture therapy of brain tumors 227
Peptide Receptor Targeting in Cancer: The Somatostatin Paradigm 226
In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity 225
Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis 224
Apoptotic cell death and impairment of L-type voltage sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment 106-126 222
Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro 219
Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231 217
SDF1 controls pituitary cell proliferation through the activation of ERK1/2 and the Ca2+-dependent cytosolic tyrosine kinase, Pyk2. 212
Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells 205
Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death 205
Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity 204
In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors 204
Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90–231 Neurotoxic Effects in Cerebellar Granule Neurons 199
Proteostasis unbalance in prion diseases: mechanisms of neurodegeneration and therapeutic targets 197
Drug-repositioning opportunities for cancer therapy: Novel molecular targets for known compounds 195
Drug design strategies focusing on the CXCR4/CXCR7/CXCL12 pathway in leukemia and lymphoma 193
Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives 192
Different structural stability and toxicity of PrPARR and PrPARQ sheep prion protein variants 190
Biological and Biochemical Basis of the Differential Efficacy of First and Second Generation Somatostatin Receptor Ligands in Neuroendocrine Neoplasms 187
Canine osteosarcoma cell lines contain stem-like cancer cells: Biological and pharmacological characterization 186
Emerging targets in pituitary adenomas: role of the CXCL12/CXCR4-R7 system 185
ACTIVATION OF AUTOPHAGY PATHWAY AS NEUROPROTECTIVE MECHANISM AGAINST AMYLOIDOGENIC PRION PEPTIDE 183
ERK1/2 and p38 MAP kinases control prion protein fragment 90-231-induced astrocyte proliferation and microglia activation 182
Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction 180
Novel celecoxib analogues inhibit glial production of prostaglandinE2, nitric oxide, and oxygen radicals reverting the neuroinflammatoryresponses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide 180
Chemokine stromal cell-derived factor 1α induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals 179
A. novel mechanism for the melatonin inhibition of testosterone secretion by rat Leydig cells: reduction of GnRH-induced cytosolic Ca2+ rise 179
Molecular pharmacology of malignant pleural mesothelioma: Challenges and perspectives from preclinical and clinical studies 178
The chemokine SDF1/CXCL12: a novel autocrine/paracrine factor involved in pituitary adenoma development 177
Excitotoxicity Through NMDA Receptors Mediates Cerebellar Granule Neuron Apoptosis Induced by Prion Protein 90-231 Fragment 177
Conformation dependent pro-apoptotic activity of the recombinant human prion protein fragment 90-231 172
Stem-like signatures in human meningioma cells are under the control of CXCL11/CXCL12 chemokine activity 171
Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: involvement of A2, purinergic receptor subtypes 170
CXCR4 expression in feline mammary carcinoma cells: evidence of a proliferative role for the SDF-1/CXCR4 axis 168
Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation 164
Ruta graveolens L. induces death of glioblastoma cells and neural progenitors, but not of neurons, via ERK 1/2 and AKT activation 163
Addressing thermal and mechanical stability of human prion protein with single molecule and ensemble measurements 162
Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity 162
Isolation of stem-like cells from spontaneous feline mammary carcinomas: phenotypic characterization and tumorigenic potential 161
Celecoxib, a COX-2 inhibitor, blocks microglial activation induced by a neurotoxic conformer of hPrP90-231 161
In silico identification and experimental validation of novel anti-Alzheimer's multitargeted ligands from marine source featuring a "2-amino-imidazole plus aromatic group" scaffold 159
p38 MAP Kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells 157
Aminoterminally truncated human Prion protein fragment 90-231 forms intracellular aggregates and causes lysosomal loss of impermeability 156
Role of prion protein aggregation in neurotoxicity 156
Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein 156
In vitro study of uptake and synthesis of creatine and its precursors by cerebellar granule cells and astrocytes suggests some hypotheses on the physiopathology of the inherited disorders of creatine metabolism 154
Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies 153
Emerging Role of Cellular Prion Protein in the Maintenance and Expansion of Glioma Stem Cells 152
High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein 151
Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2 149
Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity 149
Molecular mechanisms mediating neuronal cell death in experimental models of prion diseases, in vitro 144
MCM2 and Carbonic Anhydrase 9 Are Novel Potential Targets for Neuroblastoma Pharmacological Treatment 144
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 144
Experimental Evidence and Clinical Implications of Pituitary Adenoma Stem Cells 141
Prion protein fragment 106-126 induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell line. 137
TGF-beta1 prevents gp120-induced impairment of Ca++ homeostasis and rescues cortical neurons from apoptotic death 136
Molecular mechanisms involved in the aggregation and fibril formation of the recombinant human prion fragment PrP90-231 136
Identification of a conserved N-capping box important for the structural autonomy of the prion alpha 3-helix: the disease associated D202N mutation destabilizes the helical conformation 131
INTRACELLULAR MECHANISMS MEDIATING THE NEURONAL CELL DEATH AND ASTROGLIOSIS INDUCED BY THE PRION PROTEIN FRAGMENT 106-126 130
Identification of the hydantoin alkaloids parazoanthines as novel CXCR4 antagonists by computational and in vitro functional characterization 130
Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor 3 (SSTR3) mediated regulation of endothelial NOS and MAP kinase activities” 127
Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling 127
Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231 (hPrP90-231), as possible mechanism of its neurotoxic effects 126
Prion protein fragment 90-231 induces microglia activation: role of ERK1/2 and p38 MAP kinases in nitric oxide production and CCL5 secretion 126
Nitric oxide production stimulated by the basic fibroblast growth factor requires the synthesis of ceramide 124
Bioinspired nanoparticles for glioblastoma treatment 122
Effect of nitric Oxide Donors on GABA Uptake by Rat Brain Synaptosomes. Neurochem. Research 119
Study of the Molecular Mechanism Responsible of the Conformational Changes Induced by E200K and D202N Pathological PrP Mutation 118
Expression of somatostatin receptors mRNA in human meningiomas and their implication in in vitro antiproliferative activity 118
Molecular mechanisms mediating the neuroprotective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231) 114
Oncogene transformation of PC Cl3 clonal thyroid cell line induces an autonomous pattern of proliferation that correlates with a loss of basal and stimulated phosphotyrosine phosphatase activity 114
The activation of the phosphotyrosine phosphatase h (r-PTPh) is responsible for the somatostatin inhibition of PC Cl3 thyroid cell proliferation 113
Study of the molecular mechanisms responsible of the transition of the prion protein fragment 90-231 in a neurotoxic conformation. 113
Somatostatin controls Kaposi sarcoma growth through inhibition of angiogenesis 110
Prolonged treatment with alpha-glycerylphosphorylethanolamine facilitates the acquisition of an active avoidance behavior and selectively increases neuronal signal transduction in rats 109
Development and validation of a GC-MS method for determination of metformin in normal brain and in glioblastoma tissues 107
Intracellular transducing mechanisms modulated by activated brain somatostatin receptors 105
Somatostatinergic control of Kaposi’s sarcoma growth through the inhibition of angiogenesis 103
The expression of pro-prion, a transmembrane isoform of the prion protein, leads to the constitutive activation of the canonical Wnt/β-catenin pathway to sustain the stem-like phenotype of human glioblastoma cells 102
Synthesis of guanidinoacetate and creatine in neurons and glial cells 101
null 96
Neurotoxicity of the recombinant prion protein fragment 90-231 in SH-SY5Y cells is dependent on its conversion in beta-structured-isoform 95
Nitric Oxide and GABAA Receptor Function in the Rat Cerebral Cortex and Cerebellar Granule Cells. 94
Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro 93
Somatostatin and its analog lanreotide inhibit the proliferation of dispersed human non-functioning pituitary adenoma cells in vitro 93
Simple and Rapid Model to Generate Differentiated Endometrial Floating Organoids 77
A floating endometrial organoid model recapitulates epithelial-stromal cell interactions in vitro 77
The activation of the phosphotyrosine phosphatase eta is responsible for the somatostatin inhibition of PC Cl3 thyroid cell proliferation 70
Chemokine signaling in tumors: potential role of CXC chemokines and their receptors as glioblastoma therapeutic targets 69
Consensus based recommendations for diagnosis and medical management of Poland syndrome (sequence) 64
Ruta graveolens, but Not Rutin, Inhibits Survival, Migration, Invasion, and Vasculogenic Mimicry of Glioblastoma Cells 43
Microglia Reprogramming in Glioblastoma: Stem Cell-Derived Factors as Emerging Immunomodulators 16
The PDE5 inhibitor vardenafil enhances glutamatergic transmission through amyloid-beta and cellular prion protein 15
Totale 15.084
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Categoria #
all - tutte 46.538
article - articoli 43.959
book - libri 0
conference - conferenze 1.725
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 854
Totale 93.076
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.107 35 102 62 119 36 87 87 249 41 86 53 150
2022/20231.064 91 63 9 107 168 183 1 95 170 6 156 15
2023/2024667 45 71 16 88 45 151 44 39 28 24 44 72
2024/20252.357 71 128 72 207 309 245 225 434 92 86 229 259
2025/20263.835 454 104 515 344 437 264 507 201 248 368 208 185
2026/2027408 408 0 0 0 0 0 0 0 0 0 0 0
Totale 15.084