IRIS
BRUNO, OLGA
 Distribuzione geografica
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Continente #
EU - Europa 22.782
AS - Asia 2.564
NA - Nord America 2.531
Continente sconosciuto - Info sul continente non disponibili 319
SA - Sud America 221
AF - Africa 38
OC - Oceania 2
Totale 28.457
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Nazione #
IT - Italia 22.356
US - Stati Uniti d'America 2.396
SG - Singapore 1.064
CN - Cina 685
VN - Vietnam 432
FR - Francia 179
BR - Brasile 134
HK - Hong Kong 115
BD - Bangladesh 106
DE - Germania 64
FI - Finlandia 49
CA - Canada 43
JP - Giappone 42
AR - Argentina 35
GB - Regno Unito 33
MX - Messico 32
NL - Olanda 23
IN - India 21
ID - Indonesia 19
JM - Giamaica 18
EC - Ecuador 14
CO - Colombia 12
ES - Italia 12
VE - Venezuela 12
IQ - Iraq 11
TH - Thailandia 10
CH - Svizzera 9
IE - Irlanda 9
KR - Corea 9
ZA - Sudafrica 9
CR - Costa Rica 8
HN - Honduras 8
RU - Federazione Russa 8
PH - Filippine 7
PL - Polonia 6
DZ - Algeria 5
SA - Arabia Saudita 5
SC - Seychelles 5
TR - Turchia 5
CL - Cile 4
DO - Repubblica Dominicana 4
GT - Guatemala 4
JO - Giordania 4
KE - Kenya 4
LB - Libano 4
MA - Marocco 4
PY - Paraguay 4
RO - Romania 4
TN - Tunisia 4
UA - Ucraina 4
UZ - Uzbekistan 4
AZ - Azerbaigian 3
BO - Bolivia 3
EE - Estonia 3
HR - Croazia 3
PK - Pakistan 3
PR - Porto Rico 3
SE - Svezia 3
SV - El Salvador 3
TT - Trinidad e Tobago 3
AL - Albania 2
AU - Australia 2
BG - Bulgaria 2
BS - Bahamas 2
CZ - Repubblica Ceca 2
DK - Danimarca 2
ET - Etiopia 2
KG - Kirghizistan 2
KW - Kuwait 2
LC - Santa Lucia 2
MY - Malesia 2
NO - Norvegia 2
NP - Nepal 2
PA - Panama 2
PE - Perù 2
SI - Slovenia 2
AM - Armenia 1
AT - Austria 1
BZ - Belize 1
CG - Congo 1
CI - Costa d'Avorio 1
CY - Cipro 1
EG - Egitto 1
GP - Guadalupe 1
HU - Ungheria 1
KH - Cambogia 1
LT - Lituania 1
LV - Lettonia 1
MM - Myanmar 1
MN - Mongolia 1
MU - Mauritius 1
NE - Niger 1
NI - Nicaragua 1
OM - Oman 1
PT - Portogallo 1
TW - Taiwan 1
UY - Uruguay 1
Totale 28.138
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Città #
Genova 13.259
Genoa 5.594
Rapallo 1.891
Vado Ligure 1.431
San Jose 685
Singapore 513
Ashburn 240
Lauterbourg 164
Ho Chi Minh City 124
Beijing 113
Hong Kong 107
New York 105
Hanoi 95
Santa Clara 54
Frankfurt am Main 50
Helsinki 47
Council Bluffs 42
Chicago 39
Tokyo 38
Los Angeles 37
Dallas 27
Bordighera 25
Haiphong 25
Milan 24
Phoenix 24
Amsterdam 23
Mexico City 19
Tianjin 18
Atlanta 16
Da Nang 16
Houston 16
Brooklyn 15
Buffalo 15
Rome 15
São Paulo 15
Boardman 13
Memphis 12
Naples 12
Orem 12
Philadelphia 12
Miami 11
Des Moines 10
Kingston 10
Montreal 10
Cardiff 9
Catania 9
Denver 9
Newark 9
Seattle 9
Biên Hòa 8
Dublin 8
London 8
Bắc Ninh 7
Cleveland 7
Hải Dương 7
Salvador 7
San José 7
Toronto 7
Washington 7
Zurich 7
Charlotte 6
Jacksonville 6
Las Vegas 6
Turin 6
Bossier City 5
Campinas 5
Can Tho 5
City of London 5
Curitiba 5
Florence 5
Guayaquil 5
Jeddah 5
Monroe 5
Montego Bay 5
Ninh Bình 5
Palermo 5
Quito 5
San Francisco 5
Shanghai 5
Warsaw 5
Amman 4
Baghdad 4
Buenos Aires 4
Chennai 4
Decatur 4
Detroit 4
Guangzhou 4
Ha Long 4
Jakarta 4
Johannesburg 4
Kansas City 4
La Plata 4
Louisville 4
Milwaukee 4
Minneapolis 4
Nairobi 4
Newton 4
Paris 4
Phủ Lý 4
Queens 4
Totale 25.332
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Nome #
A novel PDE4D inhibitor increases amyloid-beta deposition in neuronal cultured cells and improves memory in rats 344
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment 261
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation 233
1,3,3-Trimethyl-N-(2-pyridyl)-2-oxabicyclo[2.2.2]octan-6-amine derivatives with hypotensive and other activities 230
Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease. 218
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors 217
An efficient synthesis of functionalized 2-pyridones by direct route or via amide/enolate ammonium salt intermediates 215
A physiological role for amyloid beta in the cyclic AMP-stimulated long term potentiation. 212
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors 203
A physiological role for amyloid beta in the cyclic AMP-stimulated long term potentiation. 196
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles 195
GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. 195
The pyrazolyl-urea GeGe3 inhibits tumor angiogenesis and reveals dystrophia myotonica protein Kinase (DMPK)1 as a novel angiogenesis target 194
Design and synthesis of 4,5,6,7‐tetrahydro‐1H‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors 193
Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors. 190
Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors 188
1-Acyl-, 3-acyl- and 1,3-diacyl-3-furfuryl-1-phenylthioureas with platelet antiaggregating and other activities. 187
3-Arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones as antiinflammatory and analgesic agents 186
Synthesis and biological evaluation of neutrophilic inflammation inhibitors 185
Relative Stereochemistry of a Diterpene from Salvia cinnabarina 184
. 3,5-diphenyl-1H-pyrazole derivatives. XI. N-aryl-5(3)-phenyl-4-(3,5- diphenyl-1-pyrazolyl)-3(5)-pyrazole amines, 5-substituted 4,5-dihydro-3-phenyl-4-(3,5-diphenyl-1-pyrazolyl)-1H-pyrazoles and 2,6-disubstituted 1,6-dihydro-4- phenyl-5-(3,5-diphenyl-1-pyrazolyl)pyrimidines with antipyretic, antiinflammatory and other activities. 184
2-Aryl-3-phenylamino-4,5-dihydro-2h-benz[g]indazoles with analgesic activity 182
A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: role of amyloid beta 181
"One-pot" synthesis of N-acyl-N-phenylcarbamate derivatives endowed with anti-HIV and/or antiproliferative activities 180
3,5-Diphenyl-1H-pyrazole derivatives. IX. 2-substituted 4-phenyl-5-(3,5-diphenyl-1H-pyrazol-1-yl) pyrimidines with platelet antiaggregating and other activities. 180
Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics 179
Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines 177
3,5-Diphenyl-1H-pyrazole derivatives. V--1-Acetyl-4-hydroxy-3,5-diphenyl-2-pyrazoline esters, 4-hydroxy-3,5-diphenyl-1H-pyrazole esters and N-substituted 4-(3-amino-2-hydroxy-1-propoxy)-1-methyl-3,5-diphenyl-1H-pyrazoles with antiarrhythmic, sedative and platelet antiaggregating activities. 175
Phosphodiesterase isoform-specific expression induced by traumatic brain injury 174
6-amino-4-oxo-1,3-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl derivatives as a new class of potent inhibitors of Interleukin-8-induced neutrophil chemotaxis 172
5-Substituted derivatives of 6-amino-1,3-diphenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one as a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis 171
Pyrazole and imidazo[1,2-b]pyrazole derivatives as new potential anti-tuberculosis agents. 171
3,3-disubstituted 1-acyl-1-phenylthioureas with platelet antiaggregating and other activities 170
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line 170
3,5-Diphenyl-1H-pyrazole derivatives. III. Ethers 1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole and its 4-bromo derivative with hypotensive, depressant, antiarrhythmic and analgesic activities 168
Docking-based CoMFA and CoMSIA analyses of tetrahydro-β-carboline derivatives as type-5 phosphodiesterase inhibitors. 166
Synthesis and biological evaluation of N-pyrazolyl-N'-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis 166
2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: New potent inhibitors of fMLP-induced neutrophil chemotaxis 166
N-Aryl-2-phenyl-2,3-dihydro-imidazo[1,2-b]pyrazole-1-carboxamides 7-substituted strongly inhibiting both fMLP-OMe- and IL-8-induced human neutrophil chemotaxis. 163
Derivati dell'1,3-benzodiossolo, potenziali inibitori delle PDE5 162
PDE4D inhibitors: a potential strategy for the treatment of memory impairment? 161
2-Amino/Azido/Hydrazino-5-alkoxy-5H-[1]benzopyrano[4,3-d]pyrimidines: Synthesis and Pharmacological Evaluation 160
N'-acyl-N,N-(1,3,3-trimethylbicyclo [2.2.1]hept-2-ylidene)benzamidines with hypotensive activity. 159
2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles with antiarrhythmic and local anaesthetic activities 159
3-(Arylamino)-6,7-dihydro-6-methylpyrano[4,3-c]pyrazol-4(1H or 2H)-ones with antipyretic, analgesic, antiarrhythmic, hypotensive and other activities. 158
Neutrophil chemotaxis inhibitors: new tools against cancer metastasis? 158
3-Cyclopentyloxy-4-Methoxyphenyl-isoxazoline derivatives as new PDE4 inhibitors. 157
A1 receptors ligands: past, present and future trends. 156
Antiinflammatory agents: new series of N-substituted amino acids with complex pyrimidine structures endowed with antiphlogistic activity 156
Differential inhibition of signaling pathways by two new imidazo-pyrazoles molecules in fMLF-OMe- and IL8-stimulated human neutrophil 155
N-Acyl-N-phenyl ureas of piperidine and substituted piperidines endowed with antiinflammatory and antiproliferative activities 155
Synthesis and pharmacological evaluation of 5H-[1]benzopyrano[4,3-d]pyrimidines effective as antiplatelet/analgesic agents 155
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 155
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors. 154
Synthesis, molecular modeling studies and pharmacological activity of selective A1 receptor antagonists 153
3,5-Diphenyl-1H-pyrazole derivatives. II--N-substituted 1-(2-aminoethyl)-3,5-diphenyl-1H-pyrazoles and their 4-bromo derivatives with analgesic and other activities 153
3,5-Diphenyl-1H-pyrazole derivatives. IV--N,N-disubstituted 3-(3,5-diphenyl-1H-pyrazol-1-yl)propanamides and 3-(3,5-diphenyl-1H-pyrazol-1-yl)propanamines with sedative, platelet antiaggregating and local anesthetic activities. 152
4-Amino-pyrazolo[3,4-d]pyrimidines with antiproliferative activity on osteosarcoma cell line SaOS-2 152
New compounds having a selective PDE4D inhibiting activity 152
New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies 151
N-acyl-N'-methyl-N-(1,3,3-trimethylbicyclo[2.2.1]hept-2-yl) benzamidines with hypotensive activity. 150
Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors 150
New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets 149
Design, synthesis and biological evaluation of new pyrazolyl-ureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis 148
Biological evaluation of pyrazolyl-urea and dihydro-imidazopyrazolyl-urea derivatives as potential anti-angiogenetic agents in the treatment of neuroblastoma 148
3,5-Diphenyl-1H-pyrazole derivatives. I--Esters and N-substituted carbamates of 1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole and its 4-bromo derivative with depressant, antiarrhythmic, analgesic and other activities. 147
Unprecedented one-pot stereoselective synthesis of Knoevenagel-type derivatives via in situ condensation of N-methyleniminium salts of ethylenethiourea and ethyleneurea with active methylene reagents 146
2,3-Dihydro-1H-imidazo[1,2-b]pyrazole derivatives as potential neutrophils functions inhibitors 146
New halogenated 4-aminopyrazolo[3,4-b]pyridines A1 adenosine receptor ligands 145
2-Aryl-6-methyl-3-phenylamino-6,7-dihydropyrano[4,3-c]pyrazol-4(2H)-ones with analgesic activity. 145
Structure-based Design, Parallel Synthesis, SAR and Molecular Modelling Studies of Thiocarbamates, New Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Isosteres of Phenethylthiazolylthiourea Derivatives. 144
3,5-Diphenyl-1H-pyrazole derivatives. VI Esters and 2-dialkylaminoethyl ethers of 1(2-hydroxy-2-phenylethyl)-3,5-diphenyl-1H-pyrazole and N,N-disubstituted 1-(2-amino-2-phenylethyl)-3,5-diphenyl-1H-pyrazoles with depressant and platelet antiaggregating activities. 144
GEBR-32A, A NEW PROMISING PDE4D INHIBITOR FOR TREATMENT OF ALZHEIMER'S DISEASE 144
3,5-Diphenyl-1H-pyrazole derivatives. XII. N-substituted 4-amino-1-(2-hydroxy- or 2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazoles with local anesthetic, analgesic and platelet antiaggregating activities. 143
3,5-Diphenyl-1H-pyrazole derivatives. VII--Esters, 2-dialkylaminoethyl ethers and N-substituted carbamates of 1-(2-hydroxy-3-phenoxypropyl)-3,5-diphenyl-1H-pyrazole with depressant and platelet antiaggregating activities 142
Gebr-7b, a novel selective PDE4D inhibitor, increases beta amyloid secretion in neuronal cultured cells and improves cognitive function in rodents 141
Preparation of new 5-aroylamino substituted 3-nicotinoyl/isonicotinoyl-1,3,4-thiadiazol-2(3H)-ones with anti-inflammatory activity 140
5-alkoxy-2-hydrazino and 5-methoxy-2-amino-5H-[1]benzopyrano[4,3-d]pyrimidines: synthesis and pharmacological activity 140
omega-Dialkylaminoalkyl esters of 3-dialkylamino-4,7,7-trimethyl-N-phenylbicyclo[2.2.1] hept-2-ene-2-iminothiolic acids with local anesthetic activity. 139
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 139
Synthesis and pharmacological evaluation of 2,5-Cycloamino-5H[1]benzopyrano[4,3-d]pyrimidines endowed with in vitro antiplatelet activity 138
Synthesis of 6-thiosubstituted 5-ethoxycarbonyl-1,3-diphenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-ones, 6-substituted 5-hydroxy-1,3-diphenyl-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-ones and their esters with local anesthetic, antiarrhythmic, antiinflammatory and analgesic activities. 137
Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model. 137
Treatment with 1-(2-hydroxyalkyl/phenyl/naphtylureido)-1H-pyrazole-4-carboxylic acid ethyl esters abrogates neutrophil migration towards fMLP and CXCL8 via the inhibition of defined signalling pathways 136
Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells 134
New fluorinated PDE4D inhibitors for the treatment of memory impairments. 134
Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1-H-pyrazolo[3,4-d]pyrimidines 4-amino substituted and their biological evaluation 133
4-Amino-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and their preparation, pharmaceutical composistion and use antitumor and antileukemic agents 133
3,5-Diphenyl-1H-pyrazole derivatives. VIII. N-substituted 3-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)-propanamides, -propanamines and 2-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)ethanamines with platelet antiaggregating, hypotensive, antiarrhythmic and other activities. 133
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities 133
5-[[ω-(Dialkylamino)alkoxy]methylene]-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ones with hypotensive, local anesthetic, antiarrhythmic and other activities 133
New insights into small-molecule inhibitors of Bcr-Abl 132
Synthesis and anti-inflammatory activity of esters derived from 5-aryl-1,2-dihydro-2-(2-hydroxyethyl)-3H-1,2,4-triazole-3-thiones 132
N-Substituted O-(3-amino-2-hydroxypropyl)oximes of 1,3,3-trimethyl-5-endo-(1-piperidinyl or 4-morpholinyl)-2-oxabicyclo[2.2.2]octan-6-ones with platelet antiaggregating and local anesthetic activities 131
Design, synthesis, SAR, and molecular modeling studies of acylthiocarbamates: a novel series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors structurally related to phenethylthiazolylthiourea derivatives 128
Synthesis and biological evaluation of [α-(1,5-disubstituted 1H-pyrazol-4-yl)benzyl]azoles, analogues of bifonazole 128
Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D 128
Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones  127
Design and synthesis of new multitarget drugs for autoimmune inflammatory diseases 127
cAMP-induced amyloid-β production and its role in long term potentiation 127
Totale 16.325
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Categoria #
all - tutte 89.583
article - articoli 61.722
book - libri 0
conference - conferenze 24.148
curatela - curatele 0
other - altro 0
patent - brevetti 2.514
selected - selezionate 0
volume - volumi 1.199
Totale 179.166
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20222.124 0 0 157 316 75 166 192 560 82 200 104 272
2022/20232.295 245 154 20 245 395 381 1 160 385 17 257 35
2023/20241.266 57 188 19 163 120 237 53 53 72 15 89 200
2024/20253.648 72 285 99 286 444 395 335 534 157 168 355 518
2025/20266.497 785 161 441 573 903 621 1.043 307 403 692 287 281
2026/20271.243 672 279 292 0 0 0 0 0 0 0 0 0
Totale 28.457