IRIS
BRUNO, OLGA
 Distribuzione geografica
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Continente #
EU - Europa 22.815
AS - Asia 2.546
NA - Nord America 1.844
SA - Sud America 212
AF - Africa 34
OC - Oceania 2
Totale 27.453
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Nazione #
IT - Italia 22.394
US - Stati Uniti d'America 1.725
SG - Singapore 1.068
CN - Cina 687
VN - Vietnam 429
FR - Francia 179
BR - Brasile 130
HK - Hong Kong 111
BD - Bangladesh 99
DE - Germania 60
FI - Finlandia 49
JP - Giappone 41
CA - Canada 36
AR - Argentina 35
GB - Regno Unito 33
MX - Messico 32
NL - Olanda 23
IN - India 20
ID - Indonesia 17
JM - Giamaica 15
EC - Ecuador 12
IQ - Iraq 12
ES - Italia 11
VE - Venezuela 11
CO - Colombia 10
CH - Svizzera 9
IE - Irlanda 9
KR - Corea 9
ZA - Sudafrica 9
RU - Federazione Russa 8
TH - Thailandia 8
CR - Costa Rica 6
PL - Polonia 6
DO - Repubblica Dominicana 5
DZ - Algeria 5
PH - Filippine 5
SA - Arabia Saudita 5
TR - Turchia 5
CL - Cile 4
JO - Giordania 4
KE - Kenya 4
LB - Libano 4
MA - Marocco 4
PR - Porto Rico 4
PY - Paraguay 4
RO - Romania 4
TN - Tunisia 4
UA - Ucraina 4
AZ - Azerbaigian 3
BO - Bolivia 3
EE - Estonia 3
GT - Guatemala 3
HN - Honduras 3
HR - Croazia 3
PK - Pakistan 3
SE - Svezia 3
SV - El Salvador 3
TT - Trinidad e Tobago 3
UZ - Uzbekistan 3
AL - Albania 2
AU - Australia 2
BG - Bulgaria 2
BS - Bahamas 2
CZ - Repubblica Ceca 2
DK - Danimarca 2
ET - Etiopia 2
KG - Kirghizistan 2
KW - Kuwait 2
LC - Santa Lucia 2
NO - Norvegia 2
NP - Nepal 2
PA - Panama 2
PE - Perù 2
SI - Slovenia 2
AM - Armenia 1
AT - Austria 1
BZ - Belize 1
CG - Congo 1
CI - Costa d'Avorio 1
CY - Cipro 1
EG - Egitto 1
GP - Guadalupe 1
HU - Ungheria 1
KH - Cambogia 1
LT - Lituania 1
LV - Lettonia 1
MM - Myanmar 1
MN - Mongolia 1
MU - Mauritius 1
MY - Malesia 1
NE - Niger 1
NI - Nicaragua 1
PT - Portogallo 1
SC - Seychelles 1
TW - Taiwan 1
UY - Uruguay 1
Totale 27.453
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Città #
Genova 13.259
Genoa 5.640
Rapallo 1.891
Vado Ligure 1.444
San Jose 524
Singapore 514
Ashburn 190
Lauterbourg 164
Ho Chi Minh City 125
Beijing 112
Hong Kong 106
New York 103
Hanoi 91
Frankfurt am Main 49
Helsinki 47
Santa Clara 45
Council Bluffs 41
Tokyo 37
Los Angeles 28
Haiphong 26
Bordighera 25
Amsterdam 23
Chicago 23
Mexico City 19
Tianjin 18
Dallas 17
Milan 17
Da Nang 16
Atlanta 15
São Paulo 15
Buffalo 13
Houston 13
Naples 12
Orem 12
Boardman 11
Brooklyn 11
Des Moines 10
Memphis 10
Rome 10
Cardiff 9
Philadelphia 9
Biên Hòa 8
Denver 8
Dublin 8
Kingston 8
London 8
Montreal 8
Bắc Ninh 7
Hải Dương 7
Phoenix 7
Toronto 7
Zurich 7
Catania 6
Miami 6
Salvador 6
Turin 6
Campinas 5
Can Tho 5
City of London 5
Curitiba 5
Florence 5
Jeddah 5
Montego Bay 5
Ninh Bình 5
Palermo 5
Quito 5
San José 5
Seattle 5
Shanghai 5
Warsaw 5
Washington 5
Amman 4
Baghdad 4
Buenos Aires 4
Chennai 4
Decatur 4
Guangzhou 4
Ha Long 4
Jakarta 4
Johannesburg 4
Louisville 4
Mumbai 4
Nairobi 4
Paris 4
Phủ Lý 4
San Francisco 4
The Dalles 4
Thái Bình 4
Vĩnh Long 4
Algiers 3
Augusta 3
Baku 3
Bangkok 3
Basingstoke 3
Belo Horizonte 3
Boston 3
Brockton 3
Caracas 3
Casablanca 3
Charlotte 3
Totale 25.031
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Nome #
A novel PDE4D inhibitor increases amyloid-beta deposition in neuronal cultured cells and improves memory in rats 337
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment 260
1,3,3-Trimethyl-N-(2-pyridyl)-2-oxabicyclo[2.2.2]octan-6-amine derivatives with hypotensive and other activities 225
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation 225
Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease. 217
An efficient synthesis of functionalized 2-pyridones by direct route or via amide/enolate ammonium salt intermediates 214
A physiological role for amyloid beta in the cyclic AMP-stimulated long term potentiation. 207
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors 207
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors 197
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles 193
GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. 191
Design and synthesis of 4,5,6,7‐tetrahydro‐1H‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors 189
Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors 188
The pyrazolyl-urea GeGe3 inhibits tumor angiogenesis and reveals dystrophia myotonica protein Kinase (DMPK)1 as a novel angiogenesis target 188
Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors. 187
A physiological role for amyloid beta in the cyclic AMP-stimulated long term potentiation. 187
1-Acyl-, 3-acyl- and 1,3-diacyl-3-furfuryl-1-phenylthioureas with platelet antiaggregating and other activities. 185
3-Arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones as antiinflammatory and analgesic agents 182
Relative Stereochemistry of a Diterpene from Salvia cinnabarina 182
Synthesis and biological evaluation of neutrophilic inflammation inhibitors 182
A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: role of amyloid beta 180
2-Aryl-3-phenylamino-4,5-dihydro-2h-benz[g]indazoles with analgesic activity 180
. 3,5-diphenyl-1H-pyrazole derivatives. XI. N-aryl-5(3)-phenyl-4-(3,5- diphenyl-1-pyrazolyl)-3(5)-pyrazole amines, 5-substituted 4,5-dihydro-3-phenyl-4-(3,5-diphenyl-1-pyrazolyl)-1H-pyrazoles and 2,6-disubstituted 1,6-dihydro-4- phenyl-5-(3,5-diphenyl-1-pyrazolyl)pyrimidines with antipyretic, antiinflammatory and other activities. 179
Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics 178
"One-pot" synthesis of N-acyl-N-phenylcarbamate derivatives endowed with anti-HIV and/or antiproliferative activities 174
Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines 173
3,5-Diphenyl-1H-pyrazole derivatives. IX. 2-substituted 4-phenyl-5-(3,5-diphenyl-1H-pyrazol-1-yl) pyrimidines with platelet antiaggregating and other activities. 173
Phosphodiesterase isoform-specific expression induced by traumatic brain injury 173
3,5-Diphenyl-1H-pyrazole derivatives. V--1-Acetyl-4-hydroxy-3,5-diphenyl-2-pyrazoline esters, 4-hydroxy-3,5-diphenyl-1H-pyrazole esters and N-substituted 4-(3-amino-2-hydroxy-1-propoxy)-1-methyl-3,5-diphenyl-1H-pyrazoles with antiarrhythmic, sedative and platelet antiaggregating activities. 172
null 168
5-Substituted derivatives of 6-amino-1,3-diphenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one as a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis 166
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line 166
3,3-disubstituted 1-acyl-1-phenylthioureas with platelet antiaggregating and other activities 165
Synthesis and biological evaluation of N-pyrazolyl-N'-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis 165
Docking-based CoMFA and CoMSIA analyses of tetrahydro-β-carboline derivatives as type-5 phosphodiesterase inhibitors. 163
3,5-Diphenyl-1H-pyrazole derivatives. III. Ethers 1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole and its 4-bromo derivative with hypotensive, depressant, antiarrhythmic and analgesic activities 163
Pyrazole and imidazo[1,2-b]pyrazole derivatives as new potential anti-tuberculosis agents. 163
N-Aryl-2-phenyl-2,3-dihydro-imidazo[1,2-b]pyrazole-1-carboxamides 7-substituted strongly inhibiting both fMLP-OMe- and IL-8-induced human neutrophil chemotaxis. 161
2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: New potent inhibitors of fMLP-induced neutrophil chemotaxis 160
2-Amino/Azido/Hydrazino-5-alkoxy-5H-[1]benzopyrano[4,3-d]pyrimidines: Synthesis and Pharmacological Evaluation 158
N'-acyl-N,N-(1,3,3-trimethylbicyclo [2.2.1]hept-2-ylidene)benzamidines with hypotensive activity. 156
PDE4D inhibitors: a potential strategy for the treatment of memory impairment? 156
Derivati dell'1,3-benzodiossolo, potenziali inibitori delle PDE5 155
2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles with antiarrhythmic and local anaesthetic activities 155
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 154
Differential inhibition of signaling pathways by two new imidazo-pyrazoles molecules in fMLF-OMe- and IL8-stimulated human neutrophil 153
Neutrophil chemotaxis inhibitors: new tools against cancer metastasis? 153
Antiinflammatory agents: new series of N-substituted amino acids with complex pyrimidine structures endowed with antiphlogistic activity 153
A1 receptors ligands: past, present and future trends. 152
3-(Arylamino)-6,7-dihydro-6-methylpyrano[4,3-c]pyrazol-4(1H or 2H)-ones with antipyretic, analgesic, antiarrhythmic, hypotensive and other activities. 152
3-Cyclopentyloxy-4-Methoxyphenyl-isoxazoline derivatives as new PDE4 inhibitors. 152
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors. 152
Synthesis and pharmacological evaluation of 5H-[1]benzopyrano[4,3-d]pyrimidines effective as antiplatelet/analgesic agents 152
N-Acyl-N-phenyl ureas of piperidine and substituted piperidines endowed with antiinflammatory and antiproliferative activities 151
Synthesis, molecular modeling studies and pharmacological activity of selective A1 receptor antagonists 150
New compounds having a selective PDE4D inhibiting activity 150
Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors 148
New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies 148
N-acyl-N'-methyl-N-(1,3,3-trimethylbicyclo[2.2.1]hept-2-yl) benzamidines with hypotensive activity. 147
Design, synthesis and biological evaluation of new pyrazolyl-ureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis 147
New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets 147
4-Amino-pyrazolo[3,4-d]pyrimidines with antiproliferative activity on osteosarcoma cell line SaOS-2 146
3,5-Diphenyl-1H-pyrazole derivatives. IV--N,N-disubstituted 3-(3,5-diphenyl-1H-pyrazol-1-yl)propanamides and 3-(3,5-diphenyl-1H-pyrazol-1-yl)propanamines with sedative, platelet antiaggregating and local anesthetic activities. 145
Biological evaluation of pyrazolyl-urea and dihydro-imidazopyrazolyl-urea derivatives as potential anti-angiogenetic agents in the treatment of neuroblastoma 145
Unprecedented one-pot stereoselective synthesis of Knoevenagel-type derivatives via in situ condensation of N-methyleniminium salts of ethylenethiourea and ethyleneurea with active methylene reagents 144
2-Aryl-6-methyl-3-phenylamino-6,7-dihydropyrano[4,3-c]pyrazol-4(2H)-ones with analgesic activity. 144
New halogenated 4-aminopyrazolo[3,4-b]pyridines A1 adenosine receptor ligands 142
3,5-Diphenyl-1H-pyrazole derivatives. II--N-substituted 1-(2-aminoethyl)-3,5-diphenyl-1H-pyrazoles and their 4-bromo derivatives with analgesic and other activities 142
2,3-Dihydro-1H-imidazo[1,2-b]pyrazole derivatives as potential neutrophils functions inhibitors 141
3,5-Diphenyl-1H-pyrazole derivatives. I--Esters and N-substituted carbamates of 1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole and its 4-bromo derivative with depressant, antiarrhythmic, analgesic and other activities. 141
3,5-Diphenyl-1H-pyrazole derivatives. VI Esters and 2-dialkylaminoethyl ethers of 1(2-hydroxy-2-phenylethyl)-3,5-diphenyl-1H-pyrazole and N,N-disubstituted 1-(2-amino-2-phenylethyl)-3,5-diphenyl-1H-pyrazoles with depressant and platelet antiaggregating activities. 140
Structure-based Design, Parallel Synthesis, SAR and Molecular Modelling Studies of Thiocarbamates, New Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Isosteres of Phenethylthiazolylthiourea Derivatives. 138
3,5-Diphenyl-1H-pyrazole derivatives. VII--Esters, 2-dialkylaminoethyl ethers and N-substituted carbamates of 1-(2-hydroxy-3-phenoxypropyl)-3,5-diphenyl-1H-pyrazole with depressant and platelet antiaggregating activities 138
omega-Dialkylaminoalkyl esters of 3-dialkylamino-4,7,7-trimethyl-N-phenylbicyclo[2.2.1] hept-2-ene-2-iminothiolic acids with local anesthetic activity. 138
5-alkoxy-2-hydrazino and 5-methoxy-2-amino-5H-[1]benzopyrano[4,3-d]pyrimidines: synthesis and pharmacological activity 138
GEBR-32A, A NEW PROMISING PDE4D INHIBITOR FOR TREATMENT OF ALZHEIMER'S DISEASE 138
Preparation of new 5-aroylamino substituted 3-nicotinoyl/isonicotinoyl-1,3,4-thiadiazol-2(3H)-ones with anti-inflammatory activity 137
Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model. 137
Synthesis and pharmacological evaluation of 2,5-Cycloamino-5H[1]benzopyrano[4,3-d]pyrimidines endowed with in vitro antiplatelet activity 137
3,5-Diphenyl-1H-pyrazole derivatives. XII. N-substituted 4-amino-1-(2-hydroxy- or 2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazoles with local anesthetic, analgesic and platelet antiaggregating activities. 136
Gebr-7b, a novel selective PDE4D inhibitor, increases beta amyloid secretion in neuronal cultured cells and improves cognitive function in rodents 136
Treatment with 1-(2-hydroxyalkyl/phenyl/naphtylureido)-1H-pyrazole-4-carboxylic acid ethyl esters abrogates neutrophil migration towards fMLP and CXCL8 via the inhibition of defined signalling pathways 134
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 133
Synthesis and anti-inflammatory activity of esters derived from 5-aryl-1,2-dihydro-2-(2-hydroxyethyl)-3H-1,2,4-triazole-3-thiones 132
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities 132
Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1-H-pyrazolo[3,4-d]pyrimidines 4-amino substituted and their biological evaluation 131
3,5-Diphenyl-1H-pyrazole derivatives. VIII. N-substituted 3-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)-propanamides, -propanamines and 2-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)ethanamines with platelet antiaggregating, hypotensive, antiarrhythmic and other activities. 131
Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells 130
Synthesis of 6-thiosubstituted 5-ethoxycarbonyl-1,3-diphenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-ones, 6-substituted 5-hydroxy-1,3-diphenyl-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-ones and their esters with local anesthetic, antiarrhythmic, antiinflammatory and analgesic activities. 130
New fluorinated PDE4D inhibitors for the treatment of memory impairments. 130
4-Amino-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and their preparation, pharmaceutical composistion and use antitumor and antileukemic agents 129
New insights into small-molecule inhibitors of Bcr-Abl 129
N-Substituted O-(3-amino-2-hydroxypropyl)oximes of 1,3,3-trimethyl-5-endo-(1-piperidinyl or 4-morpholinyl)-2-oxabicyclo[2.2.2]octan-6-ones with platelet antiaggregating and local anesthetic activities 129
5-[[ω-(Dialkylamino)alkoxy]methylene]-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ones with hypotensive, local anesthetic, antiarrhythmic and other activities 128
Synthesis and biological evaluation of [α-(1,5-disubstituted 1H-pyrazol-4-yl)benzyl]azoles, analogues of bifonazole 126
Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D 126
Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A1-adenosine receptor (A1AR) ligands 126
Design, synthesis, SAR, and molecular modeling studies of acylthiocarbamates: a novel series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors structurally related to phenethylthiazolylthiourea derivatives 125
N-Substituted 3-(arylamino)-4,5-dihydro-2H-benz[g]indazol-2-yl acetamides with antiinflammatory and analgesic activities 124
Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones  124
Totale 15.958
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Categoria #
all - tutte 86.476
article - articoli 59.731
book - libri 0
conference - conferenze 23.179
curatela - curatele 0
other - altro 0
patent - brevetti 2.418
selected - selezionate 0
volume - volumi 1.148
Totale 172.952
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20222.386 68 194 157 316 75 166 192 560 82 200 104 272
2022/20232.295 245 154 20 245 395 381 1 160 385 17 257 35
2023/20241.266 57 188 19 163 120 237 53 53 72 15 89 200
2024/20253.681 72 285 99 287 453 399 338 542 157 168 358 523
2025/20266.553 796 163 450 580 909 622 1.049 308 406 700 287 283
2026/2027467 467 0 0 0 0 0 0 0 0 0 0 0
Totale 27.770