IRIS
BRUNO, OLGA
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
EU - Europa 22.241
AS - Asia 135
SA - Sud America 52
NA - Nord America 12
AF - Africa 2
Totale 22.442
Salva come PNG Salva come JPEG
Nazione #
IT - Italia 22.241
CN - Cina 77
BR - Brasile 45
SG - Singapore 29
VN - Vietnam 22
US - Stati Uniti d'America 12
AR - Argentina 3
BD - Bangladesh 2
EC - Ecuador 2
IQ - Iraq 2
CO - Colombia 1
IN - India 1
JP - Giappone 1
MU - Mauritius 1
PY - Paraguay 1
TR - Turchia 1
ZA - Sudafrica 1
Totale 22.442
Salva come PNG Salva come JPEG
Città #
Genova 13.259
Genoa 5.622
Rapallo 1.891
Vado Ligure 1.444
Beijing 34
Bordighera 25
Ho Chi Minh City 12
Singapore 7
Ashburn 6
São Paulo 5
Council Bluffs 4
Hanoi 3
Salvador 3
Belo Horizonte 2
Biên Hòa 2
Campinas 2
Rio de Janeiro 2
Santo André 2
Ankara 1
Anápolis 1
Arenillas 1
Bady Bassitt 1
Baghdad 1
Barra Mansa 1
Belford Roxo 1
Boardman 1
Brasília 1
Buenos Aires 1
Bình Dương 1
Cabo de Santo Agostinho 1
Cariacica 1
Cataguases 1
Curitiba 1
Cássia 1
Dāganbhuiya 1
Esmeraldas 1
Fazenda Rio Grande 1
Guaramirim 1
Guarulhos 1
Ha Long 1
Hải Dương 1
Itapoá 1
Juiz de Fora 1
Kirkuk 1
Lago dos Rodrigues 1
Lagoa Santa 1
Los Angeles 1
Manaus 1
Maringá 1
Mauá 1
Mumbai 1
Nova Monte Verde 1
Paraíba do Sul 1
Parnamirim 1
Phủ Lý 1
Port Louis 1
Portoviejo 1
Ribeirão Preto 1
San Antonio de Areco 1
San Luis 1
Soacha 1
Sorocaba 1
Stellenbosch 1
São José do Rio Preto 1
São João Nepomuceno 1
Tailândia 1
Tokyo 1
Totale 22.374
Salva come PNG Salva come JPEG
Nome #
A novel PDE4D inhibitor increases amyloid-beta deposition in neuronal cultured cells and improves memory in rats 303
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment 232
1,3,3-Trimethyl-N-(2-pyridyl)-2-oxabicyclo[2.2.2]octan-6-amine derivatives with hypotensive and other activities 201
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation 201
An efficient synthesis of functionalized 2-pyridones by direct route or via amide/enolate ammonium salt intermediates 186
Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease. 184
A physiological role for amyloid beta in the cyclic AMP-stimulated long term potentiation. 174
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors 174
Relative Stereochemistry of a Diterpene from Salvia cinnabarina 171
null 168
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors 161
Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines 160
2-Aryl-3-phenylamino-4,5-dihydro-2h-benz[g]indazoles with analgesic activity 159
GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. 159
Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors 158
"One-pot" synthesis of N-acyl-N-phenylcarbamate derivatives endowed with anti-HIV and/or antiproliferative activities 156
Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors. 156
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles 155
Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics 153
3,5-Diphenyl-1H-pyrazole derivatives. IX. 2-substituted 4-phenyl-5-(3,5-diphenyl-1H-pyrazol-1-yl) pyrimidines with platelet antiaggregating and other activities. 152
1-Acyl-, 3-acyl- and 1,3-diacyl-3-furfuryl-1-phenylthioureas with platelet antiaggregating and other activities. 152
A physiological role for amyloid beta in the cyclic AMP-stimulated long term potentiation. 152
Design and synthesis of 4,5,6,7‐tetrahydro‐1H‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors 152
Synthesis and biological evaluation of neutrophilic inflammation inhibitors 152
. 3,5-diphenyl-1H-pyrazole derivatives. XI. N-aryl-5(3)-phenyl-4-(3,5- diphenyl-1-pyrazolyl)-3(5)-pyrazole amines, 5-substituted 4,5-dihydro-3-phenyl-4-(3,5-diphenyl-1-pyrazolyl)-1H-pyrazoles and 2,6-disubstituted 1,6-dihydro-4- phenyl-5-(3,5-diphenyl-1-pyrazolyl)pyrimidines with antipyretic, antiinflammatory and other activities. 151
3-Arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones as antiinflammatory and analgesic agents 150
A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: role of amyloid beta 149
The pyrazolyl-urea GeGe3 inhibits tumor angiogenesis and reveals dystrophia myotonica protein Kinase (DMPK)1 as a novel angiogenesis target 146
3,5-Diphenyl-1H-pyrazole derivatives. V--1-Acetyl-4-hydroxy-3,5-diphenyl-2-pyrazoline esters, 4-hydroxy-3,5-diphenyl-1H-pyrazole esters and N-substituted 4-(3-amino-2-hydroxy-1-propoxy)-1-methyl-3,5-diphenyl-1H-pyrazoles with antiarrhythmic, sedative and platelet antiaggregating activities. 142
PDE4D inhibitors: a potential strategy for the treatment of memory impairment? 142
Synthesis and biological evaluation of N-pyrazolyl-N'-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis 141
5-Substituted derivatives of 6-amino-1,3-diphenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one as a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis 140
Docking-based CoMFA and CoMSIA analyses of tetrahydro-β-carboline derivatives as type-5 phosphodiesterase inhibitors. 140
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line 140
N-Aryl-2-phenyl-2,3-dihydro-imidazo[1,2-b]pyrazole-1-carboxamides 7-substituted strongly inhibiting both fMLP-OMe- and IL-8-induced human neutrophil chemotaxis. 140
Phosphodiesterase isoform-specific expression induced by traumatic brain injury 139
3,5-Diphenyl-1H-pyrazole derivatives. III. Ethers 1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole and its 4-bromo derivative with hypotensive, depressant, antiarrhythmic and analgesic activities 139
Pyrazole and imidazo[1,2-b]pyrazole derivatives as new potential anti-tuberculosis agents. 139
3,3-disubstituted 1-acyl-1-phenylthioureas with platelet antiaggregating and other activities 138
N-Acyl-N-phenyl ureas of piperidine and substituted piperidines endowed with antiinflammatory and antiproliferative activities 136
Differential inhibition of signaling pathways by two new imidazo-pyrazoles molecules in fMLF-OMe- and IL8-stimulated human neutrophil 133
Antiinflammatory agents: new series of N-substituted amino acids with complex pyrimidine structures endowed with antiphlogistic activity 133
2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: New potent inhibitors of fMLP-induced neutrophil chemotaxis 132
N'-acyl-N,N-(1,3,3-trimethylbicyclo [2.2.1]hept-2-ylidene)benzamidines with hypotensive activity. 131
New compounds having a selective PDE4D inhibiting activity 130
Synthesis and pharmacological evaluation of 5H-[1]benzopyrano[4,3-d]pyrimidines effective as antiplatelet/analgesic agents 130
N-acyl-N'-methyl-N-(1,3,3-trimethylbicyclo[2.2.1]hept-2-yl) benzamidines with hypotensive activity. 129
2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles with antiarrhythmic and local anaesthetic activities 127
Design, synthesis and biological evaluation of new pyrazolyl-ureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis 127
3-(Arylamino)-6,7-dihydro-6-methylpyrano[4,3-c]pyrazol-4(1H or 2H)-ones with antipyretic, analgesic, antiarrhythmic, hypotensive and other activities. 126
New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies 126
Synthesis, molecular modeling studies and pharmacological activity of selective A1 receptor antagonists 125
Derivati dell'1,3-benzodiossolo, potenziali inibitori delle PDE5 124
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors. 124
2-Amino/Azido/Hydrazino-5-alkoxy-5H-[1]benzopyrano[4,3-d]pyrimidines: Synthesis and Pharmacological Evaluation 124
Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors 123
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 123
3,5-Diphenyl-1H-pyrazole derivatives. I--Esters and N-substituted carbamates of 1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole and its 4-bromo derivative with depressant, antiarrhythmic, analgesic and other activities. 122
3,5-Diphenyl-1H-pyrazole derivatives. IV--N,N-disubstituted 3-(3,5-diphenyl-1H-pyrazol-1-yl)propanamides and 3-(3,5-diphenyl-1H-pyrazol-1-yl)propanamines with sedative, platelet antiaggregating and local anesthetic activities. 122
omega-Dialkylaminoalkyl esters of 3-dialkylamino-4,7,7-trimethyl-N-phenylbicyclo[2.2.1] hept-2-ene-2-iminothiolic acids with local anesthetic activity. 121
A1 receptors ligands: past, present and future trends. 120
Preparation of new 5-aroylamino substituted 3-nicotinoyl/isonicotinoyl-1,3,4-thiadiazol-2(3H)-ones with anti-inflammatory activity 120
3-Cyclopentyloxy-4-Methoxyphenyl-isoxazoline derivatives as new PDE4 inhibitors. 120
Synthesis and pharmacological evaluation of 2,5-Cycloamino-5H[1]benzopyrano[4,3-d]pyrimidines endowed with in vitro antiplatelet activity 120
3,5-Diphenyl-1H-pyrazole derivatives. II--N-substituted 1-(2-aminoethyl)-3,5-diphenyl-1H-pyrazoles and their 4-bromo derivatives with analgesic and other activities 118
null 118
null 117
Neutrophil chemotaxis inhibitors: new tools against cancer metastasis? 117
3,5-Diphenyl-1H-pyrazole derivatives. VI Esters and 2-dialkylaminoethyl ethers of 1(2-hydroxy-2-phenylethyl)-3,5-diphenyl-1H-pyrazole and N,N-disubstituted 1-(2-amino-2-phenylethyl)-3,5-diphenyl-1H-pyrazoles with depressant and platelet antiaggregating activities. 117
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities 117
2-Aryl-6-methyl-3-phenylamino-6,7-dihydropyrano[4,3-c]pyrazol-4(2H)-ones with analgesic activity. 116
null 116
Unprecedented one-pot stereoselective synthesis of Knoevenagel-type derivatives via in situ condensation of N-methyleniminium salts of ethylenethiourea and ethyleneurea with active methylene reagents 115
Synthesis and anti-inflammatory activity of esters derived from 5-aryl-1,2-dihydro-2-(2-hydroxyethyl)-3H-1,2,4-triazole-3-thiones 115
Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1-H-pyrazolo[3,4-d]pyrimidines 4-amino substituted and their biological evaluation 114
Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells 113
Synthesis and biological evaluation of [α-(1,5-disubstituted 1H-pyrazol-4-yl)benzyl]azoles, analogues of bifonazole 113
New halogenated 4-aminopyrazolo[3,4-b]pyridines A1 adenosine receptor ligands 112
Treatment with 1-(2-hydroxyalkyl/phenyl/naphtylureido)-1H-pyrazole-4-carboxylic acid ethyl esters abrogates neutrophil migration towards fMLP and CXCL8 via the inhibition of defined signalling pathways 112
4-Amino-pyrazolo[3,4-d]pyrimidines with antiproliferative activity on osteosarcoma cell line SaOS-2 112
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 112
New insights into small-molecule inhibitors of Bcr-Abl 111
Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model. 111
Synthesis of 4-amino pyrazolo[3,4-d]pyrimidine derivatives as potential ligands for a1-adenosine receptors 110
Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones  110
3,5-Diphenyl-1H-pyrazole derivatives. VII--Esters, 2-dialkylaminoethyl ethers and N-substituted carbamates of 1-(2-hydroxy-3-phenoxypropyl)-3,5-diphenyl-1H-pyrazole with depressant and platelet antiaggregating activities 110
Synthesis of 6-thiosubstituted 5-ethoxycarbonyl-1,3-diphenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-ones, 6-substituted 5-hydroxy-1,3-diphenyl-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-ones and their esters with local anesthetic, antiarrhythmic, antiinflammatory and analgesic activities. 109
Synthesis and anti-HIV-1 activity of PETT structurally related O-substituted acyl (aryl) thiocarbamates 108
5-alkoxy-2-hydrazino and 5-methoxy-2-amino-5H-[1]benzopyrano[4,3-d]pyrimidines: synthesis and pharmacological activity 108
2,3-Dihydro-1H-imidazo[1,2-b]pyrazole derivatives as potential neutrophils functions inhibitors 107
3,5-Diphenyl-1H-pyrazole derivatives. XII. N-substituted 4-amino-1-(2-hydroxy- or 2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazoles with local anesthetic, analgesic and platelet antiaggregating activities. 107
Gebr-7b, a novel selective PDE4D inhibitor, increases beta amyloid secretion in neuronal cultured cells and improves cognitive function in rodents 107
Structure-based Design, Parallel Synthesis, SAR and Molecular Modelling Studies of Thiocarbamates, New Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Isosteres of Phenethylthiazolylthiourea Derivatives. 106
Design, synthesis, SAR, and molecular modeling studies of acylthiocarbamates: a novel series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors structurally related to phenethylthiazolylthiourea derivatives 106
3,5-Diphenyl-1H-pyrazole derivatives. VIII. N-substituted 3-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)-propanamides, -propanamines and 2-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)ethanamines with platelet antiaggregating, hypotensive, antiarrhythmic and other activities. 106
N-Substituted O-(3-amino-2-hydroxypropyl)oximes of 1,3,3-trimethyl-5-endo-(1-piperidinyl or 4-morpholinyl)-2-oxabicyclo[2.2.2]octan-6-ones with platelet antiaggregating and local anesthetic activities 106
Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D 106
null 106
4-Amino-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and their preparation, pharmaceutical composistion and use antitumor and antileukemic agents 105
Effects of subacute treatment with benzopyranopyrimidines in hemostasis and experimental thrombosis in mice. 104
Totale 13.452
Salva come PNG Salva come JPEG
Categoria #
all - tutte 72.559
article - articoli 50.385
book - libri 0
conference - conferenze 19.225
curatela - curatele 0
other - altro 0
patent - brevetti 2.013
selected - selezionate 0
volume - volumi 936
Totale 145.118
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021749 0 0 0 0 62 101 62 92 129 111 94 98
2021/20222.386 68 194 157 316 75 166 192 560 82 200 104 272
2022/20232.295 245 154 20 245 395 381 1 160 385 17 257 35
2023/20241.266 57 188 19 163 120 237 53 53 72 15 89 200
2024/20253.681 72 285 99 287 453 399 338 542 157 168 358 523
2025/20262.001 796 163 450 580 12 0 0 0 0 0 0 0
Totale 22.751