IRIS
BRUNO, OLGA
 Distribuzione geografica
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Continente #
EU - Europa 22.750
AS - Asia 2.463
NA - Nord America 1.332
SA - Sud America 182
AF - Africa 33
OC - Oceania 2
Totale 26.762
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Nazione #
IT - Italia 22.348
US - Stati Uniti d'America 1.262
SG - Singapore 1.066
CN - Cina 682
VN - Vietnam 428
FR - Francia 176
BR - Brasile 114
HK - Hong Kong 111
DE - Germania 60
FI - Finlandia 49
JP - Giappone 41
GB - Regno Unito 32
AR - Argentina 31
MX - Messico 31
BD - Bangladesh 28
NL - Olanda 23
IN - India 20
CA - Canada 19
ID - Indonesia 14
IQ - Iraq 12
EC - Ecuador 9
IE - Irlanda 9
KR - Corea 9
ZA - Sudafrica 9
CH - Svizzera 8
CO - Colombia 8
RU - Federazione Russa 8
TH - Thailandia 8
VE - Venezuela 8
ES - Italia 6
DZ - Algeria 5
PH - Filippine 5
PL - Polonia 5
SA - Arabia Saudita 5
TR - Turchia 5
JO - Giordania 4
KE - Kenya 4
LB - Libano 4
MA - Marocco 4
PY - Paraguay 4
TN - Tunisia 4
UA - Ucraina 4
AZ - Azerbaigian 3
BO - Bolivia 3
CL - Cile 3
EE - Estonia 3
HR - Croazia 3
JM - Giamaica 3
PK - Pakistan 3
TT - Trinidad e Tobago 3
UZ - Uzbekistan 3
AL - Albania 2
AU - Australia 2
CR - Costa Rica 2
CZ - Repubblica Ceca 2
DO - Repubblica Dominicana 2
ET - Etiopia 2
HN - Honduras 2
KG - Kirghizistan 2
KW - Kuwait 2
NO - Norvegia 2
NP - Nepal 2
PR - Porto Rico 2
RO - Romania 2
SI - Slovenia 2
AM - Armenia 1
AT - Austria 1
BG - Bulgaria 1
BS - Bahamas 1
BZ - Belize 1
CG - Congo 1
CI - Costa d'Avorio 1
CY - Cipro 1
DK - Danimarca 1
EG - Egitto 1
GP - Guadalupe 1
HU - Ungheria 1
KH - Cambogia 1
LC - Santa Lucia 1
LV - Lettonia 1
MM - Myanmar 1
MN - Mongolia 1
MU - Mauritius 1
NE - Niger 1
PA - Panama 1
PE - Perù 1
SE - Svezia 1
SV - El Salvador 1
TW - Taiwan 1
UY - Uruguay 1
Totale 26.762
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Città #
Genova 13.259
Genoa 5.629
Rapallo 1.891
Vado Ligure 1.444
Singapore 512
San Jose 433
Ashburn 164
Lauterbourg 164
Ho Chi Minh City 125
Beijing 108
Hong Kong 106
New York 96
Hanoi 90
Frankfurt am Main 49
Helsinki 47
Council Bluffs 41
Santa Clara 41
Tokyo 37
Haiphong 26
Bordighera 25
Amsterdam 23
Los Angeles 21
Mexico City 19
Tianjin 18
Da Nang 16
Milan 14
São Paulo 13
Orem 12
Boardman 11
Dallas 11
Chicago 10
Des Moines 10
Atlanta 9
Cardiff 9
Biên Hòa 8
Dublin 8
Rome 8
Bắc Ninh 7
Denver 7
Hải Dương 7
London 7
Memphis 7
Montreal 7
Naples 7
Zurich 7
Buffalo 6
Campinas 5
Can Tho 5
City of London 5
Jeddah 5
Ninh Bình 5
Phoenix 5
Salvador 5
Shanghai 5
Warsaw 5
Amman 4
Baghdad 4
Brooklyn 4
Buenos Aires 4
Catania 4
Chennai 4
Guangzhou 4
Ha Long 4
Jakarta 4
Johannesburg 4
Mumbai 4
Nairobi 4
Palermo 4
Paris 4
Phủ Lý 4
San Francisco 4
The Dalles 4
Thái Bình 4
Turin 4
Vĩnh Long 4
Algiers 3
Baku 3
Bangkok 3
Basingstoke 3
Belo Horizonte 3
Casablanca 3
Charlotte 3
Curitiba 3
Guayaquil 3
Hefei 3
Miami 3
Philadelphia 3
Quito 3
Seattle 3
Tashkent 3
Toronto 3
Wuhan 3
Zagreb 3
Zibo 3
Addis Ababa 2
Ahmedabad 2
Bedford 2
Brasília 2
Brescia 2
Bình Dương 2
Totale 24.763
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Nome #
A novel PDE4D inhibitor increases amyloid-beta deposition in neuronal cultured cells and improves memory in rats 333
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment 257
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation 222
1,3,3-Trimethyl-N-(2-pyridyl)-2-oxabicyclo[2.2.2]octan-6-amine derivatives with hypotensive and other activities 217
An efficient synthesis of functionalized 2-pyridones by direct route or via amide/enolate ammonium salt intermediates 212
Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease. 212
A physiological role for amyloid beta in the cyclic AMP-stimulated long term potentiation. 202
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors 200
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors 192
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles 191
GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. 187
The pyrazolyl-urea GeGe3 inhibits tumor angiogenesis and reveals dystrophia myotonica protein Kinase (DMPK)1 as a novel angiogenesis target 184
Design and synthesis of 4,5,6,7‐tetrahydro‐1H‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors 184
Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors. 183
1-Acyl-, 3-acyl- and 1,3-diacyl-3-furfuryl-1-phenylthioureas with platelet antiaggregating and other activities. 181
Relative Stereochemistry of a Diterpene from Salvia cinnabarina 180
A physiological role for amyloid beta in the cyclic AMP-stimulated long term potentiation. 179
Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors 178
3-Arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones as antiinflammatory and analgesic agents 177
Synthesis and biological evaluation of neutrophilic inflammation inhibitors 177
2-Aryl-3-phenylamino-4,5-dihydro-2h-benz[g]indazoles with analgesic activity 176
. 3,5-diphenyl-1H-pyrazole derivatives. XI. N-aryl-5(3)-phenyl-4-(3,5- diphenyl-1-pyrazolyl)-3(5)-pyrazole amines, 5-substituted 4,5-dihydro-3-phenyl-4-(3,5-diphenyl-1-pyrazolyl)-1H-pyrazoles and 2,6-disubstituted 1,6-dihydro-4- phenyl-5-(3,5-diphenyl-1-pyrazolyl)pyrimidines with antipyretic, antiinflammatory and other activities. 175
"One-pot" synthesis of N-acyl-N-phenylcarbamate derivatives endowed with anti-HIV and/or antiproliferative activities 172
Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics 172
A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: role of amyloid beta 171
Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines 170
3,5-Diphenyl-1H-pyrazole derivatives. IX. 2-substituted 4-phenyl-5-(3,5-diphenyl-1H-pyrazol-1-yl) pyrimidines with platelet antiaggregating and other activities. 168
null 168
3,5-Diphenyl-1H-pyrazole derivatives. V--1-Acetyl-4-hydroxy-3,5-diphenyl-2-pyrazoline esters, 4-hydroxy-3,5-diphenyl-1H-pyrazole esters and N-substituted 4-(3-amino-2-hydroxy-1-propoxy)-1-methyl-3,5-diphenyl-1H-pyrazoles with antiarrhythmic, sedative and platelet antiaggregating activities. 167
5-Substituted derivatives of 6-amino-1,3-diphenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one as a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis 164
Phosphodiesterase isoform-specific expression induced by traumatic brain injury 164
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line 163
3,3-disubstituted 1-acyl-1-phenylthioureas with platelet antiaggregating and other activities 162
Synthesis and biological evaluation of N-pyrazolyl-N'-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis 162
Docking-based CoMFA and CoMSIA analyses of tetrahydro-β-carboline derivatives as type-5 phosphodiesterase inhibitors. 161
Pyrazole and imidazo[1,2-b]pyrazole derivatives as new potential anti-tuberculosis agents. 160
N-Aryl-2-phenyl-2,3-dihydro-imidazo[1,2-b]pyrazole-1-carboxamides 7-substituted strongly inhibiting both fMLP-OMe- and IL-8-induced human neutrophil chemotaxis. 160
3,5-Diphenyl-1H-pyrazole derivatives. III. Ethers 1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole and its 4-bromo derivative with hypotensive, depressant, antiarrhythmic and analgesic activities 159
2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: New potent inhibitors of fMLP-induced neutrophil chemotaxis 156
PDE4D inhibitors: a potential strategy for the treatment of memory impairment? 155
Derivati dell'1,3-benzodiossolo, potenziali inibitori delle PDE5 153
N'-acyl-N,N-(1,3,3-trimethylbicyclo [2.2.1]hept-2-ylidene)benzamidines with hypotensive activity. 153
2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles with antiarrhythmic and local anaesthetic activities 151
2-Amino/Azido/Hydrazino-5-alkoxy-5H-[1]benzopyrano[4,3-d]pyrimidines: Synthesis and Pharmacological Evaluation 151
3-(Arylamino)-6,7-dihydro-6-methylpyrano[4,3-c]pyrazol-4(1H or 2H)-ones with antipyretic, analgesic, antiarrhythmic, hypotensive and other activities. 150
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 150
Antiinflammatory agents: new series of N-substituted amino acids with complex pyrimidine structures endowed with antiphlogistic activity 150
Synthesis, molecular modeling studies and pharmacological activity of selective A1 receptor antagonists 149
Neutrophil chemotaxis inhibitors: new tools against cancer metastasis? 149
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors. 149
N-Acyl-N-phenyl ureas of piperidine and substituted piperidines endowed with antiinflammatory and antiproliferative activities 149
A1 receptors ligands: past, present and future trends. 148
3-Cyclopentyloxy-4-Methoxyphenyl-isoxazoline derivatives as new PDE4 inhibitors. 148
Synthesis and pharmacological evaluation of 5H-[1]benzopyrano[4,3-d]pyrimidines effective as antiplatelet/analgesic agents 147
New compounds having a selective PDE4D inhibiting activity 146
Differential inhibition of signaling pathways by two new imidazo-pyrazoles molecules in fMLF-OMe- and IL8-stimulated human neutrophil 145
4-Amino-pyrazolo[3,4-d]pyrimidines with antiproliferative activity on osteosarcoma cell line SaOS-2 144
New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets 144
New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies 144
N-acyl-N'-methyl-N-(1,3,3-trimethylbicyclo[2.2.1]hept-2-yl) benzamidines with hypotensive activity. 143
3,5-Diphenyl-1H-pyrazole derivatives. IV--N,N-disubstituted 3-(3,5-diphenyl-1H-pyrazol-1-yl)propanamides and 3-(3,5-diphenyl-1H-pyrazol-1-yl)propanamines with sedative, platelet antiaggregating and local anesthetic activities. 143
Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors 143
Design, synthesis and biological evaluation of new pyrazolyl-ureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis 143
Biological evaluation of pyrazolyl-urea and dihydro-imidazopyrazolyl-urea derivatives as potential anti-angiogenetic agents in the treatment of neuroblastoma 143
Unprecedented one-pot stereoselective synthesis of Knoevenagel-type derivatives via in situ condensation of N-methyleniminium salts of ethylenethiourea and ethyleneurea with active methylene reagents 142
2-Aryl-6-methyl-3-phenylamino-6,7-dihydropyrano[4,3-c]pyrazol-4(2H)-ones with analgesic activity. 142
New halogenated 4-aminopyrazolo[3,4-b]pyridines A1 adenosine receptor ligands 140
3,5-Diphenyl-1H-pyrazole derivatives. I--Esters and N-substituted carbamates of 1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole and its 4-bromo derivative with depressant, antiarrhythmic, analgesic and other activities. 139
3,5-Diphenyl-1H-pyrazole derivatives. II--N-substituted 1-(2-aminoethyl)-3,5-diphenyl-1H-pyrazoles and their 4-bromo derivatives with analgesic and other activities 139
Structure-based Design, Parallel Synthesis, SAR and Molecular Modelling Studies of Thiocarbamates, New Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Isosteres of Phenethylthiazolylthiourea Derivatives. 137
3,5-Diphenyl-1H-pyrazole derivatives. VI Esters and 2-dialkylaminoethyl ethers of 1(2-hydroxy-2-phenylethyl)-3,5-diphenyl-1H-pyrazole and N,N-disubstituted 1-(2-amino-2-phenylethyl)-3,5-diphenyl-1H-pyrazoles with depressant and platelet antiaggregating activities. 137
2,3-Dihydro-1H-imidazo[1,2-b]pyrazole derivatives as potential neutrophils functions inhibitors 136
omega-Dialkylaminoalkyl esters of 3-dialkylamino-4,7,7-trimethyl-N-phenylbicyclo[2.2.1] hept-2-ene-2-iminothiolic acids with local anesthetic activity. 136
Preparation of new 5-aroylamino substituted 3-nicotinoyl/isonicotinoyl-1,3,4-thiadiazol-2(3H)-ones with anti-inflammatory activity 135
5-alkoxy-2-hydrazino and 5-methoxy-2-amino-5H-[1]benzopyrano[4,3-d]pyrimidines: synthesis and pharmacological activity 135
GEBR-32A, A NEW PROMISING PDE4D INHIBITOR FOR TREATMENT OF ALZHEIMER'S DISEASE 135
Synthesis and pharmacological evaluation of 2,5-Cycloamino-5H[1]benzopyrano[4,3-d]pyrimidines endowed with in vitro antiplatelet activity 135
3,5-Diphenyl-1H-pyrazole derivatives. VII--Esters, 2-dialkylaminoethyl ethers and N-substituted carbamates of 1-(2-hydroxy-3-phenoxypropyl)-3,5-diphenyl-1H-pyrazole with depressant and platelet antiaggregating activities 134
Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model. 133
3,5-Diphenyl-1H-pyrazole derivatives. XII. N-substituted 4-amino-1-(2-hydroxy- or 2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazoles with local anesthetic, analgesic and platelet antiaggregating activities. 133
Treatment with 1-(2-hydroxyalkyl/phenyl/naphtylureido)-1H-pyrazole-4-carboxylic acid ethyl esters abrogates neutrophil migration towards fMLP and CXCL8 via the inhibition of defined signalling pathways 132
Synthesis of 6-thiosubstituted 5-ethoxycarbonyl-1,3-diphenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-ones, 6-substituted 5-hydroxy-1,3-diphenyl-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-ones and their esters with local anesthetic, antiarrhythmic, antiinflammatory and analgesic activities. 130
Gebr-7b, a novel selective PDE4D inhibitor, increases beta amyloid secretion in neuronal cultured cells and improves cognitive function in rodents 130
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 129
Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1-H-pyrazolo[3,4-d]pyrimidines 4-amino substituted and their biological evaluation 128
4-Amino-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and their preparation, pharmaceutical composistion and use antitumor and antileukemic agents 128
Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells 128
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities 128
New insights into small-molecule inhibitors of Bcr-Abl 127
3,5-Diphenyl-1H-pyrazole derivatives. VIII. N-substituted 3-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)-propanamides, -propanamines and 2-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)ethanamines with platelet antiaggregating, hypotensive, antiarrhythmic and other activities. 127
Synthesis and anti-inflammatory activity of esters derived from 5-aryl-1,2-dihydro-2-(2-hydroxyethyl)-3H-1,2,4-triazole-3-thiones 127
N-Substituted O-(3-amino-2-hydroxypropyl)oximes of 1,3,3-trimethyl-5-endo-(1-piperidinyl or 4-morpholinyl)-2-oxabicyclo[2.2.2]octan-6-ones with platelet antiaggregating and local anesthetic activities 126
New fluorinated PDE4D inhibitors for the treatment of memory impairments. 126
5-[[ω-(Dialkylamino)alkoxy]methylene]-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ones with hypotensive, local anesthetic, antiarrhythmic and other activities 125
Design, synthesis, SAR, and molecular modeling studies of acylthiocarbamates: a novel series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors structurally related to phenethylthiazolylthiourea derivatives 124
Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D 124
Synthesis and biological evaluation of [α-(1,5-disubstituted 1H-pyrazol-4-yl)benzyl]azoles, analogues of bifonazole 123
Synthesis of 4-amino pyrazolo[3,4-d]pyrimidine derivatives as potential ligands for a1-adenosine receptors 121
Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones  121
Synthesis and anti-HIV-1 activity of PETT structurally related O-substituted acyl (aryl) thiocarbamates 120
Totale 15.600
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Categoria #
all - tutte 82.840
article - articoli 57.195
book - libri 0
conference - conferenze 22.224
curatela - curatele 0
other - altro 0
patent - brevetti 2.321
selected - selezionate 0
volume - volumi 1.100
Totale 165.680
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202198 0 0 0 0 0 0 0 0 0 0 0 98
2021/20222.386 68 194 157 316 75 166 192 560 82 200 104 272
2022/20232.295 245 154 20 245 395 381 1 160 385 17 257 35
2023/20241.266 57 188 19 163 120 237 53 53 72 15 89 200
2024/20253.681 72 285 99 287 453 399 338 542 157 168 358 523
2025/20266.327 796 163 450 580 909 622 1.049 308 406 700 292 52
Totale 27.077