IRIS
TONELLI, MICHELE
 Distribuzione geografica
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Continente #
EU - Europa 8.108
AS - Asia 995
NA - Nord America 693
SA - Sud America 97
AF - Africa 24
OC - Oceania 2
Totale 9.919
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Nazione #
IT - Italia 7.922
US - Stati Uniti d'America 657
SG - Singapore 410
CN - Cina 283
VN - Vietnam 190
FR - Francia 80
BR - Brasile 54
HK - Hong Kong 36
CA - Canada 21
DE - Germania 20
FI - Finlandia 19
AR - Argentina 17
BD - Bangladesh 15
JP - Giappone 15
GB - Regno Unito 14
ZA - Sudafrica 12
CH - Svizzera 11
MX - Messico 11
IQ - Iraq 7
VE - Venezuela 7
CL - Cile 6
ID - Indonesia 6
NL - Olanda 6
PH - Filippine 6
RU - Federazione Russa 6
GR - Grecia 5
IN - India 5
DZ - Algeria 4
IE - Irlanda 4
PT - Portogallo 4
PY - Paraguay 4
PL - Polonia 3
SE - Svezia 3
TR - Turchia 3
UA - Ucraina 3
UY - Uruguay 3
BH - Bahrain 2
EC - Ecuador 2
EG - Egitto 2
IR - Iran 2
MA - Marocco 2
NP - Nepal 2
PE - Perù 2
PK - Pakistan 2
TH - Thailandia 2
TN - Tunisia 2
AE - Emirati Arabi Uniti 1
AF - Afghanistan, Repubblica islamica di 1
AL - Albania 1
AO - Angola 1
AT - Austria 1
AU - Australia 1
AZ - Azerbaigian 1
BZ - Belize 1
CI - Costa d'Avorio 1
CO - Colombia 1
CZ - Repubblica Ceca 1
GY - Guiana 1
HN - Honduras 1
KR - Corea 1
KZ - Kazakistan 1
LI - Liechtenstein 1
MD - Moldavia 1
NZ - Nuova Zelanda 1
PR - Porto Rico 1
PS - Palestinian Territory 1
RS - Serbia 1
SA - Arabia Saudita 1
SI - Slovenia 1
SK - Slovacchia (Repubblica Slovacca) 1
TT - Trinidad e Tobago 1
TW - Taiwan 1
UZ - Uzbekistan 1
Totale 9.919
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Città #
Genova 3.813
Genoa 2.732
Rapallo 684
Vado Ligure 596
San Jose 208
Singapore 187
Ashburn 76
Council Bluffs 62
Ho Chi Minh City 56
Lauterbourg 56
Beijing 48
Hanoi 43
Hong Kong 32
New York 30
Milan 24
Santa Clara 23
Helsinki 18
Paris 18
Frankfurt am Main 16
Tokyo 14
Haiphong 11
Biên Hòa 10
Boardman 10
Bordighera 10
Los Angeles 10
Zurich 10
Buffalo 9
Chicago 8
Mexico City 8
Da Nang 7
Dallas 7
Amsterdam 6
Johannesburg 6
Montreal 6
Tianjin 6
Athens 5
São Paulo 5
Toronto 5
Cagliari 4
City of London 4
Dublin 4
Orem 4
Baghdad 3
Bari 3
Can Tho 3
Cavernago 3
Covilha 3
Denver 3
Guangzhou 3
Jakarta 3
Long Xuyen 3
Saint-Denis 3
Santiago 3
Sorocaba 3
Vĩnh Long 3
Warsaw 3
Asunción 2
Basingstoke 2
Bengaluru 2
Brescia 2
Brooklyn 2
Bắc Ninh 2
Campinas 2
Caracas 2
Cardiff 2
Florence 2
Guarujá 2
Hamad Town 2
Hangzhou 2
Houston 2
Hải Dương 2
Istanbul 2
Kyiv 2
London 2
Manchester 2
Manila 2
Marietta 2
Monte Grande 2
Montevideo 2
Nashville 2
Natal 2
Nha Trang 2
Ninh Bình 2
Paderno Dugnano 2
Phủ Lý 2
Prato 2
Rome 2
Sori 2
Stockholm 2
Vancouver 2
Volta Redonda 2
Yên Bái 2
Abidjan 1
Acarigua 1
Adamsville 1
Ahmedabad 1
Algiers 1
Allen Park 1
Ammi Moussa 1
Anaheim 1
Totale 9.013
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Nome #
Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents 246
Antiviral activity of benzimidazole derivatives. II Antiviral activity of 2-phenylbenzimidazole derivatives. 240
Clofazimine analogs with antileishmanial and antiplasmodial activity 236
Antiviral and cytotoxic activities of aminoarylazo compounds and aryltriazene derivatives 219
Benzimidazole derivatives endowed with potent antileishmanial activity 214
Acridine derivatives as anti-BVDV agents 208
Antiviral activity of benzotriazole derivatives. 5-[4-(Benzotriazol-2-yl)phenoxy]-2,2-dimethylpentanoic acids potently and selectively inhibit Coxsackie Virus B5 207
Quinolizidinyl-benzimidazoles as platelet-antiaggregating agents 206
Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells 203
Inhibition of chloride intracellular channel 1 (CLIC1) as biguanide class-effect to impair human glioblastoma stem cell viability 197
Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR) 196
Rational design, chemical synthesis and biological evaluation of novel biguanides exploring species-specificity responsiveness of TAAR1 agonists 193
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles 191
Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives 187
Discovery of Guanfacine as a Novel TAAR1 Agonist: A Combination Strategy through Molecular Modeling Studies and Biological Assays 181
Novel celecoxib analogues inhibit glial production of prostaglandinE2, nitric oxide, and oxygen radicals reverting the neuroinflammatoryresponses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide 180
State-of-the-art Review on the Antiparasitic Activity of Benzimidazole-based Derivatives: Facing Malaria, Leishmaniasis, and Trypanosomiasis 179
Antitubercular activity of quinolizidinyl/pyrrolizidinylalkyliminophenazines 177
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus 175
Antimicrobial and cytotoxic arylazoenamines. Part III: Antiviral activity of selected classes of arylazoenamines 166
Multitarget Therapeutic Leads for Alzheimer’s Disease: Quinolizidinyl Derivatives of Bi- and Tricyclic Systems as Dual Inhibitors of Cholinesterases and beta-Amyloid (Abeta) Aggregation 166
Novel quinolizidinyl derivatives as antiarrhythmic agents: 2. Further investigation 163
Pyrazole and imidazo[1,2-b]pyrazole derivatives as new potential anti-tuberculosis agents. 160
Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity 159
Antitubercular and antiprotozoal activities of quinolizidinyl/pyrrolizidinylalkyliminophenazines 156
Celecoxib, a COX-2 inhibitor, blocks microglial activation induced by a neurotoxic conformer of hPrP90-231 156
New arylsparteine derivatives as positive inotropic drugs 153
Antiviral Activity of Benzimidazole Derivatives. I. Antiviral Activity of 1-Substituted-2-[(Benzotriazol-1/2-yl)methyl]benzimidazoles. 152
3-(4-Chlorophenyldiazenyl)-1-methyl-1,4,5,6-tetrahydropyridine, 150
9-Aminoacridine-based agents impair the bovine viral diarrhea virus (BVDV) replication targeting the RNA-dependent RNA polymerase (RdRp) 148
Pharmacophore modeling, resistant mutant isolation, docking, and MM-PBSA analysis: Combined experimental/computer-assisted approaches to identify new inhibitors of the bovine viral diarrhea virus (BVDV) 145
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands 141
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease 137
Chapter 1. Non-Nucleoside Benzimidazoles As Antiviral Drugs Against HIV Infections 130
Multitarget Biological Profiling of New Naphthoquinone and Anthraquinone-Based Derivatives for the Treatment of Alzheimer's Disease 129
Fight against H1N1 Influenza A Virus: Recent Insights towards the Development of Druggable Compounds 124
Exploring the effectiveness of novel benzimidazoles as CB2 ligands: synthesis, biological evaluation, molecular docking studies and ADMET prediction 123
Synergistic experimental/computational studies on arylazoenamine derivatives that target the bovine viral diarrhea virus RNA-dependent RNA polymerase 122
Novel biguanide-based derivatives scouted as TAAR1 agonists: synthesis, biological evaluation, ADME prediction and molecular docking studies 122
New insights into the binding features of f508del cftr potentiators: A molecular docking, pharmacophore mapping and qsar analysis approach 122
Journey on naphthoquinone and anthraquinone derivatives: New insights in alzheimer’s disease 120
Anti-α-glucosidase and antiglycation activities of α-mangostin and new xanthenone derivatives: Enzymatic kinetics and mechanistic insights through in vitro studies 120
Discovery of a Novel Chemo-Type for TAAR1 Agonism via Molecular Modeling 113
Molecular Docking and QSAR Studies as Computational Tools Exploring the Rescue Ability of F508del CFTR Correctors 113
Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays 112
Synthesis and biological evaluation of novel (thio)semicarbazone-based benzimidazoles as antiviral agents against human respiratory viruses 111
Molecular mechanisms mediating the neuroprotective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231) 109
Chapter 2. Non-Nucleoside Benzimidazoles As Antiviral Drugs Against HCV and RSV Infections. 108
A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists 106
Probing In Silico the Benzimidazole Privileged Scaffold for the Development of Drug-like Anti-RSV Agents 103
Synthesis and antiplasmodial activity of novel chloroquine analogues with bulky basic side chains 101
Quinolizidinyl derivatives of bi- and tricyclic systems as AChE/BchE and beta-amyloid aggregation inhibitors, 100
Novel 1-amidino-4-phenylpiperazines as potent agonists at human taar1 receptor: Rational design, synthesis, biological evaluation and molecular docking studies 99
Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease 93
Look Back in Anger. Toxicity vs. Activity for Acridine Derivatives as HCV RNA Dependent RNA-polymerase Inhibitors 93
Quinone-based derivatives: a new class of multi-target agents against Alzheimer’s disease 89
Evidence of pyrimethamine and cycloguanil analogues as dual inhibitors of trypanosoma brucei pteridine reductase and dihydrofolate reductase 87
Optimization of the clofazimine structure leads to a highly water-soluble C3-aminopyridinyl riminophenazine endowed with improved anti-Wnt and anti-cancer activity in vitro and in vivo 86
Primary anti-proliferative activity evaluation of 1-(quinolizidin-1'-yl)methyl- and 1-([Formula: see text]-tert-amino)alkyl-substituted 2-phenyl-, 2-benzyl- and 2-[(benzotriazol-1/2-yl)methyl]benzimidazoles on human cancer cell lines. 85
Antitarget, Anti-SARS-CoV‑2 Leads, Drugs, and the Drug Discovery−Genetics Alliance Perspective 84
Trace amine associated receptor 1 (TAAR1) modulators: a patent review (2010-present) 78
Targeting species-specific TAAR1 ligands: to date perspective of the rational drug design process 76
Quinolizidine-derived lucanthone and amitriptyline analogues endowed with potent antileishmanial activity 74
Exploring the selectivity profile of sigma receptor ligands by molecular docking and pharmacophore analyses. 71
Further quinolizidine derivatives as antiarrhythmic agents-3 71
Host DHFR-directed cycloguanil analogues endowed with promising activity against influenza virus and respiratory syncytial virus 71
Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents 70
Fragment based design of GLS1 allosteric inhibitors for cancer therapy 67
null 66
New insights into the structure of the Trace Amine-Associated Receptor 2 (TAAR2): homology modeling studies exploring the binding mode of 3-iodothyronamine 64
An in silico fragment-based strategy for the rational design of new glutaminase inhibitors 63
New naphtho- and anthraquinone derivatives as Cholinesterase inhibitors for the treatment of Alzheimer's disease 62
Magnolol and Luteolin Inhibition of α-Glucosidase Activity: Kinetics and Type of Interaction Detected by In Vitro and In Silico Studies 61
High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents 61
Assessing the Multitarget Therapeutic Potential of Novel 9-Aminoacridine Derivatives for Alzheimer's Disease 54
Deciphering the landscape of allosteric glutaminase 1 inhibitors as anticancer agents 52
Identification of a theranostic prodrug candidate against glioblastoma 49
The fragment-based strategy: an effective approach for designing new small molecules that act as GLS1 inhibitors. 46
In Vitro Screening of an In-House Library of Structurally Distinct Chemotypes Towards the Identification of Novel SARS-CoV-2 Inhibitors 44
The breakthrough of TAAR1 agonists for the treatment of neuropsychiatric disorders: One step away 41
The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents 37
GLUTAMINASE 1 (GLS1) ALLOSTERIC INHIBITORS: SYNTHESIS OF KEY INTERMEDIATES 11
Design of New GLS1 Allosteric Inhibitors by the Fragment_Based Strategy 8
A Fragment‑Based Computational Strategy for the Discovery of New‑Generation Glutaminase Inhibitors 1
Totale 10.189
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Categoria #
all - tutte 33.035
article - articoli 30.038
book - libri 0
conference - conferenze 2.300
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 697
Totale 66.070
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202140 0 0 0 0 0 0 0 0 0 0 0 40
2021/2022824 49 33 94 70 22 45 47 175 59 59 57 114
2022/2023804 67 45 22 78 144 146 3 65 121 5 92 16
2023/2024542 24 67 38 73 37 112 33 32 18 7 44 57
2024/20251.619 37 99 41 75 234 152 188 303 46 69 177 198
2025/20263.214 382 79 403 304 389 234 402 187 252 346 187 49
Totale 10.189