IRIS
TONELLI, MICHELE
 Distribuzione geografica
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Continente #
EU - Europa 7.840
AS - Asia 407
SA - Sud America 63
NA - Nord America 35
AF - Africa 11
OC - Oceania 1
Totale 8.357
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Nazione #
IT - Italia 7.809
SG - Singapore 170
CN - Cina 112
VN - Vietnam 91
BR - Brasile 37
US - Stati Uniti d'America 25
FR - Francia 16
AR - Argentina 14
HK - Hong Kong 12
MX - Messico 7
RU - Federazione Russa 6
ZA - Sudafrica 6
GR - Grecia 5
ID - Indonesia 5
IQ - Iraq 4
BD - Bangladesh 3
PY - Paraguay 3
CA - Canada 2
CL - Cile 2
IN - India 2
MA - Marocco 2
PE - Perù 2
SE - Svezia 2
UY - Uruguay 2
VE - Venezuela 2
AF - Afghanistan, Repubblica islamica di 1
AO - Angola 1
BH - Bahrain 1
DZ - Algeria 1
EC - Ecuador 1
IR - Iran 1
JP - Giappone 1
KZ - Kazakistan 1
NP - Nepal 1
NZ - Nuova Zelanda 1
PH - Filippine 1
PK - Pakistan 1
PL - Polonia 1
SK - Slovacchia (Repubblica Slovacca) 1
TN - Tunisia 1
TT - Trinidad e Tobago 1
Totale 8.357
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Città #
Genova 3.813
Genoa 2.694
Rapallo 684
Vado Ligure 596
Singapore 56
Ho Chi Minh City 29
Beijing 25
Hanoi 20
Paris 16
Hong Kong 12
Ashburn 11
Bordighera 10
Milan 8
Biên Hòa 7
Haiphong 6
Tianjin 6
Athens 5
Da Nang 5
Mexico City 5
Baghdad 3
Johannesburg 3
Bắc Ninh 2
Florence 2
Guarujá 2
Hangzhou 2
Hải Dương 2
Jakarta 2
Los Angeles 2
Monte Grande 2
Montevideo 2
Ninh Bình 2
Phủ Lý 2
Sorocaba 2
São Paulo 2
Yên Bái 2
Ahmedabad 1
Angered 1
Araguari 1
Arapiraca 1
Arraias 1
Asunción 1
Bab Ezzouar 1
Baoding 1
Bengaluru 1
Berazategui 1
Brasília 1
Brits 1
Bình Dương 1
Bắc Giang 1
Caacupé 1
Caloocan City 1
Camaçari 1
Campinas 1
Campo Grande 1
Candelaria 1
Canoas 1
Cao Lanh 1
Caracas 1
Casablanca 1
Cañuelas 1
Chicago 1
Chiclayo 1
Clorinda 1
Colombo 1
Couva 1
Dali 1
Del Viso 1
Denver 1
Draper 1
Erbil 1
Florianópolis 1
Goianira 1
Guangzhou 1
Hamad Town 1
Hefei 1
Honolulu 1
Houston 1
Hưng Yên 1
Itararé 1
Jiaxing 1
José C. Paz 1
Juiz de Fora 1
Kasur 1
Košice 1
La Plata 1
Lima 1
Long Xuyen 1
Luanda 1
Magé 1
Mendoza 1
Mesquita 1
Montreal 1
Morrinhos 1
Morón 1
Mossoró 1
Nabeul 1
Nam Định 1
Natal 1
Neuquén 1
New York 1
Totale 8.107
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Nome #
Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents 233
Clofazimine analogs with antileishmanial and antiplasmodial activity 227
Antiviral activity of benzimidazole derivatives. II Antiviral activity of 2-phenylbenzimidazole derivatives. 210
Antiviral and cytotoxic activities of aminoarylazo compounds and aryltriazene derivatives 199
Acridine derivatives as anti-BVDV agents 187
Quinolizidinyl-benzimidazoles as platelet-antiaggregating agents 185
Antiviral activity of benzotriazole derivatives. 5-[4-(Benzotriazol-2-yl)phenoxy]-2,2-dimethylpentanoic acids potently and selectively inhibit Coxsackie Virus B5 184
Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR) 183
Benzimidazole derivatives endowed with potent antileishmanial activity 181
Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells 175
Rational design, chemical synthesis and biological evaluation of novel biguanides exploring species-specificity responsiveness of TAAR1 agonists 175
Inhibition of chloride intracellular channel 1 (CLIC1) as biguanide class-effect to impair human glioblastoma stem cell viability 168
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles 163
Novel celecoxib analogues inhibit glial production of prostaglandinE2, nitric oxide, and oxygen radicals reverting the neuroinflammatoryresponses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide 160
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus 159
Antitubercular activity of quinolizidinyl/pyrrolizidinylalkyliminophenazines 156
Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives 152
Multitarget Therapeutic Leads for Alzheimer’s Disease: Quinolizidinyl Derivatives of Bi- and Tricyclic Systems as Dual Inhibitors of Cholinesterases and beta-Amyloid (Abeta) Aggregation 151
Novel quinolizidinyl derivatives as antiarrhythmic agents: 2. Further investigation 149
Antimicrobial and cytotoxic arylazoenamines. Part III: Antiviral activity of selected classes of arylazoenamines 148
Pyrazole and imidazo[1,2-b]pyrazole derivatives as new potential anti-tuberculosis agents. 146
Discovery of Guanfacine as a Novel TAAR1 Agonist: A Combination Strategy through Molecular Modeling Studies and Biological Assays 141
Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity 140
State-of-the-art Review on the Antiparasitic Activity of Benzimidazole-based Derivatives: Facing Malaria, Leishmaniasis, and Trypanosomiasis 138
Antiviral Activity of Benzimidazole Derivatives. I. Antiviral Activity of 1-Substituted-2-[(Benzotriazol-1/2-yl)methyl]benzimidazoles. 138
Antitubercular and antiprotozoal activities of quinolizidinyl/pyrrolizidinylalkyliminophenazines 137
Celecoxib, a COX-2 inhibitor, blocks microglial activation induced by a neurotoxic conformer of hPrP90-231 137
New arylsparteine derivatives as positive inotropic drugs 137
9-Aminoacridine-based agents impair the bovine viral diarrhea virus (BVDV) replication targeting the RNA-dependent RNA polymerase (RdRp) 132
Pharmacophore modeling, resistant mutant isolation, docking, and MM-PBSA analysis: Combined experimental/computer-assisted approaches to identify new inhibitors of the bovine viral diarrhea virus (BVDV) 131
3-(4-Chlorophenyldiazenyl)-1-methyl-1,4,5,6-tetrahydropyridine, 130
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands 126
Chapter 1. Non-Nucleoside Benzimidazoles As Antiviral Drugs Against HIV Infections 116
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease 116
Fight against H1N1 Influenza A Virus: Recent Insights towards the Development of Druggable Compounds 115
Exploring the effectiveness of novel benzimidazoles as CB2 ligands: synthesis, biological evaluation, molecular docking studies and ADMET prediction 115
Synergistic experimental/computational studies on arylazoenamine derivatives that target the bovine viral diarrhea virus RNA-dependent RNA polymerase 113
A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists 106
Novel biguanide-based derivatives scouted as TAAR1 agonists: synthesis, biological evaluation, ADME prediction and molecular docking studies 104
Multitarget Biological Profiling of New Naphthoquinone and Anthraquinone-Based Derivatives for the Treatment of Alzheimer's Disease 102
Journey on naphthoquinone and anthraquinone derivatives: New insights in alzheimer’s disease 98
Molecular mechanisms mediating the neuroprotective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231) 97
Chapter 2. Non-Nucleoside Benzimidazoles As Antiviral Drugs Against HCV and RSV Infections. 96
Molecular Docking and QSAR Studies as Computational Tools Exploring the Rescue Ability of F508del CFTR Correctors 96
Synthesis and biological evaluation of novel (thio)semicarbazone-based benzimidazoles as antiviral agents against human respiratory viruses 93
Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays 92
Synthesis and antiplasmodial activity of novel chloroquine analogues with bulky basic side chains 92
Discovery of a Novel Chemo-Type for TAAR1 Agonism via Molecular Modeling 90
Quinolizidinyl derivatives of bi- and tricyclic systems as AChE/BchE and beta-amyloid aggregation inhibitors, 87
New insights into the binding features of f508del cftr potentiators: A molecular docking, pharmacophore mapping and qsar analysis approach 86
Look Back in Anger. Toxicity vs. Activity for Acridine Derivatives as HCV RNA Dependent RNA-polymerase Inhibitors 85
Probing In Silico the Benzimidazole Privileged Scaffold for the Development of Drug-like Anti-RSV Agents 85
Anti-α-glucosidase and antiglycation activities of α-mangostin and new xanthenone derivatives: Enzymatic kinetics and mechanistic insights through in vitro studies 83
Novel 1-amidino-4-phenylpiperazines as potent agonists at human taar1 receptor: Rational design, synthesis, biological evaluation and molecular docking studies 77
Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease 75
Primary anti-proliferative activity evaluation of 1-(quinolizidin-1'-yl)methyl- and 1-([Formula: see text]-tert-amino)alkyl-substituted 2-phenyl-, 2-benzyl- and 2-[(benzotriazol-1/2-yl)methyl]benzimidazoles on human cancer cell lines. 74
Trace amine associated receptor 1 (TAAR1) modulators: a patent review (2010-present) 71
Evidence of pyrimethamine and cycloguanil analogues as dual inhibitors of trypanosoma brucei pteridine reductase and dihydrofolate reductase 70
null 66
Targeting species-specific TAAR1 ligands: to date perspective of the rational drug design process 65
Quinone-based derivatives: a new class of multi-target agents against Alzheimer’s disease 65
Antitarget, Anti-SARS-CoV‑2 Leads, Drugs, and the Drug Discovery−Genetics Alliance Perspective 62
Optimization of the clofazimine structure leads to a highly water-soluble C3-aminopyridinyl riminophenazine endowed with improved anti-Wnt and anti-cancer activity in vitro and in vivo 61
Quinolizidine-derived lucanthone and amitriptyline analogues endowed with potent antileishmanial activity 60
Host DHFR-directed cycloguanil analogues endowed with promising activity against influenza virus and respiratory syncytial virus 59
Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents 56
New insights into the structure of the Trace Amine-Associated Receptor 2 (TAAR2): homology modeling studies exploring the binding mode of 3-iodothyronamine 55
Further quinolizidine derivatives as antiarrhythmic agents-3 53
Exploring the selectivity profile of sigma receptor ligands by molecular docking and pharmacophore analyses. 52
New naphtho- and anthraquinone derivatives as Cholinesterase inhibitors for the treatment of Alzheimer's disease 51
Magnolol and Luteolin Inhibition of α-Glucosidase Activity: Kinetics and Type of Interaction Detected by In Vitro and In Silico Studies 47
High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents 47
Fragment based design of GLS1 allosteric inhibitors for cancer therapy 40
An in silico fragment-based strategy for the rational design of new glutaminase inhibitors 34
Deciphering the landscape of allosteric glutaminase 1 inhibitors as anticancer agents 29
The breakthrough of TAAR1 agonists for the treatment of neuropsychiatric disorders: One step away 29
In Vitro Screening of an In-House Library of Structurally Distinct Chemotypes Towards the Identification of Novel SARS-CoV-2 Inhibitors 27
The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents 22
Identification of a theranostic prodrug candidate against glioblastoma 22
Totale 8.614
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Categoria #
all - tutte 29.610
article - articoli 27.120
book - libri 0
conference - conferenze 1.859
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 631
Totale 59.220
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021386 0 0 0 0 0 53 28 51 52 85 77 40
2021/2022824 49 33 94 70 22 45 47 175 59 59 57 114
2022/2023804 67 45 22 78 144 146 3 65 121 5 92 16
2023/2024542 24 67 38 73 37 112 33 32 18 7 44 57
2024/20251.619 37 99 41 75 234 152 188 303 46 69 177 198
2025/20261.639 382 79 403 304 389 82 0 0 0 0 0 0
Totale 8.614