IRIS
TONELLI, MICHELE
 Distribuzione geografica
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Continente #
EU - Europa 8.178
AS - Asia 1.042
NA - Nord America 952
Continente sconosciuto - Info sul continente non disponibili 270
SA - Sud America 109
AF - Africa 28
OC - Oceania 2
Totale 10.581
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Nazione #
IT - Italia 7.981
US - Stati Uniti d'America 898
SG - Singapore 411
CN - Cina 286
VN - Vietnam 192
FR - Francia 81
BR - Brasile 58
BD - Bangladesh 44
HK - Hong Kong 36
CA - Canada 26
DE - Germania 20
AR - Argentina 19
FI - Finlandia 19
GB - Regno Unito 15
JP - Giappone 15
ZA - Sudafrica 12
CH - Svizzera 11
MX - Messico 11
VE - Venezuela 9
PK - Pakistan 8
AE - Emirati Arabi Uniti 7
CL - Cile 7
IQ - Iraq 7
NL - Olanda 7
ID - Indonesia 6
PH - Filippine 6
RU - Federazione Russa 6
GR - Grecia 5
IN - India 5
PT - Portogallo 5
PY - Paraguay 5
AT - Austria 4
DZ - Algeria 4
IE - Irlanda 4
SC - Seychelles 4
SE - Svezia 4
UA - Ucraina 4
UY - Uruguay 4
PL - Polonia 3
TR - Turchia 3
BH - Bahrain 2
CO - Colombia 2
CR - Costa Rica 2
EC - Ecuador 2
EG - Egitto 2
ES - Italia 2
GT - Guatemala 2
IR - Iran 2
JM - Giamaica 2
MA - Marocco 2
NP - Nepal 2
PE - Perù 2
SV - El Salvador 2
TH - Thailandia 2
TN - Tunisia 2
TT - Trinidad e Tobago 2
AF - Afghanistan, Repubblica islamica di 1
AL - Albania 1
AO - Angola 1
AU - Australia 1
AZ - Azerbaigian 1
BS - Bahamas 1
BZ - Belize 1
CI - Costa d'Avorio 1
CZ - Repubblica Ceca 1
DO - Repubblica Dominicana 1
GY - Guiana 1
HN - Honduras 1
KR - Corea 1
KZ - Kazakistan 1
LI - Liechtenstein 1
MD - Moldavia 1
MQ - Martinica 1
NZ - Nuova Zelanda 1
PR - Porto Rico 1
PS - Palestinian Territory 1
RS - Serbia 1
SA - Arabia Saudita 1
SI - Slovenia 1
SK - Slovacchia (Repubblica Slovacca) 1
TW - Taiwan 1
UZ - Uzbekistan 1
VC - Saint Vincent e Grenadine 1
Totale 10.311
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Città #
Genova 3.813
Genoa 2.735
Rapallo 684
Vado Ligure 596
San Jose 228
Singapore 187
Ashburn 106
Council Bluffs 62
Ho Chi Minh City 57
Lauterbourg 56
Beijing 48
Hanoi 44
New York 35
Hong Kong 32
Milan 30
Santa Clara 27
Helsinki 18
Los Angeles 18
Paris 18
Frankfurt am Main 16
Dallas 15
Tokyo 14
Bordighera 11
Haiphong 11
Biên Hòa 10
Boardman 10
Zurich 10
Buffalo 9
Chicago 8
Mexico City 8
Da Nang 7
Montreal 7
Rome 7
Amsterdam 6
Johannesburg 6
Tianjin 6
Athens 5
Cagliari 5
Karachi 5
London 5
Naples 5
São Paulo 5
Toronto 5
Turin 5
Brooklyn 4
City of London 4
Dublin 4
Houston 4
Orem 4
Phoenix 4
Plymouth 4
Santiago 4
Sorocaba 4
Vienna 4
Asunción 3
Baghdad 3
Bari 3
Boydton 3
Brescia 3
Can Tho 3
Cavernago 3
Covilha 3
Davenport 3
Denver 3
Florence 3
Guangzhou 3
Jakarta 3
Las Vegas 3
Long Xuyen 3
Montevideo 3
Saint-Denis 3
Springfield 3
Staten Island 3
Vĩnh Long 3
Warsaw 3
Acarigua 2
Atlanta 2
Augusta 2
Basingstoke 2
Bengaluru 2
Bianzè 2
Boston 2
Bắc Ninh 2
Campinas 2
Caracas 2
Cardiff 2
Catania 2
Couva 2
Fayetteville 2
Guarujá 2
Guatemala City 2
Hamad Town 2
Hangzhou 2
Houma 2
Hải Dương 2
Iowa City 2
Istanbul 2
Kapolei 2
Kingston 2
Kyiv 2
Totale 9.148
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Nome #
Antiviral activity of benzimidazole derivatives. III. Novel anti-CVB-5, anti-RSV and anti-Sb-1 agents 251
Antiviral activity of benzimidazole derivatives. II Antiviral activity of 2-phenylbenzimidazole derivatives. 251
Clofazimine analogs with antileishmanial and antiplasmodial activity 240
Antiviral and cytotoxic activities of aminoarylazo compounds and aryltriazene derivatives 227
Benzimidazole derivatives endowed with potent antileishmanial activity 221
Acridine derivatives as anti-BVDV agents 215
Antiviral activity of benzotriazole derivatives. 5-[4-(Benzotriazol-2-yl)phenoxy]-2,2-dimethylpentanoic acids potently and selectively inhibit Coxsackie Virus B5 213
Quinolizidinyl-benzimidazoles as platelet-antiaggregating agents 211
Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells 205
Inhibition of chloride intracellular channel 1 (CLIC1) as biguanide class-effect to impair human glioblastoma stem cell viability 201
Rational design, chemical synthesis and biological evaluation of novel biguanides exploring species-specificity responsiveness of TAAR1 agonists 200
Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR) 198
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles 193
Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives 192
Discovery of Guanfacine as a Novel TAAR1 Agonist: A Combination Strategy through Molecular Modeling Studies and Biological Assays 185
Antitubercular activity of quinolizidinyl/pyrrolizidinylalkyliminophenazines 183
State-of-the-art Review on the Antiparasitic Activity of Benzimidazole-based Derivatives: Facing Malaria, Leishmaniasis, and Trypanosomiasis 181
Novel celecoxib analogues inhibit glial production of prostaglandinE2, nitric oxide, and oxygen radicals reverting the neuroinflammatoryresponses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide 180
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus 178
Multitarget Therapeutic Leads for Alzheimer’s Disease: Quinolizidinyl Derivatives of Bi- and Tricyclic Systems as Dual Inhibitors of Cholinesterases and beta-Amyloid (Abeta) Aggregation 176
Antimicrobial and cytotoxic arylazoenamines. Part III: Antiviral activity of selected classes of arylazoenamines 170
Novel quinolizidinyl derivatives as antiarrhythmic agents: 2. Further investigation 165
Antitubercular and antiprotozoal activities of quinolizidinyl/pyrrolizidinylalkyliminophenazines 165
Pyrazole and imidazo[1,2-b]pyrazole derivatives as new potential anti-tuberculosis agents. 165
Celecoxib, a COX-2 inhibitor, blocks microglial activation induced by a neurotoxic conformer of hPrP90-231 163
Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity 162
Antiviral Activity of Benzimidazole Derivatives. I. Antiviral Activity of 1-Substituted-2-[(Benzotriazol-1/2-yl)methyl]benzimidazoles. 159
New arylsparteine derivatives as positive inotropic drugs 155
3-(4-Chlorophenyldiazenyl)-1-methyl-1,4,5,6-tetrahydropyridine, 154
9-Aminoacridine-based agents impair the bovine viral diarrhea virus (BVDV) replication targeting the RNA-dependent RNA polymerase (RdRp) 152
Pharmacophore modeling, resistant mutant isolation, docking, and MM-PBSA analysis: Combined experimental/computer-assisted approaches to identify new inhibitors of the bovine viral diarrhea virus (BVDV) 149
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands 143
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease 139
Multitarget Biological Profiling of New Naphthoquinone and Anthraquinone-Based Derivatives for the Treatment of Alzheimer's Disease 136
Chapter 1. Non-Nucleoside Benzimidazoles As Antiviral Drugs Against HIV Infections 133
Journey on naphthoquinone and anthraquinone derivatives: New insights in alzheimer’s disease 128
Novel biguanide-based derivatives scouted as TAAR1 agonists: synthesis, biological evaluation, ADME prediction and molecular docking studies 127
Fight against H1N1 Influenza A Virus: Recent Insights towards the Development of Druggable Compounds 125
Exploring the effectiveness of novel benzimidazoles as CB2 ligands: synthesis, biological evaluation, molecular docking studies and ADMET prediction 125
New insights into the binding features of f508del cftr potentiators: A molecular docking, pharmacophore mapping and qsar analysis approach 125
Anti-α-glucosidase and antiglycation activities of α-mangostin and new xanthenone derivatives: Enzymatic kinetics and mechanistic insights through in vitro studies 124
Synergistic experimental/computational studies on arylazoenamine derivatives that target the bovine viral diarrhea virus RNA-dependent RNA polymerase 122
Discovery of a Novel Chemo-Type for TAAR1 Agonism via Molecular Modeling 118
Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays 118
Synthesis and biological evaluation of novel (thio)semicarbazone-based benzimidazoles as antiviral agents against human respiratory viruses 118
Molecular Docking and QSAR Studies as Computational Tools Exploring the Rescue Ability of F508del CFTR Correctors 117
Probing In Silico the Benzimidazole Privileged Scaffold for the Development of Drug-like Anti-RSV Agents 116
Molecular mechanisms mediating the neuroprotective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231) 114
Chapter 2. Non-Nucleoside Benzimidazoles As Antiviral Drugs Against HCV and RSV Infections. 113
Synthesis and antiplasmodial activity of novel chloroquine analogues with bulky basic side chains 108
A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists 106
Novel 1-amidino-4-phenylpiperazines as potent agonists at human taar1 receptor: Rational design, synthesis, biological evaluation and molecular docking studies 103
Quinolizidinyl derivatives of bi- and tricyclic systems as AChE/BchE and beta-amyloid aggregation inhibitors, 102
Look Back in Anger. Toxicity vs. Activity for Acridine Derivatives as HCV RNA Dependent RNA-polymerase Inhibitors 97
Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease 94
Quinone-based derivatives: a new class of multi-target agents against Alzheimer’s disease 91
Optimization of the clofazimine structure leads to a highly water-soluble C3-aminopyridinyl riminophenazine endowed with improved anti-Wnt and anti-cancer activity in vitro and in vivo 90
Evidence of pyrimethamine and cycloguanil analogues as dual inhibitors of trypanosoma brucei pteridine reductase and dihydrofolate reductase 89
Primary anti-proliferative activity evaluation of 1-(quinolizidin-1'-yl)methyl- and 1-([Formula: see text]-tert-amino)alkyl-substituted 2-phenyl-, 2-benzyl- and 2-[(benzotriazol-1/2-yl)methyl]benzimidazoles on human cancer cell lines. 87
Antitarget, Anti-SARS-CoV‑2 Leads, Drugs, and the Drug Discovery−Genetics Alliance Perspective 86
Trace amine associated receptor 1 (TAAR1) modulators: a patent review (2010-present) 79
Further quinolizidine derivatives as antiarrhythmic agents-3 77
Targeting species-specific TAAR1 ligands: to date perspective of the rational drug design process 77
Quinolizidine-derived lucanthone and amitriptyline analogues endowed with potent antileishmanial activity 76
Fragment based design of GLS1 allosteric inhibitors for cancer therapy 75
Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents 74
Exploring the selectivity profile of sigma receptor ligands by molecular docking and pharmacophore analyses. 74
An in silico fragment-based strategy for the rational design of new glutaminase inhibitors 72
Host DHFR-directed cycloguanil analogues endowed with promising activity against influenza virus and respiratory syncytial virus 72
null 66
Assessing the Multitarget Therapeutic Potential of Novel 9-Aminoacridine Derivatives for Alzheimer's Disease 64
New insights into the structure of the Trace Amine-Associated Receptor 2 (TAAR2): homology modeling studies exploring the binding mode of 3-iodothyronamine 64
New naphtho- and anthraquinone derivatives as Cholinesterase inhibitors for the treatment of Alzheimer's disease 64
Magnolol and Luteolin Inhibition of α-Glucosidase Activity: Kinetics and Type of Interaction Detected by In Vitro and In Silico Studies 62
Deciphering the landscape of allosteric glutaminase 1 inhibitors as anticancer agents 61
High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents 61
Identification of a theranostic prodrug candidate against glioblastoma 56
The fragment-based strategy: an effective approach for designing new small molecules that act as GLS1 inhibitors. 53
In Vitro Screening of an In-House Library of Structurally Distinct Chemotypes Towards the Identification of Novel SARS-CoV-2 Inhibitors 48
The breakthrough of TAAR1 agonists for the treatment of neuropsychiatric disorders: One step away 44
The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents 41
GLUTAMINASE 1 (GLS1) ALLOSTERIC INHIBITORS: SYNTHESIS OF KEY INTERMEDIATES 29
Design of New GLS1 Allosteric Inhibitors by the Fragment_Based Strategy 20
A Fragment‑Based Computational Strategy for the Discovery of New‑Generation Glutaminase Inhibitors 18
Totale 10.581
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Categoria #
all - tutte 34.912
article - articoli 31.601
book - libri 0
conference - conferenze 2.584
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 727
Totale 69.824
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022824 49 33 94 70 22 45 47 175 59 59 57 114
2022/2023804 67 45 22 78 144 146 3 65 121 5 92 16
2023/2024542 24 67 38 73 37 112 33 32 18 7 44 57
2024/20251.619 37 99 41 75 234 152 188 303 46 69 177 198
2025/20263.310 382 79 403 304 389 234 402 187 252 346 187 145
2026/2027296 296 0 0 0 0 0 0 0 0 0 0 0
Totale 10.581