IRIS
FOSSA, PAOLA
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
EU - Europa 19.057
AS - Asia 81
SA - Sud America 11
AF - Africa 1
Totale 19.150
Salva come PNG Salva come JPEG
Nazione #
IT - Italia 19.056
CN - Cina 55
SG - Singapore 22
BR - Brasile 9
VN - Vietnam 4
CL - Cile 1
FI - Finlandia 1
MA - Marocco 1
PY - Paraguay 1
Totale 19.150
Salva come PNG Salva come JPEG
Città #
Genova 11.477
Genoa 4.942
Vado Ligure 1.307
Rapallo 1.304
Bordighera 26
Beijing 25
Singapore 6
Ho Chi Minh City 3
Agadir 1
Belo Horizonte 1
Chapecó 1
Conceição do Coité 1
Esmeraldas 1
Estación Colina 1
Guarulhos 1
Hefei 1
Joinville 1
Lappeenranta 1
Manaus 1
Mauá 1
São José 1
Tianjin 1
Tây Ninh 1
Totale 19.105
Salva come PNG Salva come JPEG
Nome #
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment 231
Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists 223
Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis 202
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation 201
1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: Structure-affinity/activity relationship at alpha(1)-adrenoceptor subtypes and at 5-HT(1A) receptors. 201
Ligand-based homology modelling of the human CB2 receptor SR144528 antagonist binding site: a computational approach to explore the 1,5-diaryl pyrazole scaffold 195
Molecular Chaperones in the Pathogenesis of Amyotrophic Lateral Sclerosis: The Role of HSPB1 189
1-Phenyl-1H-Indazole derivatives with analgesic and anti-inflammatory activities. 188
Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools 186
Identification of a high affinity binding site for abscisic acid on human Lanthionine synthetase component C-like protein 2 184
Fast course ALS presenting with vocal cord paralysis: clinical features, bioinformatic and modelling analysis of the novel SOD1 Gly147Ser mutation. 180
A complex phenotype in a child with familial HDL deficiency due to a novel frameshift mutation in APOA1 gene (apoA-IGuastalla) 180
Synthesis of 4-Thiophen-2’-yl-1,4-dihydropyridines as Potentiators of the CFTR Chloride Channel 170
Synthesis, in vitro antiplatelet activity and molecular modelling studies of 10-substituted 2-(1-piperazinyl)pyrimido[1,2-a]benzimidazol-4(10H)-ones 168
Modelling the interaction of steroid receptors with endocrine disrupting chemicals 167
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5 167
Hit-to-lead optimization of mouse Trace Amine Associated Receptor 1 (mTAAR1) agonists with a diphenylmethane-scaffold: Design, Synthesis, and biological study 166
3,4,5-Trisubstituted-1,2,4-4H-triazoles as WT and Y188L mutant HIV-1 non-nucleoside reverse transcriptase inhibitors: docking-based CoMFA and CoMSIA analyses. 165
Chemometric study and validation strategies in the structure-activity relationships of new cardiotonic agents 164
CoMFA and CoMSIA analyses on 1,2,3,4-tetrahydropyrrolo[3,4-b]indole and benzimidazole derivatives as selective CB2 receptor agonists. 160
Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents 160
A novel mutation in the N-terminal acting-binding domain of Filamin C protein causing a distal myofibrillar myopathy 160
Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors 155
Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors. 155
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles 154
Exploring the QSAR of pyrazolo[3,4-b]pyridine, pyrazolo[3,4-b]pyridone and pyrazolo[3,4-b]pyrimidine derivatives as antagonists for A1 adenosine receptor. 153
Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics 153
a1-Adrenoceptor Antagonists. Rational Design, Synthesis and Biological Evaluation of New Trazodone-like Compounds 152
Design and synthesis of 4,5,6,7‐tetrahydro‐1H‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors 152
Synthesis, molecular modeling and SAR study of novel pyrazolo[5,1-f][1,6]naphthyridines as CB2receptor antagonists/inverse agonists 152
Affinity prediction on A1 adenosine receptor agonists: the chemometric approach 151
HSPB1 and HSPB8 in inherited neuropathies: study of an Italian cohort of dHMN and CMT2 patients 151
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists 151
Activity of 3-Carbethoxyangelicin Photolysis Products 146
T137A variant is a pathogenetic SOD1 mutation associated with a slowly progressive ALS phenotype. 145
Discovery of a new series of 5-HT1A receptor agonists 144
Matrine modulates HSC70 levels and rescues DF508-CFTR 143
A chemometric approach to predict A1 agonist effect of adenosine analogues 142
Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB1receptor ligand antagonists 141
2- substituted 5-acetyl-1,6-dihydro-6-oxo-3-pyridinecarboxylates: synthesis and cardiotonic activity 140
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line 140
Exploitation of a novel biosensor based on the full-length human F508del-CFTR with computational study, biochemical and biological assays for the characterization of a new Lumacaftor/Tezacaftor analogue. 140
4-Substituted 1,5-diarylpyrazoles, analogues of celecoxib: synthesis and preliminary evaluation of biological properties 138
Docking-based CoMFA and CoMSIA analyses of tetrahydro-β-carboline derivatives as type-5 phosphodiesterase inhibitors. 138
Structural basis for selective PDE 3 inhibition: a docking study 134
4-Substituted 1-methyl-1H-indazoles with analgesic, antiinflammatory and antipyretic activities 133
Reaction of 2-Dimethylaminomethylene-1,3-diones with Dinucleophiles. X. Synthesis of 5-Substituted Ethyl or Methyl 4-Isoxazolecarboxylates and Methyl 4-(2,2-Dimethyl-1-oxopropyl)-5-isoxazolecarboxylate 133
New arylsparteine derivatives as positive inotropic drugs 133
Impaired Chaperone Activity of Human Heat Shock Protein Hsp27 Site-Specifically Modified with Argpyrimidine 133
CoMFA and CoMSIA analyses on 4-oxo-1,4-dihydroquinoline and 4-oxo-1,4-dihydro-1,5-, -1,6- and -1,8-naphthyridine derivatives as selective CB2 receptor agonists 133
Synthesis and Cardiotonic Activity of Novel Pyrimidine Derivatives. Crystallographic and Quantum Chemical Studies 133
In silico evaluation of human small heat shock protein HSP27: Homology modeling, mutation analyses and docking studies 131
Synthesis and preliminary biological evaluation of novel N-substituted 1-amino-3-[1-methyl(phenyl)-1H-indazol-4-yloxy]-propan-2-ols interesting as potential antiarrhythmic, local anaesthetic and analgesic agents 131
New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking 131
5-Substituted 4-Isoxazoleacetic acids with analgesic activity. 130
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 1: parallel synthesis, molecular modelling and structure-activity relationship studies on O-[2-(hetero)arylethyl]-N-phenylthiocarbamates 129
An updated topographical model for phosphodiesterase 4 (PDE4) catalytic site 127
Computational approaches for the design and chemical synthesis of novel F508del correctors in the treatment of cystic fibrosis 126
New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies 126
Synthesis, molecular modeling studies and pharmacological activity of selective A1 receptor antagonists 125
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands 125
A New Milrinone analog: Role of Binding to A1 Adenosine Receptor in its Positive Inotropic Effect on Isolated Guinea Pig and Rat Atria 125
5-Substituted 4-Isoxazolecarboxamides with platelet antiaggregating and other activities 124
Novel pyrrolocycloalkylpyrazole analogues as CB1 ligands 124
Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors 123
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 123
Synthesis and secretion of Ch 21 protein in embryonic chick skeletal tissue 121
Exploring the binding features of rimonabant analogues and acyclic CB1 antagonists: docking studies and QSAR analysis 119
Ionization Behaviour and Tautomerism-Dependent Lipophilicity of Pyridine-2(1H)-one Cardiotonic Agents 119
Docking-based 3D-QSAR analyses of pyrazole derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors. 119
Synthesis and in vitro antiplatelet activity of new 4-(1-piperazinyl)coumarin derivatives. Human platelet phosphodiesterase 3 inhibitory properties of the two most effective compounds described and molecular modeling study on their interactions with phosphodiesterase 3A catalytic site 118
null 117
Further Insights Into the Pharmacology of the Human Trace Amine-Associated Receptors: Discovery of Novel Ligands for TAAR1 by a Virtual Screening Approach. 116
null 116
Exploring the molecular basis of selectivity in A1 adenosine receptors antagonist: a case study 116
Unprecedented one-pot stereoselective synthesis of Knoevenagel-type derivatives via in situ condensation of N-methyleniminium salts of ethylenethiourea and ethyleneurea with active methylene reagents 115
Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1-H-pyrazolo[3,4-d]pyrimidines 4-amino substituted and their biological evaluation 114
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors. 114
Insights into Structure-Activity Relationships from Lipophilicity Profiles of Pyridin-2(1H)-one Analogs of the Cardiotonic Agent Milrinone 113
Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells 113
Synthesis and Pharmacological Characterization of Functionalized 2-Pyridones Structurally Related to the Cardiotonic Agent Milrinone 113
2-Pyridone derivatives as inotropic agents: synthesis, pharmacology and molecular modeling study 113
New halogenated 4-aminopyrazolo[3,4-b]pyridines A1 adenosine receptor ligands 112
Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties. 112
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 112
4-Amino-pyrazolo[3,4-d]pyrimidines with antiproliferative activity on osteosarcoma cell line SaOS-2 111
Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT1A receptor agonists for CNS disorders and neuropathic pain 111
Exploring the effectiveness of novel benzimidazoles as CB2 ligands: synthesis, biological evaluation, molecular docking studies and ADMET prediction 111
Synthesis of 4-amino pyrazolo[3,4-d]pyrimidine derivatives as potential ligands for a1-adenosine receptors 110
Developmentally regulated synthesis of a low molecular weight protein (Ch 21) by differentiating chondrocytes. 110
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors: docking-based CoMFA and CoMSIA analyses 108
Clinical features and molecular modelling of novel MPZ mutations in demyelinating and axonal neuropathies 108
Structure-based Design, Parallel Synthesis, SAR and Molecular Modelling Studies of Thiocarbamates, New Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Isosteres of Phenethylthiazolylthiourea Derivatives. 106
A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists 106
Synthesis of indole imminun salts as key-intermediates in a convergent multi-step one-pot stereoselective synthesis of new potent antiproliferative Knoevenagel-type agent 105
Quinolinedione nucleus as a novel scaffold for A1 and A2A adenosine receptor antagonists. 105
Towards the identification of the cardiac cAMP phosphodiesterase receptor site 104
Development of a new topographical model for myocardial cGI-PDE catalytic site 104
Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A1-adenosine receptor (A1AR) ligands 104
Novel angular furo and thieno-quinolinones: synthesis and preliminary photobiological studies 104
Totale 13.874
Salva come PNG Salva come JPEG
Categoria #
all - tutte 63.820
article - articoli 53.054
book - libri 0
conference - conferenze 10.766
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 127.640
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.041 0 0 0 85 100 134 84 132 110 182 117 97
2021/20222.115 101 112 175 200 60 153 132 466 137 206 102 271
2022/20231.615 160 94 21 158 287 237 15 110 271 14 203 45
2023/20241.034 51 132 42 155 76 148 46 59 38 40 109 138
2024/20253.338 87 219 111 231 435 356 347 531 210 150 307 354
2025/20261.771 683 165 487 436 0 0 0 0 0 0 0 0
Totale 19.609