IRIS
FOSSA, PAOLA
 Distribuzione geografica
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Continente #
EU - Europa 19.745
AS - Asia 2.298
NA - Nord America 1.243
SA - Sud America 174
AF - Africa 32
OC - Oceania 2
Continente sconosciuto - Info sul continente non disponibili 1
Totale 23.495
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Nazione #
IT - Italia 19.335
US - Stati Uniti d'America 1.177
SG - Singapore 1.008
CN - Cina 611
VN - Vietnam 395
FR - Francia 180
HK - Hong Kong 109
BR - Brasile 105
DE - Germania 50
FI - Finlandia 50
AR - Argentina 31
JP - Giappone 31
MX - Messico 31
GB - Regno Unito 27
BD - Bangladesh 26
CA - Canada 25
IN - India 22
CH - Svizzera 20
ID - Indonesia 13
IQ - Iraq 13
NL - Olanda 13
ZA - Sudafrica 13
RU - Federazione Russa 10
IE - Irlanda 9
PH - Filippine 9
CL - Cile 8
ES - Italia 8
UA - Ucraina 8
VE - Venezuela 8
CO - Colombia 7
EC - Ecuador 7
NP - Nepal 6
TH - Thailandia 6
TR - Turchia 6
PL - Polonia 5
TW - Taiwan 5
MA - Marocco 4
PK - Pakistan 4
PY - Paraguay 4
RO - Romania 4
SE - Svezia 4
SK - Slovacchia (Repubblica Slovacca) 4
UZ - Uzbekistan 4
CR - Costa Rica 3
CZ - Repubblica Ceca 3
EG - Egitto 3
HR - Croazia 3
IL - Israele 3
JO - Giordania 3
KE - Kenya 3
KH - Cambogia 3
KR - Corea 3
SA - Arabia Saudita 3
AE - Emirati Arabi Uniti 2
AU - Australia 2
AZ - Azerbaigian 2
BO - Bolivia 2
DZ - Algeria 2
IR - Iran 2
SI - Slovenia 2
SV - El Salvador 2
TN - Tunisia 2
AL - Albania 1
AT - Austria 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BE - Belgio 1
BN - Brunei Darussalam 1
CG - Congo 1
CI - Costa d'Avorio 1
DO - Repubblica Dominicana 1
EE - Estonia 1
ET - Etiopia 1
GP - Guadalupe 1
GR - Grecia 1
GY - Guiana 1
HN - Honduras 1
HU - Ungheria 1
IS - Islanda 1
JM - Giamaica 1
KW - Kuwait 1
KZ - Kazakistan 1
LA - Repubblica Popolare Democratica del Laos 1
LT - Lituania 1
LY - Libia 1
MN - Mongolia 1
MY - Malesia 1
NG - Nigeria 1
OM - Oman 1
PE - Perù 1
PS - Palestinian Territory 1
PT - Portogallo 1
QA - Qatar 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 23.495
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Città #
Genova 11.477
Genoa 4.999
Vado Ligure 1.307
Rapallo 1.304
Singapore 538
San Jose 460
Ashburn 138
Lauterbourg 138
Ho Chi Minh City 125
Beijing 104
Hong Kong 102
Hanoi 91
New York 74
Milan 66
Council Bluffs 52
Helsinki 48
Santa Clara 44
Frankfurt am Main 42
Paris 35
Tokyo 31
Bordighera 26
Mexico City 24
Zurich 17
Haiphong 16
Los Angeles 16
Da Nang 15
São Paulo 15
Chicago 14
Tianjin 14
Dallas 13
Atlanta 11
Rome 11
Orem 10
Buffalo 9
Naples 9
San Lazzaro di Savena 9
Amsterdam 8
Boardman 8
Montreal 8
Biên Hòa 7
Can Tho 7
City of London 7
Hải Dương 7
Johannesburg 7
Cardiff 6
Des Moines 6
Dublin 6
Vancouver 6
Madrid 5
Warsaw 5
Wuhan 5
Baghdad 4
Breda 4
Cagliari 4
Chennai 4
Denver 4
Houston 4
Las Vegas 4
London 4
Nha Trang 4
Palermo 4
Phoenix 4
Phủ Lý 4
Porto Alegre 4
Prato 4
Santiago 4
Thái Nguyên 4
Bari 3
Basingstoke 3
Belo Horizonte 3
Bologna 3
Brescia 3
Buenos Aires 3
Cairo 3
Caracas 3
Catania 3
Cavernago 3
Curitiba 3
Córdoba 3
Davao City 3
Erbil 3
Guangzhou 3
Hangzhou 3
Jakarta 3
Long Xuyen 3
Memphis 3
New Delhi 3
Newark 3
Philadelphia 3
Phnom Penh 3
San Francisco 3
Seattle 3
Stockholm 3
Toronto 3
Turin 3
Vĩnh Long 3
Zagreb 3
Zhengzhou 3
Zibo 3
Amman 2
Totale 21.664
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Nome #
Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists 272
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment 257
Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis 243
Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools 232
1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: Structure-affinity/activity relationship at alpha(1)-adrenoceptor subtypes and at 5-HT(1A) receptors. 230
Molecular Chaperones in the Pathogenesis of Amyotrophic Lateral Sclerosis: The Role of HSPB1 229
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation 222
Ligand-based homology modelling of the human CB2 receptor SR144528 antagonist binding site: a computational approach to explore the 1,5-diaryl pyrazole scaffold 217
1-Phenyl-1H-Indazole derivatives with analgesic and anti-inflammatory activities. 210
Identification of a high affinity binding site for abscisic acid on human Lanthionine synthetase component C-like protein 2 210
Chemometric study and validation strategies in the structure-activity relationships of new cardiotonic agents 207
A complex phenotype in a child with familial HDL deficiency due to a novel frameshift mutation in APOA1 gene (apoA-IGuastalla) 207
Synthesis of 4-Thiophen-2’-yl-1,4-dihydropyridines as Potentiators of the CFTR Chloride Channel 204
HSPB1 and HSPB8 in inherited neuropathies: study of an Italian cohort of dHMN and CMT2 patients 203
Fast course ALS presenting with vocal cord paralysis: clinical features, bioinformatic and modelling analysis of the novel SOD1 Gly147Ser mutation. 200
3,4,5-Trisubstituted-1,2,4-4H-triazoles as WT and Y188L mutant HIV-1 non-nucleoside reverse transcriptase inhibitors: docking-based CoMFA and CoMSIA analyses. 199
A novel mutation in the N-terminal acting-binding domain of Filamin C protein causing a distal myofibrillar myopathy 193
CoMFA and CoMSIA analyses on 1,2,3,4-tetrahydropyrrolo[3,4-b]indole and benzimidazole derivatives as selective CB2 receptor agonists. 191
Affinity prediction on A1 adenosine receptor agonists: the chemometric approach 191
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles 191
Hit-to-lead optimization of mouse Trace Amine Associated Receptor 1 (mTAAR1) agonists with a diphenylmethane-scaffold: Design, Synthesis, and biological study 189
Modelling the interaction of steroid receptors with endocrine disrupting chemicals 184
Design and synthesis of 4,5,6,7‐tetrahydro‐1H‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors 184
Exploring the QSAR of pyrazolo[3,4-b]pyridine, pyrazolo[3,4-b]pyridone and pyrazolo[3,4-b]pyrimidine derivatives as antagonists for A1 adenosine receptor. 183
Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors. 183
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5 181
Synthesis, in vitro antiplatelet activity and molecular modelling studies of 10-substituted 2-(1-piperazinyl)pyrimido[1,2-a]benzimidazol-4(10H)-ones 179
Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents 178
Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors 178
Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics 172
A chemometric approach to predict A1 agonist effect of adenosine analogues 171
a1-Adrenoceptor Antagonists. Rational Design, Synthesis and Biological Evaluation of New Trazodone-like Compounds 171
2- substituted 5-acetyl-1,6-dihydro-6-oxo-3-pyridinecarboxylates: synthesis and cardiotonic activity 168
Matrine modulates HSC70 levels and rescues DF508-CFTR 168
Synthesis, molecular modeling and SAR study of novel pyrazolo[5,1-f][1,6]naphthyridines as CB2receptor antagonists/inverse agonists 167
4-Substituted 1,5-diarylpyrazoles, analogues of celecoxib: synthesis and preliminary evaluation of biological properties 166
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists 166
Activity of 3-Carbethoxyangelicin Photolysis Products 166
T137A variant is a pathogenetic SOD1 mutation associated with a slowly progressive ALS phenotype. 163
Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB1receptor ligand antagonists 163
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line 163
Docking-based CoMFA and CoMSIA analyses of tetrahydro-β-carboline derivatives as type-5 phosphodiesterase inhibitors. 161
Structural basis for selective PDE 3 inhibition: a docking study 160
Reaction of 2-Dimethylaminomethylene-1,3-diones with Dinucleophiles. X. Synthesis of 5-Substituted Ethyl or Methyl 4-Isoxazolecarboxylates and Methyl 4-(2,2-Dimethyl-1-oxopropyl)-5-isoxazolecarboxylate 160
Exploitation of a novel biosensor based on the full-length human F508del-CFTR with computational study, biochemical and biological assays for the characterization of a new Lumacaftor/Tezacaftor analogue. 160
Development of new theranostic probes targeting PSMA: computational strategies to explore ligand-target interactions 159
4-Substituted 1-methyl-1H-indazoles with analgesic, antiinflammatory and antipyretic activities 159
5-Substituted 4-Isoxazoleacetic acids with analgesic activity. 158
CoMFA and CoMSIA analyses on 4-oxo-1,4-dihydroquinoline and 4-oxo-1,4-dihydro-1,5-, -1,6- and -1,8-naphthyridine derivatives as selective CB2 receptor agonists 158
Computational approaches for the design and chemical synthesis of novel F508del correctors in the treatment of cystic fibrosis 156
5-Substituted 4-Isoxazolecarboxamides with platelet antiaggregating and other activities 155
A New Milrinone analog: Role of Binding to A1 Adenosine Receptor in its Positive Inotropic Effect on Isolated Guinea Pig and Rat Atria 155
Synthesis and preliminary biological evaluation of novel N-substituted 1-amino-3-[1-methyl(phenyl)-1H-indazol-4-yloxy]-propan-2-ols interesting as potential antiarrhythmic, local anaesthetic and analgesic agents 154
Discovery of a new series of 5-HT1A receptor agonists 154
New arylsparteine derivatives as positive inotropic drugs 153
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 1: parallel synthesis, molecular modelling and structure-activity relationship studies on O-[2-(hetero)arylethyl]-N-phenylthiocarbamates 152
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 150
Synthesis and Cardiotonic Activity of Novel Pyrimidine Derivatives. Crystallographic and Quantum Chemical Studies 150
Synthesis, molecular modeling studies and pharmacological activity of selective A1 receptor antagonists 149
An updated topographical model for phosphodiesterase 4 (PDE4) catalytic site 148
New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking 148
Impaired Chaperone Activity of Human Heat Shock Protein Hsp27 Site-Specifically Modified with Argpyrimidine 147
2-Pyridone derivatives as inotropic agents: synthesis, pharmacology and molecular modeling study 145
4-Amino-pyrazolo[3,4-d]pyrimidines with antiproliferative activity on osteosarcoma cell line SaOS-2 144
New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies 144
Unprecedented one-pot stereoselective synthesis of Knoevenagel-type derivatives via in situ condensation of N-methyleniminium salts of ethylenethiourea and ethyleneurea with active methylene reagents 142
In silico evaluation of human small heat shock protein HSP27: Homology modeling, mutation analyses and docking studies 142
Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors 142
Novel pyrrolocycloalkylpyrazole analogues as CB1 ligands 142
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands 141
New halogenated 4-aminopyrazolo[3,4-b]pyridines A1 adenosine receptor ligands 140
Exploring the molecular basis of selectivity in A1 adenosine receptors antagonist: a case study 140
Exploring the binding features of rimonabant analogues and acyclic CB1 antagonists: docking studies and QSAR analysis 138
Synthesis and secretion of Ch 21 protein in embryonic chick skeletal tissue 138
Structure-based Design, Parallel Synthesis, SAR and Molecular Modelling Studies of Thiocarbamates, New Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Isosteres of Phenethylthiazolylthiourea Derivatives. 137
Charcot-Marie-Tooth Type 2B: A New Phenotype Associated with a Novel RAB7A Mutation and Inhibited EGFR Degradation 136
Novel angular furo and thieno-quinolinones: synthesis and preliminary photobiological studies 135
Clinical features and molecular modelling of novel MPZ mutations in demyelinating and axonal neuropathies 134
Ionization Behaviour and Tautomerism-Dependent Lipophilicity of Pyridine-2(1H)-one Cardiotonic Agents 133
Docking-based 3D-QSAR analyses of pyrazole derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors. 133
Synthesis of indole imminun salts as key-intermediates in a convergent multi-step one-pot stereoselective synthesis of new potent antiproliferative Knoevenagel-type agent 131
Characterization of sulfur compounds and antiviral activity against Tomato brown rugose fruit virus (ToBRFV) of Italian “Vessalico” garlic compared to other cultivars and landrace 130
Synthesis and in vitro antiplatelet activity of new 4-(1-piperazinyl)coumarin derivatives. Human platelet phosphodiesterase 3 inhibitory properties of the two most effective compounds described and molecular modeling study on their interactions with phosphodiesterase 3A catalytic site 130
Synthesis and Pharmacological Characterization of Functionalized 2-Pyridones Structurally Related to the Cardiotonic Agent Milrinone 130
2-Pyridone derivatives as inotropic agents: synthesis, pharmacology and molecular modeling study 129
Developmentally regulated synthesis of a low molecular weight protein (Ch 21) by differentiating chondrocytes. 129
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 129
Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1-H-pyrazolo[3,4-d]pyrimidines 4-amino substituted and their biological evaluation 128
Insights into Structure-Activity Relationships from Lipophilicity Profiles of Pyridin-2(1H)-one Analogs of the Cardiotonic Agent Milrinone 128
Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells 128
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors. 127
Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT1A receptor agonists for CNS disorders and neuropathic pain 127
EARLY ONSET DEMYELINATING CHARCOT‐MARIE‐TOOTH DISEASE CAUSED BY A NOVEL IN‐FRAME ISOLEUCINE DELETION IN PERIPHERAL MYELIN PROTEIN 2 127
Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties. 125
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors: docking-based CoMFA and CoMSIA analyses 124
Further Insights Into the Pharmacology of the Human Trace Amine-Associated Receptors: Discovery of Novel Ligands for TAAR1 by a Virtual Screening Approach. 124
Exploring the effectiveness of novel benzimidazoles as CB2 ligands: synthesis, biological evaluation, molecular docking studies and ADMET prediction 123
Development of a new topographical model for myocardial cGI-PDE catalytic site 122
New insights into the binding features of f508del cftr potentiators: A molecular docking, pharmacophore mapping and qsar analysis approach 122
Synthesis of 4-amino pyrazolo[3,4-d]pyrimidine derivatives as potential ligands for a1-adenosine receptors 121
Totale 16.237
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Categoria #
all - tutte 73.991
article - articoli 60.734
book - libri 0
conference - conferenze 13.257
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 147.982
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202197 0 0 0 0 0 0 0 0 0 0 0 97
2021/20222.115 101 112 175 200 60 153 132 466 137 206 102 271
2022/20231.615 160 94 21 158 287 237 15 110 271 14 203 45
2023/20241.034 51 132 42 155 76 148 46 59 38 40 109 138
2024/20253.338 87 219 111 231 435 356 347 531 210 150 307 354
2025/20266.132 683 165 487 483 901 559 1.029 345 441 639 323 77
Totale 23.970