IRIS
FOSSA, PAOLA
 Distribuzione geografica
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Continente #
EU - Europa 19.905
AS - Asia 2.428
NA - Nord America 1.926
Continente sconosciuto - Info sul continente non disponibili 477
SA - Sud America 205
AF - Africa 32
OC - Oceania 4
Totale 24.977
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Nazione #
IT - Italia 19.471
US - Stati Uniti d'America 1.819
SG - Singapore 1.011
CN - Cina 622
VN - Vietnam 401
FR - Francia 183
BD - Bangladesh 122
BR - Brasile 117
HK - Hong Kong 109
DE - Germania 53
FI - Finlandia 50
CA - Canada 39
AR - Argentina 37
JP - Giappone 31
MX - Messico 31
GB - Regno Unito 28
IN - India 22
CH - Svizzera 21
ID - Indonesia 14
ES - Italia 13
IQ - Iraq 13
NL - Olanda 13
ZA - Sudafrica 13
EC - Ecuador 11
RU - Federazione Russa 11
VE - Venezuela 11
CO - Colombia 10
CR - Costa Rica 10
PH - Filippine 10
PK - Pakistan 10
CL - Cile 9
IE - Irlanda 9
UA - Ucraina 8
AE - Emirati Arabi Uniti 7
TR - Turchia 7
JM - Giamaica 6
NP - Nepal 6
PL - Polonia 6
TH - Thailandia 6
SE - Svezia 5
SK - Slovacchia (Repubblica Slovacca) 5
TT - Trinidad e Tobago 5
TW - Taiwan 5
AT - Austria 4
AU - Australia 4
MA - Marocco 4
PY - Paraguay 4
RO - Romania 4
UZ - Uzbekistan 4
CZ - Repubblica Ceca 3
EG - Egitto 3
HN - Honduras 3
HR - Croazia 3
IL - Israele 3
JO - Giordania 3
KE - Kenya 3
KH - Cambogia 3
KR - Corea 3
NO - Norvegia 3
PR - Porto Rico 3
SA - Arabia Saudita 3
AZ - Azerbaigian 2
BO - Bolivia 2
DO - Repubblica Dominicana 2
DZ - Algeria 2
IR - Iran 2
PE - Perù 2
SI - Slovenia 2
SV - El Salvador 2
TN - Tunisia 2
AL - Albania 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BE - Belgio 1
BN - Brunei Darussalam 1
CG - Congo 1
CI - Costa d'Avorio 1
DK - Danimarca 1
EE - Estonia 1
ET - Etiopia 1
GP - Guadalupe 1
GR - Grecia 1
GT - Guatemala 1
GY - Guiana 1
HU - Ungheria 1
IS - Islanda 1
KW - Kuwait 1
KZ - Kazakistan 1
LA - Repubblica Popolare Democratica del Laos 1
LT - Lituania 1
LY - Libia 1
MF - Saint Martin 1
MN - Mongolia 1
MQ - Martinica 1
MY - Malesia 1
NG - Nigeria 1
NI - Nicaragua 1
OM - Oman 1
PS - Palestinian Territory 1
PT - Portogallo 1
Totale 24.498
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Città #
Genova 11.477
Genoa 5.017
Vado Ligure 1.307
Rapallo 1.304
Singapore 539
San Jose 515
Ashburn 207
Lauterbourg 138
Ho Chi Minh City 125
Beijing 111
Hong Kong 102
Hanoi 93
New York 83
Milan 77
Council Bluffs 54
Santa Clara 53
Helsinki 48
Frankfurt am Main 42
Paris 35
Chicago 33
Tokyo 31
Los Angeles 28
Bordighera 27
Mexico City 24
Dallas 23
Atlanta 17
Rome 17
Zurich 17
Da Nang 16
Haiphong 16
Naples 16
São Paulo 16
Houston 15
Buffalo 14
Tianjin 14
Miami 12
Philadelphia 12
Carmichael 10
Orem 10
Montreal 9
Phoenix 9
San Lazzaro di Savena 9
Amsterdam 8
Boardman 8
San José 8
Biên Hòa 7
Can Tho 7
City of London 7
Davenport 7
Des Moines 7
Hải Dương 7
Johannesburg 7
Palermo 7
Smithtown 7
Turin 7
Boston 6
Cardiff 6
Dublin 6
Karachi 6
Las Vegas 6
London 6
Monroe 6
Toronto 6
Vancouver 6
Warsaw 6
Bologna 5
Brescia 5
Cagliari 5
Catania 5
Denver 5
Hinesville 5
Madrid 5
Memphis 5
Newark 5
Odessa 5
Richmond 5
Tinley Park 5
Wuhan 5
Alexandria 4
Baghdad 4
Bari 4
Breda 4
Brooklyn 4
Caracas 4
Chennai 4
Curitiba 4
Detroit 4
Grants Pass 4
Guayaquil 4
Kingston 4
Monument 4
Munich 4
Nha Trang 4
Phủ Lý 4
Porto Alegre 4
Prato 4
Queens 4
San Diego 4
San Francisco 4
Santiago 4
Totale 22.029
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Nome #
Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists 276
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment 260
Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis 248
Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools 243
Molecular Chaperones in the Pathogenesis of Amyotrophic Lateral Sclerosis: The Role of HSPB1 234
1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: Structure-affinity/activity relationship at alpha(1)-adrenoceptor subtypes and at 5-HT(1A) receptors. 234
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation 227
Ligand-based homology modelling of the human CB2 receptor SR144528 antagonist binding site: a computational approach to explore the 1,5-diaryl pyrazole scaffold 222
A complex phenotype in a child with familial HDL deficiency due to a novel frameshift mutation in APOA1 gene (apoA-IGuastalla) 215
Identification of a high affinity binding site for abscisic acid on human Lanthionine synthetase component C-like protein 2 215
1-Phenyl-1H-Indazole derivatives with analgesic and anti-inflammatory activities. 214
Chemometric study and validation strategies in the structure-activity relationships of new cardiotonic agents 212
HSPB1 and HSPB8 in inherited neuropathies: study of an Italian cohort of dHMN and CMT2 patients 208
Synthesis of 4-Thiophen-2’-yl-1,4-dihydropyridines as Potentiators of the CFTR Chloride Channel 208
3,4,5-Trisubstituted-1,2,4-4H-triazoles as WT and Y188L mutant HIV-1 non-nucleoside reverse transcriptase inhibitors: docking-based CoMFA and CoMSIA analyses. 205
Fast course ALS presenting with vocal cord paralysis: clinical features, bioinformatic and modelling analysis of the novel SOD1 Gly147Ser mutation. 203
A novel mutation in the N-terminal acting-binding domain of Filamin C protein causing a distal myofibrillar myopathy 197
CoMFA and CoMSIA analyses on 1,2,3,4-tetrahydropyrrolo[3,4-b]indole and benzimidazole derivatives as selective CB2 receptor agonists. 196
Affinity prediction on A1 adenosine receptor agonists: the chemometric approach 195
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles 193
Hit-to-lead optimization of mouse Trace Amine Associated Receptor 1 (mTAAR1) agonists with a diphenylmethane-scaffold: Design, Synthesis, and biological study 193
Design and synthesis of 4,5,6,7‐tetrahydro‐1H‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors 191
Modelling the interaction of steroid receptors with endocrine disrupting chemicals 190
Exploring the QSAR of pyrazolo[3,4-b]pyridine, pyrazolo[3,4-b]pyridone and pyrazolo[3,4-b]pyrimidine derivatives as antagonists for A1 adenosine receptor. 188
Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors 188
Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors. 187
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5 185
Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents 182
Synthesis, in vitro antiplatelet activity and molecular modelling studies of 10-substituted 2-(1-piperazinyl)pyrimido[1,2-a]benzimidazol-4(10H)-ones 182
a1-Adrenoceptor Antagonists. Rational Design, Synthesis and Biological Evaluation of New Trazodone-like Compounds 178
Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics 178
A chemometric approach to predict A1 agonist effect of adenosine analogues 177
2- substituted 5-acetyl-1,6-dihydro-6-oxo-3-pyridinecarboxylates: synthesis and cardiotonic activity 172
4-Substituted 1,5-diarylpyrazoles, analogues of celecoxib: synthesis and preliminary evaluation of biological properties 171
Synthesis, molecular modeling and SAR study of novel pyrazolo[5,1-f][1,6]naphthyridines as CB2receptor antagonists/inverse agonists 171
Matrine modulates HSC70 levels and rescues DF508-CFTR 170
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists 170
Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB1receptor ligand antagonists 169
Activity of 3-Carbethoxyangelicin Photolysis Products 169
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line 168
T137A variant is a pathogenetic SOD1 mutation associated with a slowly progressive ALS phenotype. 167
Development of new theranostic probes targeting PSMA: computational strategies to explore ligand-target interactions 166
Structural basis for selective PDE 3 inhibition: a docking study 166
4-Substituted 1-methyl-1H-indazoles with analgesic, antiinflammatory and antipyretic activities 166
Reaction of 2-Dimethylaminomethylene-1,3-diones with Dinucleophiles. X. Synthesis of 5-Substituted Ethyl or Methyl 4-Isoxazolecarboxylates and Methyl 4-(2,2-Dimethyl-1-oxopropyl)-5-isoxazolecarboxylate 166
Docking-based CoMFA and CoMSIA analyses of tetrahydro-β-carboline derivatives as type-5 phosphodiesterase inhibitors. 163
5-Substituted 4-Isoxazoleacetic acids with analgesic activity. 163
Exploitation of a novel biosensor based on the full-length human F508del-CFTR with computational study, biochemical and biological assays for the characterization of a new Lumacaftor/Tezacaftor analogue. 161
CoMFA and CoMSIA analyses on 4-oxo-1,4-dihydroquinoline and 4-oxo-1,4-dihydro-1,5-, -1,6- and -1,8-naphthyridine derivatives as selective CB2 receptor agonists 160
A New Milrinone analog: Role of Binding to A1 Adenosine Receptor in its Positive Inotropic Effect on Isolated Guinea Pig and Rat Atria 159
Discovery of a new series of 5-HT1A receptor agonists 158
Impaired Chaperone Activity of Human Heat Shock Protein Hsp27 Site-Specifically Modified with Argpyrimidine 157
Computational approaches for the design and chemical synthesis of novel F508del correctors in the treatment of cystic fibrosis 157
5-Substituted 4-Isoxazolecarboxamides with platelet antiaggregating and other activities 156
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 1: parallel synthesis, molecular modelling and structure-activity relationship studies on O-[2-(hetero)arylethyl]-N-phenylthiocarbamates 155
New arylsparteine derivatives as positive inotropic drugs 155
Synthesis and preliminary biological evaluation of novel N-substituted 1-amino-3-[1-methyl(phenyl)-1H-indazol-4-yloxy]-propan-2-ols interesting as potential antiarrhythmic, local anaesthetic and analgesic agents 155
Rescuing defective CFTR applying a drug repositioning strategy based on computational studies, surface plasmon resonance and cell-based assays 155
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 154
Synthesis and Cardiotonic Activity of Novel Pyrimidine Derivatives. Crystallographic and Quantum Chemical Studies 154
An updated topographical model for phosphodiesterase 4 (PDE4) catalytic site 153
Synthesis, molecular modeling studies and pharmacological activity of selective A1 receptor antagonists 151
2-Pyridone derivatives as inotropic agents: synthesis, pharmacology and molecular modeling study 151
New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies 150
New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking 150
Novel pyrrolocycloalkylpyrazole analogues as CB1 ligands 149
Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors 148
4-Amino-pyrazolo[3,4-d]pyrimidines with antiproliferative activity on osteosarcoma cell line SaOS-2 147
Unprecedented one-pot stereoselective synthesis of Knoevenagel-type derivatives via in situ condensation of N-methyleniminium salts of ethylenethiourea and ethyleneurea with active methylene reagents 144
In silico evaluation of human small heat shock protein HSP27: Homology modeling, mutation analyses and docking studies 144
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands 143
Synthesis and secretion of Ch 21 protein in embryonic chick skeletal tissue 143
Exploring the molecular basis of selectivity in A1 adenosine receptors antagonist: a case study 143
Structure-based Design, Parallel Synthesis, SAR and Molecular Modelling Studies of Thiocarbamates, New Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Isosteres of Phenethylthiazolylthiourea Derivatives. 142
Exploring the binding features of rimonabant analogues and acyclic CB1 antagonists: docking studies and QSAR analysis 142
New halogenated 4-aminopyrazolo[3,4-b]pyridines A1 adenosine receptor ligands 142
Charcot-Marie-Tooth Type 2B: A New Phenotype Associated with a Novel RAB7A Mutation and Inhibited EGFR Degradation 140
Clinical features and molecular modelling of novel MPZ mutations in demyelinating and axonal neuropathies 138
Novel angular furo and thieno-quinolinones: synthesis and preliminary photobiological studies 138
Docking-based 3D-QSAR analyses of pyrazole derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors. 137
Synthesis of indole imminun salts as key-intermediates in a convergent multi-step one-pot stereoselective synthesis of new potent antiproliferative Knoevenagel-type agent 136
2-Pyridone derivatives as inotropic agents: synthesis, pharmacology and molecular modeling study 136
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 136
Ionization Behaviour and Tautomerism-Dependent Lipophilicity of Pyridine-2(1H)-one Cardiotonic Agents 135
Synthesis and Pharmacological Characterization of Functionalized 2-Pyridones Structurally Related to the Cardiotonic Agent Milrinone 135
Developmentally regulated synthesis of a low molecular weight protein (Ch 21) by differentiating chondrocytes. 135
Synthesis and in vitro antiplatelet activity of new 4-(1-piperazinyl)coumarin derivatives. Human platelet phosphodiesterase 3 inhibitory properties of the two most effective compounds described and molecular modeling study on their interactions with phosphodiesterase 3A catalytic site 134
Virtual Drug Repositioning as a Tool to Identify Natural Small Molecules That Synergize with Lumacaftor in F508del-CFTR Binding and Rescuing 133
Characterization of sulfur compounds and antiviral activity against Tomato brown rugose fruit virus (ToBRFV) of Italian “Vessalico” garlic compared to other cultivars and landrace 132
Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells 132
Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1-H-pyrazolo[3,4-d]pyrimidines 4-amino substituted and their biological evaluation 131
Insights into Structure-Activity Relationships from Lipophilicity Profiles of Pyridin-2(1H)-one Analogs of the Cardiotonic Agent Milrinone 130
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors. 130
Autoxidation Products of the Methanolic Extract of the Leaves of Combretum micranthum Exert Antiviral Activity against Tomato Brown Rugose Fruit Virus (ToBRFV) 130
Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties. 129
Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT1A receptor agonists for CNS disorders and neuropathic pain 129
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors: docking-based CoMFA and CoMSIA analyses 127
EARLY ONSET DEMYELINATING CHARCOT‐MARIE‐TOOTH DISEASE CAUSED BY A NOVEL IN‐FRAME ISOLEUCINE DELETION IN PERIPHERAL MYELIN PROTEIN 2 127
Further Insights Into the Pharmacology of the Human Trace Amine-Associated Receptors: Discovery of Novel Ligands for TAAR1 by a Virtual Screening Approach. 126
Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A1-adenosine receptor (A1AR) ligands 126
Totale 16.701
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Categoria #
all - tutte 78.351
article - articoli 63.973
book - libri 0
conference - conferenze 14.378
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 156.702
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20222.115 101 112 175 200 60 153 132 466 137 206 102 271
2022/20231.615 160 94 21 158 287 237 15 110 271 14 203 45
2023/20241.034 51 132 42 155 76 148 46 59 38 40 109 138
2024/20253.338 87 219 111 231 435 356 347 531 210 150 307 354
2025/20266.400 683 165 487 483 901 559 1.029 345 441 639 323 345
2026/2027739 739 0 0 0 0 0 0 0 0 0 0 0
Totale 24.977