IRIS
SCHENONE, SILVIA
 Distribuzione geografica
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Continente #
EU - Europa 30.837
NA - Nord America 3.970
AS - Asia 3.941
Continente sconosciuto - Info sul continente non disponibili 596
SA - Sud America 349
AF - Africa 57
OC - Oceania 4
Totale 39.754
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Nazione #
IT - Italia 30.210
US - Stati Uniti d'America 3.753
SG - Singapore 1.604
CN - Cina 1.021
VN - Vietnam 602
FR - Francia 275
BD - Bangladesh 200
BR - Brasile 198
HK - Hong Kong 184
DE - Germania 89
JP - Giappone 88
CA - Canada 73
FI - Finlandia 64
AR - Argentina 58
MX - Messico 47
IN - India 43
GB - Regno Unito 42
JM - Giamaica 30
NL - Olanda 30
ES - Italia 29
ID - Indonesia 27
EC - Ecuador 24
CO - Colombia 19
TW - Taiwan 19
PH - Filippine 18
VE - Venezuela 18
CH - Svizzera 15
CL - Cile 14
KR - Corea 14
PK - Pakistan 14
CR - Costa Rica 12
IQ - Iraq 12
PL - Polonia 11
RU - Federazione Russa 11
SA - Arabia Saudita 11
TH - Thailandia 10
TR - Turchia 10
IE - Irlanda 9
MY - Malesia 9
AE - Emirati Arabi Uniti 8
GT - Guatemala 8
KE - Kenya 8
PY - Paraguay 8
DZ - Algeria 7
HN - Honduras 7
JO - Giordania 7
PT - Portogallo 7
SV - El Salvador 7
ZA - Sudafrica 7
AZ - Azerbaigian 6
ET - Etiopia 6
GR - Grecia 6
NP - Nepal 6
PR - Porto Rico 6
SE - Svezia 6
TT - Trinidad e Tobago 6
UA - Ucraina 6
AT - Austria 5
PA - Panama 5
SC - Seychelles 5
AU - Australia 4
EG - Egitto 4
HR - Croazia 4
IL - Israele 4
PE - Perù 4
TN - Tunisia 4
UZ - Uzbekistan 4
AM - Armenia 3
BO - Bolivia 3
BY - Bielorussia 3
CI - Costa d'Avorio 3
DO - Repubblica Dominicana 3
KG - Kirghizistan 3
MA - Marocco 3
NI - Nicaragua 3
SN - Senegal 3
AL - Albania 2
BB - Barbados 2
CY - Cipro 2
CZ - Repubblica Ceca 2
HU - Ungheria 2
IR - Iran 2
KH - Cambogia 2
KW - Kuwait 2
LC - Santa Lucia 2
RO - Romania 2
SI - Slovenia 2
UY - Uruguay 2
BF - Burkina Faso 1
BG - Bulgaria 1
BH - Bahrain 1
BM - Bermuda 1
BZ - Belize 1
CU - Cuba 1
DK - Danimarca 1
EE - Estonia 1
GH - Ghana 1
GY - Guiana 1
HT - Haiti 1
KZ - Kazakistan 1
Totale 39.145
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Città #
Genova 17.675
Genoa 7.595
Rapallo 2.357
Vado Ligure 2.117
San Jose 1.018
Singapore 805
Ashburn 415
Lauterbourg 234
Beijing 175
Council Bluffs 175
Ho Chi Minh City 169
New York 160
Hong Kong 147
Hanoi 136
Milan 90
Santa Clara 85
Frankfurt am Main 79
Los Angeles 77
Tokyo 76
Chicago 73
Helsinki 62
Rome 48
Dallas 37
Phoenix 35
Bordighera 33
Haiphong 32
Mexico City 30
Naples 28
Boardman 27
Da Nang 27
São Paulo 26
Amsterdam 24
Paris 24
Tianjin 23
Atlanta 22
Buffalo 22
Houston 19
Brooklyn 18
Miami 18
Kingston 17
Montreal 16
Biên Hòa 15
Orem 15
Philadelphia 15
San Francisco 15
Las Vegas 14
Seattle 14
Memphis 13
St Louis 12
Denver 11
Guayaquil 11
Newark 11
Zurich 11
Brasília 10
Cagliari 10
Jakarta 10
San José 10
Buenos Aires 9
City of London 9
Columbus 9
Dublin 9
Montgomery 9
Palermo 9
Quito 9
Santiago 9
Turin 9
Washington 9
Baltimore 8
Bogotá 8
Can Tho 8
Cleveland 8
Detroit 8
Florence 8
Guatemala City 8
Jeddah 8
Karachi 8
Louisville 8
Madrid 8
Milwaukee 8
Queens 8
Amman 7
Boston 7
Caracas 7
Cardiff 7
Charlotte 7
Des Moines 7
Jacksonville 7
London 7
Nairobi 7
Phủ Lý 7
Tampa 7
Addis Ababa 6
Athens 6
Augusta 6
Baghdad 6
Baku 6
Davenport 6
Dhaka 6
Guangzhou 6
Hải Dương 6
Totale 34.768
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Nome #
Antiproliferative and pro-apoptotic effects afforded by novel Src-kinase inhibitors in human neuroblastoma cells. 211
SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW 4-AMINO-PYRAZOLO[3,4-d]PYRIMIDINES AS POTENTIAL SRC KINASE INHIBITORS 210
Analogs, formulations and derivatives of imatinib: A patent review 209
A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. 206
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors 203
Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors 202
Affinity prediction on A1 adenosine receptor agonists: the chemometric approach 199
ATP-competitive inhibitors of mTOR: an update. 198
Click Chemistry, A Potent Tool in Medicinal Sciences 198
N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds. 197
The search for a common structural moiety among selected pharmacological correctors of the mutant CFTR chloride channel. 196
Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives 195
Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers. 194
4-Amine-substituted derivatives of pyrazolo[3,4-d]pyrimidine and their preparation, pharmaceutical compositions, and use as antitumor agents 192
An update on dual Src/Abl inhibitors 191
Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors 190
A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant 188
Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma 188
State-of-the-art Review on the Antiparasitic Activity of Benzimidazole-based Derivatives: Facing Malaria, Leishmaniasis, and Trypanosomiasis 187
3-Arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones as antiinflammatory and analgesic agents 187
1-Acyl-, 3-acyl- and 1,3-diacyl-3-furfuryl-1-phenylthioureas with platelet antiaggregating and other activities. 187
Bcr-Abl tyrosine kinase inhibitors: A patent review 185
Synthesis and biological evaluation of neutrophilic inflammation inhibitors 185
Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma. 184
2-Aryl-3-phenylamino-4,5-dihydro-2h-benz[g]indazoles with analgesic activity 183
A chemometric approach to predict A1 agonist effect of adenosine analogues 182
"One-pot" synthesis of N-acyl-N-phenylcarbamate derivatives endowed with anti-HIV and/or antiproliferative activities 181
Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells. 181
Fyn kinase in brain diseases and cancer: the search for inhibitors. 179
Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines 177
Pyrrolo[2,3-d]pyrimidines as kinase inhibitors 172
3,3-disubstituted 1-acyl-1-phenylthioureas with platelet antiaggregating and other activities 170
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line 170
3-Cyano-4,6-diphenyl-pyridine amino acid derivatives active as influenza A polymerase inhibitors 167
Synthesis and biological evaluation of N-pyrazolyl-N'-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis 166
2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: New potent inhibitors of fMLP-induced neutrophil chemotaxis 166
The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme 165
A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. 164
Derivati dell'1,3-benzodiossolo, potenziali inibitori delle PDE5 162
2-Amino/Azido/Hydrazino-5-alkoxy-5H-[1]benzopyrano[4,3-d]pyrimidines: Synthesis and Pharmacological Evaluation 161
3-(Arylamino)-6,7-dihydro-6-methylpyrano[4,3-c]pyrazol-4(1H or 2H)-ones with antipyretic, analgesic, antiarrhythmic, hypotensive and other activities. 160
2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles with antiarrhythmic and local anaesthetic activities 160
A1 receptors ligands: past, present and future trends. 158
Last findings on dual inhibitors of abl and SRC tyrosine-kinases. 158
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 158
Antiinflammatory agents: new series of N-substituted amino acids with complex pyrimidine structures endowed with antiphlogistic activity 158
2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors. 157
Src kinase inhibitors: an update on patented compounds 157
Matrine in association with FD‑2 stimulates F508del‑cystic fibrosis transmembrane conductance regulator activity in the presence of corrector VX809 157
Synthetic SRC-kinase domain inhibitors and their structural requirements 156
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors. 156
N-Acyl-N-phenyl ureas of piperidine and substituted piperidines endowed with antiinflammatory and antiproliferative activities 156
Water Solubility Enhancement of Pyrazolo[3,4-d]pyrimidine Derivatives via Miniaturized Polymer–Drug Microarrays 156
F508del-CFTR rescue: a matter of cell stress response. 155
Synthesis and pharmacological evaluation of 5H-[1]benzopyrano[4,3-d]pyrimidines effective as antiplatelet/analgesic agents 155
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 154
Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction 154
Recent Studies on Ponatinib in Cancers Other Than Chronic Myeloid Leukemia 154
Pyrazolo-pyrimidine-derived c-Src inhibitor reduces angiogenesis and survival of squamous carcinoma cells by suppressing vascular endothelial growth factor production and signaling. 153
Synthesis, molecular modeling studies and pharmacological activity of selective A1 receptor antagonists 153
Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents. 153
Biologically driven synthesis of pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors: an old scaffold as a new tool for medicinal chemistry and chemical biology studies 153
SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: A new route of epigenomic regulation 153
New pyrazolo-[3,4-d]-pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cells. 152
4-Amino-pyrazolo[3,4-d]pyrimidines with antiproliferative activity on osteosarcoma cell line SaOS-2 152
Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists. 152
An Update on JAK Inhibitors 152
Phenylhydrazones as Correctors of a Mutant Cystic Fibrosis Transmembrane Conductance Regulator 151
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data. 149
Hit identification and biological evaluation of anticancer pyrazolopyrimidines endowed with anti-inflammatory activity 148
Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment 148
Exploring SAR of a new generation of pyrazolo[3,4-d]pyrimidines as Fyn tyrosine kinase inhibitors 148
2,3-Dihydro-1H-imidazo[1,2-b]pyrazole derivatives as potential neutrophils functions inhibitors 147
Synthesis of 6-thiosubstituted 5-ethoxycarbonyl-1,3-diphenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-ones, 6-substituted 5-hydroxy-1,3-diphenyl-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-ones and their esters with local anesthetic, antiarrhythmic, antiinflammatory and analgesic activities. 147
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation. 147
Unprecedented one-pot stereoselective synthesis of Knoevenagel-type derivatives via in situ condensation of N-methyleniminium salts of ethylenethiourea and ethyleneurea with active methylene reagents 146
Insight into the allosteric inhibition of Abl kinase 146
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant. 146
Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors 146
Synthesis of new piperazine-pyridazinone derivatives and their binding affinity toward alpha1-, alpha2-adrenergic and 5-HT1A serotoninergic receptors. 146
Exploring the molecular basis of selectivity in A1 adenosine receptors antagonist: a case study 146
New halogenated 4-aminopyrazolo[3,4-b]pyridines A1 adenosine receptor ligands 145
Synthesis, Biological Activity, and ADME Properties of Novel S-DABOs/N-DABOs as HIV Reverse Transcriptase Inhibitors 145
2-Aryl-6-methyl-3-phenylamino-6,7-dihydropyrano[4,3-c]pyrazol-4(2H)-ones with analgesic activity. 145
New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization 145
6-Substituted pyrazolo[3,4-d]pyrimidines: new promising compounds in the fight against Neuroblastoma 145
Structure-based Design, Parallel Synthesis, SAR and Molecular Modelling Studies of Thiocarbamates, New Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Isosteres of Phenethylthiazolylthiourea Derivatives. 144
Synthesis of a small library of potential SGK1 inihibitors 144
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells 143
3,5-Diphenyl-1H-pyrazole derivatives. XII. N-substituted 4-amino-1-(2-hydroxy- or 2-alkylaminoethyl)-3,5-diphenyl-1H-pyrazoles with local anesthetic, analgesic and platelet antiaggregating activities. 143
Antiangiogenic agents: an update on small molecule VEGFR inhibitors 142
Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition. 142
Preparation of new 5-aroylamino substituted 3-nicotinoyl/isonicotinoyl-1,3,4-thiadiazol-2(3H)-ones with anti-inflammatory activity 141
Allosteric inhibitors of Bcr-Abl: towards novel myristate-pocket binders. 141
In silico identification and biological evaluation of novel selective serum/glucocorticoid-inducible kinase 1 inhibitors based on the pyrazolo-pyrimidine scaffold 141
Pyrazolo[3,4-d]pyrimidine active on neuroblastoma cells 141
Combining repositioning and de novo synthesis of pyrazolo[3,4-d]pyrimidines to discover potent SIRT-2 inhibitors 140
5-alkoxy-2-hydrazino and 5-methoxy-2-amino-5H-[1]benzopyrano[4,3-d]pyrimidines: synthesis and pharmacological activity 140
A Pyrazolo[3,4-d]pyrimidine compound inhibits Fyn phosphorylation and induces apoptosis in natural killer cell leukemia 140
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 140
Totale 16.388
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Categoria #
all - tutte 128.752
article - articoli 96.147
book - libri 0
conference - conferenze 28.760
curatela - curatele 0
other - altro 0
patent - brevetti 2.678
selected - selezionate 0
volume - volumi 1.167
Totale 257.504
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20222.923 0 0 291 409 95 221 233 766 158 222 135 393
2022/20232.864 290 171 31 321 450 512 0 206 527 25 286 45
2023/20241.626 70 265 47 186 121 193 98 62 103 52 133 296
2024/20254.951 87 384 173 327 777 581 432 679 181 288 415 627
2025/202610.199 983 254 933 770 1.265 1.022 1.594 579 705 1.060 515 519
2026/20272.026 1.007 408 611 0 0 0 0 0 0 0 0 0
Totale 39.754