IRIS
MUSUMECI, FRANCESCA MICHELA
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
EU - Europa 9.202
AS - Asia 1.481
NA - Nord America 721
SA - Sud America 89
AF - Africa 22
OC - Oceania 1
Totale 11.516
Salva come PNG Salva come JPEG
Nazione #
IT - Italia 8.970
US - Stati Uniti d'America 693
SG - Singapore 594
CN - Cina 386
VN - Vietnam 266
FR - Francia 83
HK - Hong Kong 82
JP - Giappone 54
BR - Brasile 47
DE - Germania 32
FI - Finlandia 26
GB - Regno Unito 21
AR - Argentina 19
TW - Taiwan 18
MX - Messico 17
ES - Italia 16
IN - India 13
BD - Bangladesh 12
KR - Corea 11
NL - Olanda 10
CL - Cile 7
RU - Federazione Russa 7
CH - Svizzera 6
GR - Grecia 6
IQ - Iraq 6
ID - Indonesia 5
PH - Filippine 5
SA - Arabia Saudita 5
CA - Canada 4
NP - Nepal 4
PT - Portogallo 4
TR - Turchia 4
ZA - Sudafrica 4
CO - Colombia 3
DZ - Algeria 3
EC - Ecuador 3
ET - Etiopia 3
IE - Irlanda 3
PA - Panama 3
PL - Polonia 3
PY - Paraguay 3
SN - Senegal 3
TH - Thailandia 3
VE - Venezuela 3
AZ - Azerbaigian 2
BY - Bielorussia 2
EG - Egitto 2
HU - Ungheria 2
JM - Giamaica 2
KE - Kenya 2
MA - Marocco 2
PE - Perù 2
PK - Pakistan 2
SE - Svezia 2
SI - Slovenia 2
UA - Ucraina 2
UZ - Uzbekistan 2
AL - Albania 1
AM - Armenia 1
AT - Austria 1
AU - Australia 1
BB - Barbados 1
BG - Bulgaria 1
CY - Cipro 1
CZ - Repubblica Ceca 1
GY - Guiana 1
IL - Israele 1
JO - Giordania 1
KG - Kirghizistan 1
LV - Lettonia 1
LY - Libia 1
MN - Mongolia 1
MY - Malesia 1
NE - Niger 1
NI - Nicaragua 1
TN - Tunisia 1
UY - Uruguay 1
Totale 11.516
Salva come PNG Salva come JPEG
Città #
Genova 4.326
Genoa 2.971
Rapallo 812
Vado Ligure 769
Singapore 291
San Jose 247
Council Bluffs 113
Ashburn 92
Ho Chi Minh City 78
Lauterbourg 78
Hanoi 72
Beijing 55
Hong Kong 52
Tokyo 46
New York 36
Frankfurt am Main 30
Helsinki 25
Los Angeles 17
Santa Clara 17
Bordighera 14
Da Nang 13
Mexico City 12
Milan 12
Haiphong 11
St Louis 10
Chicago 8
Amsterdam 7
Biên Hòa 7
Orem 7
Tianjin 7
Athens 6
São Paulo 6
City of London 5
Quảng Ngãi 5
Santiago 5
Seattle 5
Taipei 5
Zurich 5
Baghdad 4
Buffalo 4
Dhaka 4
Dobong-gu 4
Hải Dương 4
Madrid 4
Paris 4
Phoenix 4
Phủ Lý 4
Seoul 4
Thái Bình 4
Tukwila 4
Turin 4
Addis Ababa 3
Alessandria 3
Dakar 3
Dallas 3
Des Moines 3
Draper 3
Dublin 3
Ha Kwai Chung 3
Hangzhou 3
Hyderabad 3
Johannesburg 3
Naples 3
New Delhi 3
Panama City 3
Pisa 3
Richardson 3
Rome 3
Salt Lake City 3
Taichung 3
Andria 2
Asunción 2
Atlanta 2
Baku 2
Bangkok 2
Basingstoke 2
Brooklyn 2
Buenos Aires 2
Bình Dương 2
Bắc Ninh 2
Can Tho 2
Carapicuíba 2
Cardiff 2
Casalnuovo di Napoli 2
Chai Wan 2
Cheung Sha Lan 2
Covilha 2
Dammam 2
Guarulhos 2
Jakarta 2
Jeddah 2
Kunming 2
Lahore 2
Lisbon 2
Ljubljana 2
London 2
Manchester 2
Manila 2
Nha Trang 2
Ninh Bình 2
Totale 10.446
Salva come PNG Salva come JPEG
Nome #
Analogs, formulations and derivatives of imatinib: A patent review 200
A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. 194
SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW 4-AMINO-PYRAZOLO[3,4-d]PYRIMIDINES AS POTENTIAL SRC KINASE INHIBITORS 192
ATP-competitive inhibitors of mTOR: an update. 188
Click Chemistry, A Potent Tool in Medicinal Sciences 185
A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant 180
Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma 180
An update on dual Src/Abl inhibitors 178
Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma. 177
Fyn kinase in brain diseases and cancer: the search for inhibitors. 175
Bcr-Abl tyrosine kinase inhibitors: A patent review 169
The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme 159
3-Cyano-4,6-diphenyl-pyridine amino acid derivatives active as influenza A polymerase inhibitors 152
Recent Studies on Ponatinib in Cancers Other Than Chronic Myeloid Leukemia 149
A1 receptors ligands: past, present and future trends. 148
Src kinase inhibitors: an update on patented compounds 147
Matrine in association with FD‑2 stimulates F508del‑cystic fibrosis transmembrane conductance regulator activity in the presence of corrector VX809 146
Biologically driven synthesis of pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors: an old scaffold as a new tool for medicinal chemistry and chemical biology studies 145
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 144
Water Solubility Enhancement of Pyrazolo[3,4-d]pyrimidine Derivatives via Miniaturized Polymer–Drug Microarrays 142
Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment 142
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant. 141
An Update on JAK Inhibitors 141
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation. 141
Pyrrolo[2,3-d]pyrimidines as kinase inhibitors 139
In silico identification and biological evaluation of novel selective serum/glucocorticoid-inducible kinase 1 inhibitors based on the pyrazolo-pyrimidine scaffold 137
Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction 136
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells 136
Prodrugs of Pyrazolo[3,4-d]pyrimidines: From Library Synthesis to Evaluation as Potential Anticancer Agents in an Orthotopic Glioblastoma Model 135
Exploring SAR of a new generation of pyrazolo[3,4-d]pyrimidines as Fyn tyrosine kinase inhibitors 135
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction. 132
Synthesis of a small library of potential SGK1 inihibitors 132
Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study. 131
6-Substituted pyrazolo[3,4-d]pyrimidines: new promising compounds in the fight against Neuroblastoma 131
SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells 129
Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors. 127
Pyrazolo[3,4-d]pyrimidine active on neuroblastoma cells 126
Combining repositioning and de novo synthesis of pyrazolo[3,4-d]pyrimidines to discover potent SIRT-2 inhibitors 124
SI113, a specific inhibitor of the Sgk1 kinase activity that counteracts cancer cell proliferation 122
Novel dual Src/Abl inhibitors for hematologic and solid malignancies. 121
PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES AS SIRTUIN INHIBITORS: DESIGN, SYNTHESIS AND PRELIMINARY in vitro EVALUATION 120
SGK1 as a new target for anticancer agents: a hit-to-lead study 119
Pyrazolo[3,4-d]pyrimidines as tyrosine kinase inhibitors: synthesis and biological evaluation 119
Synthesis of pyrazolo[3,4-d]pyrimidine derivatives active in a preclinical glioblastoma model. 118
Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors 116
Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists. 115
Anti-Survival Effect of SI306 and Its Derivatives on Human Glioblastoma Cells 113
The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells 112
Hck inhibitors as potential therapeutic agents in cancer and HIV infection 111
A family of nitrogen-containing heterocycles as sirtuin inhibitors: synthesis and invitro biological evaluation 111
Selective chemical oxidation of risperidone: a straightforward and cost-effective synthesis of paliperidone 110
Optimization of Aminoimidazole Derivatives as Src Family Kinase Inhibitors 108
Identification of a new family of pyrimidine and pyridine derivatives as disruptors of the viral RNA-dependent RNA polymerase 108
Discovery of a Novel Chemo-Type for TAAR1 Agonism via Molecular Modeling 107
Virtual Screening Combined with Enzymatic Assays to Guide the Discovery of Novel SIRT2 Inhibitors 105
Synthesis of heterocyclic compounds to be tested as potentiators or correctors of mutant CFTR in cystic fibrosis 105
In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity 105
Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device 104
Synthesis of a new generation of pyrazolo[3,4-d]pyrimidine as SGK-1 inhibitors. 103
Synthesis of new pyrazolo[3,4-d]pyrimidines 6-alkyl substituted Bcr-Abl tyrosine kinase inhibitors 103
Formulation Of Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors For The Treatment Of Glioblastoma Multiforme 103
The SGK1 Kinase Inhibitor SI113 Sensitizes Theranostic Effects of the64CuCl2in Human Glioblastoma Multiforme Cells 102
Substituted pyrazolo[3,4-b]pyridines as human A(1) adenosine antagonists: Developments in understanding the receptor stereoselectivity 101
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors 101
Synthesis of a new generation of pyrazolo[3,4-d]pyrimidines as Fyn inhibitors 101
Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines 100
Identification and Biological Characterization of the Pyrazolo[3,4-d]pyrimidine Derivative SI388 Active as Src Inhibitor 98
One-pot synthesis of indolyl- pyrrolones as Pim1 inhibitors 95
Formulated pyrazolo[3,4-d]pyrimidines active on GBM cell lines 95
Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4-d]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme 93
Pyrazolo[3,4-d]pyrimidines as Sirtuin Inhibitors: A Preliminary Synthetic and Biological Study 92
Early investigation of a novel SI306 theranostic prodrug for glioblastoma treatment 92
Synthesis of pyrazolo[3,4-d]pyrimidine derivatives active against the T315I Abl mutation. 92
New Insights into the LANCL2-ABA Binding Mode towards the Evaluation of New LANCL Agonists 91
Synthesis of pyrazolo[3,4-d]pyrimidines active on Bcr-Abl T315I mutation. 89
Exploring a New Generation of Pyrimidine and Pyridine Derivatives as Anti-Influenza Agents Targeting the Polymerase PA–PB1 Subunits Interaction 87
The small molecule SI113 hinders epithelial-to-mesenchymal transition and subverts cytoskeletal organization in human cancer cells 86
Development of Pyrazolo[3,4- d]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme 84
Inhibition of serum- and glucocorticoid-induced kinase 1 ameliorates hydrocephalus in preclinical models 83
Insight into Fyn and SGK1 kinases as new targets in medicinal chemistry: design and synthesis of pyrazolo[3,4-d]pyrimidine libraries 83
Small Molecule Tyrosine Kinase Inhibitors (TKIs) for Glioblastoma Treatment 82
Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors 82
Sweet Cherry Extract as Permeation Enhancer of Tyrosine Kinase Inhibitors: A Promising Prospective for Future Oral Anticancer Therapies 79
Insights into RNA-dependent RNA Polymerase Inhibitors as Anti-influenza Virus Agents 78
Synthesis of a new series of optimized pyrazolo[3,4‑d]pyrimidines as Src Inhibitors 78
In silico exploration of LANCL2-ABA binding mode towards the identification of novel LANCL2 agonists 78
Synthetic Heterocyclic Derivatives as Kinase Inhibitors Tested for the Treatment of Neuroblastoma 75
Recent Advances in the Discovery of SIRT1/2 Inhibitors via Computational Methods: A Perspective 72
Novel pyrazolo[3,4-d]pyrimidines as dual Src/Bcr-Abl kinase inhibitors: Synthesis and biological evaluation for chronic myeloid leukemia treatment 68
Applying molecular hybridization to design a new class of pyrazolo[3,4-d] pyrimidines as Src inhibitors active in hepatocellular carcinoma 68
Alzheimer's Disease Etiology Hypotheses and Therapeutic Strategies: A Perspective 68
Synthesis of hybrid small molecules as potential PA-PB1 heterodimer disruptors of Influenza virus Polymerase 68
Development of a new potential theranostic prodrug for targeting glioblastoma multiforme 65
Synthesis of pyrazolo[3,4-d]pyrimidine derivatives endowed with activity against the T315I Abl mutation 64
New potential anti-flu agents acting by disrupting the PA-PB1 interaction of viral polymerase. 62
Design, synthesis, and biological evaluation of a new series of pyrazolo[3,4-d]pyrimidines active as SGK1 inhibitors. A lead optimization study. 60
Synthesis of a new generation of potential anti-influenza agents targeting the PA-PB1 protein-protein interaction. 59
Structure-Based Virtual Screening (SBVS) for the discovery of Sirtuin-2 inhibitors 58
Approaching Gallium-68 radiopharmaceuticals for tumor diagnosis: a Medicinal Chemist’s perspective 57
IN SILICO INVESTIGATION OF LANCL-2 ACTIVATION MECHANISM: THE CASE OF BT-11 (OMILANCOR). 56
Totale 11.465
Salva come PNG Salva come JPEG
Categoria #
all - tutte 37.241
article - articoli 25.634
book - libri 0
conference - conferenze 11.607
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 74.482
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021189 0 0 0 0 0 0 0 0 0 81 49 59
2021/2022891 16 38 77 104 18 76 37 214 75 62 40 134
2022/2023997 95 90 7 133 125 164 0 72 173 8 115 15
2023/2024657 19 76 17 94 45 52 34 25 38 43 66 148
2024/20251.957 48 122 89 101 272 214 196 318 64 137 154 242
2025/20263.675 401 94 369 214 598 356 630 299 318 396 0 0
Totale 11.798