IRIS
MUSUMECI, FRANCESCA MICHELA
 Distribuzione geografica
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Continente #
EU - Europa 8.909
AS - Asia 572
NA - Nord America 70
SA - Sud America 60
AF - Africa 8
Totale 9.619
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Nazione #
IT - Italia 8.886
SG - Singapore 241
CN - Cina 174
VN - Vietnam 125
US - Stati Uniti d'America 55
BR - Brasile 29
AR - Argentina 17
HK - Hong Kong 13
MX - Messico 10
GR - Grecia 6
BD - Bangladesh 5
FR - Francia 4
RU - Federazione Russa 4
CL - Cile 3
CO - Colombia 3
DE - Germania 3
IN - India 3
PA - Panama 3
AZ - Azerbaigian 2
BY - Bielorussia 2
DZ - Algeria 2
EG - Egitto 2
ID - Indonesia 2
PE - Perù 2
PY - Paraguay 2
SI - Slovenia 2
SN - Senegal 2
VE - Venezuela 2
BB - Barbados 1
CA - Canada 1
EC - Ecuador 1
ES - Italia 1
ET - Etiopia 1
IQ - Iraq 1
KG - Kirghizistan 1
MN - Mongolia 1
NE - Niger 1
SA - Arabia Saudita 1
TR - Turchia 1
TW - Taiwan 1
UA - Ucraina 1
UY - Uruguay 1
UZ - Uzbekistan 1
Totale 9.619
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Città #
Genova 4.326
Genoa 2.954
Rapallo 812
Vado Ligure 769
Singapore 94
Beijing 49
Ho Chi Minh City 45
Hanoi 36
Ashburn 22
Bordighera 14
Hong Kong 12
Los Angeles 9
Council Bluffs 8
Mexico City 8
Tianjin 7
Athens 6
Biên Hòa 5
Haiphong 5
Paris 4
Thái Bình 4
Da Nang 3
Panama City 3
Quảng Ngãi 3
Santiago 3
São Paulo 3
Baku 2
Bình Dương 2
Bắc Ninh 2
Carapicuíba 2
Dakar 2
Hangzhou 2
Hải Dương 2
Ljubljana 2
Milan 2
Phú Thọ 2
San Jose 2
Tukwila 2
Turin 2
Xiamen 2
Addis Ababa 1
Annaba 1
Anápolis 1
Apóstoles 1
Asunción 1
Baghdad 1
Belo Horizonte 1
Belén de Escobar 1
Blainville 1
Blida 1
Bogotá 1
Bom Jesus da Lapa 1
Brasília 1
Brescia 1
Brest 1
Bridgetown 1
Brooklyn 1
Buenos Aires 1
Cairo 1
Campinas 1
Can Tho 1
Cao Lanh 1
Caracas 1
Carúpano 1
Catanduva 1
Changsha 1
Chengdu 1
Chennai 1
Chongqing 1
Ciudad Evita 1
Colombo 1
Cubatão 1
Córdoba 1
Denver 1
Detroit 1
Dhaka 1
Don Torcuato 1
Draper 1
Frankfurt am Main 1
Freiburg im Breisgau 1
General Rodríguez 1
Gorno-Altaysk 1
Guarulhos 1
Hengshui 1
Hortolândia 1
Ibagué 1
Ismailia 1
Jacareí 1
Jakarta 1
Jequié 1
Juiz de Fora 1
Kunming 1
La Consulta 1
La Plata 1
Las Heras 1
Lima 1
Lima region 1
Limoeiro do Norte 1
Luoyang 1
Lấp Vò 1
Makkah 1
Totale 9.293
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Nome #
Analogs, formulations and derivatives of imatinib: A patent review 181
A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. 173
Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma. 167
ATP-competitive inhibitors of mTOR: an update. 166
Click Chemistry, A Potent Tool in Medicinal Sciences 164
A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant 162
Fyn kinase in brain diseases and cancer: the search for inhibitors. 162
Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma 160
Bcr-Abl tyrosine kinase inhibitors: A patent review 156
An update on dual Src/Abl inhibitors 152
Src kinase inhibitors: an update on patented compounds 138
The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme 136
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant. 133
Recent Studies on Ponatinib in Cancers Other Than Chronic Myeloid Leukemia 133
3-Cyano-4,6-diphenyl-pyridine amino acid derivatives active as influenza A polymerase inhibitors 132
A1 receptors ligands: past, present and future trends. 131
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 131
In silico identification and biological evaluation of novel selective serum/glucocorticoid-inducible kinase 1 inhibitors based on the pyrazolo-pyrimidine scaffold 128
Matrine in association with FD‑2 stimulates F508del‑cystic fibrosis transmembrane conductance regulator activity in the presence of corrector VX809 128
Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment 127
An Update on JAK Inhibitors 127
Biologically driven synthesis of pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors: an old scaffold as a new tool for medicinal chemistry and chemical biology studies 126
Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction 124
Water Solubility Enhancement of Pyrazolo[3,4-d]pyrimidine Derivatives via Miniaturized Polymer–Drug Microarrays 123
Pyrrolo[2,3-d]pyrimidines as kinase inhibitors 122
Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors. 121
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction. 120
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation. 120
Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study. 119
SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells 119
6-Substituted pyrazolo[3,4-d]pyrimidines: new promising compounds in the fight against Neuroblastoma 116
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells 116
Novel dual Src/Abl inhibitors for hematologic and solid malignancies. 115
Prodrugs of Pyrazolo[3,4-d]pyrimidines: From Library Synthesis to Evaluation as Potential Anticancer Agents in an Orthotopic Glioblastoma Model 115
SI113, a specific inhibitor of the Sgk1 kinase activity that counteracts cancer cell proliferation 109
Exploring SAR of a new generation of pyrazolo[3,4-d]pyrimidines as Fyn tyrosine kinase inhibitors 107
Synthesis of a small library of potential SGK1 inihibitors 106
Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists. 103
SGK1 as a new target for anticancer agents: a hit-to-lead study 103
Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors 102
Synthesis of pyrazolo[3,4-d]pyrimidine derivatives active in a preclinical glioblastoma model. 101
Pyrazolo[3,4-d]pyrimidine active on neuroblastoma cells 101
Combining repositioning and de novo synthesis of pyrazolo[3,4-d]pyrimidines to discover potent SIRT-2 inhibitors 100
Selective chemical oxidation of risperidone: a straightforward and cost-effective synthesis of paliperidone 100
Hck inhibitors as potential therapeutic agents in cancer and HIV infection 99
The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells 99
A family of nitrogen-containing heterocycles as sirtuin inhibitors: synthesis and invitro biological evaluation 95
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors 94
Synthesis of heterocyclic compounds to be tested as potentiators or correctors of mutant CFTR in cystic fibrosis 94
PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES AS SIRTUIN INHIBITORS: DESIGN, SYNTHESIS AND PRELIMINARY in vitro EVALUATION 93
Substituted pyrazolo[3,4-b]pyridines as human A(1) adenosine antagonists: Developments in understanding the receptor stereoselectivity 92
Synthesis of a new generation of pyrazolo[3,4-d]pyrimidines as Fyn inhibitors 92
Synthesis of new pyrazolo[3,4-d]pyrimidines 6-alkyl substituted Bcr-Abl tyrosine kinase inhibitors 92
Optimization of Aminoimidazole Derivatives as Src Family Kinase Inhibitors 91
Pyrazolo[3,4-d]pyrimidines as tyrosine kinase inhibitors: synthesis and biological evaluation 91
Formulation Of Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors For The Treatment Of Glioblastoma Multiforme 91
Discovery of a Novel Chemo-Type for TAAR1 Agonism via Molecular Modeling 90
Synthesis of a new generation of pyrazolo[3,4-d]pyrimidine as SGK-1 inhibitors. 90
Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines 90
Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device 89
Anti-Survival Effect of SI306 and Its Derivatives on Human Glioblastoma Cells 88
Identification of a new family of pyrimidine and pyridine derivatives as disruptors of the viral RNA-dependent RNA polymerase 86
In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity 85
Synthesis of pyrazolo[3,4-d]pyrimidine derivatives active against the T315I Abl mutation. 84
Identification and Biological Characterization of the Pyrazolo[3,4-d]pyrimidine Derivative SI388 Active as Src Inhibitor 83
Formulated pyrazolo[3,4-d]pyrimidines active on GBM cell lines 83
Synthesis of pyrazolo[3,4-d]pyrimidines active on Bcr-Abl T315I mutation. 81
The SGK1 Kinase Inhibitor SI113 Sensitizes Theranostic Effects of the64CuCl2in Human Glioblastoma Multiforme Cells 81
One-pot synthesis of indolyl- pyrrolones as Pim1 inhibitors 80
Early investigation of a novel SI306 theranostic prodrug for glioblastoma treatment 77
The small molecule SI113 hinders epithelial-to-mesenchymal transition and subverts cytoskeletal organization in human cancer cells 76
Virtual Screening Combined with Enzymatic Assays to Guide the Discovery of Novel SIRT2 Inhibitors 75
Inhibition of serum- and glucocorticoid-induced kinase 1 ameliorates hydrocephalus in preclinical models 74
New Insights into the LANCL2-ABA Binding Mode towards the Evaluation of New LANCL Agonists 72
Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors 71
Insight into Fyn and SGK1 kinases as new targets in medicinal chemistry: design and synthesis of pyrazolo[3,4-d]pyrimidine libraries 67
Synthesis of a new series of optimized pyrazolo[3,4‑d]pyrimidines as Src Inhibitors 67
Small Molecule Tyrosine Kinase Inhibitors (TKIs) for Glioblastoma Treatment 66
Development of Pyrazolo[3,4- d]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme 66
Insights into RNA-dependent RNA Polymerase Inhibitors as Anti-influenza Virus Agents 65
Sweet Cherry Extract as Permeation Enhancer of Tyrosine Kinase Inhibitors: A Promising Prospective for Future Oral Anticancer Therapies 61
Pyrazolo[3,4-d]pyrimidines as Sirtuin Inhibitors: A Preliminary Synthetic and Biological Study 61
Novel pyrazolo[3,4-d]pyrimidines as dual Src/Bcr-Abl kinase inhibitors: Synthesis and biological evaluation for chronic myeloid leukemia treatment 60
In silico exploration of LANCL2-ABA binding mode towards the identification of novel LANCL2 agonists 59
Synthesis of pyrazolo[3,4-d]pyrimidine derivatives endowed with activity against the T315I Abl mutation 58
Synthetic Heterocyclic Derivatives as Kinase Inhibitors Tested for the Treatment of Neuroblastoma 58
Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4-d]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme 57
Exploring a New Generation of Pyrimidine and Pyridine Derivatives as Anti-Influenza Agents Targeting the Polymerase PA–PB1 Subunits Interaction 57
Development of a new potential theranostic prodrug for targeting glioblastoma multiforme 55
Synthesis of hybrid small molecules as potential PA-PB1 heterodimer disruptors of Influenza virus Polymerase 55
SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW 4-AMINO-PYRAZOLO[3,4-d]PYRIMIDINES AS POTENTIAL SRC KINASE INHIBITORS 53
Design, synthesis, and biological evaluation of a new series of pyrazolo[3,4-d]pyrimidines active as SGK1 inhibitors. A lead optimization study. 51
Applying molecular hybridization to design a new class of pyrazolo[3,4-d] pyrimidines as Src inhibitors active in hepatocellular carcinoma 50
New potential anti-flu agents acting by disrupting the PA-PB1 interaction of viral polymerase. 49
Synthesis of a new generation of potential anti-influenza agents targeting the PA-PB1 protein-protein interaction. 48
Recent Advances in the Discovery of SIRT1/2 Inhibitors via Computational Methods: A Perspective 46
Structure-Based Virtual Screening (SBVS) for the discovery of Sirtuin-2 inhibitors 44
IN SILICO INVESTIGATION OF LANCL-2 ACTIVATION MECHANISM: THE CASE OF BT-11 (OMILANCOR). 41
Alzheimer's Disease Etiology Hypotheses and Therapeutic Strategies: A Perspective 36
Design and synthesis of a new series of pyrazolo[3,4- d]pyrimidines active as SGK1 inhibitors in ovarian cancer cell models 31
Totale 9.714
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Categoria #
all - tutte 34.416
article - articoli 23.982
book - libri 0
conference - conferenze 10.434
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 68.832
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021490 0 0 0 0 0 71 115 56 59 81 49 59
2021/2022891 16 38 77 104 18 76 37 214 75 62 40 134
2022/2023997 95 90 7 133 125 164 0 72 173 8 115 15
2023/2024657 19 76 17 94 45 52 34 25 38 43 66 148
2024/20251.957 48 122 89 101 272 214 196 318 64 137 154 242
2025/20261.760 401 94 369 214 598 84 0 0 0 0 0 0
Totale 9.883