We report a case of hepatosplenic candidiasis (HSC) in a neutropenic child with ovarian teratoma. Using high-frequency ultrasonography, we detected subtle hypoechoic pseudonodules in the spleen during profound neutropenia (ANC 30/mu L), challenging the dogma that lesions only appear after immune recovery. These precursors evolved into classic "bull's-eye" lesions. Candida tropicalis was confirmed via splenectomy. This case highlights high-frequency ultrasound's role in early HSC diagnosis before neutrophil recovery.
Redefining Ultrasound's role in early diagnosis of hepatosplenic candidiasis during neutropenia: A pediatric case report in solid tumor
Cappozzo F.;Nebiolo M.;Livellara V.;Damasio M. B.;Anfigeno L.;De Luca C.;Avanzini S.;Palo F.;Conte M.;Castagnola E.
2026-01-01
Abstract
We report a case of hepatosplenic candidiasis (HSC) in a neutropenic child with ovarian teratoma. Using high-frequency ultrasonography, we detected subtle hypoechoic pseudonodules in the spleen during profound neutropenia (ANC 30/mu L), challenging the dogma that lesions only appear after immune recovery. These precursors evolved into classic "bull's-eye" lesions. Candida tropicalis was confirmed via splenectomy. This case highlights high-frequency ultrasound's role in early HSC diagnosis before neutrophil recovery.
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