Burden of human rabies disease: its potential prevention by means of Rabipur® vaccine

Rabies is a zoonotic viral disease transmitted mainly by bites of purified cell-culture and embryonated egg-based vaccines of infected animals, especially dogs, which are responsible for (CCEEVs). 99% of human cases. Despite being preventable, it remains a Rabipur® is one of the available anti-rabies vaccines and is neglected disease in low-income countries, with approximately indicated for active immunization in individuals of all ages. Its 60,000 deaths per year, mostly concentrated in Africa and efficacy and safety have been amply demonstrated. Asia. The real worldwide burden of rabies is probably In rabies-free countries, PrEP is indicated for individuals who underestimated, as death-reporting systems are inadequate and face occupational and/or travel-related exposure to the rabies active surveillance is limited. virus in specific settings or over an extended period. Rabies prevention implies two main, non-exclusive strategies: Wider use of human rabies vaccination for PrEP and PEP in (i) dog vaccination, in order to interrupt virus transmission to conjunction with programs to eradicate rabies from animal humans, and (ii) human vaccination i.e. pre-exposure prophylaxis populations is the challenging goal in order to reduce the burden (PrEP) and Post-Esposure Prophylaxis (PEP) through the use of disease and achieve zero rabies.