Assessing the chemical cross-reaction from cefixime and some non-steroidal anti-inflammatory agents in a soluble formulation

The presence of chemical cross-reactivity betwen drugs may be an underestimated factor, responsible for decreased bio-availability of a drug active component(s); the absence of chemical cross-reactivity between drugs is undoubtedly the prerequisite for their simultaneous co-administration. Here, by means of thin layer chromatography, we show that cefixime, a third generation oral cephalosporin, does not display chemical reactivity versus a series of non-steroidal antiinflammatory agents. The four compounds tested can therefore be safely soluted together with the cephalosporin.